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Protein

C-C motif chemokine 2

Gene

CCL2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Chemotactic factor that attracts monocytes, but not neutrophils.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

ReactomeiR-BTA-380108. Chemokine receptors bind chemokines.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 2
Alternative name(s):
Acidic seminal fluid protein
Monocyte chemotactic protein 1A
Short name:
MCP-1
Short name:
MCP-1A
Small-inducible cytokine A2
Gene namesi
Name:CCL2
Synonyms:SCYA2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 9976C-C motif chemokine 2PRO_0000005244Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241Pyrrolidone carboxylic acidBy similarity
Disulfide bondi34 ↔ 59By similarity
Disulfide bondi35 ↔ 75By similarity

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP28291.
PRIDEiP28291.

Expressioni

Gene expression databases

BgeeiENSBTAG00000037811.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013146.

Structurei

3D structure databases

ProteinModelPortaliP28291.
SMRiP28291. Positions 24-98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1ST. Eukaryota.
ENOG410YXJU. LUCA.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiP28291.
KOiK14624.
OMAiNKEICAD.
OrthoDBiEOG091G14KV.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28291-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVSAALLCL LLTVAAFSTE VLAQPDAINS QVACCYTFNS KKISMQRLMN
60 70 80 90
YRRVTSSKCP KEAVIFKTIL GKELCADPKQ KWVQDSINYL NKKNQTPKP
Length:99
Mass (Da):11,114
Last modified:December 1, 1992 - v1
Checksum:i0FD79FC1AB0CBE88
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84602 mRNA. Translation: AAA30651.1.
L32659 Genomic DNA. Translation: AAA60956.1.
EU276059 mRNA. Translation: ABX72057.1.
PIRiA39296.
RefSeqiNP_776431.1. NM_174006.2.
UniGeneiBt.2408.

Genome annotation databases

EnsembliENSBTAT00000013146; ENSBTAP00000013146; ENSBTAG00000037811.
GeneIDi281043.
KEGGibta:281043.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84602 mRNA. Translation: AAA30651.1.
L32659 Genomic DNA. Translation: AAA60956.1.
EU276059 mRNA. Translation: ABX72057.1.
PIRiA39296.
RefSeqiNP_776431.1. NM_174006.2.
UniGeneiBt.2408.

3D structure databases

ProteinModelPortaliP28291.
SMRiP28291. Positions 24-98.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013146.

Proteomic databases

PaxDbiP28291.
PRIDEiP28291.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000013146; ENSBTAP00000013146; ENSBTAG00000037811.
GeneIDi281043.
KEGGibta:281043.

Organism-specific databases

CTDi6347.

Phylogenomic databases

eggNOGiENOG410J1ST. Eukaryota.
ENOG410YXJU. LUCA.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiP28291.
KOiK14624.
OMAiNKEICAD.
OrthoDBiEOG091G14KV.
TreeFamiTF334888.

Enzyme and pathway databases

ReactomeiR-BTA-380108. Chemokine receptors bind chemokines.

Gene expression databases

BgeeiENSBTAG00000037811.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCL2_BOVIN
AccessioniPrimary (citable) accession number: P28291
Secondary accession number(s): A9QWP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: September 7, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.