Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P28291

- CCL2_BOVIN

UniProt

P28291 - CCL2_BOVIN

Protein

C-C motif chemokine 2

Gene

CCL2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
  1. Functioni

    Chemotactic factor that attracts monocytes, but not neutrophils.

    GO - Biological processi

    1. astrocyte cell migration Source: Ensembl
    2. cellular response to fibroblast growth factor stimulus Source: Ensembl
    3. cellular response to interferon-gamma Source: Ensembl
    4. cellular response to interleukin-1 Source: Ensembl
    5. cellular response to organic cyclic compound Source: Ensembl
    6. cellular response to tumor necrosis factor Source: Ensembl
    7. cytokine-mediated signaling pathway Source: Ensembl
    8. cytoskeleton organization Source: Ensembl
    9. helper T cell extravasation Source: Ensembl
    10. inflammatory response Source: Ensembl
    11. lipopolysaccharide-mediated signaling pathway Source: Ensembl
    12. macrophage chemotaxis Source: Ensembl
    13. MAPK cascade Source: Ensembl
    14. monocyte chemotaxis Source: Ensembl
    15. negative regulation of angiogenesis Source: Ensembl
    16. negative regulation of glial cell apoptotic process Source: Ensembl
    17. negative regulation of natural killer cell chemotaxis Source: Ensembl
    18. negative regulation of neuron apoptotic process Source: Ensembl
    19. positive regulation of apoptotic cell clearance Source: Ensembl
    20. positive regulation of immune complex clearance by monocytes and macrophages Source: Ensembl
    21. positive regulation of macrophage chemotaxis Source: Ensembl
    22. positive regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
    23. positive regulation of T cell activation Source: Ensembl
    24. protein kinase B signaling Source: Ensembl
    25. regulation of cell shape Source: Ensembl
    26. regulation of vascular endothelial growth factor production Source: Ensembl

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis

    Enzyme and pathway databases

    ReactomeiREACT_204438. ATF4 activates genes.
    REACT_212617. Chemokine receptors bind chemokines.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 2
    Alternative name(s):
    Acidic seminal fluid protein
    Monocyte chemotactic protein 1A
    Short name:
    MCP-1
    Short name:
    MCP-1A
    Small-inducible cytokine A2
    Gene namesi
    Name:CCL2
    Synonyms:SCYA2
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 19

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323By similarityAdd
    BLAST
    Chaini24 – 9976C-C motif chemokine 2PRO_0000005244Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei24 – 241Pyrrolidone carboxylic acidBy similarity
    Disulfide bondi34 ↔ 59By similarity
    Disulfide bondi35 ↔ 75By similarity

    Keywords - PTMi

    Disulfide bond, Pyrrolidone carboxylic acid

    Proteomic databases

    PRIDEiP28291.

    Structurei

    3D structure databases

    ProteinModelPortaliP28291.
    SMRiP28291. Positions 24-98.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG46819.
    GeneTreeiENSGT00730000110714.
    HOGENOMiHOG000036686.
    HOVERGENiHBG017871.
    InParanoidiP28291.
    KOiK14624.
    OMAiNKEICAD.
    OrthoDBiEOG7C5MC2.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P28291-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVSAALLCL LLTVAAFSTE VLAQPDAINS QVACCYTFNS KKISMQRLMN   50
    YRRVTSSKCP KEAVIFKTIL GKELCADPKQ KWVQDSINYL NKKNQTPKP 99
    Length:99
    Mass (Da):11,114
    Last modified:December 1, 1992 - v1
    Checksum:i0FD79FC1AB0CBE88
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M84602 mRNA. Translation: AAA30651.1.
    L32659 Genomic DNA. Translation: AAA60956.1.
    EU276059 mRNA. Translation: ABX72057.1.
    PIRiA39296.
    RefSeqiNP_776431.1. NM_174006.2.
    UniGeneiBt.2408.

    Genome annotation databases

    EnsembliENSBTAT00000013146; ENSBTAP00000013146; ENSBTAG00000037811.
    GeneIDi281043.
    KEGGibta:281043.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M84602 mRNA. Translation: AAA30651.1 .
    L32659 Genomic DNA. Translation: AAA60956.1 .
    EU276059 mRNA. Translation: ABX72057.1 .
    PIRi A39296.
    RefSeqi NP_776431.1. NM_174006.2.
    UniGenei Bt.2408.

    3D structure databases

    ProteinModelPortali P28291.
    SMRi P28291. Positions 24-98.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P28291.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000013146 ; ENSBTAP00000013146 ; ENSBTAG00000037811 .
    GeneIDi 281043.
    KEGGi bta:281043.

    Organism-specific databases

    CTDi 6347.

    Phylogenomic databases

    eggNOGi NOG46819.
    GeneTreei ENSGT00730000110714.
    HOGENOMi HOG000036686.
    HOVERGENi HBG017871.
    InParanoidi P28291.
    KOi K14624.
    OMAi NKEICAD.
    OrthoDBi EOG7C5MC2.
    TreeFami TF334888.

    Enzyme and pathway databases

    Reactomei REACT_204438. ATF4 activates genes.
    REACT_212617. Chemokine receptors bind chemokines.

    Miscellaneous databases

    NextBioi 20805129.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Gene expression and cDNA cloning identified a major basic protein constituent of bovine seminal plasma as bovine monocyte-chemoattractant protein-1 (MCP-1)."
      Wempe F., Henschen A., Scheit K.H.
      DNA Cell Biol. 10:671-679(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Seminal plasma.
    2. "Characterization by cDNA cloning of the mRNA of a new growth factor from bovine seminal plasma: acidic seminal fluid protein."
      Wempe F., Einspanier R., Scheit K.H.
      Biochem. Biophys. Res. Commun. 183:232-237(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Seminal plasma.
    3. "Characterization of the bovine monocyte chemoattractant protein-1 gene."
      Wempe F., Kuhlmann J.K., Scheit K.H.
      Biochem. Biophys. Res. Commun. 202:1272-1279(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "U.S. veterinary immune reagent network: expressed bovine gene sequences."
      U.S. Veterinary Immune Reagent Network
      Hudgens T., Tompkins D., Baldwin C.L.
      Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Belted Galloway.
      Tissue: Peripheral blood.

    Entry informationi

    Entry nameiCCL2_BOVIN
    AccessioniPrimary (citable) accession number: P28291
    Secondary accession number(s): A9QWP7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: December 1, 1992
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3