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P28291

- CCL2_BOVIN

UniProt

P28291 - CCL2_BOVIN

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Protein
C-C motif chemokine 2
Gene
CCL2, SCYA2
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

Chemotactic factor that attracts monocytes, but not neutrophils.

GO - Biological processi

  1. MAPK cascade Source: Ensembl
  2. astrocyte cell migration Source: Ensembl
  3. cellular response to fibroblast growth factor stimulus Source: Ensembl
  4. cellular response to interferon-gamma Source: Ensembl
  5. cellular response to interleukin-1 Source: Ensembl
  6. cellular response to organic cyclic compound Source: Ensembl
  7. cellular response to tumor necrosis factor Source: Ensembl
  8. cytokine-mediated signaling pathway Source: Ensembl
  9. cytoskeleton organization Source: Ensembl
  10. helper T cell extravasation Source: Ensembl
  11. inflammatory response Source: Ensembl
  12. lipopolysaccharide-mediated signaling pathway Source: Ensembl
  13. macrophage chemotaxis Source: Ensembl
  14. monocyte chemotaxis Source: Ensembl
  15. negative regulation of angiogenesis Source: Ensembl
  16. negative regulation of glial cell apoptotic process Source: Ensembl
  17. negative regulation of natural killer cell chemotaxis Source: Ensembl
  18. negative regulation of neuron apoptotic process Source: Ensembl
  19. positive regulation of T cell activation Source: Ensembl
  20. positive regulation of apoptotic cell clearance Source: Ensembl
  21. positive regulation of immune complex clearance by monocytes and macrophages Source: Ensembl
  22. positive regulation of macrophage chemotaxis Source: Ensembl
  23. positive regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
  24. protein kinase B signaling Source: Ensembl
  25. regulation of cell shape Source: Ensembl
  26. regulation of vascular endothelial growth factor production Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

ReactomeiREACT_204438. ATF4 activates genes.
REACT_212617. Chemokine receptors bind chemokines.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 2
Alternative name(s):
Acidic seminal fluid protein
Monocyte chemotactic protein 1A
Short name:
MCP-1
Short name:
MCP-1A
Small-inducible cytokine A2
Gene namesi
Name:CCL2
Synonyms:SCYA2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 19

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 By similarity
Add
BLAST
Chaini24 – 9976C-C motif chemokine 2
PRO_0000005244Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241Pyrrolidone carboxylic acid By similarity
Disulfide bondi34 ↔ 59 By similarity
Disulfide bondi35 ↔ 75 By similarity

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PRIDEiP28291.

Structurei

3D structure databases

ProteinModelPortaliP28291.
SMRiP28291. Positions 24-98.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46819.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiP28291.
KOiK14624.
OMAiNKEICAD.
OrthoDBiEOG7C5MC2.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28291-1 [UniParc]FASTAAdd to Basket

« Hide

MKVSAALLCL LLTVAAFSTE VLAQPDAINS QVACCYTFNS KKISMQRLMN   50
YRRVTSSKCP KEAVIFKTIL GKELCADPKQ KWVQDSINYL NKKNQTPKP 99
Length:99
Mass (Da):11,114
Last modified:December 1, 1992 - v1
Checksum:i0FD79FC1AB0CBE88
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M84602 mRNA. Translation: AAA30651.1.
L32659 Genomic DNA. Translation: AAA60956.1.
EU276059 mRNA. Translation: ABX72057.1.
PIRiA39296.
RefSeqiNP_776431.1. NM_174006.2.
UniGeneiBt.2408.

Genome annotation databases

EnsembliENSBTAT00000013146; ENSBTAP00000013146; ENSBTAG00000037811.
GeneIDi281043.
KEGGibta:281043.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M84602 mRNA. Translation: AAA30651.1 .
L32659 Genomic DNA. Translation: AAA60956.1 .
EU276059 mRNA. Translation: ABX72057.1 .
PIRi A39296.
RefSeqi NP_776431.1. NM_174006.2.
UniGenei Bt.2408.

3D structure databases

ProteinModelPortali P28291.
SMRi P28291. Positions 24-98.
ModBasei Search...

Proteomic databases

PRIDEi P28291.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000013146 ; ENSBTAP00000013146 ; ENSBTAG00000037811 .
GeneIDi 281043.
KEGGi bta:281043.

Organism-specific databases

CTDi 6347.

Phylogenomic databases

eggNOGi NOG46819.
GeneTreei ENSGT00730000110714.
HOGENOMi HOG000036686.
HOVERGENi HBG017871.
InParanoidi P28291.
KOi K14624.
OMAi NKEICAD.
OrthoDBi EOG7C5MC2.
TreeFami TF334888.

Enzyme and pathway databases

Reactomei REACT_204438. ATF4 activates genes.
REACT_212617. Chemokine receptors bind chemokines.

Miscellaneous databases

NextBioi 20805129.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Gene expression and cDNA cloning identified a major basic protein constituent of bovine seminal plasma as bovine monocyte-chemoattractant protein-1 (MCP-1)."
    Wempe F., Henschen A., Scheit K.H.
    DNA Cell Biol. 10:671-679(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Seminal plasma.
  2. "Characterization by cDNA cloning of the mRNA of a new growth factor from bovine seminal plasma: acidic seminal fluid protein."
    Wempe F., Einspanier R., Scheit K.H.
    Biochem. Biophys. Res. Commun. 183:232-237(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Seminal plasma.
  3. "Characterization of the bovine monocyte chemoattractant protein-1 gene."
    Wempe F., Kuhlmann J.K., Scheit K.H.
    Biochem. Biophys. Res. Commun. 202:1272-1279(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "U.S. veterinary immune reagent network: expressed bovine gene sequences."
    U.S. Veterinary Immune Reagent Network
    Hudgens T., Tompkins D., Baldwin C.L.
    Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Belted Galloway.
    Tissue: Peripheral blood.

Entry informationi

Entry nameiCCL2_BOVIN
AccessioniPrimary (citable) accession number: P28291
Secondary accession number(s): A9QWP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: September 3, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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