P28291 (CCL2_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C-C motif chemokine 2

Alternative name(s):
Acidic seminal fluid protein
Monocyte chemotactic protein 1A
Short name=MCP-1
Short name=MCP-1A
Small-inducible cytokine A2

Gene names

Name:	CCL2
Synonyms:	SCYA2

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	99 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Chemotactic factor that attracts monocytes, but not neutrophils.
Sequence similarities	Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
Biological process	Chemotaxis
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond Pyrrolidone carboxylic acid
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	MAPK cascade Inferred from electronic annotation. Source: Compara astrocyte cell migration Inferred from electronic annotation. Source: Compara cellular response to fibroblast growth factor stimulus Inferred from electronic annotation. Source: Compara cellular response to interferon-gamma Inferred from electronic annotation. Source: Compara cellular response to interleukin-1 Inferred from electronic annotation. Source: Compara cellular response to organic cyclic compound Inferred from electronic annotation. Source: Compara cellular response to tumor necrosis factor Inferred from electronic annotation. Source: Compara cytokine-mediated signaling pathway Inferred from electronic annotation. Source: Compara cytoskeleton organization Inferred from electronic annotation. Source: Compara helper T cell extravasation Inferred from electronic annotation. Source: Compara inflammatory response Inferred from electronic annotation. Source: Compara lipopolysaccharide-mediated signaling pathway Inferred from electronic annotation. Source: Compara macrophage chemotaxis Inferred from electronic annotation. Source: Compara monocyte chemotaxis Inferred from electronic annotation. Source: Compara negative regulation of angiogenesis Inferred from electronic annotation. Source: Compara negative regulation of apoptotic process Inferred from electronic annotation. Source: Compara negative regulation of natural killer cell chemotaxis Inferred from electronic annotation. Source: Compara positive regulation of T cell activation Inferred from electronic annotation. Source: Compara positive regulation of apoptotic cell clearance Inferred from electronic annotation. Source: Compara positive regulation of immune complex clearance by monocytes and macrophages Inferred from electronic annotation. Source: Compara positive regulation of macrophage chemotaxis Inferred from electronic annotation. Source: Compara positive regulation of nitric-oxide synthase biosynthetic process Inferred from electronic annotation. Source: Compara protein kinase B signaling cascade Inferred from electronic annotation. Source: Compara regulation of cell shape Inferred from electronic annotation. Source: Compara regulation of vascular endothelial growth factor production Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	By similarity
	Chain	24 – 99	76	C-C motif chemokine 2		PRO_0000005244
Amino acid modifications
	Modified residue	24	1	Pyrrolidone carboxylic acid By similarity
	Disulfide bond	34 ↔ 59		By similarity
	Disulfide bond	35 ↔ 75		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P28291 [UniParc]. Last modified December 1, 1992. Version 1. Checksum: 0FD79FC1AB0CBE88	FASTA	99	11,114
	10 20 30 40 50 60 MKVSAALLCL LLTVAAFSTE VLAQPDAINS QVACCYTFNS KKISMQRLMN YRRVTSSKCP 70 80 90 KEAVIFKTIL GKELCADPKQ KWVQDSINYL NKKNQTPKP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Gene expression and cDNA cloning identified a major basic protein constituent of bovine seminal plasma as bovine monocyte-chemoattractant protein-1 (MCP-1)." Wempe F., Henschen A., Scheit K.H. DNA Cell Biol. 10:671-679(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Seminal plasma.
[2]	"Characterization by cDNA cloning of the mRNA of a new growth factor from bovine seminal plasma: acidic seminal fluid protein." Wempe F., Einspanier R., Scheit K.H. Biochem. Biophys. Res. Commun. 183:232-237(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Seminal plasma.
[3]	"Characterization of the bovine monocyte chemoattractant protein-1 gene." Wempe F., Kuhlmann J.K., Scheit K.H. Biochem. Biophys. Res. Commun. 202:1272-1279(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"U.S. veterinary immune reagent network: expressed bovine gene sequences." U.S. Veterinary Immune Reagent Network Hudgens T., Tompkins D., Baldwin C.L. Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Belted Galloway. Tissue: Peripheral blood.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M84602 mRNA. Translation: AAA30651.1. L32659 Genomic DNA. Translation: AAA60956.1. EU276059 mRNA. Translation: ABX72057.1.
IPI	IPI00690357.
PIR	A39296.
RefSeq	NP_776431.1. NM_174006.2.
UniGene	Bt.2408.
3D structure databases
ProteinModelPortal	P28291.
SMR	P28291. Positions 24-98.
ModBase	Search...
Proteomic databases
PRIDE	P28291.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000013146; ENSBTAP00000013146; ENSBTAG00000037811.
GeneID	281043.
KEGG	bta:281043.
Organism-specific databases
CTD	6347.
Phylogenomic databases
eggNOG	NOG46819.
GeneTree	ENSGT00560000076972.
HOGENOM	HOG000036686.
HOVERGEN	HBG017871.
InParanoid	P28291.
KO	K14624.
OMA	MSYRRVT.
OrthoDB	EOG45DWR1.
Family and domain databases
InterPro	IPR000827. Chemokine_CC_CS. IPR001811. Chemokine_IL8-like_dom. [Graphical view]
Pfam	PF00048. IL8. 1 hit. [Graphical view]
SMART	SM00199. SCY. 1 hit. [Graphical view]
SUPFAM	SSF54117. Chemokine_IL8. 1 hit.
PROSITE	PS00472. SMALL_CYTOKINES_CC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20805129.

Entry information

Entry name

CCL2_BOVIN

Accession

Primary (citable) accession number: P28291
Secondary accession number(s): A9QWP7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	December 1, 1992
Last modified:	April 3, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program