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Protein

Tropomodulin-1

Gene

TMOD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus.1 Publication

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • actin filament binding Source: InterPro
  • tropomyosin binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

ReactomeiR-HSA-390522. Striated Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Tropomodulin-1
Alternative name(s):
Erythrocyte tropomodulin
Short name:
E-Tmod
Gene namesi
Name:TMOD1
Synonyms:D9S57E, TMOD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:11871. TMOD1.

Subcellular locationi

GO - Cellular componenti

  • actin filament Source: UniProtKB
  • cortical cytoskeleton Source: Ensembl
  • cytosol Source: Reactome
  • membrane Source: Ensembl
  • myofibril Source: UniProtKB
  • sarcomere Source: UniProtKB
  • striated muscle thin filament Source: UniProtKB

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi7111.
OpenTargetsiENSG00000136842.
PharmGKBiPA36572.

Polymorphism and mutation databases

BioMutaiTMOD1.
DMDMi135922.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001861281 – 359Tropomodulin-1Add BLAST359

Proteomic databases

EPDiP28289.
MaxQBiP28289.
PaxDbiP28289.
PeptideAtlasiP28289.
PRIDEiP28289.

PTM databases

iPTMnetiP28289.
PhosphoSitePlusiP28289.

Expressioni

Tissue specificityi

Highly expressed in the erythrocyte, heart and skeletal muscle.

Gene expression databases

BgeeiENSG00000136842.
CleanExiHS_TMOD1.
GenevisibleiP28289. HS.

Organism-specific databases

HPAiHPA051202.

Interactioni

Subunit structurei

Binds to the N-terminus of isoforms 2/3 of TPM3 and to actin.

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • actin filament binding Source: InterPro
  • tropomyosin binding Source: GO_Central

Protein-protein interaction databases

BioGridi112966. 53 interactors.
IntActiP28289. 46 interactors.
STRINGi9606.ENSP00000259365.

Structurei

Secondary structure

1359
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi64 – 76Combined sources13
Helixi180 – 191Combined sources12
Beta strandi199 – 201Combined sources3
Helixi210 – 220Combined sources11
Beta strandi228 – 230Combined sources3
Helixi238 – 248Combined sources11
Beta strandi256 – 258Combined sources3
Helixi266 – 274Combined sources9
Helixi275 – 278Combined sources4
Beta strandi284 – 286Combined sources3
Helixi296 – 306Combined sources11
Beta strandi314 – 316Combined sources3
Helixi322 – 345Combined sources24
Turni346 – 348Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4PKGX-ray1.80G50-101[»]
4PKHX-ray2.15B/E/G/J50-101[»]
4PKIX-ray2.30G160-349[»]
4Z8GX-ray2.10A163-228[»]
4Z94X-ray2.40G160-228[»]
ProteinModelPortaliP28289.
SMRiP28289.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni39 – 138Tropomyosin-bindingSequence analysisAdd BLAST100

Sequence similaritiesi

Belongs to the tropomodulin family.Curated

Phylogenomic databases

eggNOGiKOG3735. Eukaryota.
ENOG410YAHM. LUCA.
GeneTreeiENSGT00760000119226.
HOGENOMiHOG000261624.
HOVERGENiHBG056172.
InParanoidiP28289.
KOiK10370.
OMAiSTIVNKQ.
OrthoDBiEOG091G0C3H.
PhylomeDBiP28289.
TreeFamiTF315841.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiView protein in InterPro
IPR032675. L_dom-like.
IPR004934. TMOD.
IPR030135. TMOD1.
PANTHERiPTHR10901. PTHR10901. 1 hit.
PTHR10901:SF24. PTHR10901:SF24. 1 hit.
PfamiView protein in Pfam
PF03250. Tropomodulin. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P28289-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSYRRELEKY RDLDEDEILG ALTEEELRTL ENELDELDPD NALLPAGLRQ
60 70 80 90 100
KDQTTKAPTG PFKREELLDH LEKQAKEFKD REDLVPYTGE KRGKVWVPKQ
110 120 130 140 150
KPLDPVLESV TLEPELEEAL ANASDAELCD IAAILGMHTL MSNQQYYQAL
160 170 180 190 200
SSSSIMNKEG LNSVIKPTQY KPVPDEEPNS TDVEETLERI KNNDPKLEEV
210 220 230 240 250
NLNNIRNIPI PTLKAYAEAL KENSYVKKFS IVGTRSNDPV AYALAEMLKE
260 270 280 290 300
NKVLKTLNVE SNFISGAGIL RLVEALPYNT SLVEMKIDNQ SQPLGNKVEM
310 320 330 340 350
EIVSMLEKNA TLLKFGYHFT QQGPRLRASN AMMNNNDLVR KRRLADLTGP

IIPKCRSGV
Length:359
Mass (Da):40,569
Last modified:December 1, 1992 - v1
Checksum:i732B7D7798B88A48
GO
Isoform 2 (identifier: P28289-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MSYRRE → MSQVLS
     7-133: Missing.

Note: No experimental confirmation available.
Show »
Length:232
Mass (Da):26,014
Checksum:i80DEC95EB154DF1F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17E → K in AAH02660 (PubMed:15489334).Curated1
Sequence conflicti76K → E in BAG37124 (PubMed:14702039).Curated1
Sequence conflicti289N → S in BAG37124 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0568631 – 6MSYRRE → MSQVLS in isoform 2. 1 Publication6
Alternative sequenceiVSP_0568647 – 133Missing in isoform 2. 1 PublicationAdd BLAST127

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77016 mRNA. Translation: AAA61224.1.
AF288155
, AF288147, AF288148, AF288149, AF288150, AF288151, AF288152, AF288153, AF288154 Genomic DNA. Translation: AAG30124.1.
AK095748 mRNA. Translation: BAG53119.1.
AK314533 mRNA. Translation: BAG37124.1.
AL162385 Genomic DNA. No translation available.
BC002660 mRNA. Translation: AAH02660.1.
CCDSiCCDS6726.1. [P28289-1]
PIRiA42336.
RefSeqiNP_001159588.1. NM_001166116.1. [P28289-1]
NP_003266.1. NM_003275.3. [P28289-1]
UniGeneiHs.404289.
Hs.723236.

Genome annotation databases

EnsembliENST00000259365; ENSP00000259365; ENSG00000136842. [P28289-1]
ENST00000375175; ENSP00000364318; ENSG00000136842. [P28289-2]
ENST00000395211; ENSP00000378637; ENSG00000136842. [P28289-1]
GeneIDi7111.
KEGGihsa:7111.
UCSCiuc004axk.3. human. [P28289-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTMOD1_HUMAN
AccessioniPrimary (citable) accession number: P28289
Secondary accession number(s): B2RB77, Q5T7W3, Q9BUF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: August 30, 2017
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families