Reviewed, UniProtKB/Swiss-Prot P28270 (DHE3_ELEEL)

Names and origin

Protein names	Recommended name:     Glutamate dehydrogenase       Short name=GDH     EC=1.4.1.3
Organism	Electrophorus electricus (Electric eel)
Taxonomic identifier	8005 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Gymnotiformes › Electrophoridae › Electrophorus

Protein attributes

Sequence length	51 AA.
Sequence status	Fragments.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H.
Subunit structure	Homohexamer.
Subcellular location	Mitochondrion matrix By similarity.
Sequence similarities	Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

Ontologies

Keywords
Cellular component	Mitochondrion
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glutamate dehydrogenase [NAD(P)+] activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›51	›51	Glutamate dehydrogenase		PRO_0000182744
Sites
	Binding site	31	1	Substrate By similarity
Experimental info
	Non-adjacent residues	43 – 44	2
	Non-terminal residue	51	1

Sequences

	Sequence		Length	Mass (Da)
	P28270-1 [UniParc]. Last modified December 1, 1992. Version 1. Checksum: 499A36DF9A05B004	FASTA	51	5,650
	10 20 30 40 50 SEAVAEKEDD PNFFKMVEGF FDKGAAIVEN KLVEDLKTRG SPEVEGNLTF T

References

[1]	"The trypsin-catalyzed activation of glutamate dehydrogenase purified from eel liver." Tang M.-Q., Ando S., Yamada S., Hayashi S. J. Biochem. 111:655-661(1992) [PubMed: 1639763] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Liver.

Cross-references

3D structure databases
HSSP	HSSP built from PDB template 1L1F based on UniProtKB P00367.
ModBase	Search...
Phylogenomic databases
HOVERGEN	P28270.
Enzyme and pathway databases
BRENDA	1.4.1.3. 81624.
Family and domain databases
InterPro	IPR006095. Glu/Leu/Phe/Val_DH. [Graphical view]
PROSITE	PS00074. GLFV_DEHYDROGENASE. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DHE3_ELEEL

Accession

Primary (citable) accession number: P28270

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	December 1, 1992
Last modified:	June 16, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)