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Protein

Omega-amino acid--pyruvate aminotransferase

Gene
N/A
Organism
Pseudomonas putida (Arthrobacter siderocapsulatus)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes transamination between a variety of omega-amino acids, mono and diamines, and pyruvate. Plays a pivotal role in the metabolism of the omega amino acids.1 Publication

Catalytic activityi

L-alanine + 3-oxopropanoate = pyruvate + beta-alanine.

Cofactori

pyridoxal 5'-phosphate2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei60SubstrateBy similarity1
Binding sitei327Pyridoxal phosphateBy similarity1
Binding sitei414SubstrateBy similarity1
Binding sitei421SubstrateBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Omega-amino acid--pyruvate aminotransferase (EC:2.6.1.18)
Short name:
Omega-APT
Alternative name(s):
Beta-alanine--pyruvate aminotransferase
OrganismiPseudomonas putida (Arthrobacter siderocapsulatus)
Taxonomic identifieri303 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001204941 – 449Omega-amino acid--pyruvate aminotransferaseAdd BLAST449

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei288N6-(pyridoxal phosphate)lysine1

Proteomic databases

PRIDEiP28269.

Interactioni

Subunit structurei

Homotetramer.3 Publications

Structurei

Secondary structure

1449
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi11 – 13Combined sources3
Helixi16 – 18Combined sources3
Helixi26 – 31Combined sources6
Beta strandi36 – 41Combined sources6
Beta strandi43 – 46Combined sources4
Beta strandi51 – 54Combined sources4
Helixi57 – 60Combined sources4
Helixi69 – 78Combined sources10
Turni79 – 81Combined sources3
Beta strandi87 – 89Combined sources3
Helixi93 – 103Combined sources11
Beta strandi110 – 118Combined sources9
Helixi119 – 136Combined sources18
Beta strandi144 – 148Combined sources5
Helixi157 – 162Combined sources6
Helixi166 – 169Combined sources4
Turni170 – 172Combined sources3
Beta strandi178 – 182Combined sources5
Helixi188 – 190Combined sources3
Beta strandi194 – 196Combined sources3
Beta strandi198 – 200Combined sources3
Helixi201 – 215Combined sources15
Helixi217 – 219Combined sources3
Beta strandi220 – 225Combined sources6
Beta strandi227 – 229Combined sources3
Turni230 – 233Combined sources4
Helixi241 – 252Combined sources12
Beta strandi255 – 259Combined sources5
Turni261 – 268Combined sources8
Beta strandi269 – 272Combined sources4
Helixi273 – 277Combined sources5
Beta strandi282 – 286Combined sources5
Helixi288 – 291Combined sources4
Beta strandi298 – 303Combined sources6
Helixi304 – 311Combined sources8
Turni327 – 330Combined sources4
Helixi332 – 347Combined sources16
Helixi350 – 366Combined sources17
Turni367 – 370Combined sources4
Beta strandi374 – 380Combined sources7
Beta strandi383 – 388Combined sources6
Beta strandi394 – 396Combined sources3
Helixi397 – 409Combined sources13
Beta strandi414 – 416Combined sources3
Beta strandi419 – 422Combined sources4
Helixi430 – 446Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3A8UX-ray1.40X1-449[»]
ProteinModelPortaliP28269.
SMRiP28269.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP28269.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni119 – 120Pyridoxal phosphate binding2

Sequence similaritiesi

Family and domain databases

CDDicd00610. OAT_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProiIPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28269-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
NMPEHAGASL ASQLKLDAHW MPYTANRNFL RDPRLIVAAE GSWLVDDKGR
60 70 80 90 100
KVYDSLSGLW TCGAGHTRKE IQEAVAKQLS TLDYSPGFQY GHPLSFQLAE
110 120 130 140 150
KITDLTPGNL NHVFFTDSGS ECALTAVKMV RAYWRLKGQA TKTKMIGRAR
160 170 180 190 200
GYHGVNIAGT SLGGVNGNRK LFGQPMQDVD HLPHTLLASN AYSRGMPKEG
210 220 230 240 250
GIALADELLK LIELHDASNI AAVFVEPLAG SAGVLVPPEG YLKRNREICN
260 270 280 290 300
QHNILLVFDE VITGFGRTGS MFGADSFGVT PDLMCIAKQV TNGAIPMGAV
310 320 330 340 350
IASTEIYQTF MNQPTPEYAV EFPHGYTYSA HPVACAAGLA ALCLLQKENL
360 370 380 390 400
VQSVAEVAPH FEKALHGIKG AKNVIDIRNF GLAGAIQIAP RDGDAIVRPF
410 420 430 440
EAGMALWKAG FYVRFGGDTL QFGPTFNSKP QDLDRLFDAV GEVLNKLLD
Length:449
Mass (Da):48,614
Last modified:December 1, 1992 - v1
Checksum:iEC139EB6B0C1FBD9
GO

Sequence databases

PIRiA42800.

Cross-referencesi

Sequence databases

PIRiA42800.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3A8UX-ray1.40X1-449[»]
ProteinModelPortaliP28269.
SMRiP28269.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP28269.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP28269.

Family and domain databases

CDDicd00610. OAT_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProiIPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOAPT_PSEPU
AccessioniPrimary (citable) accession number: P28269
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: November 2, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.