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Protein

Omega-amino acid--pyruvate aminotransferase

Gene
N/A
Organism
Pseudomonas putida (Arthrobacter siderocapsulatus)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes transamination between a variety of omega-amino acids, mono and diamines, and pyruvate. Plays a pivotal role in the metabolism of the omega amino acids.1 Publication

Catalytic activityi

L-alanine + 3-oxopropanoate = pyruvate + beta-alanine.

Cofactori

pyridoxal 5'-phosphate2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei60 – 601SubstrateBy similarity
Binding sitei327 – 3271Pyridoxal phosphateBy similarity
Binding sitei414 – 4141SubstrateBy similarity
Binding sitei421 – 4211SubstrateBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-3136-MONOMER.
RETL1328306-WGS:GSTH-4682-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Omega-amino acid--pyruvate aminotransferase (EC:2.6.1.18)
Short name:
Omega-APT
Alternative name(s):
Beta-alanine--pyruvate aminotransferase
OrganismiPseudomonas putida (Arthrobacter siderocapsulatus)
Taxonomic identifieri303 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 449449Omega-amino acid--pyruvate aminotransferasePRO_0000120494Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei288 – 2881N6-(pyridoxal phosphate)lysine

Interactioni

Subunit structurei

Homotetramer.3 Publications

Structurei

Secondary structure

1
449
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi11 – 133Combined sources
Helixi16 – 183Combined sources
Helixi26 – 316Combined sources
Beta strandi36 – 416Combined sources
Beta strandi43 – 464Combined sources
Beta strandi51 – 544Combined sources
Helixi57 – 604Combined sources
Helixi69 – 7810Combined sources
Turni79 – 813Combined sources
Beta strandi87 – 893Combined sources
Helixi93 – 10311Combined sources
Beta strandi110 – 1189Combined sources
Helixi119 – 13618Combined sources
Beta strandi144 – 1485Combined sources
Helixi157 – 1626Combined sources
Helixi166 – 1694Combined sources
Turni170 – 1723Combined sources
Beta strandi178 – 1825Combined sources
Helixi188 – 1903Combined sources
Beta strandi194 – 1963Combined sources
Beta strandi198 – 2003Combined sources
Helixi201 – 21515Combined sources
Helixi217 – 2193Combined sources
Beta strandi220 – 2256Combined sources
Beta strandi227 – 2293Combined sources
Turni230 – 2334Combined sources
Helixi241 – 25212Combined sources
Beta strandi255 – 2595Combined sources
Turni261 – 2688Combined sources
Beta strandi269 – 2724Combined sources
Helixi273 – 2775Combined sources
Beta strandi282 – 2865Combined sources
Helixi288 – 2914Combined sources
Beta strandi298 – 3036Combined sources
Helixi304 – 3118Combined sources
Turni327 – 3304Combined sources
Helixi332 – 34716Combined sources
Helixi350 – 36617Combined sources
Turni367 – 3704Combined sources
Beta strandi374 – 3807Combined sources
Beta strandi383 – 3886Combined sources
Beta strandi394 – 3963Combined sources
Helixi397 – 40913Combined sources
Beta strandi414 – 4163Combined sources
Beta strandi419 – 4224Combined sources
Helixi430 – 44617Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3A8UX-ray1.40X1-449[»]
ProteinModelPortaliP28269.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP28269.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni119 – 1202Pyridoxal phosphate binding

Sequence similaritiesi

Family and domain databases

CDDicd00610. OAT_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProiIPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28269-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
NMPEHAGASL ASQLKLDAHW MPYTANRNFL RDPRLIVAAE GSWLVDDKGR
60 70 80 90 100
KVYDSLSGLW TCGAGHTRKE IQEAVAKQLS TLDYSPGFQY GHPLSFQLAE
110 120 130 140 150
KITDLTPGNL NHVFFTDSGS ECALTAVKMV RAYWRLKGQA TKTKMIGRAR
160 170 180 190 200
GYHGVNIAGT SLGGVNGNRK LFGQPMQDVD HLPHTLLASN AYSRGMPKEG
210 220 230 240 250
GIALADELLK LIELHDASNI AAVFVEPLAG SAGVLVPPEG YLKRNREICN
260 270 280 290 300
QHNILLVFDE VITGFGRTGS MFGADSFGVT PDLMCIAKQV TNGAIPMGAV
310 320 330 340 350
IASTEIYQTF MNQPTPEYAV EFPHGYTYSA HPVACAAGLA ALCLLQKENL
360 370 380 390 400
VQSVAEVAPH FEKALHGIKG AKNVIDIRNF GLAGAIQIAP RDGDAIVRPF
410 420 430 440
EAGMALWKAG FYVRFGGDTL QFGPTFNSKP QDLDRLFDAV GEVLNKLLD
Length:449
Mass (Da):48,614
Last modified:December 1, 1992 - v1
Checksum:iEC139EB6B0C1FBD9
GO

Sequence databases

PIRiA42800.

Cross-referencesi

Sequence databases

PIRiA42800.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3A8UX-ray1.40X1-449[»]
ProteinModelPortaliP28269.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-3136-MONOMER.
RETL1328306-WGS:GSTH-4682-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP28269.

Family and domain databases

CDDicd00610. OAT_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProiIPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOAPT_PSEPU
AccessioniPrimary (citable) accession number: P28269
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: September 7, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.