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P28248

- DCD_ECOLI

UniProt

P28248 - DCD_ECOLI

Protein

Deoxycytidine triphosphate deaminase

Gene

dcd

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Dec 1992)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    dCTP + H2O = dUTP + NH3.

    Pathwayi

    GO - Molecular functioni

    1. dCTP deaminase activity Source: EcoCyc

    GO - Biological processi

    1. dUMP biosynthetic process Source: UniProtKB-UniPathway
    2. dUTP biosynthetic process Source: InterPro
    3. nucleobase-containing small molecule interconversion Source: EcoCyc
    4. pyrimidine ribonucleotide biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Enzyme and pathway databases

    BioCyciEcoCyc:DCTP-DEAM-MONOMER.
    ECOL316407:JW2050-MONOMER.
    MetaCyc:DCTP-DEAM-MONOMER.
    UniPathwayiUPA00610; UER00665.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxycytidine triphosphate deaminase (EC:3.5.4.13)
    Short name:
    dCTP deaminase
    Gene namesi
    Name:dcd
    Synonyms:dus, paxA
    Ordered Locus Names:b2065, JW2050
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG11418. dcd.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 193193Deoxycytidine triphosphate deaminasePRO_0000155984Add
    BLAST

    Proteomic databases

    PaxDbiP28248.
    PRIDEiP28248.

    Expressioni

    Gene expression databases

    GenevestigatoriP28248.

    Interactioni

    Subunit structurei

    Homotetramer.Curated

    Protein-protein interaction databases

    IntActiP28248. 2 interactions.
    STRINGi511145.b2065.

    Structurei

    Secondary structure

    1
    193
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi5 – 1410
    Beta strandi15 – 217
    Helixi25 – 273
    Beta strandi32 – 376
    Beta strandi39 – 424
    Helixi46 – 483
    Beta strandi54 – 563
    Helixi58 – 6811
    Beta strandi81 – 833
    Beta strandi89 – 9810
    Beta strandi103 – 1086
    Helixi111 – 1144
    Turni115 – 1173
    Beta strandi118 – 1203
    Beta strandi132 – 14110
    Beta strandi143 – 1453
    Beta strandi147 – 1493
    Beta strandi153 – 16210
    Helixi171 – 1733
    Beta strandi180 – 1823
    Helixi190 – 1923

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1XS1X-ray1.80A/B/C/D/E/F1-193[»]
    1XS4X-ray2.53A/B/C/D/E/F1-193[»]
    1XS6X-ray2.00A/B/C/D/E/F1-193[»]
    2J4HX-ray2.70A/B1-193[»]
    2J4QX-ray2.60A/B1-193[»]
    2V9XX-ray2.20A/B/C/D/E/F/G/H/I/J/K/L1-193[»]
    ProteinModelPortaliP28248.
    SMRiP28248. Positions 1-193.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP28248.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the dCTP deaminase family.Curated

    Phylogenomic databases

    eggNOGiCOG0717.
    HOGENOMiHOG000228601.
    KOiK01494.
    OMAiRPGMMIG.
    OrthoDBiEOG67DPKR.
    PhylomeDBiP28248.

    Family and domain databases

    Gene3Di2.70.40.10. 1 hit.
    HAMAPiMF_00146. dCTP_deaminase.
    InterProiIPR011962. dCTP_deam.
    IPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    [Graphical view]
    PfamiPF00692. dUTPase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51283. SSF51283. 1 hit.
    TIGRFAMsiTIGR02274. dCTP_deam. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P28248-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLCDRDIEA WLDEGRLSIN PRPPVERING ATVDVRLGNK FRTFRGHTAA    50
    FIDLSGPKDE VSAALDRVMS DEIVLDEGEA FYLHPGELAL AVTLESVTLP 100
    ADLVGWLDGR SSLARLGLMV HVTAHRIDPG WSGCIVLEFY NSGKLPLALR 150
    PGMLIGALSF EPLSGPAVRP YNRREDAKYR NQQGAVASRI DKD 193
    Length:193
    Mass (Da):21,249
    Last modified:December 1, 1992 - v1
    Checksum:iB0044051ADE7F919
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M90069 Genomic DNA. Translation: AAA23669.1.
    U00096 Genomic DNA. Translation: AAC75126.1.
    AP009048 Genomic DNA. Translation: BAA15918.1.
    PIRiA42940.
    RefSeqiNP_416569.1. NC_000913.3.
    YP_490307.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC75126; AAC75126; b2065.
    BAA15918; BAA15918; BAA15918.
    GeneIDi12930690.
    946593.
    KEGGiecj:Y75_p2028.
    eco:b2065.
    PATRICi32119463. VBIEscCol129921_2142.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M90069 Genomic DNA. Translation: AAA23669.1 .
    U00096 Genomic DNA. Translation: AAC75126.1 .
    AP009048 Genomic DNA. Translation: BAA15918.1 .
    PIRi A42940.
    RefSeqi NP_416569.1. NC_000913.3.
    YP_490307.1. NC_007779.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1XS1 X-ray 1.80 A/B/C/D/E/F 1-193 [» ]
    1XS4 X-ray 2.53 A/B/C/D/E/F 1-193 [» ]
    1XS6 X-ray 2.00 A/B/C/D/E/F 1-193 [» ]
    2J4H X-ray 2.70 A/B 1-193 [» ]
    2J4Q X-ray 2.60 A/B 1-193 [» ]
    2V9X X-ray 2.20 A/B/C/D/E/F/G/H/I/J/K/L 1-193 [» ]
    ProteinModelPortali P28248.
    SMRi P28248. Positions 1-193.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P28248. 2 interactions.
    STRINGi 511145.b2065.

    Proteomic databases

    PaxDbi P28248.
    PRIDEi P28248.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC75126 ; AAC75126 ; b2065 .
    BAA15918 ; BAA15918 ; BAA15918 .
    GeneIDi 12930690.
    946593.
    KEGGi ecj:Y75_p2028.
    eco:b2065.
    PATRICi 32119463. VBIEscCol129921_2142.

    Organism-specific databases

    EchoBASEi EB1389.
    EcoGenei EG11418. dcd.

    Phylogenomic databases

    eggNOGi COG0717.
    HOGENOMi HOG000228601.
    KOi K01494.
    OMAi RPGMMIG.
    OrthoDBi EOG67DPKR.
    PhylomeDBi P28248.

    Enzyme and pathway databases

    UniPathwayi UPA00610 ; UER00665 .
    BioCyci EcoCyc:DCTP-DEAM-MONOMER.
    ECOL316407:JW2050-MONOMER.
    MetaCyc:DCTP-DEAM-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P28248.
    PROi P28248.

    Gene expression databases

    Genevestigatori P28248.

    Family and domain databases

    Gene3Di 2.70.40.10. 1 hit.
    HAMAPi MF_00146. dCTP_deaminase.
    InterProi IPR011962. dCTP_deam.
    IPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    [Graphical view ]
    Pfami PF00692. dUTPase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51283. SSF51283. 1 hit.
    TIGRFAMsi TIGR02274. dCTP_deam. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "dcd (dCTP deaminase) gene of Escherichia coli: mapping, cloning, sequencing, and identification as a locus of suppressors of lethal dut (dUTPase) mutations."
      Wang L., Weiss B.
      J. Bacteriol. 174:5647-5653(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-10.
      Strain: K12.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

    Entry informationi

    Entry nameiDCD_ECOLI
    AccessioniPrimary (citable) accession number: P28248
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: December 1, 1992
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3