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P28248

- DCD_ECOLI

UniProt

P28248 - DCD_ECOLI

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Protein

Deoxycytidine triphosphate deaminase

Gene

dcd

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

dCTP + H2O = dUTP + NH3.

Pathwayi

GO - Molecular functioni

  1. dCTP deaminase activity Source: EcoCyc

GO - Biological processi

  1. dUMP biosynthetic process Source: UniProtKB-UniPathway
  2. dUTP biosynthetic process Source: InterPro
  3. nucleobase-containing small molecule interconversion Source: EcoCyc
  4. pyrimidine ribonucleotide biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Enzyme and pathway databases

BioCyciEcoCyc:DCTP-DEAM-MONOMER.
ECOL316407:JW2050-MONOMER.
MetaCyc:DCTP-DEAM-MONOMER.
UniPathwayiUPA00610; UER00665.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxycytidine triphosphate deaminase (EC:3.5.4.13)
Short name:
dCTP deaminase
Gene namesi
Name:dcd
Synonyms:dus, paxA
Ordered Locus Names:b2065, JW2050
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG11418. dcd.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 193193Deoxycytidine triphosphate deaminasePRO_0000155984Add
BLAST

Proteomic databases

PaxDbiP28248.
PRIDEiP28248.

Expressioni

Gene expression databases

GenevestigatoriP28248.

Interactioni

Subunit structurei

Homotetramer.Curated

Protein-protein interaction databases

IntActiP28248. 2 interactions.
STRINGi511145.b2065.

Structurei

Secondary structure

1
193
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 1410Combined sources
Beta strandi15 – 217Combined sources
Helixi25 – 273Combined sources
Beta strandi32 – 376Combined sources
Beta strandi39 – 424Combined sources
Helixi46 – 483Combined sources
Beta strandi54 – 563Combined sources
Helixi58 – 6811Combined sources
Beta strandi81 – 833Combined sources
Beta strandi89 – 9810Combined sources
Beta strandi103 – 1086Combined sources
Helixi111 – 1144Combined sources
Turni115 – 1173Combined sources
Beta strandi118 – 1203Combined sources
Beta strandi132 – 14110Combined sources
Beta strandi143 – 1453Combined sources
Beta strandi147 – 1493Combined sources
Beta strandi153 – 16210Combined sources
Helixi171 – 1733Combined sources
Beta strandi180 – 1823Combined sources
Helixi190 – 1923Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XS1X-ray1.80A/B/C/D/E/F1-193[»]
1XS4X-ray2.53A/B/C/D/E/F1-193[»]
1XS6X-ray2.00A/B/C/D/E/F1-193[»]
2J4HX-ray2.70A/B1-193[»]
2J4QX-ray2.60A/B1-193[»]
2V9XX-ray2.20A/B/C/D/E/F/G/H/I/J/K/L1-193[»]
ProteinModelPortaliP28248.
SMRiP28248. Positions 1-193.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP28248.

Family & Domainsi

Sequence similaritiesi

Belongs to the dCTP deaminase family.Curated

Phylogenomic databases

eggNOGiCOG0717.
HOGENOMiHOG000228601.
InParanoidiP28248.
KOiK01494.
OMAiRPGMMIG.
OrthoDBiEOG67DPKR.
PhylomeDBiP28248.

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
HAMAPiMF_00146. dCTP_deaminase.
InterProiIPR011962. dCTP_deam.
IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR02274. dCTP_deam. 1 hit.

Sequencei

Sequence statusi: Complete.

P28248-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLCDRDIEA WLDEGRLSIN PRPPVERING ATVDVRLGNK FRTFRGHTAA
60 70 80 90 100
FIDLSGPKDE VSAALDRVMS DEIVLDEGEA FYLHPGELAL AVTLESVTLP
110 120 130 140 150
ADLVGWLDGR SSLARLGLMV HVTAHRIDPG WSGCIVLEFY NSGKLPLALR
160 170 180 190
PGMLIGALSF EPLSGPAVRP YNRREDAKYR NQQGAVASRI DKD
Length:193
Mass (Da):21,249
Last modified:December 1, 1992 - v1
Checksum:iB0044051ADE7F919
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M90069 Genomic DNA. Translation: AAA23669.1.
U00096 Genomic DNA. Translation: AAC75126.1.
AP009048 Genomic DNA. Translation: BAA15918.1.
PIRiA42940.
RefSeqiNP_416569.1. NC_000913.3.
YP_490307.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC75126; AAC75126; b2065.
BAA15918; BAA15918; BAA15918.
GeneIDi12930690.
946593.
KEGGiecj:Y75_p2028.
eco:b2065.
PATRICi32119463. VBIEscCol129921_2142.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M90069 Genomic DNA. Translation: AAA23669.1 .
U00096 Genomic DNA. Translation: AAC75126.1 .
AP009048 Genomic DNA. Translation: BAA15918.1 .
PIRi A42940.
RefSeqi NP_416569.1. NC_000913.3.
YP_490307.1. NC_007779.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1XS1 X-ray 1.80 A/B/C/D/E/F 1-193 [» ]
1XS4 X-ray 2.53 A/B/C/D/E/F 1-193 [» ]
1XS6 X-ray 2.00 A/B/C/D/E/F 1-193 [» ]
2J4H X-ray 2.70 A/B 1-193 [» ]
2J4Q X-ray 2.60 A/B 1-193 [» ]
2V9X X-ray 2.20 A/B/C/D/E/F/G/H/I/J/K/L 1-193 [» ]
ProteinModelPortali P28248.
SMRi P28248. Positions 1-193.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P28248. 2 interactions.
STRINGi 511145.b2065.

Proteomic databases

PaxDbi P28248.
PRIDEi P28248.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC75126 ; AAC75126 ; b2065 .
BAA15918 ; BAA15918 ; BAA15918 .
GeneIDi 12930690.
946593.
KEGGi ecj:Y75_p2028.
eco:b2065.
PATRICi 32119463. VBIEscCol129921_2142.

Organism-specific databases

EchoBASEi EB1389.
EcoGenei EG11418. dcd.

Phylogenomic databases

eggNOGi COG0717.
HOGENOMi HOG000228601.
InParanoidi P28248.
KOi K01494.
OMAi RPGMMIG.
OrthoDBi EOG67DPKR.
PhylomeDBi P28248.

Enzyme and pathway databases

UniPathwayi UPA00610 ; UER00665 .
BioCyci EcoCyc:DCTP-DEAM-MONOMER.
ECOL316407:JW2050-MONOMER.
MetaCyc:DCTP-DEAM-MONOMER.

Miscellaneous databases

EvolutionaryTracei P28248.
PROi P28248.

Gene expression databases

Genevestigatori P28248.

Family and domain databases

Gene3Di 2.70.40.10. 1 hit.
HAMAPi MF_00146. dCTP_deaminase.
InterProi IPR011962. dCTP_deam.
IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view ]
Pfami PF00692. dUTPase. 1 hit.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 1 hit.
TIGRFAMsi TIGR02274. dCTP_deam. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "dcd (dCTP deaminase) gene of Escherichia coli: mapping, cloning, sequencing, and identification as a locus of suppressors of lethal dut (dUTPase) mutations."
    Wang L., Weiss B.
    J. Bacteriol. 174:5647-5653(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-10.
    Strain: K12.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiDCD_ECOLI
AccessioniPrimary (citable) accession number: P28248
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: November 26, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3