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P28248 (DCD_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Deoxycytidine triphosphate deaminase

Short name=dCTP deaminase
EC=3.5.4.13
Gene names
Name:dcd
Synonyms:dus, paxA
Ordered Locus Names:b2065, JW2050
OrganismEscherichia coli (strain K12) [Reference proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length193 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

dCTP + H2O = dUTP + NH3. HAMAP-Rule MF_00146

Pathway

Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 1/2. HAMAP-Rule MF_00146

Subunit structure

Homotetramer Probable.

Sequence similarities

Belongs to the dCTP deaminase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 193193Deoxycytidine triphosphate deaminase HAMAP-Rule MF_00146
PRO_0000155984

Secondary structure

........................................ 193
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P28248 [UniParc].

Last modified December 1, 1992. Version 1.
Checksum: B0044051ADE7F919

FASTA19321,249
        10         20         30         40         50         60 
MRLCDRDIEA WLDEGRLSIN PRPPVERING ATVDVRLGNK FRTFRGHTAA FIDLSGPKDE 

        70         80         90        100        110        120 
VSAALDRVMS DEIVLDEGEA FYLHPGELAL AVTLESVTLP ADLVGWLDGR SSLARLGLMV 

       130        140        150        160        170        180 
HVTAHRIDPG WSGCIVLEFY NSGKLPLALR PGMLIGALSF EPLSGPAVRP YNRREDAKYR 

       190 
NQQGAVASRI DKD 

« Hide

References

« Hide 'large scale' references
[1]"dcd (dCTP deaminase) gene of Escherichia coli: mapping, cloning, sequencing, and identification as a locus of suppressors of lethal dut (dUTPase) mutations."
Wang L., Weiss B.
J. Bacteriol. 174:5647-5653(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-10.
Strain: K12.
[2]"A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map."
Itoh T., Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Kasai H., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T., Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S. expand/collapse author list , Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Wada C., Yamamoto Y., Horiuchi T.
DNA Res. 3:379-392(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[3]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1462(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[4]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M90069 Genomic DNA. Translation: AAA23669.1.
U00096 Genomic DNA. Translation: AAC75126.1.
AP009048 Genomic DNA. Translation: BAA15918.1.
PIRA42940.
RefSeqNP_416569.1. NC_000913.3.
YP_490307.1. NC_007779.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1XS1X-ray1.80A/B/C/D/E/F1-193[»]
1XS4X-ray2.53A/B/C/D/E/F1-193[»]
1XS6X-ray2.00A/B/C/D/E/F1-193[»]
2J4HX-ray2.70A/B1-193[»]
2J4QX-ray2.60A/B1-193[»]
2V9XX-ray2.20A/B/C/D/E/F/G/H/I/J/K/L1-193[»]
ProteinModelPortalP28248.
SMRP28248. Positions 1-193.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP28248. 2 interactions.
STRING511145.b2065.

Proteomic databases

PaxDbP28248.
PRIDEP28248.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC75126; AAC75126; b2065.
BAA15918; BAA15918; BAA15918.
GeneID12930690.
946593.
KEGGecj:Y75_p2028.
eco:b2065.
PATRIC32119463. VBIEscCol129921_2142.

Organism-specific databases

EchoBASEEB1389.
EcoGeneEG11418. dcd.

Phylogenomic databases

eggNOGCOG0717.
HOGENOMHOG000228601.
KOK01494.
OMARPGMMIG.
OrthoDBEOG67DPKR.
PhylomeDBP28248.

Enzyme and pathway databases

BioCycEcoCyc:DCTP-DEAM-MONOMER.
ECOL316407:JW2050-MONOMER.
MetaCyc:DCTP-DEAM-MONOMER.
UniPathwayUPA00610; UER00665.

Gene expression databases

GenevestigatorP28248.

Family and domain databases

Gene3D2.70.40.10. 1 hit.
HAMAPMF_00146. dCTP_deaminase.
InterProIPR011962. dCTP_deam.
IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view]
PfamPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMSSF51283. SSF51283. 1 hit.
TIGRFAMsTIGR02274. dCTP_deam. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP28248.
PROP28248.

Entry information

Entry nameDCD_ECOLI
AccessionPrimary (citable) accession number: P28248
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: June 11, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene