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Protein

Inorganic pyrophosphatase, mitochondrial

Gene

PPA2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in energy production. Its activity is stimulated by uncouplers of ATP synthesis.

Catalytic activityi

Diphosphate + H2O = 2 phosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi152Magnesium 1By similarity1
Metal bindingi157Magnesium 1By similarity1
Metal bindingi157Magnesium 2By similarity1
Metal bindingi189Magnesium 1By similarity1

GO - Molecular functioni

  • inorganic diphosphatase activity Source: SGD
  • magnesium ion binding Source: InterPro

GO - Biological processi

  • aerobic respiration Source: SGD
  • phosphate-containing compound metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:YMR267W-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Inorganic pyrophosphatase, mitochondrial (EC:3.6.1.1)
Alternative name(s):
Pyrophosphate phospho-hydrolase
Short name:
PPase
Gene namesi
Name:PPA2
Synonyms:IPP2
Ordered Locus Names:YMR267W
ORF Names:YM8156.09
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR267W.
SGDiS000004880. PPA2.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 30MitochondrionSequence analysisAdd BLAST30
ChainiPRO_000002541331 – 310Inorganic pyrophosphatase, mitochondrialAdd BLAST280

Proteomic databases

MaxQBiP28239.
PRIDEiP28239.

Interactioni

Subunit structurei

Homodimer that binds non-covalently to a protein complex in the inner mitochondrial membrane.By similarity

Protein-protein interaction databases

BioGridi35445. 352 interactors.
DIPiDIP-1522N.
IntActiP28239. 6 interactors.
MINTiMINT-385495.

Structurei

3D structure databases

ProteinModelPortaliP28239.
SMRiP28239.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000195569.
InParanoidiP28239.
KOiK01507.
OMAiETTRQWF.
OrthoDBiEOG092C3VG0.

Family and domain databases

CDDicd00412. pyrophosphatase. 1 hit.
Gene3Di3.90.80.10. 1 hit.
InterProiIPR008162. Pyrophosphatase.
[Graphical view]
PANTHERiPTHR10286. PTHR10286. 1 hit.
PfamiPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF50324. SSF50324. 1 hit.
PROSITEiPS00387. PPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28239-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLLRMNALT SKARSIERLK QTLNILSIRN HRQFSTIQQG SKYTLGFKKY
60 70 80 90 100
LTLLNGEVGS FFHDVPLDLN EHEKTVNMIV EVPRWTTGKF EISKELRFNP
110 120 130 140 150
IVQDTKNGKL RFVNNIFPYH GYIHNYGAIP QTWEDPTIEH KLGKCDVALK
160 170 180 190 200
GDNDPLDCCE IGSDVLEMGS IKKVKVLGSL ALIDDGELDW KVIVIDVNDP
210 220 230 240 250
LSSKIDDLEK IEEYFPGILD TTREWFRKYK VPAGKPLNSF AFHEQYQNSN
260 270 280 290 300
KTIQTIKKCH NSWKNLISGS LQEKYDNLPN TERAGNGVTL EDSVKPPSQI
310
PPEVQKWYYV
Length:310
Mass (Da):35,573
Last modified:December 1, 1992 - v1
Checksum:i985F6E9BDD50BA25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81880 Genomic DNA. Translation: AAA34893.1.
Z49260 Genomic DNA. Translation: CAA89250.1.
BK006946 Genomic DNA. Translation: DAA10167.1.
PIRiA40867.
RefSeqiNP_013994.1. NM_001182774.1.

Genome annotation databases

EnsemblFungiiYMR267W; YMR267W; YMR267W.
GeneIDi855309.
KEGGisce:YMR267W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81880 Genomic DNA. Translation: AAA34893.1.
Z49260 Genomic DNA. Translation: CAA89250.1.
BK006946 Genomic DNA. Translation: DAA10167.1.
PIRiA40867.
RefSeqiNP_013994.1. NM_001182774.1.

3D structure databases

ProteinModelPortaliP28239.
SMRiP28239.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35445. 352 interactors.
DIPiDIP-1522N.
IntActiP28239. 6 interactors.
MINTiMINT-385495.

Proteomic databases

MaxQBiP28239.
PRIDEiP28239.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR267W; YMR267W; YMR267W.
GeneIDi855309.
KEGGisce:YMR267W.

Organism-specific databases

EuPathDBiFungiDB:YMR267W.
SGDiS000004880. PPA2.

Phylogenomic databases

HOGENOMiHOG000195569.
InParanoidiP28239.
KOiK01507.
OMAiETTRQWF.
OrthoDBiEOG092C3VG0.

Enzyme and pathway databases

BioCyciYEAST:YMR267W-MONOMER.

Miscellaneous databases

PROiP28239.

Family and domain databases

CDDicd00412. pyrophosphatase. 1 hit.
Gene3Di3.90.80.10. 1 hit.
InterProiIPR008162. Pyrophosphatase.
[Graphical view]
PANTHERiPTHR10286. PTHR10286. 1 hit.
PfamiPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF50324. SSF50324. 1 hit.
PROSITEiPS00387. PPASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIPYR2_YEAST
AccessioniPrimary (citable) accession number: P28239
Secondary accession number(s): D6W093
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: November 2, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 195 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.