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P28237 (BADH_BETVU) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Betaine aldehyde dehydrogenase, chloroplastic

Short name=BADH
EC=1.2.1.8
OrganismBeta vulgaris (Sugar beet)
Taxonomic identifier161934 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeCaryophyllalesAmaranthaceaeBeta

Protein attributes

Sequence length500 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Betaine aldehyde + NAD+ + H2O = betaine + NADH.

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1.

Subunit structure

Homodimer.

Subcellular location

Plastidchloroplast.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   Cellular componentChloroplast
Plastid
   DomainTransit peptide
   LigandNAD
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processglycine betaine biosynthetic process from choline

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentchloroplast

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionbetaine-aldehyde dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 77Chloroplast Potential
Chain8 – 500493Betaine aldehyde dehydrogenase, chloroplastic
PRO_0000007181

Regions

Nucleotide binding238 – 2436NAD By similarity

Sites

Active site2601Proton acceptor By similarity
Active site2941Nucleophile By similarity
Site1621Transition state stabilizer By similarity

Natural variations

Natural variant4121E → D.

Sequences

Sequence LengthMass (Da)Tools
P28237 [UniParc].

Last modified December 1, 1992. Version 1.
Checksum: 512859FBC27B67B8

FASTA50054,721
        10         20         30         40         50         60 
MSMPIPSRQL FIDGEWREPI KKNRIPIINP SNEEIIGDIP AGSSEDIEVA VAAARRALKR 

        70         80         90        100        110        120 
NKGREWAATS GAHRARYLRA IAAKVTERKD HFVKLETIDS GKPFDEAVLD IDDVATCFEY 

       130        140        150        160        170        180 
FAGQAEAMDA KQKAPVTLPM ERFKSHVLRQ PIGVVGLITP WNYPLLMATW KIAPALAAGC 

       190        200        210        220        230        240 
TAVLKPSELA SITCLEFGEV CNEVGLPPGV LNIVTGLGPD AGAPLAAHPD VDKVAFTGSS 

       250        260        270        280        290        300 
ATGSKVMASA AQLVKPVTLE LGGKSPIIVF EDVDIDQVVE WTMFGCFWTN GQICSATSRL 

       310        320        330        340        350        360 
LVHESIAAEF IDRLVKWTKN IKISDPFEEG CRLGPVISKG QYDKIMKFIS TAKSEGATIL 

       370        380        390        400        410        420 
CGGSRPEHLK KGYFIEPTII SDISTSMQIW REEVFGPVLC VKTFSSEDEA LELANDTEYG 

       430        440        450        460        470        480 
LASAVFSKDL ERCERVSKLL ESGAVWVNCS QPCFVHAPWG GIKRSGFGRE LGEWGIENYL 

       490        500 
NIKQVTSDIS NEPWGWYKSP 

« Hide

References

[1]"Salt-inducible betaine aldehyde dehydrogenase from sugar beet: cDNA cloning and expression."
McCue K.F., Hanson A.D.
Plant Mol. Biol. 18:1-11(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X58463 mRNA. Translation: CAA41377.1.
X58462 mRNA. Translation: CAA41376.1.
PIRS19135.

3D structure databases

ProteinModelPortalP28237.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP28237.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00529; UER00386.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. SSF53720. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBADH_BETVU
AccessionPrimary (citable) accession number: P28237
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: June 11, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways