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P28235

- CXA4_MOUSE

UniProt

P28235 - CXA4_MOUSE

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Protein

Gap junction alpha-4 protein

Gene

Gja4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Biological processi

  1. blood vessel development Source: MGI
  2. calcium ion transport Source: Ensembl
  3. cell-cell signaling Source: Ensembl
  4. endothelium development Source: Ensembl
  5. response to pain Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction alpha-4 protein
Alternative name(s):
Connexin-37
Short name:
Cx37
Gene namesi
Name:Gja4
Synonyms:Cxn-37
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:95715. Gja4.

Subcellular locationi

GO - Cellular componenti

  1. connexon complex Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 333333Gap junction alpha-4 proteinPRO_0000057815Add
BLAST

Proteomic databases

PRIDEiP28235.

Expressioni

Tissue specificityi

Highly expressed in lung.

Gene expression databases

BgeeiP28235.
CleanExiMM_GJA4.
ExpressionAtlasiP28235. baseline and differential.
GenevestigatoriP28235.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.

Structurei

3D structure databases

ProteinModelPortaliP28235.
SMRiP28235. Positions 3-234.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini41 – 7636ExtracellularSequence AnalysisAdd
BLAST
Topological domaini100 – 14849CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini172 – 20837ExtracellularSequence AnalysisAdd
BLAST
Topological domaini232 – 333102CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4020HelicalSequence AnalysisAdd
BLAST
Transmembranei77 – 9923HelicalSequence AnalysisAdd
BLAST
Transmembranei149 – 17123HelicalSequence AnalysisAdd
BLAST
Transmembranei209 – 23123HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG39708.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiP28235.
KOiK07613.
OMAiQNWANLT.
OrthoDBiEOG7P2XSS.
PhylomeDBiP28235.
TreeFamiTF329606.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002263. Connexin37.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01134. CONNEXINA4.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28235-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGDWGFLEKL LDQVQEHSTV VGKIWLTVLF IFRILILGLA GESVWGDEQS
60 70 80 90 100
DFECNTAQPG CTNVCYDQAF PISHIRYWVL QFLFVSTPTL IYLGHVIYLS
110 120 130 140 150
RREERLRQKE GELRALPSKD LHVERALAAI EHQMAKISVA EDGRLRIRGA
160 170 180 190 200
LMGTYVVSVL CKSVLEAGFL YGQWRLYGWT MEPVFVCQRA PCPHIVDCYV
210 220 230 240 250
SRPTEKTIFI IFMLVVGVIS LVLNLLELVH LLCRCVSREI KARRDHDARP
260 270 280 290 300
AQGSASDPYP EQVFFYLPMG EGPSSPPCPT YNGLSSTEQN WANLTTEERL
310 320 330
TSSRPPPFVN TAPQGGRKSP SRPNSSASKK QYV
Length:333
Mass (Da):37,596
Last modified:January 23, 2007 - v2
Checksum:iC73D2B2AC0D926C1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti54 – 541C → Q Requires 2 nucleotide substitutions. 1 Publication
Natural varianti59 – 591P → A.1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X57971 Genomic DNA. Translation: CAA41037.1.
AF216832 mRNA. Translation: AAF91221.1.
CCDSiCCDS18667.1.
PIRiA40548.
RefSeqiNP_032146.1. NM_008120.3.
UniGeneiMm.24615.

Genome annotation databases

EnsembliENSMUST00000053753; ENSMUSP00000062320; ENSMUSG00000050234.
GeneIDi14612.
KEGGimmu:14612.
UCSCiuc008uur.1. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X57971 Genomic DNA. Translation: CAA41037.1 .
AF216832 mRNA. Translation: AAF91221.1 .
CCDSi CCDS18667.1.
PIRi A40548.
RefSeqi NP_032146.1. NM_008120.3.
UniGenei Mm.24615.

3D structure databases

ProteinModelPortali P28235.
SMRi P28235. Positions 3-234.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P28235.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000053753 ; ENSMUSP00000062320 ; ENSMUSG00000050234 .
GeneIDi 14612.
KEGGi mmu:14612.
UCSCi uc008uur.1. mouse.

Organism-specific databases

CTDi 2701.
MGIi MGI:95715. Gja4.

Phylogenomic databases

eggNOGi NOG39708.
HOGENOMi HOG000231127.
HOVERGENi HBG009576.
InParanoidi P28235.
KOi K07613.
OMAi QNWANLT.
OrthoDBi EOG7P2XSS.
PhylomeDBi P28235.
TreeFami TF329606.

Miscellaneous databases

ChiTaRSi GJA4. mouse.
NextBioi 286416.
PROi P28235.
SOURCEi Search...

Gene expression databases

Bgeei P28235.
CleanExi MM_GJA4.
ExpressionAtlasi P28235. baseline and differential.
Genevestigatori P28235.

Family and domain databases

InterProi IPR000500. Connexin.
IPR002263. Connexin37.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view ]
PANTHERi PTHR11984. PTHR11984. 1 hit.
Pfami PF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view ]
PRINTSi PR00206. CONNEXIN.
PR01134. CONNEXINA4.
SMARTi SM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view ]
PROSITEi PS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mouse connexin37: cloning and functional expression of a gap junction gene highly expressed in lung."
    Willecke K., Heynkes R., Dahl E., Stutenkemper R., Hennemann H., Jungbluth S., Suchyna T., Nicholson B.J.
    J. Cell Biol. 114:1049-1057(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C57BL/6.
  2. "Mouse connexin37: gene structure and promoter analysis."
    Seul K.H., Beyer E.C.
    Biochim. Biophys. Acta 1492:499-504(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129/SvJ.
    Tissue: Lung.
  3. "CTL induction by a tumour-associated antigen octapeptide derived from a murine lung carcinoma."
    Mandelboim O., Berke G., Fridkin M., Feldman M., Eisenstein M., Eisenbach L.
    Nature 369:67-71(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 52-59, VARIANTS GLN-54 AND ALA-59.
    Tissue: Lung tumor.

Entry informationi

Entry nameiCXA4_MOUSE
AccessioniPrimary (citable) accession number: P28235
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3