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P28235 (CXA4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gap junction alpha-4 protein
Alternative name(s):
Connexin-37
Short name=Cx37
Gene names
Name:Gja4
Synonyms:Cxn-37
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length333 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

Subunit structure

A connexon is composed of a hexamer of connexins.

Subcellular location

Cell membrane; Multi-pass membrane protein. Cell junctiongap junction.

Tissue specificity

Highly expressed in lung.

Sequence similarities

Belongs to the connexin family. Alpha-type (group II) subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 333333Gap junction alpha-4 protein
PRO_0000057815

Regions

Topological domain1 – 2020Cytoplasmic Potential
Transmembrane21 – 4020Helical; Potential
Topological domain41 – 7636Extracellular Potential
Transmembrane77 – 9923Helical; Potential
Topological domain100 – 14849Cytoplasmic Potential
Transmembrane149 – 17123Helical; Potential
Topological domain172 – 20837Extracellular Potential
Transmembrane209 – 23123Helical; Potential
Topological domain232 – 333102Cytoplasmic Potential

Natural variations

Natural variant541C → Q Requires 2 nucleotide substitutions. Ref.3
Natural variant591P → A. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P28235 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: C73D2B2AC0D926C1

FASTA33337,596
        10         20         30         40         50         60 
MGDWGFLEKL LDQVQEHSTV VGKIWLTVLF IFRILILGLA GESVWGDEQS DFECNTAQPG 

        70         80         90        100        110        120 
CTNVCYDQAF PISHIRYWVL QFLFVSTPTL IYLGHVIYLS RREERLRQKE GELRALPSKD 

       130        140        150        160        170        180 
LHVERALAAI EHQMAKISVA EDGRLRIRGA LMGTYVVSVL CKSVLEAGFL YGQWRLYGWT 

       190        200        210        220        230        240 
MEPVFVCQRA PCPHIVDCYV SRPTEKTIFI IFMLVVGVIS LVLNLLELVH LLCRCVSREI 

       250        260        270        280        290        300 
KARRDHDARP AQGSASDPYP EQVFFYLPMG EGPSSPPCPT YNGLSSTEQN WANLTTEERL 

       310        320        330 
TSSRPPPFVN TAPQGGRKSP SRPNSSASKK QYV 

« Hide

References

[1]"Mouse connexin37: cloning and functional expression of a gap junction gene highly expressed in lung."
Willecke K., Heynkes R., Dahl E., Stutenkemper R., Hennemann H., Jungbluth S., Suchyna T., Nicholson B.J.
J. Cell Biol. 114:1049-1057(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: C57BL/6.
[2]"Mouse connexin37: gene structure and promoter analysis."
Seul K.H., Beyer E.C.
Biochim. Biophys. Acta 1492:499-504(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: 129/SvJ.
Tissue: Lung.
[3]"CTL induction by a tumour-associated antigen octapeptide derived from a murine lung carcinoma."
Mandelboim O., Berke G., Fridkin M., Feldman M., Eisenstein M., Eisenbach L.
Nature 369:67-71(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 52-59, VARIANTS GLN-54 AND ALA-59.
Tissue: Lung tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X57971 Genomic DNA. Translation: CAA41037.1.
AF216832 mRNA. Translation: AAF91221.1.
CCDSCCDS18667.1.
PIRA40548.
RefSeqNP_032146.1. NM_008120.3.
UniGeneMm.24615.

3D structure databases

ProteinModelPortalP28235.
SMRP28235. Positions 3-234.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP28235.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000053753; ENSMUSP00000062320; ENSMUSG00000050234.
GeneID14612.
KEGGmmu:14612.
UCSCuc008uur.1. mouse.

Organism-specific databases

CTD2701.
MGIMGI:95715. Gja4.

Phylogenomic databases

eggNOGNOG39708.
HOGENOMHOG000231127.
HOVERGENHBG009576.
InParanoidP28235.
KOK07613.
OMAQNWANLT.
OrthoDBEOG7P2XSS.
PhylomeDBP28235.
TreeFamTF329606.

Gene expression databases

ArrayExpressP28235.
BgeeP28235.
CleanExMM_GJA4.
GenevestigatorP28235.

Family and domain databases

InterProIPR000500. Connexin.
IPR002263. Connexin37.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERPTHR11984. PTHR11984. 1 hit.
PfamPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSPR00206. CONNEXIN.
PR01134. CONNEXINA4.
SMARTSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSGJA4. mouse.
NextBio286416.
PROP28235.
SOURCESearch...

Entry information

Entry nameCXA4_MOUSE
AccessionPrimary (citable) accession number: P28235
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot