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P28235

- CXA4_MOUSE

UniProt

P28235 - CXA4_MOUSE

Protein

Gap junction alpha-4 protein

Gene

Gja4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

    GO - Biological processi

    1. blood vessel development Source: MGI
    2. calcium ion transport Source: Ensembl
    3. cell-cell signaling Source: Ensembl
    4. endothelium development Source: Ensembl
    5. response to pain Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gap junction alpha-4 protein
    Alternative name(s):
    Connexin-37
    Short name:
    Cx37
    Gene namesi
    Name:Gja4
    Synonyms:Cxn-37
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:95715. Gja4.

    Subcellular locationi

    GO - Cellular componenti

    1. connexon complex Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Gap junction, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 333333Gap junction alpha-4 proteinPRO_0000057815Add
    BLAST

    Proteomic databases

    PRIDEiP28235.

    Expressioni

    Tissue specificityi

    Highly expressed in lung.

    Gene expression databases

    ArrayExpressiP28235.
    BgeeiP28235.
    CleanExiMM_GJA4.
    GenevestigatoriP28235.

    Interactioni

    Subunit structurei

    A connexon is composed of a hexamer of connexins.

    Structurei

    3D structure databases

    ProteinModelPortaliP28235.
    SMRiP28235. Positions 3-234.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2020CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini41 – 7636ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini100 – 14849CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini172 – 20837ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini232 – 333102CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei21 – 4020HelicalSequence AnalysisAdd
    BLAST
    Transmembranei77 – 9923HelicalSequence AnalysisAdd
    BLAST
    Transmembranei149 – 17123HelicalSequence AnalysisAdd
    BLAST
    Transmembranei209 – 23123HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG39708.
    HOGENOMiHOG000231127.
    HOVERGENiHBG009576.
    InParanoidiP28235.
    KOiK07613.
    OMAiQNWANLT.
    OrthoDBiEOG7P2XSS.
    PhylomeDBiP28235.
    TreeFamiTF329606.

    Family and domain databases

    InterProiIPR000500. Connexin.
    IPR002263. Connexin37.
    IPR019570. Connexin_CCC.
    IPR017990. Connexin_CS.
    IPR013092. Connexin_N.
    [Graphical view]
    PANTHERiPTHR11984. PTHR11984. 1 hit.
    PfamiPF00029. Connexin. 1 hit.
    PF10582. Connexin_CCC. 1 hit.
    [Graphical view]
    PRINTSiPR00206. CONNEXIN.
    PR01134. CONNEXINA4.
    SMARTiSM00037. CNX. 1 hit.
    SM01089. Connexin_CCC. 1 hit.
    [Graphical view]
    PROSITEiPS00407. CONNEXINS_1. 1 hit.
    PS00408. CONNEXINS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P28235-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGDWGFLEKL LDQVQEHSTV VGKIWLTVLF IFRILILGLA GESVWGDEQS    50
    DFECNTAQPG CTNVCYDQAF PISHIRYWVL QFLFVSTPTL IYLGHVIYLS 100
    RREERLRQKE GELRALPSKD LHVERALAAI EHQMAKISVA EDGRLRIRGA 150
    LMGTYVVSVL CKSVLEAGFL YGQWRLYGWT MEPVFVCQRA PCPHIVDCYV 200
    SRPTEKTIFI IFMLVVGVIS LVLNLLELVH LLCRCVSREI KARRDHDARP 250
    AQGSASDPYP EQVFFYLPMG EGPSSPPCPT YNGLSSTEQN WANLTTEERL 300
    TSSRPPPFVN TAPQGGRKSP SRPNSSASKK QYV 333
    Length:333
    Mass (Da):37,596
    Last modified:January 23, 2007 - v2
    Checksum:iC73D2B2AC0D926C1
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti54 – 541C → Q Requires 2 nucleotide substitutions. 1 Publication
    Natural varianti59 – 591P → A.1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X57971 Genomic DNA. Translation: CAA41037.1.
    AF216832 mRNA. Translation: AAF91221.1.
    CCDSiCCDS18667.1.
    PIRiA40548.
    RefSeqiNP_032146.1. NM_008120.3.
    UniGeneiMm.24615.

    Genome annotation databases

    EnsembliENSMUST00000053753; ENSMUSP00000062320; ENSMUSG00000050234.
    GeneIDi14612.
    KEGGimmu:14612.
    UCSCiuc008uur.1. mouse.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X57971 Genomic DNA. Translation: CAA41037.1 .
    AF216832 mRNA. Translation: AAF91221.1 .
    CCDSi CCDS18667.1.
    PIRi A40548.
    RefSeqi NP_032146.1. NM_008120.3.
    UniGenei Mm.24615.

    3D structure databases

    ProteinModelPortali P28235.
    SMRi P28235. Positions 3-234.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P28235.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000053753 ; ENSMUSP00000062320 ; ENSMUSG00000050234 .
    GeneIDi 14612.
    KEGGi mmu:14612.
    UCSCi uc008uur.1. mouse.

    Organism-specific databases

    CTDi 2701.
    MGIi MGI:95715. Gja4.

    Phylogenomic databases

    eggNOGi NOG39708.
    HOGENOMi HOG000231127.
    HOVERGENi HBG009576.
    InParanoidi P28235.
    KOi K07613.
    OMAi QNWANLT.
    OrthoDBi EOG7P2XSS.
    PhylomeDBi P28235.
    TreeFami TF329606.

    Miscellaneous databases

    ChiTaRSi GJA4. mouse.
    NextBioi 286416.
    PROi P28235.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P28235.
    Bgeei P28235.
    CleanExi MM_GJA4.
    Genevestigatori P28235.

    Family and domain databases

    InterProi IPR000500. Connexin.
    IPR002263. Connexin37.
    IPR019570. Connexin_CCC.
    IPR017990. Connexin_CS.
    IPR013092. Connexin_N.
    [Graphical view ]
    PANTHERi PTHR11984. PTHR11984. 1 hit.
    Pfami PF00029. Connexin. 1 hit.
    PF10582. Connexin_CCC. 1 hit.
    [Graphical view ]
    PRINTSi PR00206. CONNEXIN.
    PR01134. CONNEXINA4.
    SMARTi SM00037. CNX. 1 hit.
    SM01089. Connexin_CCC. 1 hit.
    [Graphical view ]
    PROSITEi PS00407. CONNEXINS_1. 1 hit.
    PS00408. CONNEXINS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse connexin37: cloning and functional expression of a gap junction gene highly expressed in lung."
      Willecke K., Heynkes R., Dahl E., Stutenkemper R., Hennemann H., Jungbluth S., Suchyna T., Nicholson B.J.
      J. Cell Biol. 114:1049-1057(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: C57BL/6.
    2. "Mouse connexin37: gene structure and promoter analysis."
      Seul K.H., Beyer E.C.
      Biochim. Biophys. Acta 1492:499-504(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: 129/SvJ.
      Tissue: Lung.
    3. "CTL induction by a tumour-associated antigen octapeptide derived from a murine lung carcinoma."
      Mandelboim O., Berke G., Fridkin M., Feldman M., Eisenstein M., Eisenbach L.
      Nature 369:67-71(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 52-59, VARIANTS GLN-54 AND ALA-59.
      Tissue: Lung tumor.

    Entry informationi

    Entry nameiCXA4_MOUSE
    AccessioniPrimary (citable) accession number: P28235
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3