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Protein

Gap junction alpha-4 protein

Gene

Gja4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Biological processi

  1. blood vessel development Source: MGI
  2. calcium ion transport Source: Ensembl
  3. cell-cell signaling Source: Ensembl
  4. endothelium development Source: Ensembl
  5. response to pain Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction alpha-4 protein
Alternative name(s):
Connexin-37
Short name:
Cx37
Gene namesi
Name:Gja4
Synonyms:Cxn-37
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:95715. Gja4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei21 – 4020HelicalSequence AnalysisAdd
BLAST
Topological domaini41 – 7636ExtracellularSequence AnalysisAdd
BLAST
Transmembranei77 – 9923HelicalSequence AnalysisAdd
BLAST
Topological domaini100 – 14849CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei149 – 17123HelicalSequence AnalysisAdd
BLAST
Topological domaini172 – 20837ExtracellularSequence AnalysisAdd
BLAST
Transmembranei209 – 23123HelicalSequence AnalysisAdd
BLAST
Topological domaini232 – 333102CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. connexon complex Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 333333Gap junction alpha-4 proteinPRO_0000057815Add
BLAST

Proteomic databases

PRIDEiP28235.

Expressioni

Tissue specificityi

Highly expressed in lung.

Gene expression databases

BgeeiP28235.
CleanExiMM_GJA4.
ExpressionAtlasiP28235. baseline and differential.
GenevestigatoriP28235.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.

Structurei

3D structure databases

ProteinModelPortaliP28235.
SMRiP28235. Positions 3-234.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG39708.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiP28235.
KOiK07613.
OMAiQNWANLT.
OrthoDBiEOG7P2XSS.
PhylomeDBiP28235.
TreeFamiTF329606.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002263. Connexin37.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01134. CONNEXINA4.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28235-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDWGFLEKL LDQVQEHSTV VGKIWLTVLF IFRILILGLA GESVWGDEQS
60 70 80 90 100
DFECNTAQPG CTNVCYDQAF PISHIRYWVL QFLFVSTPTL IYLGHVIYLS
110 120 130 140 150
RREERLRQKE GELRALPSKD LHVERALAAI EHQMAKISVA EDGRLRIRGA
160 170 180 190 200
LMGTYVVSVL CKSVLEAGFL YGQWRLYGWT MEPVFVCQRA PCPHIVDCYV
210 220 230 240 250
SRPTEKTIFI IFMLVVGVIS LVLNLLELVH LLCRCVSREI KARRDHDARP
260 270 280 290 300
AQGSASDPYP EQVFFYLPMG EGPSSPPCPT YNGLSSTEQN WANLTTEERL
310 320 330
TSSRPPPFVN TAPQGGRKSP SRPNSSASKK QYV
Length:333
Mass (Da):37,596
Last modified:January 22, 2007 - v2
Checksum:iC73D2B2AC0D926C1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti54 – 541C → Q Requires 2 nucleotide substitutions. 1 Publication
Natural varianti59 – 591P → A.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57971 Genomic DNA. Translation: CAA41037.1.
AF216832 mRNA. Translation: AAF91221.1.
CCDSiCCDS18667.1.
PIRiA40548.
RefSeqiNP_032146.1. NM_008120.3.
UniGeneiMm.24615.

Genome annotation databases

EnsembliENSMUST00000053753; ENSMUSP00000062320; ENSMUSG00000050234.
GeneIDi14612.
KEGGimmu:14612.
UCSCiuc008uur.1. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57971 Genomic DNA. Translation: CAA41037.1.
AF216832 mRNA. Translation: AAF91221.1.
CCDSiCCDS18667.1.
PIRiA40548.
RefSeqiNP_032146.1. NM_008120.3.
UniGeneiMm.24615.

3D structure databases

ProteinModelPortaliP28235.
SMRiP28235. Positions 3-234.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP28235.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053753; ENSMUSP00000062320; ENSMUSG00000050234.
GeneIDi14612.
KEGGimmu:14612.
UCSCiuc008uur.1. mouse.

Organism-specific databases

CTDi2701.
MGIiMGI:95715. Gja4.

Phylogenomic databases

eggNOGiNOG39708.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiP28235.
KOiK07613.
OMAiQNWANLT.
OrthoDBiEOG7P2XSS.
PhylomeDBiP28235.
TreeFamiTF329606.

Miscellaneous databases

ChiTaRSiGja4. mouse.
NextBioi286416.
PROiP28235.
SOURCEiSearch...

Gene expression databases

BgeeiP28235.
CleanExiMM_GJA4.
ExpressionAtlasiP28235. baseline and differential.
GenevestigatoriP28235.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002263. Connexin37.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01134. CONNEXINA4.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Mouse connexin37: cloning and functional expression of a gap junction gene highly expressed in lung."
    Willecke K., Heynkes R., Dahl E., Stutenkemper R., Hennemann H., Jungbluth S., Suchyna T., Nicholson B.J.
    J. Cell Biol. 114:1049-1057(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C57BL/6.
  2. "Mouse connexin37: gene structure and promoter analysis."
    Seul K.H., Beyer E.C.
    Biochim. Biophys. Acta 1492:499-504(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129/SvJ.
    Tissue: Lung.
  3. "CTL induction by a tumour-associated antigen octapeptide derived from a murine lung carcinoma."
    Mandelboim O., Berke G., Fridkin M., Feldman M., Eisenstein M., Eisenbach L.
    Nature 369:67-71(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 52-59, VARIANTS GLN-54 AND ALA-59.
    Tissue: Lung tumor.

Entry informationi

Entry nameiCXA4_MOUSE
AccessioniPrimary (citable) accession number: P28235
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 30, 1992
Last sequence update: January 22, 2007
Last modified: January 6, 2015
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.