ID   CXA5_RAT                Reviewed;         356 AA.
AC   P28234;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   25-JAN-2012, entry version 89.
DE   RecName: Full=Gap junction alpha-5 protein;
DE   AltName: Full=Connexin-40;
DE            Short=Cx40;
GN   Name=Gja5; Synonyms=Cxn-40;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Sprague-Dawley;
RX   MEDLINE=92112940; PubMed=1370487;
RA   Haefliger J.-A., Bruzzone R., Jenkins N.A., Gilbert D.J.,
RA   Copeland N.G., Paul D.L.;
RT   "Four novel members of the connexin family of gap junction proteins.
RT   Molecular cloning, expression, and chromosome mapping.";
RL   J. Biol. Chem. 267:2057-2064(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=93021055; PubMed=1328644; DOI=10.1007/BF00232759;
RA   Beyer E.C., Reed K.E., Westphale E.M., Kanter H.L., Larson D.M.;
RT   "Molecular cloning and expression of rat connexin40, a gap junction
RT   protein expressed in vascular smooth muscle.";
RL   J. Membr. Biol. 127:69-76(1992).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX   MEDLINE=98066770; PubMed=9403066; DOI=10.1006/geno.1997.5025;
RA   Seul K.H., Tadros P.N., Beyer E.C.;
RT   "Mouse connexin40: gene structure and promoter analysis.";
RL   Genomics 46:120-126(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC       pairs of transmembrane channels, the connexons, through which
CC       materials of low MW diffuse from one cell to a neighboring cell.
CC   -!- SUBUNIT: A connexon is composed of a hexamer of connexins.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC       Cell junction, gap junction.
CC   -!- TISSUE SPECIFICITY: Highly expressed in lung.
CC   -!- SIMILARITY: Belongs to the connexin family. Alpha-type (group II)
CC       subfamily.
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DR   EMBL; M76535; AAA41000.1; -; Genomic_DNA.
DR   EMBL; M83092; AAA41194.1; -; mRNA.
DR   EMBL; AF021806; AAC53502.1; -; mRNA.
DR   EMBL; AF022136; AAC53503.1; -; Genomic_DNA.
DR   EMBL; BC070935; AAH70935.1; -; mRNA.
DR   IPI; IPI00230782; -.
DR   PIR; A42053; A42053.
DR   RefSeq; NP_062153.1; NM_019280.1.
DR   UniGene; Rn.88300; -.
DR   PDB; 2K7M; NMR; -; A=252-356.
DR   PDBsum; 2K7M; -.
DR   ProteinModelPortal; P28234; -.
DR   STRING; P28234; -.
DR   PRIDE; P28234; -.
DR   Ensembl; ENSRNOT00000023488; ENSRNOP00000023488; ENSRNOG00000017484.
DR   GeneID; 50563; -.
DR   KEGG; rno:50563; -.
DR   UCSC; NM_019280; rat.
DR   CTD; 2702; -.
DR   RGD; 2692; Gja5.
DR   eggNOG; roNOG11929; -.
DR   GeneTree; ENSGT00560000076859; -.
DR   HOVERGEN; HBG009576; -.
DR   InParanoid; P28234; -.
DR   OMA; DWSFLGE; -.
DR   OrthoDB; EOG4MSCZF; -.
DR   PhylomeDB; P28234; -.
DR   NextBio; 610390; -.
DR   ArrayExpress; P28234; -.
DR   Genevestigator; P28234; -.
DR   GermOnline; ENSRNOG00000017484; Rattus norvegicus.
DR   GO; GO:0005922; C:connexon complex; IDA:RGD.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005243; F:gap junction channel activity; IDA:RGD.
DR   GO; GO:0007267; P:cell-cell signaling; IDA:RGD.
DR   InterPro; IPR000500; Connexin.
DR   InterPro; IPR002264; Connexin40.
DR   InterPro; IPR019570; Connexin_CCC.
DR   InterPro; IPR017990; Connexin_CS.
DR   InterPro; IPR013092; Connexin_N.
DR   KO; K07614; -.
DR   PANTHER; PTHR11984; Connexin; 1.
DR   PANTHER; PTHR11984:SF13; Connexin40; 1.
DR   Pfam; PF00029; Connexin; 1.
DR   Pfam; PF10582; Connexin_CCC; 1.
DR   PRINTS; PR00206; CONNEXIN.
DR   PRINTS; PR01135; CONNEXINA5.
DR   SMART; SM00037; CNX; 1.
DR   SMART; SM01089; Connexin_CCC; 1.
DR   PROSITE; PS00407; CONNEXINS_1; 1.
DR   PROSITE; PS00408; CONNEXINS_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell junction; Cell membrane; Complete proteome;
KW   Gap junction; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    356       Gap junction alpha-5 protein.
FT                                /FTId=PRO_0000057821.
FT   TOPO_DOM      2     19       Cytoplasmic (Potential).
FT   TRANSMEM     20     40       Helical; (Potential).
FT   TOPO_DOM     41     76       Extracellular (Potential).
FT   TRANSMEM     77     97       Helical; (Potential).
FT   TOPO_DOM     98    163       Cytoplasmic (Potential).
FT   TRANSMEM    164    184       Helical; (Potential).
FT   TOPO_DOM    185    204       Extracellular (Potential).
FT   TRANSMEM    205    225       Helical; (Potential).
FT   TOPO_DOM    226    356       Cytoplasmic (Potential).
FT   STRAND      261    263
FT   TURN        266    269
FT   STRAND      293    297
FT   STRAND      300    303
SQ   SEQUENCE   356 AA;  40233 MW;  7D459FE69D9ACF0C CRC64;
     MGDWSFLGEF LEEVHKHSTV IGKVWLTVLF IFRMLVLGTA AESSWGDEQA DFRCDTIQPG
     CQNVCYDQAF PISHIRYWVL QIIFVSTPSL VYMGHAMHTV RMQEKQKLRE AEKAKEAGGT
     GTYEYLAEKA ELSCWKEVNG KIVLQGTLLN TYVCTILIRT AMEVAFMVGQ YLLYGIFLDT
     LHVCRRSPCP HPVNCYVSRP TEKNVFIVFM MAVAGLSLFL SLAELYHLGW KKIRQRLAKS
     RQGDKHQLLG PSTSLVQGLT PPPDFNQCLK NSPDEKFFSD FSNNMGSRKN PDPLATEEVP
     NQEQIPEEGF IHTQYGQKPE QPSGASAGHR FPQGYHSDKR RLSKASSKAR SDDLSV
//