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Protein

Gap junction alpha-5 protein

Gene

Gja5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-190861 Gap junction assembly

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction alpha-5 protein
Alternative name(s):
Connexin-40
Short name:
Cx40
Gene namesi
Name:Gja5
Synonyms:Cxn-40
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi2692 Gja5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19CytoplasmicSequence analysisAdd BLAST19
Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Topological domaini41 – 76ExtracellularSequence analysisAdd BLAST36
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Topological domaini98 – 163CytoplasmicSequence analysisAdd BLAST66
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Topological domaini185 – 204ExtracellularSequence analysisAdd BLAST20
Transmembranei205 – 225HelicalSequence analysisAdd BLAST21
Topological domaini226 – 356CytoplasmicSequence analysisAdd BLAST131

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000578211 – 356Gap junction alpha-5 proteinAdd BLAST356

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei351PhosphoserineCombined sources1
Modified residuei355PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP28234
PRIDEiP28234

PTM databases

iPTMnetiP28234
PhosphoSitePlusiP28234

Expressioni

Tissue specificityi

Highly expressed in lung.

Gene expression databases

BgeeiENSRNOG00000017484
GenevisibleiP28234 RN

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.

GO - Molecular functioni

  • connexin binding Source: RGD
  • disordered domain specific binding Source: CAFA

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023488

Structurei

Secondary structure

1356
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi261 – 263Combined sources3
Turni266 – 269Combined sources4
Beta strandi293 – 297Combined sources5
Beta strandi300 – 303Combined sources4
Beta strandi323 – 325Combined sources3
Beta strandi327 – 329Combined sources3
Turni332 – 334Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K7MNMR-A252-356[»]
ProteinModelPortaliP28234
SMRiP28234
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP28234

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF3Z Eukaryota
ENOG410ZC96 LUCA
GeneTreeiENSGT00910000143998
HOGENOMiHOG000231127
HOVERGENiHBG009576
InParanoidiP28234
KOiK07614
OMAiYLLYGIF
OrthoDBiEOG091G0FKH
PhylomeDBiP28234
TreeFamiTF329606

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR002264 Connexin40
IPR034634 Connexin_C
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
IPR031862 Cx40_C
PANTHERiPTHR11984 PTHR11984, 1 hit
PTHR11984:SF13 PTHR11984:SF13, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PF16791 Connexin40_C, 1 hit
PRINTSiPR00206 CONNEXIN
PR01135 CONNEXINA5
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
SUPFAMiSSF118220 SSF118220, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit

Sequencei

Sequence statusi: Complete.

P28234-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDWSFLGEF LEEVHKHSTV IGKVWLTVLF IFRMLVLGTA AESSWGDEQA
60 70 80 90 100
DFRCDTIQPG CQNVCYDQAF PISHIRYWVL QIIFVSTPSL VYMGHAMHTV
110 120 130 140 150
RMQEKQKLRE AEKAKEAGGT GTYEYLAEKA ELSCWKEVNG KIVLQGTLLN
160 170 180 190 200
TYVCTILIRT AMEVAFMVGQ YLLYGIFLDT LHVCRRSPCP HPVNCYVSRP
210 220 230 240 250
TEKNVFIVFM MAVAGLSLFL SLAELYHLGW KKIRQRLAKS RQGDKHQLLG
260 270 280 290 300
PSTSLVQGLT PPPDFNQCLK NSPDEKFFSD FSNNMGSRKN PDPLATEEVP
310 320 330 340 350
NQEQIPEEGF IHTQYGQKPE QPSGASAGHR FPQGYHSDKR RLSKASSKAR

SDDLSV
Length:356
Mass (Da):40,233
Last modified:January 23, 2007 - v2
Checksum:i7D459FE69D9ACF0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76535 Genomic DNA Translation: AAA41000.1
M83092 mRNA Translation: AAA41194.1
AF021806 mRNA Translation: AAC53502.1
AF022136 Genomic DNA Translation: AAC53503.1
BC070935 mRNA Translation: AAH70935.1
PIRiA42053
RefSeqiNP_062153.1, NM_019280.1
UniGeneiRn.88300

Genome annotation databases

EnsembliENSRNOT00000023488; ENSRNOP00000023488; ENSRNOG00000017484
GeneIDi50563
KEGGirno:50563
UCSCiRGD:2692 rat

Similar proteinsi

Entry informationi

Entry nameiCXA5_RAT
AccessioniPrimary (citable) accession number: P28234
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health