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P28234

- CXA5_RAT

UniProt

P28234 - CXA5_RAT

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Protein

Gap junction alpha-5 protein

Gene

Gja5

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Molecular functioni

  1. connexin binding Source: RGD
  2. gap junction channel activity Source: RGD
  3. gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling Source: Ensembl
  4. gap junction hemi-channel activity Source: Ensembl

GO - Biological processi

  1. angiogenesis Source: Ensembl
  2. artery morphogenesis Source: Ensembl
  3. atrial cardiac muscle cell action potential Source: Ensembl
  4. atrial septum morphogenesis Source: Ensembl
  5. atrial ventricular junction remodeling Source: Ensembl
  6. bundle of His cell to Purkinje myocyte communication Source: Ensembl
  7. cardiac conduction system development Source: Ensembl
  8. cell communication by chemical coupling Source: RGD
  9. cell communication by electrical coupling Source: RGD
  10. embryonic heart tube development Source: Ensembl
  11. embryonic limb morphogenesis Source: Ensembl
  12. endothelium development Source: RGD
  13. foramen ovale closure Source: Ensembl
  14. gap junction assembly Source: Ensembl
  15. heart development Source: RGD
  16. mitral valve development Source: Ensembl
  17. negative regulation of blood pressure Source: RGD
  18. negative regulation of glomerular filtration Source: RGD
  19. outflow tract morphogenesis Source: Ensembl
  20. positive regulation of cell communication by chemical coupling Source: RGD
  21. positive regulation of vasoconstriction Source: RGD
  22. positive regulation of vasodilation Source: RGD
  23. potassium ion transport Source: RGD
  24. protein oligomerization Source: RGD
  25. pulmonary valve formation Source: Ensembl
  26. regulation of atrial cardiac muscle cell membrane depolarization Source: Ensembl
  27. regulation of heart rate by cardiac conduction Source: Ensembl
  28. regulation of membrane depolarization during cardiac muscle cell action potential Source: Ensembl
  29. regulation of renin secretion into blood stream Source: Ensembl
  30. regulation of ventricular cardiac muscle cell membrane depolarization Source: Ensembl
  31. regulation of ventricular cardiac muscle cell membrane repolarization Source: Ensembl
  32. SA node cell action potential Source: Ensembl
  33. septum primum development Source: Ensembl
  34. skeletal system development Source: Ensembl
  35. transmembrane transport Source: GOC
  36. vasomotion Source: RGD
  37. ventricular cardiac muscle cell action potential Source: Ensembl
  38. ventricular septum morphogenesis Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction alpha-5 protein
Alternative name(s):
Connexin-40
Short name:
Cx40
Gene namesi
Name:Gja5
Synonyms:Cxn-40
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 2

Organism-specific databases

RGDi2692. Gja5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei20 – 4021HelicalSequence AnalysisAdd
BLAST
Topological domaini41 – 7636ExtracellularSequence AnalysisAdd
BLAST
Transmembranei77 – 9721HelicalSequence AnalysisAdd
BLAST
Topological domaini98 – 16366CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei164 – 18421HelicalSequence AnalysisAdd
BLAST
Topological domaini185 – 20420ExtracellularSequence AnalysisAdd
BLAST
Transmembranei205 – 22521HelicalSequence AnalysisAdd
BLAST
Topological domaini226 – 356131CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell projection Source: RGD
  2. connexon complex Source: RGD
  3. integral component of plasma membrane Source: Ensembl
  4. intercalated disc Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 356356Gap junction alpha-5 proteinPRO_0000057821Add
BLAST

Proteomic databases

PRIDEiP28234.

Expressioni

Tissue specificityi

Highly expressed in lung.

Gene expression databases

GenevestigatoriP28234.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023488.

Structurei

Secondary structure

1
356
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi261 – 2633Combined sources
Turni266 – 2694Combined sources
Beta strandi293 – 2975Combined sources
Beta strandi300 – 3034Combined sources
Beta strandi323 – 3253Combined sources
Beta strandi327 – 3293Combined sources
Turni332 – 3343Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2K7MNMR-A252-356[»]
ProteinModelPortaliP28234.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP28234.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45265.
GeneTreeiENSGT00760000118780.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiP28234.
KOiK07614.
OMAiDWSFLGE.
OrthoDBiEOG7P2XSS.
PhylomeDBiP28234.
TreeFamiTF329606.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002264. Connexin40.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PTHR11984:SF13. PTHR11984:SF13. 1 hit.
PfamiPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01135. CONNEXINA5.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28234-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGDWSFLGEF LEEVHKHSTV IGKVWLTVLF IFRMLVLGTA AESSWGDEQA
60 70 80 90 100
DFRCDTIQPG CQNVCYDQAF PISHIRYWVL QIIFVSTPSL VYMGHAMHTV
110 120 130 140 150
RMQEKQKLRE AEKAKEAGGT GTYEYLAEKA ELSCWKEVNG KIVLQGTLLN
160 170 180 190 200
TYVCTILIRT AMEVAFMVGQ YLLYGIFLDT LHVCRRSPCP HPVNCYVSRP
210 220 230 240 250
TEKNVFIVFM MAVAGLSLFL SLAELYHLGW KKIRQRLAKS RQGDKHQLLG
260 270 280 290 300
PSTSLVQGLT PPPDFNQCLK NSPDEKFFSD FSNNMGSRKN PDPLATEEVP
310 320 330 340 350
NQEQIPEEGF IHTQYGQKPE QPSGASAGHR FPQGYHSDKR RLSKASSKAR

SDDLSV
Length:356
Mass (Da):40,233
Last modified:January 23, 2007 - v2
Checksum:i7D459FE69D9ACF0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76535 Genomic DNA. Translation: AAA41000.1.
M83092 mRNA. Translation: AAA41194.1.
AF021806 mRNA. Translation: AAC53502.1.
AF022136 Genomic DNA. Translation: AAC53503.1.
BC070935 mRNA. Translation: AAH70935.1.
PIRiA42053.
RefSeqiNP_062153.1. NM_019280.1.
XP_008759550.1. XM_008761328.1.
UniGeneiRn.88300.

Genome annotation databases

EnsembliENSRNOT00000023488; ENSRNOP00000023488; ENSRNOG00000017484.
GeneIDi50563.
KEGGirno:50563.
UCSCiRGD:2692. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76535 Genomic DNA. Translation: AAA41000.1 .
M83092 mRNA. Translation: AAA41194.1 .
AF021806 mRNA. Translation: AAC53502.1 .
AF022136 Genomic DNA. Translation: AAC53503.1 .
BC070935 mRNA. Translation: AAH70935.1 .
PIRi A42053.
RefSeqi NP_062153.1. NM_019280.1.
XP_008759550.1. XM_008761328.1.
UniGenei Rn.88300.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2K7M NMR - A 252-356 [» ]
ProteinModelPortali P28234.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000023488.

Proteomic databases

PRIDEi P28234.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000023488 ; ENSRNOP00000023488 ; ENSRNOG00000017484 .
GeneIDi 50563.
KEGGi rno:50563.
UCSCi RGD:2692. rat.

Organism-specific databases

CTDi 2702.
RGDi 2692. Gja5.

Phylogenomic databases

eggNOGi NOG45265.
GeneTreei ENSGT00760000118780.
HOGENOMi HOG000231127.
HOVERGENi HBG009576.
InParanoidi P28234.
KOi K07614.
OMAi DWSFLGE.
OrthoDBi EOG7P2XSS.
PhylomeDBi P28234.
TreeFami TF329606.

Miscellaneous databases

EvolutionaryTracei P28234.
NextBioi 610390.
PROi P28234.

Gene expression databases

Genevestigatori P28234.

Family and domain databases

InterProi IPR000500. Connexin.
IPR002264. Connexin40.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view ]
PANTHERi PTHR11984. PTHR11984. 1 hit.
PTHR11984:SF13. PTHR11984:SF13. 1 hit.
Pfami PF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view ]
PRINTSi PR00206. CONNEXIN.
PR01135. CONNEXINA5.
SMARTi SM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view ]
PROSITEi PS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping."
    Haefliger J.-A., Bruzzone R., Jenkins N.A., Gilbert D.J., Copeland N.G., Paul D.L.
    J. Biol. Chem. 267:2057-2064(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-Dawley.
  2. "Molecular cloning and expression of rat connexin40, a gap junction protein expressed in vascular smooth muscle."
    Beyer E.C., Reed K.E., Westphale E.M., Kanter H.L., Larson D.M.
    J. Membr. Biol. 127:69-76(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Mouse connexin40: gene structure and promoter analysis."
    Seul K.H., Tadros P.N., Beyer E.C.
    Genomics 46:120-126(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiCXA5_RAT
AccessioniPrimary (citable) accession number: P28234
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3