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P28233

- CXA6_RAT

UniProt

P28233 - CXA6_RAT

Protein

Gap junction alpha-6 protein

Gene

Gja6

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Dec 1992)
      Previous versions | rss
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    Functioni

    One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

    GO - Molecular functioni

    1. gap junction channel activity Source: RGD

    GO - Biological processi

    1. cell communication Source: InterPro
    2. gap junction assembly Source: RGD
    3. transmembrane transport Source: GOC

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gap junction alpha-6 protein
    Alternative name(s):
    Connexin-33
    Short name:
    Cx33
    Gene namesi
    Name:Gja6
    Synonyms:Cxn-33
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi2693. Gja6.

    Subcellular locationi

    GO - Cellular componenti

    1. connexon complex Source: RGD
    2. gap junction Source: RGD
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Gap junction, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 286286Gap junction alpha-6 proteinPRO_0000057824Add
    BLAST

    Proteomic databases

    PRIDEiP28233.

    Expressioni

    Tissue specificityi

    Expressed in testis.

    Gene expression databases

    GenevestigatoriP28233.

    Interactioni

    Subunit structurei

    A connexon is composed of a hexamer of connexins.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2323CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini42 – 7635ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini100 – 15152CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini175 – 20935ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini233 – 28654CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei24 – 4118HelicalSequence AnalysisAdd
    BLAST
    Transmembranei77 – 9923HelicalSequence AnalysisAdd
    BLAST
    Transmembranei152 – 17423HelicalSequence AnalysisAdd
    BLAST
    Transmembranei210 – 23223HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG009576.
    KOiK07615.
    PhylomeDBiP28233.

    Family and domain databases

    InterProiIPR000500. Connexin.
    IPR019570. Connexin_CCC.
    IPR017990. Connexin_CS.
    IPR013092. Connexin_N.
    [Graphical view]
    PANTHERiPTHR11984. PTHR11984. 1 hit.
    PfamiPF00029. Connexin. 1 hit.
    PF10582. Connexin_CCC. 1 hit.
    [Graphical view]
    PRINTSiPR00206. CONNEXIN.
    SMARTiSM00037. CNX. 1 hit.
    SM01089. Connexin_CCC. 1 hit.
    [Graphical view]
    PROSITEiPS00407. CONNEXINS_1. 1 hit.
    PS00408. CONNEXINS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P28233-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDWSALHQL LEKVQPYSTA GGKVWIKVLF IFRILLLGTA IESAWSDEQF    50
    EFHCNTQQPG CENVCYDQAF PISHVRLWVL QVIFVSVPTL LHLAHVYYVI 100
    RQNEKLKKQE EEELKVAHFN GASGERRLQK HTGKHIKCGS KEHGNRKMRG 150
    RLLLTYMASI FFKSVFEVAF LLIQWYLYGF TLSAVYICEQ SPCPHRVDCF 200
    LSRPTEKTIF ILFMLVVSMV SFVLNVIELF YVLFKAIKNH LGNEKEEVYC 250
    NPVELQKPSC VSSSAVLTTI CSSDQVVPVG LSSFYM 286
    Length:286
    Mass (Da):32,860
    Last modified:December 1, 1992 - v1
    Checksum:iA585266ACA2ACCF2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M76534 Genomic DNA. Translation: AAA40998.1.
    PIRiC42053.
    RefSeqiNP_062181.1. NM_019308.1.
    XP_006256956.1. XM_006256894.1.
    UniGeneiRn.209042.

    Genome annotation databases

    GeneIDi54256.
    KEGGirno:54256.
    UCSCiRGD:2693. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M76534 Genomic DNA. Translation: AAA40998.1 .
    PIRi C42053.
    RefSeqi NP_062181.1. NM_019308.1.
    XP_006256956.1. XM_006256894.1.
    UniGenei Rn.209042.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P28233.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 54256.
    KEGGi rno:54256.
    UCSCi RGD:2693. rat.

    Organism-specific databases

    CTDi 414089.
    RGDi 2693. Gja6.

    Phylogenomic databases

    HOVERGENi HBG009576.
    KOi K07615.
    PhylomeDBi P28233.

    Miscellaneous databases

    NextBioi 610766.

    Gene expression databases

    Genevestigatori P28233.

    Family and domain databases

    InterProi IPR000500. Connexin.
    IPR019570. Connexin_CCC.
    IPR017990. Connexin_CS.
    IPR013092. Connexin_N.
    [Graphical view ]
    PANTHERi PTHR11984. PTHR11984. 1 hit.
    Pfami PF00029. Connexin. 1 hit.
    PF10582. Connexin_CCC. 1 hit.
    [Graphical view ]
    PRINTSi PR00206. CONNEXIN.
    SMARTi SM00037. CNX. 1 hit.
    SM01089. Connexin_CCC. 1 hit.
    [Graphical view ]
    PROSITEi PS00407. CONNEXINS_1. 1 hit.
    PS00408. CONNEXINS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping."
      Haefliger J.-A., Bruzzone R., Jenkins N.A., Gilbert D.J., Copeland N.G., Paul D.L.
      J. Biol. Chem. 267:2057-2064(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiCXA6_RAT
    AccessioniPrimary (citable) accession number: P28233
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: December 1, 1992
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3