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Protein

Gap junction alpha-6 protein

Gene

Gja6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction alpha-6 protein
Alternative name(s):
Connexin-33
Short name:
Cx33
Gene namesi
Name:Gja6
Synonyms:Cxn-33
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2693 Gja6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23CytoplasmicSequence analysisAdd BLAST23
Transmembranei24 – 41HelicalSequence analysisAdd BLAST18
Topological domaini42 – 76ExtracellularSequence analysisAdd BLAST35
Transmembranei77 – 99HelicalSequence analysisAdd BLAST23
Topological domaini100 – 151CytoplasmicSequence analysisAdd BLAST52
Transmembranei152 – 174HelicalSequence analysisAdd BLAST23
Topological domaini175 – 209ExtracellularSequence analysisAdd BLAST35
Transmembranei210 – 232HelicalSequence analysisAdd BLAST23
Topological domaini233 – 286CytoplasmicSequence analysisAdd BLAST54

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000578241 – 286Gap junction alpha-6 proteinAdd BLAST286

Proteomic databases

PRIDEiP28233

Expressioni

Tissue specificityi

Expressed in testis.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG009576
InParanoidiP28233
KOiK07615
PhylomeDBiP28233

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PRINTSiPR00206 CONNEXIN
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit

Sequencei

Sequence statusi: Complete.

P28233-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDWSALHQL LEKVQPYSTA GGKVWIKVLF IFRILLLGTA IESAWSDEQF
60 70 80 90 100
EFHCNTQQPG CENVCYDQAF PISHVRLWVL QVIFVSVPTL LHLAHVYYVI
110 120 130 140 150
RQNEKLKKQE EEELKVAHFN GASGERRLQK HTGKHIKCGS KEHGNRKMRG
160 170 180 190 200
RLLLTYMASI FFKSVFEVAF LLIQWYLYGF TLSAVYICEQ SPCPHRVDCF
210 220 230 240 250
LSRPTEKTIF ILFMLVVSMV SFVLNVIELF YVLFKAIKNH LGNEKEEVYC
260 270 280
NPVELQKPSC VSSSAVLTTI CSSDQVVPVG LSSFYM
Length:286
Mass (Da):32,860
Last modified:December 1, 1992 - v1
Checksum:iA585266ACA2ACCF2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76534 Genomic DNA Translation: AAA40998.1
PIRiC42053
RefSeqiNP_062181.1, NM_019308.1
UniGeneiRn.209042

Genome annotation databases

GeneIDi54256
KEGGirno:54256
UCSCiRGD:2693 rat

Similar proteinsi

Entry informationi

Entry nameiCXA6_RAT
AccessioniPrimary (citable) accession number: P28233
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: April 25, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health