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P28233 (CXA6_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gap junction alpha-6 protein
Alternative name(s):
Connexin-33
Short name=Cx33
Gene names
Name:Gja6
Synonyms:Cxn-33
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length286 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

Subunit structure

A connexon is composed of a hexamer of connexins.

Subcellular location

Cell membrane; Multi-pass membrane protein. Cell junctiongap junction.

Tissue specificity

Expressed in testis.

Sequence similarities

Belongs to the connexin family. Alpha-type (group II) subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 286286Gap junction alpha-6 protein
PRO_0000057824

Regions

Topological domain1 – 2323Cytoplasmic Potential
Transmembrane24 – 4118Helical; Potential
Topological domain42 – 7635Extracellular Potential
Transmembrane77 – 9923Helical; Potential
Topological domain100 – 15152Cytoplasmic Potential
Transmembrane152 – 17423Helical; Potential
Topological domain175 – 20935Extracellular Potential
Transmembrane210 – 23223Helical; Potential
Topological domain233 – 28654Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
P28233 [UniParc].

Last modified December 1, 1992. Version 1.
Checksum: A585266ACA2ACCF2

FASTA28632,860
        10         20         30         40         50         60 
MSDWSALHQL LEKVQPYSTA GGKVWIKVLF IFRILLLGTA IESAWSDEQF EFHCNTQQPG 

        70         80         90        100        110        120 
CENVCYDQAF PISHVRLWVL QVIFVSVPTL LHLAHVYYVI RQNEKLKKQE EEELKVAHFN 

       130        140        150        160        170        180 
GASGERRLQK HTGKHIKCGS KEHGNRKMRG RLLLTYMASI FFKSVFEVAF LLIQWYLYGF 

       190        200        210        220        230        240 
TLSAVYICEQ SPCPHRVDCF LSRPTEKTIF ILFMLVVSMV SFVLNVIELF YVLFKAIKNH 

       250        260        270        280 
LGNEKEEVYC NPVELQKPSC VSSSAVLTTI CSSDQVVPVG LSSFYM 

« Hide

References

[1]"Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping."
Haefliger J.-A., Bruzzone R., Jenkins N.A., Gilbert D.J., Copeland N.G., Paul D.L.
J. Biol. Chem. 267:2057-2064(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M76534 Genomic DNA. Translation: AAA40998.1.
PIRC42053.
RefSeqNP_062181.1. NM_019308.1.
XP_006256956.1. XM_006256894.1.
UniGeneRn.209042.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP28233.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID54256.
KEGGrno:54256.
UCSCRGD:2693. rat.

Organism-specific databases

CTD414089.
RGD2693. Gja6.

Phylogenomic databases

HOVERGENHBG009576.
KOK07615.
PhylomeDBP28233.

Gene expression databases

GenevestigatorP28233.

Family and domain databases

InterProIPR000500. Connexin.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERPTHR11984. PTHR11984. 1 hit.
PfamPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSPR00206. CONNEXIN.
SMARTSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio610766.

Entry information

Entry nameCXA6_RAT
AccessionPrimary (citable) accession number: P28233
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: April 16, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families