P28233 (CXA6_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Gap junction alpha-6 protein

Alternative name(s):
Connexin-33
Short name=Cx33

Gene names

Name:	Gja6
Synonyms:	Cxn-33

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	286 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subunit structure	A connexon is composed of a hexamer of connexins.
Subcellular location	Cell membrane; Multi-pass membrane protein. Cell junction › gap junction.
Tissue specificity	Expressed in testis.
Sequence similarities	Belongs to the connexin family. Alpha-type (group II) subfamily.

Ontologies

Keywords
Cellular component	Cell junction Cell membrane Gap junction Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell communication Inferred from electronic annotation. Source: InterPro gap junction assembly Traceable author statement Ref.1. Source: RGD
Cellular_component	connexon complex Traceable author statement Ref.1. Source: RGD integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	gap junction channel activity Traceable author statement Ref.1. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 286	286	Gap junction alpha-6 protein		PRO_0000057824
Regions
	Topological domain	1 – 23	23	Cytoplasmic Potential
	Transmembrane	24 – 41	18	Helical; Potential
	Topological domain	42 – 76	35	Extracellular Potential
	Transmembrane	77 – 99	23	Helical; Potential
	Topological domain	100 – 151	52	Cytoplasmic Potential
	Transmembrane	152 – 174	23	Helical; Potential
	Topological domain	175 – 209	35	Extracellular Potential
	Transmembrane	210 – 232	23	Helical; Potential
	Topological domain	233 – 286	54	Cytoplasmic Potential

Sequences

	Sequence		Length	Mass (Da)
	P28233 [UniParc]. Last modified December 1, 1992. Version 1. Checksum: A585266ACA2ACCF2	FASTA	286	32,860
	10 20 30 40 50 60 MSDWSALHQL LEKVQPYSTA GGKVWIKVLF IFRILLLGTA IESAWSDEQF EFHCNTQQPG 70 80 90 100 110 120 CENVCYDQAF PISHVRLWVL QVIFVSVPTL LHLAHVYYVI RQNEKLKKQE EEELKVAHFN 130 140 150 160 170 180 GASGERRLQK HTGKHIKCGS KEHGNRKMRG RLLLTYMASI FFKSVFEVAF LLIQWYLYGF 190 200 210 220 230 240 TLSAVYICEQ SPCPHRVDCF LSRPTEKTIF ILFMLVVSMV SFVLNVIELF YVLFKAIKNH 250 260 270 280 LGNEKEEVYC NPVELQKPSC VSSSAVLTTI CSSDQVVPVG LSSFYM

References

[1]

"Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping." Haefliger J.-A., Bruzzone R., Jenkins N.A., Gilbert D.J., Copeland N.G., Paul D.L. J. Biol. Chem. 267:2057-2064(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M76534 Genomic DNA. Translation: AAA40998.1.
IPI	IPI00198662.
PIR	C42053.
RefSeq	NP_062181.1. NM_019308.1.
UniGene	Rn.209042.
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	P28233.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	54256.
KEGG	rno:54256.
UCSC	RGD:2693. rat.
Organism-specific databases
CTD	414089.
RGD	2693. Gja6.
Phylogenomic databases
HOVERGEN	HBG009576.
KO	K07615.
Gene expression databases
Genevestigator	P28233.
Family and domain databases
InterPro	IPR000500. Connexin. IPR019570. Connexin_CCC. IPR017990. Connexin_CS. IPR013092. Connexin_N. [Graphical view]
PANTHER	PTHR11984. PTHR11984. 1 hit.
Pfam	PF00029. Connexin. 1 hit. PF10582. Connexin_CCC. 1 hit. [Graphical view]
PRINTS	PR00206. CONNEXIN.
SMART	SM00037. CNX. 1 hit. SM01089. Connexin_CCC. 1 hit. [Graphical view]
PROSITE	PS00407. CONNEXINS_1. 1 hit. PS00408. CONNEXINS_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	610766.

Entry information

Entry name

CXA6_RAT

Accession

Primary (citable) accession number: P28233

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	December 1, 1992
Last modified:	April 3, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program