Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Gap junction alpha-6 protein

Gene

Gja6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Molecular functioni

  1. gap junction channel activity Source: RGD

GO - Biological processi

  1. cell communication Source: InterPro
  2. gap junction assembly Source: RGD
  3. transmembrane transport Source: GOC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction alpha-6 protein
Alternative name(s):
Connexin-33
Short name:
Cx33
Gene namesi
Name:Gja6
Synonyms:Cxn-33
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2693. Gja6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei24 – 4118HelicalSequence AnalysisAdd
BLAST
Topological domaini42 – 7635ExtracellularSequence AnalysisAdd
BLAST
Transmembranei77 – 9923HelicalSequence AnalysisAdd
BLAST
Topological domaini100 – 15152CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei152 – 17423HelicalSequence AnalysisAdd
BLAST
Topological domaini175 – 20935ExtracellularSequence AnalysisAdd
BLAST
Transmembranei210 – 23223HelicalSequence AnalysisAdd
BLAST
Topological domaini233 – 28654CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. connexon complex Source: RGD
  2. gap junction Source: RGD
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 286286Gap junction alpha-6 proteinPRO_0000057824Add
BLAST

Proteomic databases

PRIDEiP28233.

Expressioni

Tissue specificityi

Expressed in testis.

Gene expression databases

GenevestigatoriP28233.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG009576.
InParanoidiP28233.
KOiK07615.
PhylomeDBiP28233.

Family and domain databases

InterProiIPR000500. Connexin.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28233-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDWSALHQL LEKVQPYSTA GGKVWIKVLF IFRILLLGTA IESAWSDEQF
60 70 80 90 100
EFHCNTQQPG CENVCYDQAF PISHVRLWVL QVIFVSVPTL LHLAHVYYVI
110 120 130 140 150
RQNEKLKKQE EEELKVAHFN GASGERRLQK HTGKHIKCGS KEHGNRKMRG
160 170 180 190 200
RLLLTYMASI FFKSVFEVAF LLIQWYLYGF TLSAVYICEQ SPCPHRVDCF
210 220 230 240 250
LSRPTEKTIF ILFMLVVSMV SFVLNVIELF YVLFKAIKNH LGNEKEEVYC
260 270 280
NPVELQKPSC VSSSAVLTTI CSSDQVVPVG LSSFYM
Length:286
Mass (Da):32,860
Last modified:December 1, 1992 - v1
Checksum:iA585266ACA2ACCF2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76534 Genomic DNA. Translation: AAA40998.1.
PIRiC42053.
RefSeqiNP_062181.1. NM_019308.1.
XP_006256956.1. XM_006256894.2.
UniGeneiRn.209042.

Genome annotation databases

GeneIDi54256.
KEGGirno:54256.
UCSCiRGD:2693. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76534 Genomic DNA. Translation: AAA40998.1.
PIRiC42053.
RefSeqiNP_062181.1. NM_019308.1.
XP_006256956.1. XM_006256894.2.
UniGeneiRn.209042.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP28233.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi54256.
KEGGirno:54256.
UCSCiRGD:2693. rat.

Organism-specific databases

CTDi414089.
RGDi2693. Gja6.

Phylogenomic databases

HOVERGENiHBG009576.
InParanoidiP28233.
KOiK07615.
PhylomeDBiP28233.

Miscellaneous databases

NextBioi610766.

Gene expression databases

GenevestigatoriP28233.

Family and domain databases

InterProiIPR000500. Connexin.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping."
    Haefliger J.-A., Bruzzone R., Jenkins N.A., Gilbert D.J., Copeland N.G., Paul D.L.
    J. Biol. Chem. 267:2057-2064(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCXA6_RAT
AccessioniPrimary (citable) accession number: P28233
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: January 7, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.