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Protein

Gap junction beta-5 protein

Gene

Gjb5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction beta-5 protein
Alternative name(s):
Connexin-31.1
Short name:
Cx31.1
Gene namesi
Name:Gjb5
Synonyms:Cxn-31.1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi2696. Gjb5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020CytoplasmicSequence analysisAdd
BLAST
Transmembranei21 – 4020HelicalSequence analysisAdd
BLAST
Topological domaini41 – 7535ExtracellularSequence analysisAdd
BLAST
Transmembranei76 – 9823HelicalSequence analysisAdd
BLAST
Topological domaini99 – 12426CytoplasmicSequence analysisAdd
BLAST
Transmembranei125 – 14723HelicalSequence analysisAdd
BLAST
Topological domaini148 – 18235ExtracellularSequence analysisAdd
BLAST
Transmembranei183 – 20523HelicalSequence analysisAdd
BLAST
Topological domaini206 – 27166CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271Gap junction beta-5 proteinPRO_0000057870Add
BLAST

Proteomic databases

PaxDbiP28232.

Expressioni

Tissue specificityi

Expressed in skin.

Gene expression databases

GenevisibleiP28232. RN.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019315.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE21. Eukaryota.
ENOG410Y9C2. LUCA.
GeneTreeiENSGT00840000129674.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiP28232.
KOiK07624.
OMAiVWSDDHK.
OrthoDBiEOG7P2XSS.
PhylomeDBiP28232.
TreeFamiTF329606.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002271. Connexin303.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PTHR11984:SF29. PTHR11984:SF29. 1 hit.
PfamiPF00029. Connexin. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01141. CONNEXINB4.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28232-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNWSVFEGLL SGVNKYSTAF GRIWLSLVFV FRVLVYLVTA ERVWGDDQKD
60 70 80 90 100
FDCNTRQPGC TNVCYDEFFP VSHVRLWALQ LILVTCPSLL VVMHVAYRKA
110 120 130 140 150
REKKYQQEVG KGYLYPNPGK KRGGLWWTYV CSLLFKATID IIFLYLFHAF
160 170 180 190 200
YPRYTLPSMV KCHSAPCPNT VDCFIAKPSE KNIFIVFMLV TAIVCILLNL
210 220 230 240 250
VELLYLVIKR CSECAPAKRP PTAHAKNDPN WANPSSKEKD FLSSDLIFLG
260 270
SDTHPPLLPD RPRAHVKKTI L
Length:271
Mass (Da):31,047
Last modified:December 1, 1992 - v1
Checksum:i7753FC96909015CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76533 Genomic DNA. Translation: AAB38538.1.
PIRiD42053.
RefSeqiNP_062114.1. NM_019241.1.
XP_008762212.1. XM_008763990.1.
UniGeneiRn.16074.

Genome annotation databases

EnsembliENSRNOT00000081919; ENSRNOP00000075127; ENSRNOG00000059897.
GeneIDi29586.
KEGGirno:29586.
UCSCiRGD:2696. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76533 Genomic DNA. Translation: AAB38538.1.
PIRiD42053.
RefSeqiNP_062114.1. NM_019241.1.
XP_008762212.1. XM_008763990.1.
UniGeneiRn.16074.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019315.

Proteomic databases

PaxDbiP28232.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000081919; ENSRNOP00000075127; ENSRNOG00000059897.
GeneIDi29586.
KEGGirno:29586.
UCSCiRGD:2696. rat.

Organism-specific databases

CTDi2709.
RGDi2696. Gjb5.

Phylogenomic databases

eggNOGiENOG410IE21. Eukaryota.
ENOG410Y9C2. LUCA.
GeneTreeiENSGT00840000129674.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiP28232.
KOiK07624.
OMAiVWSDDHK.
OrthoDBiEOG7P2XSS.
PhylomeDBiP28232.
TreeFamiTF329606.

Miscellaneous databases

NextBioi609710.
PROiP28232.

Gene expression databases

GenevisibleiP28232. RN.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002271. Connexin303.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PTHR11984:SF29. PTHR11984:SF29. 1 hit.
PfamiPF00029. Connexin. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01141. CONNEXINB4.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping."
    Haefliger J.-A., Bruzzone R., Jenkins N.A., Gilbert D.J., Copeland N.G., Paul D.L.
    J. Biol. Chem. 267:2057-2064(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCXB5_RAT
AccessioniPrimary (citable) accession number: P28232
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: May 11, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.