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Protein

Gap junction beta-3 protein

Gene

Gjb3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Biological processi

  • cell communication Source: InterPro
  • in utero embryonic development Source: Ensembl
  • placenta development Source: MGI
  • sensory perception of sound Source: Ensembl
  • skin development Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction beta-3 protein
Alternative name(s):
Connexin-31
Short name:
Cx31
Gene namesi
Name:Gjb3
Synonyms:Cxn-31
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:95721. Gjb3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
Transmembranei21 – 40HelicalSequence analysisAdd BLAST20
Topological domaini41 – 75ExtracellularSequence analysisAdd BLAST35
Transmembranei76 – 98HelicalSequence analysisAdd BLAST23
Topological domaini99 – 126CytoplasmicSequence analysisAdd BLAST28
Transmembranei127 – 149HelicalSequence analysisAdd BLAST23
Topological domaini150 – 188ExtracellularSequence analysisAdd BLAST39
Transmembranei189 – 211HelicalSequence analysisAdd BLAST23
Topological domaini212 – 270CytoplasmicSequence analysisAdd BLAST59

GO - Cellular componenti

  • cell-cell junction Source: MGI
  • connexin complex Source: InterPro
  • cytoplasm Source: MGI
  • gap junction Source: MGI
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000578631 – 270Gap junction beta-3 proteinAdd BLAST270

Proteomic databases

PaxDbiP28231.
PeptideAtlasiP28231.
PRIDEiP28231.

PTM databases

iPTMnetiP28231.
PhosphoSitePlusiP28231.

Expressioni

Gene expression databases

BgeeiENSMUSG00000042367.
CleanExiMM_GJB3.
GenevisibleiP28231. MM.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins. Interacts with CNST.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Gja1P232422EBI-1767245,EBI-298630

Protein-protein interaction databases

BioGridi199933. 1 interactor.
IntActiP28231. 2 interactors.
STRINGi10090.ENSMUSP00000046755.

Structurei

3D structure databases

ProteinModelPortaliP28231.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE21. Eukaryota.
ENOG410Y9C2. LUCA.
GeneTreeiENSGT00860000133694.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiP28231.
KOiK07622.
OMAiHTLWHGF.
OrthoDBiEOG091G0FKH.
PhylomeDBiP28231.
TreeFamiTF329606.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002269. Connexin31.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PTHR11984:SF65. PTHR11984:SF65. 1 hit.
PfamiPF00029. Connexin. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01140. CONNEXINB3.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28231-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDWKKLQDLL SGVNQYSTAF GRIWLSVVFV FRVLVYVVAA ERVWGDEQKD
60 70 80 90 100
FDCNTRQPGC TNVCYDNFFP ISNIRLWALQ LIFVTCPSML VILHVAYREE
110 120 130 140 150
RERKHRQKHG EQCAKLYSHP GKKHGGLWWT YLFSLIFKLI IELVFLYVLH
160 170 180 190 200
TLWHGFTMPR LVQCASIVPC PNTVDCYIAR PTEKKVFTYF MVGASAVCII
210 220 230 240 250
LTICEICYLI FHRIMRGISK GKSTKSISSP KSSSRASTCR CHHKLLESGD
260 270
PEADPASEKL QASAPSLTPI
Length:270
Mass (Da):30,902
Last modified:December 1, 1992 - v1
Checksum:iA91AB784E03E5869
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63099 mRNA. Translation: CAA44813.1.
AK083716 mRNA. Translation: BAC39002.1.
BC024387 mRNA. Translation: AAH24387.1.
CCDSiCCDS18668.1.
PIRiS23590.
RefSeqiNP_001153484.1. NM_001160012.1.
NP_032152.1. NM_008126.2.
UniGeneiMm.90003.

Genome annotation databases

EnsembliENSMUST00000046532; ENSMUSP00000046755; ENSMUSG00000042367.
ENSMUST00000106091; ENSMUSP00000101697; ENSMUSG00000042367.
GeneIDi14620.
KEGGimmu:14620.
UCSCiuc008uus.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63099 mRNA. Translation: CAA44813.1.
AK083716 mRNA. Translation: BAC39002.1.
BC024387 mRNA. Translation: AAH24387.1.
CCDSiCCDS18668.1.
PIRiS23590.
RefSeqiNP_001153484.1. NM_001160012.1.
NP_032152.1. NM_008126.2.
UniGeneiMm.90003.

3D structure databases

ProteinModelPortaliP28231.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199933. 1 interactor.
IntActiP28231. 2 interactors.
STRINGi10090.ENSMUSP00000046755.

PTM databases

iPTMnetiP28231.
PhosphoSitePlusiP28231.

Proteomic databases

PaxDbiP28231.
PeptideAtlasiP28231.
PRIDEiP28231.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046532; ENSMUSP00000046755; ENSMUSG00000042367.
ENSMUST00000106091; ENSMUSP00000101697; ENSMUSG00000042367.
GeneIDi14620.
KEGGimmu:14620.
UCSCiuc008uus.2. mouse.

Organism-specific databases

CTDi2707.
MGIiMGI:95721. Gjb3.

Phylogenomic databases

eggNOGiENOG410IE21. Eukaryota.
ENOG410Y9C2. LUCA.
GeneTreeiENSGT00860000133694.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiP28231.
KOiK07622.
OMAiHTLWHGF.
OrthoDBiEOG091G0FKH.
PhylomeDBiP28231.
TreeFamiTF329606.

Miscellaneous databases

PROiP28231.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042367.
CleanExiMM_GJB3.
GenevisibleiP28231. MM.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002269. Connexin31.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PTHR11984:SF65. PTHR11984:SF65. 1 hit.
PfamiPF00029. Connexin. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01140. CONNEXINB3.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCXB3_MOUSE
AccessioniPrimary (citable) accession number: P28231
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: November 30, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.