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P28229 (CXG1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gap junction gamma-1 protein
Alternative name(s):
Connexin-45
Short name=Cx45
Gap junction alpha-7 protein
Gene names
Name:Gjc1
Synonyms:Cxn-45, Gja7
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length396 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

Subunit structure

A connexon is composed of a hexamer of connexins. Interacts with CNST. Ref.4

Subcellular location

Cell membrane; Multi-pass membrane protein. Cell junctiongap junction.

Sequence similarities

Belongs to the connexin family. Gamma-type subfamily.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Gja1P232422EBI-1767271,EBI-298630

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 396396Gap junction gamma-1 protein
PRO_0000057827

Regions

Topological domain1 – 2222Cytoplasmic Potential
Transmembrane23 – 4523Helical; Potential
Topological domain46 – 7530Extracellular Potential
Transmembrane76 – 9520Helical; Potential
Topological domain96 – 17580Cytoplasmic Potential
Transmembrane176 – 19823Helical; Potential
Topological domain199 – 22830Extracellular Potential
Transmembrane229 – 24820Helical; Potential
Topological domain249 – 396148Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
P28229 [UniParc].

Last modified December 1, 1992. Version 1.
Checksum: 9CD5721BB071B65C

FASTA39645,666
        10         20         30         40         50         60 
MSWSFLTRLL EEIHNHSTFV GKIWLTVLIV FRIVLTAVGG ESIYYDEQSK FVCNTEQPGC 

        70         80         90        100        110        120 
ENVCYDAFAP LSHVRFWVFQ IILVATPSVM YLGYAIHKIA KMEHGEADKK AARSKPYAMR 

       130        140        150        160        170        180 
WKQHRALEET EEDHEEDPMM YPEMELESEK ENKEQSQPKP KHDGRRRIRE DGLMKIYVLQ 

       190        200        210        220        230        240 
LLARTVFEVG FLIGQYFLYG FQVHPFYVCS RLPCPHKIDC FISRPTEKTI FLLIMYGVTG 

       250        260        270        280        290        300 
LCLLLNIWEM LHLGFGTIRD SLNSKRRELD DPGAYNYPFT WNTPSAPPGY NIAVKPDQIQ 

       310        320        330        340        350        360 
YTELSNAKIA YKQNKANIAQ EQQYGSHEEH LPADLETLQR EIRMAQERLD LAIQAYHHQN 

       370        380        390 
NPHGPREKKA KVGSKSGSNK SSISSKSGDG KTSVWI 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of gap junction genes expressed in F9 embryonic carcinoma cells: molecular cloning of mouse connexin31 and -45 cDNAs."
Hennemann H., Schwarz H.J., Willecke K.
Eur. J. Cell Biol. 57:51-58(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Sequence and structure of the mouse connexin45 gene."
Baldridge D., Lecanda F., Shin C.S., Stains J., Civitelli R.
Biosci. Rep. 21:683-689(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryo.
[4]"Consortin, a trans-Golgi network cargo receptor for the plasma membrane targeting and recycling of connexins."
del Castillo F.J., Cohen-Salmon M., Charollais A., Caille D., Lampe P.D., Chavrier P., Meda P., Petit C.
Hum. Mol. Genet. 19:262-275(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CNST.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X63100 mRNA. Translation: CAA44814.1.
AJ300716 Genomic DNA. Translation: CAC21557.1.
BC050840 mRNA. Translation: AAH50840.1.
BC071230 mRNA. Translation: AAH71230.1.
CCDSCCDS25504.1.
PIRS23589.
RefSeqNP_001152854.1. NM_001159382.1.
NP_001152855.1. NM_001159383.1.
NP_032148.1. NM_008122.3.
XP_006532289.1. XM_006532226.1.
XP_006532290.1. XM_006532227.1.
UniGeneMm.390369.

3D structure databases

ProteinModelPortalP28229.
SMRP28229. Positions 3-253.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid199928. 1 interaction.
IntActP28229. 4 interactions.
MINTMINT-210461.
STRING10090.ENSMUSP00000090228.

PTM databases

PhosphoSiteP28229.

Proteomic databases

PRIDEP28229.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000068933; ENSMUSP00000066901; ENSMUSG00000034520.
ENSMUST00000092567; ENSMUSP00000090228; ENSMUSG00000034520.
ENSMUST00000107075; ENSMUSP00000102690; ENSMUSG00000034520.
GeneID14615.
KEGGmmu:14615.
UCSCuc007lsk.2. mouse.

Organism-specific databases

CTD10052.
MGIMGI:95718. Gjc1.

Phylogenomic databases

eggNOGNOG44555.
GeneTreeENSGT00750000117376.
HOGENOMHOG000231126.
HOVERGENHBG009576.
InParanoidP28229.
KOK07616.
OMARWKQHRG.
OrthoDBEOG7QVM2S.
PhylomeDBP28229.
TreeFamTF329606.

Gene expression databases

ArrayExpressP28229.
BgeeP28229.
CleanExMM_GJC1.
GenevestigatorP28229.

Family and domain databases

InterProIPR000500. Connexin.
IPR002265. Connexin45.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERPTHR11984. PTHR11984. 1 hit.
PfamPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSPR00206. CONNEXIN.
PR01136. CONNEXINA6.
SMARTSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSGJC1. mouse.
NextBio286424.
PROP28229.
SOURCESearch...

Entry information

Entry nameCXG1_MOUSE
AccessionPrimary (citable) accession number: P28229
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: July 9, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot