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Protein

Gap junction gamma-1 protein

Gene

Gjc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Molecular functioni

  1. gap junction channel activity Source: Ensembl
  2. ion channel activity Source: MGI

GO - Biological processi

  1. cardiac muscle tissue development Source: MGI
  2. cell-cell signaling Source: MGI
  3. cell development Source: MGI
  4. heart development Source: MGI
  5. ion transmembrane transport Source: GOC
  6. synaptic transmission Source: MGI
  7. vasculogenesis Source: MGI
  8. visual perception Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_286010. Electric Transmission Across Gap Junctions.
REACT_295993. Gap junction assembly.

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction gamma-1 protein
Alternative name(s):
Connexin-45
Short name:
Cx45
Gap junction alpha-7 protein
Gene namesi
Name:Gjc1
Synonyms:Cxn-45, Gja7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:95718. Gjc1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2222CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei23 – 4523HelicalSequence AnalysisAdd
BLAST
Topological domaini46 – 7530ExtracellularSequence AnalysisAdd
BLAST
Transmembranei76 – 9520HelicalSequence AnalysisAdd
BLAST
Topological domaini96 – 17580CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei176 – 19823HelicalSequence AnalysisAdd
BLAST
Topological domaini199 – 22830ExtracellularSequence AnalysisAdd
BLAST
Transmembranei229 – 24820HelicalSequence AnalysisAdd
BLAST
Topological domaini249 – 396148CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. connexon complex Source: MGI
  2. gap junction Source: MGI
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396Gap junction gamma-1 proteinPRO_0000057827Add
BLAST

Proteomic databases

PRIDEiP28229.

PTM databases

PhosphoSiteiP28229.

Expressioni

Gene expression databases

BgeeiP28229.
CleanExiMM_GJC1.
ExpressionAtlasiP28229. baseline and differential.
GenevestigatoriP28229.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins. Interacts with CNST.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Gja1P232422EBI-1767271,EBI-298630

Protein-protein interaction databases

BioGridi199928. 1 interaction.
IntActiP28229. 4 interactions.
MINTiMINT-210461.
STRINGi10090.ENSMUSP00000090228.

Structurei

3D structure databases

ProteinModelPortaliP28229.
SMRiP28229. Positions 3-253.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the connexin family. Gamma-type subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG44555.
GeneTreeiENSGT00780000121881.
HOGENOMiHOG000231126.
HOVERGENiHBG009576.
InParanoidiP28229.
KOiK07616.
OMAiRWKQHRG.
OrthoDBiEOG7QVM2S.
PhylomeDBiP28229.
TreeFamiTF329606.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002265. Connexin45.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01136. CONNEXINA6.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28229-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWSFLTRLL EEIHNHSTFV GKIWLTVLIV FRIVLTAVGG ESIYYDEQSK
60 70 80 90 100
FVCNTEQPGC ENVCYDAFAP LSHVRFWVFQ IILVATPSVM YLGYAIHKIA
110 120 130 140 150
KMEHGEADKK AARSKPYAMR WKQHRALEET EEDHEEDPMM YPEMELESEK
160 170 180 190 200
ENKEQSQPKP KHDGRRRIRE DGLMKIYVLQ LLARTVFEVG FLIGQYFLYG
210 220 230 240 250
FQVHPFYVCS RLPCPHKIDC FISRPTEKTI FLLIMYGVTG LCLLLNIWEM
260 270 280 290 300
LHLGFGTIRD SLNSKRRELD DPGAYNYPFT WNTPSAPPGY NIAVKPDQIQ
310 320 330 340 350
YTELSNAKIA YKQNKANIAQ EQQYGSHEEH LPADLETLQR EIRMAQERLD
360 370 380 390
LAIQAYHHQN NPHGPREKKA KVGSKSGSNK SSISSKSGDG KTSVWI
Length:396
Mass (Da):45,666
Last modified:December 1, 1992 - v1
Checksum:i9CD5721BB071B65C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63100 mRNA. Translation: CAA44814.1.
AJ300716 Genomic DNA. Translation: CAC21557.1.
BC050840 mRNA. Translation: AAH50840.1.
BC071230 mRNA. Translation: AAH71230.1.
CCDSiCCDS25504.1.
PIRiS23589.
RefSeqiNP_001152854.1. NM_001159382.1.
NP_001152855.1. NM_001159383.1.
NP_032148.1. NM_008122.3.
XP_006532289.1. XM_006532226.2.
XP_006532290.1. XM_006532227.2.
UniGeneiMm.390369.

Genome annotation databases

EnsembliENSMUST00000068933; ENSMUSP00000066901; ENSMUSG00000034520.
ENSMUST00000092567; ENSMUSP00000090228; ENSMUSG00000034520.
ENSMUST00000107075; ENSMUSP00000102690; ENSMUSG00000034520.
GeneIDi14615.
KEGGimmu:14615.
UCSCiuc007lsk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63100 mRNA. Translation: CAA44814.1.
AJ300716 Genomic DNA. Translation: CAC21557.1.
BC050840 mRNA. Translation: AAH50840.1.
BC071230 mRNA. Translation: AAH71230.1.
CCDSiCCDS25504.1.
PIRiS23589.
RefSeqiNP_001152854.1. NM_001159382.1.
NP_001152855.1. NM_001159383.1.
NP_032148.1. NM_008122.3.
XP_006532289.1. XM_006532226.2.
XP_006532290.1. XM_006532227.2.
UniGeneiMm.390369.

3D structure databases

ProteinModelPortaliP28229.
SMRiP28229. Positions 3-253.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199928. 1 interaction.
IntActiP28229. 4 interactions.
MINTiMINT-210461.
STRINGi10090.ENSMUSP00000090228.

PTM databases

PhosphoSiteiP28229.

Proteomic databases

PRIDEiP28229.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068933; ENSMUSP00000066901; ENSMUSG00000034520.
ENSMUST00000092567; ENSMUSP00000090228; ENSMUSG00000034520.
ENSMUST00000107075; ENSMUSP00000102690; ENSMUSG00000034520.
GeneIDi14615.
KEGGimmu:14615.
UCSCiuc007lsk.2. mouse.

Organism-specific databases

CTDi10052.
MGIiMGI:95718. Gjc1.

Phylogenomic databases

eggNOGiNOG44555.
GeneTreeiENSGT00780000121881.
HOGENOMiHOG000231126.
HOVERGENiHBG009576.
InParanoidiP28229.
KOiK07616.
OMAiRWKQHRG.
OrthoDBiEOG7QVM2S.
PhylomeDBiP28229.
TreeFamiTF329606.

Enzyme and pathway databases

ReactomeiREACT_286010. Electric Transmission Across Gap Junctions.
REACT_295993. Gap junction assembly.

Miscellaneous databases

ChiTaRSiGjc1. mouse.
NextBioi286424.
PROiP28229.
SOURCEiSearch...

Gene expression databases

BgeeiP28229.
CleanExiMM_GJC1.
ExpressionAtlasiP28229. baseline and differential.
GenevestigatoriP28229.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002265. Connexin45.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01136. CONNEXINA6.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of gap junction genes expressed in F9 embryonic carcinoma cells: molecular cloning of mouse connexin31 and -45 cDNAs."
    Hennemann H., Schwarz H.J., Willecke K.
    Eur. J. Cell Biol. 57:51-58(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Sequence and structure of the mouse connexin45 gene."
    Baldridge D., Lecanda F., Shin C.S., Stains J., Civitelli R.
    Biosci. Rep. 21:683-689(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  4. "Consortin, a trans-Golgi network cargo receptor for the plasma membrane targeting and recycling of connexins."
    del Castillo F.J., Cohen-Salmon M., Charollais A., Caille D., Lampe P.D., Chavrier P., Meda P., Petit C.
    Hum. Mol. Genet. 19:262-275(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CNST.

Entry informationi

Entry nameiCXG1_MOUSE
AccessioniPrimary (citable) accession number: P28229
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: April 1, 2015
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.