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P28229

- CXG1_MOUSE

UniProt

P28229 - CXG1_MOUSE

Protein

Gap junction gamma-1 protein

Gene

Gjc1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 1 (01 Dec 1992)
      Previous versions | rss
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    Functioni

    One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

    GO - Molecular functioni

    1. gap junction channel activity Source: Ensembl
    2. ion channel activity Source: MGI
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. cardiac muscle tissue development Source: MGI
    2. cell-cell signaling Source: MGI
    3. cell development Source: MGI
    4. heart development Source: MGI
    5. ion transmembrane transport Source: GOC
    6. synaptic transmission Source: MGI
    7. vasculogenesis Source: MGI
    8. visual perception Source: MGI

    Enzyme and pathway databases

    ReactomeiREACT_227366. Gap junction assembly.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gap junction gamma-1 protein
    Alternative name(s):
    Connexin-45
    Short name:
    Cx45
    Gap junction alpha-7 protein
    Gene namesi
    Name:Gjc1
    Synonyms:Cxn-45, Gja7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:95718. Gjc1.

    Subcellular locationi

    GO - Cellular componenti

    1. connexon complex Source: MGI
    2. gap junction Source: MGI
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Gap junction, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 396396Gap junction gamma-1 proteinPRO_0000057827Add
    BLAST

    Proteomic databases

    PRIDEiP28229.

    PTM databases

    PhosphoSiteiP28229.

    Expressioni

    Gene expression databases

    ArrayExpressiP28229.
    BgeeiP28229.
    CleanExiMM_GJC1.
    GenevestigatoriP28229.

    Interactioni

    Subunit structurei

    A connexon is composed of a hexamer of connexins. Interacts with CNST.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Gja1P232422EBI-1767271,EBI-298630

    Protein-protein interaction databases

    BioGridi199928. 1 interaction.
    IntActiP28229. 4 interactions.
    MINTiMINT-210461.
    STRINGi10090.ENSMUSP00000090228.

    Structurei

    3D structure databases

    ProteinModelPortaliP28229.
    SMRiP28229. Positions 3-253.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2222CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini46 – 7530ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini96 – 17580CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini199 – 22830ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini249 – 396148CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei23 – 4523HelicalSequence AnalysisAdd
    BLAST
    Transmembranei76 – 9520HelicalSequence AnalysisAdd
    BLAST
    Transmembranei176 – 19823HelicalSequence AnalysisAdd
    BLAST
    Transmembranei229 – 24820HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the connexin family. Gamma-type subfamily.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG44555.
    GeneTreeiENSGT00750000117376.
    HOGENOMiHOG000231126.
    HOVERGENiHBG009576.
    InParanoidiP28229.
    KOiK07616.
    OMAiRWKQHRG.
    OrthoDBiEOG7QVM2S.
    PhylomeDBiP28229.
    TreeFamiTF329606.

    Family and domain databases

    InterProiIPR000500. Connexin.
    IPR002265. Connexin45.
    IPR019570. Connexin_CCC.
    IPR017990. Connexin_CS.
    IPR013092. Connexin_N.
    [Graphical view]
    PANTHERiPTHR11984. PTHR11984. 1 hit.
    PfamiPF00029. Connexin. 1 hit.
    PF10582. Connexin_CCC. 1 hit.
    [Graphical view]
    PRINTSiPR00206. CONNEXIN.
    PR01136. CONNEXINA6.
    SMARTiSM00037. CNX. 1 hit.
    SM01089. Connexin_CCC. 1 hit.
    [Graphical view]
    PROSITEiPS00407. CONNEXINS_1. 1 hit.
    PS00408. CONNEXINS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P28229-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSWSFLTRLL EEIHNHSTFV GKIWLTVLIV FRIVLTAVGG ESIYYDEQSK    50
    FVCNTEQPGC ENVCYDAFAP LSHVRFWVFQ IILVATPSVM YLGYAIHKIA 100
    KMEHGEADKK AARSKPYAMR WKQHRALEET EEDHEEDPMM YPEMELESEK 150
    ENKEQSQPKP KHDGRRRIRE DGLMKIYVLQ LLARTVFEVG FLIGQYFLYG 200
    FQVHPFYVCS RLPCPHKIDC FISRPTEKTI FLLIMYGVTG LCLLLNIWEM 250
    LHLGFGTIRD SLNSKRRELD DPGAYNYPFT WNTPSAPPGY NIAVKPDQIQ 300
    YTELSNAKIA YKQNKANIAQ EQQYGSHEEH LPADLETLQR EIRMAQERLD 350
    LAIQAYHHQN NPHGPREKKA KVGSKSGSNK SSISSKSGDG KTSVWI 396
    Length:396
    Mass (Da):45,666
    Last modified:December 1, 1992 - v1
    Checksum:i9CD5721BB071B65C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X63100 mRNA. Translation: CAA44814.1.
    AJ300716 Genomic DNA. Translation: CAC21557.1.
    BC050840 mRNA. Translation: AAH50840.1.
    BC071230 mRNA. Translation: AAH71230.1.
    CCDSiCCDS25504.1.
    PIRiS23589.
    RefSeqiNP_001152854.1. NM_001159382.1.
    NP_001152855.1. NM_001159383.1.
    NP_032148.1. NM_008122.3.
    XP_006532289.1. XM_006532226.1.
    XP_006532290.1. XM_006532227.1.
    UniGeneiMm.390369.

    Genome annotation databases

    EnsembliENSMUST00000068933; ENSMUSP00000066901; ENSMUSG00000034520.
    ENSMUST00000092567; ENSMUSP00000090228; ENSMUSG00000034520.
    ENSMUST00000107075; ENSMUSP00000102690; ENSMUSG00000034520.
    GeneIDi14615.
    KEGGimmu:14615.
    UCSCiuc007lsk.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X63100 mRNA. Translation: CAA44814.1 .
    AJ300716 Genomic DNA. Translation: CAC21557.1 .
    BC050840 mRNA. Translation: AAH50840.1 .
    BC071230 mRNA. Translation: AAH71230.1 .
    CCDSi CCDS25504.1.
    PIRi S23589.
    RefSeqi NP_001152854.1. NM_001159382.1.
    NP_001152855.1. NM_001159383.1.
    NP_032148.1. NM_008122.3.
    XP_006532289.1. XM_006532226.1.
    XP_006532290.1. XM_006532227.1.
    UniGenei Mm.390369.

    3D structure databases

    ProteinModelPortali P28229.
    SMRi P28229. Positions 3-253.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199928. 1 interaction.
    IntActi P28229. 4 interactions.
    MINTi MINT-210461.
    STRINGi 10090.ENSMUSP00000090228.

    PTM databases

    PhosphoSitei P28229.

    Proteomic databases

    PRIDEi P28229.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000068933 ; ENSMUSP00000066901 ; ENSMUSG00000034520 .
    ENSMUST00000092567 ; ENSMUSP00000090228 ; ENSMUSG00000034520 .
    ENSMUST00000107075 ; ENSMUSP00000102690 ; ENSMUSG00000034520 .
    GeneIDi 14615.
    KEGGi mmu:14615.
    UCSCi uc007lsk.2. mouse.

    Organism-specific databases

    CTDi 10052.
    MGIi MGI:95718. Gjc1.

    Phylogenomic databases

    eggNOGi NOG44555.
    GeneTreei ENSGT00750000117376.
    HOGENOMi HOG000231126.
    HOVERGENi HBG009576.
    InParanoidi P28229.
    KOi K07616.
    OMAi RWKQHRG.
    OrthoDBi EOG7QVM2S.
    PhylomeDBi P28229.
    TreeFami TF329606.

    Enzyme and pathway databases

    Reactomei REACT_227366. Gap junction assembly.

    Miscellaneous databases

    ChiTaRSi GJC1. mouse.
    NextBioi 286424.
    PROi P28229.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P28229.
    Bgeei P28229.
    CleanExi MM_GJC1.
    Genevestigatori P28229.

    Family and domain databases

    InterProi IPR000500. Connexin.
    IPR002265. Connexin45.
    IPR019570. Connexin_CCC.
    IPR017990. Connexin_CS.
    IPR013092. Connexin_N.
    [Graphical view ]
    PANTHERi PTHR11984. PTHR11984. 1 hit.
    Pfami PF00029. Connexin. 1 hit.
    PF10582. Connexin_CCC. 1 hit.
    [Graphical view ]
    PRINTSi PR00206. CONNEXIN.
    PR01136. CONNEXINA6.
    SMARTi SM00037. CNX. 1 hit.
    SM01089. Connexin_CCC. 1 hit.
    [Graphical view ]
    PROSITEi PS00407. CONNEXINS_1. 1 hit.
    PS00408. CONNEXINS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of gap junction genes expressed in F9 embryonic carcinoma cells: molecular cloning of mouse connexin31 and -45 cDNAs."
      Hennemann H., Schwarz H.J., Willecke K.
      Eur. J. Cell Biol. 57:51-58(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Sequence and structure of the mouse connexin45 gene."
      Baldridge D., Lecanda F., Shin C.S., Stains J., Civitelli R.
      Biosci. Rep. 21:683-689(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo.
    4. "Consortin, a trans-Golgi network cargo receptor for the plasma membrane targeting and recycling of connexins."
      del Castillo F.J., Cohen-Salmon M., Charollais A., Caille D., Lampe P.D., Chavrier P., Meda P., Petit C.
      Hum. Mol. Genet. 19:262-275(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CNST.

    Entry informationi

    Entry nameiCXG1_MOUSE
    AccessioniPrimary (citable) accession number: P28229
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: December 1, 1992
    Last modified: October 1, 2014
    This is version 126 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3