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Protein

Membrane-bound lysozyme inhibitor of C-type lysozyme

Gene

mliC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Specifically inhibits C-type lysozymes.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei71Directly involved in lysozyme active site inhibitionBy similarity1
Sitei85Directly involved in lysozyme active site inhibitionBy similarity1

GO - Molecular functioni

  • lysozyme inhibitor activity Source: EcoCyc

Enzyme and pathway databases

BioCyciEcoCyc:EG11488-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-bound lysozyme inhibitor of C-type lysozyme1 Publication
Gene namesi
Name:mliC1 Publication
Synonyms:ydhA
Ordered Locus Names:b1639, JW1631
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11488 mliC

Subcellular locationi

GO - Cellular componenti

  • cell outer membrane Source: EcoCyc

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17PROSITE-ProRule annotationAdd BLAST17
ChainiPRO_000016897418 – 109Membrane-bound lysozyme inhibitor of C-type lysozymeAdd BLAST92

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi18N-palmitoyl cysteinePROSITE-ProRule annotation1
Lipidationi18S-diacylglycerol cysteinePROSITE-ProRule annotation1
Disulfide bondi37 ↔ 1021 Publication

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP28224
PRIDEiP28224

Interactioni

Subunit structurei

Monomer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
hslRP0ACG83EBI-562851,EBI-562824

Protein-protein interaction databases

BioGridi4263489, 136 interactors
DIPiDIP-11726N
IntActiP28224, 5 interactors
STRINGi316385.ECDH10B_1773

Structurei

Secondary structure

1109
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi38 – 40Combined sources3
Beta strandi44 – 46Combined sources3
Beta strandi50 – 66Combined sources17
Beta strandi70 – 76Combined sources7
Beta strandi81 – 84Combined sources4
Beta strandi86 – 92Combined sources7
Beta strandi97 – 100Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2F09NMR-A28-109[»]
ProteinModelPortaliP28224
SMRiP28224
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP28224

Family & Domainsi

Sequence similaritiesi

Belongs to the MliC family. Type 1 subfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410642K Bacteria
COG3895 LUCA
HOGENOMiHOG000272969
InParanoidiP28224
OMAiEYRCDEK

Family and domain databases

Gene3Di2.40.128.200, 1 hit
InterProiView protein in InterPro
IPR018660 MliC
IPR036328 MliC_sf
PfamiView protein in Pfam
PF09864 MliC, 1 hit
SUPFAMiSSF141488 SSF141488, 1 hit
PROSITEiView protein in PROSITE
PS51257 PROKAR_LIPOPROTEIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28224-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMKKLLIII LPVLLSGCSA FNQLVERMQT DTLEYQCDEK PLTVKLNNPR
60 70 80 90 100
QEVSFVYDNQ LLHLKQGISA SGARYTDGIY VFWSKGDEAT VYKRDRIVLN

NCQLQNPQR
Length:109
Mass (Da):12,568
Last modified:November 1, 1997 - v2
Checksum:iFB6E5F97F6893224
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74711.2
AP009048 Genomic DNA Translation: BAA15400.2
M92351 Genomic DNA Translation: AAA24708.1
PIRiA43261
RefSeqiNP_416156.4, NC_000913.3
WP_000178044.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74711; AAC74711; b1639
BAA15400; BAA15400; BAA15400
GeneIDi946811
KEGGiecj:JW1631
eco:b1639
PATRICifig|511145.12.peg.1710

Similar proteinsi

Entry informationi

Entry nameiMLIC_ECOLI
AccessioniPrimary (citable) accession number: P28224
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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