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Protein

Membrane-bound lysozyme inhibitor of C-type lysozyme

Gene

mliC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Specifically inhibits C-type lysozymes.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei71 – 711Directly involved in lysozyme active site inhibitionBy similarity
Sitei85 – 851Directly involved in lysozyme active site inhibitionBy similarity

GO - Molecular functioni

  • lysozyme inhibitor activity Source: EcoCyc

GO - Biological processi

  • negative regulation of catalytic activity Source: GOC
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:EG11488-MONOMER.
ECOL316407:JW1631-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-bound lysozyme inhibitor of C-type lysozyme1 Publication
Gene namesi
Name:mliC1 Publication
Synonyms:ydhA
Ordered Locus Names:b1639, JW1631
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11488. mliC.

Subcellular locationi

GO - Cellular componenti

  • cell outer membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717PROSITE-ProRule annotationAdd
BLAST
Chaini18 – 10992Membrane-bound lysozyme inhibitor of C-type lysozymePRO_0000168974Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi18 – 181N-palmitoyl cysteinePROSITE-ProRule annotation
Lipidationi18 – 181S-diacylglycerol cysteinePROSITE-ProRule annotation
Disulfide bondi37 ↔ 1021 Publication

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP28224.

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

BioGridi4263489. 136 interactions.
DIPiDIP-11726N.
IntActiP28224. 5 interactions.
STRINGi511145.b1639.

Structurei

Secondary structure

1
109
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi38 – 403Combined sources
Beta strandi44 – 463Combined sources
Beta strandi50 – 6617Combined sources
Beta strandi70 – 767Combined sources
Beta strandi81 – 844Combined sources
Beta strandi86 – 927Combined sources
Beta strandi97 – 1004Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2F09NMR-A28-109[»]
ProteinModelPortaliP28224.
SMRiP28224. Positions 28-109.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP28224.

Family & Domainsi

Sequence similaritiesi

Belongs to the MliC family. Type 1 subfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410642K. Bacteria.
COG3895. LUCA.
HOGENOMiHOG000272969.
InParanoidiP28224.
OMAiEYRCDEK.
OrthoDBiEOG6SJJMJ.

Family and domain databases

InterProiIPR018660. C-type_lysozyme_inhibitor.
[Graphical view]
PfamiPF09864. MliC. 1 hit.
[Graphical view]
SUPFAMiSSF141488. SSF141488. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28224-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMKKLLIII LPVLLSGCSA FNQLVERMQT DTLEYQCDEK PLTVKLNNPR
60 70 80 90 100
QEVSFVYDNQ LLHLKQGISA SGARYTDGIY VFWSKGDEAT VYKRDRIVLN

NCQLQNPQR
Length:109
Mass (Da):12,568
Last modified:November 1, 1997 - v2
Checksum:iFB6E5F97F6893224
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74711.2.
AP009048 Genomic DNA. Translation: BAA15400.2.
M92351 Genomic DNA. Translation: AAA24708.1.
PIRiA43261.
RefSeqiNP_416156.4. NC_000913.3.
WP_000178044.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74711; AAC74711; b1639.
BAA15400; BAA15400; BAA15400.
GeneIDi946811.
KEGGiecj:JW1631.
eco:b1639.
PATRICi32118580. VBIEscCol129921_1710.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74711.2.
AP009048 Genomic DNA. Translation: BAA15400.2.
M92351 Genomic DNA. Translation: AAA24708.1.
PIRiA43261.
RefSeqiNP_416156.4. NC_000913.3.
WP_000178044.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2F09NMR-A28-109[»]
ProteinModelPortaliP28224.
SMRiP28224. Positions 28-109.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263489. 136 interactions.
DIPiDIP-11726N.
IntActiP28224. 5 interactions.
STRINGi511145.b1639.

Proteomic databases

PaxDbiP28224.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74711; AAC74711; b1639.
BAA15400; BAA15400; BAA15400.
GeneIDi946811.
KEGGiecj:JW1631.
eco:b1639.
PATRICi32118580. VBIEscCol129921_1710.

Organism-specific databases

EchoBASEiEB1451.
EcoGeneiEG11488. mliC.

Phylogenomic databases

eggNOGiENOG410642K. Bacteria.
COG3895. LUCA.
HOGENOMiHOG000272969.
InParanoidiP28224.
OMAiEYRCDEK.
OrthoDBiEOG6SJJMJ.

Enzyme and pathway databases

BioCyciEcoCyc:EG11488-MONOMER.
ECOL316407:JW1631-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP28224.
PROiP28224.

Family and domain databases

InterProiIPR018660. C-type_lysozyme_inhibitor.
[Graphical view]
PfamiPF09864. MliC. 1 hit.
[Graphical view]
SUPFAMiSSF141488. SSF141488. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Characterization of the complex pdxH-tyrS operon of Escherichia coli K-12 and pleiotropic phenotypes caused by pdxH insertion mutations."
    Lam H.-M., Winkler M.E.
    J. Bacteriol. 174:6033-6045(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 28-109.
    Strain: K12.
  5. Cited for: FUNCTION, SUBCELLULAR LOCATION.
  6. "The solution structure of the protein ydhA from Escherichia coli."
    Revington M., Semesi A., Yee A., Arrowsmith C.H., Shaw G.S.
    J. Biomol. NMR 35:295-300(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 28-109, SUBUNIT, DISULFIDE BOND.

Entry informationi

Entry nameiMLIC_ECOLI
AccessioniPrimary (citable) accession number: P28224
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: November 1, 1997
Last modified: April 13, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.