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P28223

- 5HT2A_HUMAN

UniProt

P28223 - 5HT2A_HUMAN

Protein

5-hydroxytryptamine receptor 2A

Gene

HTR2A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 150 (01 Oct 2014)
      Sequence version 2 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca2+ ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.6 Publications

    GO - Molecular functioni

    1. 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding Source: UniProtKB
    2. drug binding Source: UniProtKB
    3. serotonin binding Source: UniProtKB
    4. serotonin receptor activity Source: UniProtKB

    GO - Biological processi

    1. activation of phospholipase C activity Source: UniProtKB
    2. aging Source: Ensembl
    3. artery smooth muscle contraction Source: Ensembl
    4. behavioral response to cocaine Source: Ensembl
    5. cell death Source: Ensembl
    6. cellular calcium ion homeostasis Source: UniProtKB
    7. detection of mechanical stimulus involved in sensory perception of pain Source: Ensembl
    8. detection of temperature stimulus involved in sensory perception of pain Source: Ensembl
    9. memory Source: Ensembl
    10. negative regulation of potassium ion transport Source: Ensembl
    11. negative regulation of synaptic transmission, glutamatergic Source: Ensembl
    12. phosphatidylinositol 3-kinase signaling Source: UniProtKB
    13. phospholipase C-activating serotonin receptor signaling pathway Source: Ensembl
    14. positive regulation of cell proliferation Source: Ensembl
    15. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
    16. positive regulation of MAP kinase activity Source: Ensembl
    17. positive regulation of phosphatidylinositol biosynthetic process Source: UniProtKB
    18. positive regulation of vasoconstriction Source: Ensembl
    19. regulation of behavior Source: InterPro
    20. regulation of dopamine secretion Source: Ensembl
    21. regulation of hormone secretion Source: InterPro
    22. release of sequestered calcium ion into cytosol Source: UniProtKB
    23. response to drug Source: UniProtKB
    24. serotonin receptor signaling pathway Source: UniProtKB
    25. sleep Source: Ensembl
    26. synaptic transmission Source: ProtInc
    27. temperature homeostasis Source: Ensembl
    28. urinary bladder smooth muscle contraction Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Behavior

    Enzyme and pathway databases

    ReactomeiREACT_17064. Serotonin receptors.
    REACT_18283. G alpha (q) signalling events.
    SignaLinkiP28223.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-hydroxytryptamine receptor 2A
    Short name:
    5-HT-2
    Short name:
    5-HT-2A
    Alternative name(s):
    Serotonin receptor 2A
    Gene namesi
    Name:HTR2A
    Synonyms:HTR2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:5293. HTR2A.

    Subcellular locationi

    Cell membrane; Multi-pass membrane protein. Cell projectiondendrite By similarity. Cell projectionaxon By similarity. Cytoplasmic vesicle By similarity. Membranecaveola By similarity
    Note: Localizes to the postsynaptic thickening of axo-dendritic synapses.By similarity

    GO - Cellular componenti

    1. axon Source: UniProtKB-SubCell
    2. caveola Source: UniProtKB-SubCell
    3. cell body fiber Source: Ensembl
    4. cytoplasmic membrane-bounded vesicle Source: UniProtKB-SubCell
    5. cytosol Source: Ensembl
    6. dendritic shaft Source: Ensembl
    7. integral component of plasma membrane Source: ProtInc
    8. neuronal cell body Source: Ensembl
    9. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Cytoplasmic vesicle, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi463 – 4631G → V: Loss of interaction with INADL. 1 Publication
    Mutagenesisi465 – 4651N → S: No effect on interaction with INADL. Acquires the binding properties of HTR2C; when associated with S-470. 1 Publication
    Mutagenesisi470 – 4701C → S: No effect on interaction with INADL. Acquires the binding properties of HTR2C; when associated with S-465. 1 Publication
    Mutagenesisi471 – 4711V → A: Loss of interaction with INADL, CASK, APBA1, DLG1 and DLG4. 1 Publication

    Organism-specific databases

    PharmGKBiPA193.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4714715-hydroxytryptamine receptor 2APRO_0000068946Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi8 – 81N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi38 – 381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi44 – 441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi51 – 511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi54 – 541N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi148 ↔ 227PROSITE-ProRule annotation
    Disulfide bondi349 ↔ 353PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP28223.
    PRIDEiP28223.

    PTM databases

    PhosphoSiteiP28223.

    Expressioni

    Tissue specificityi

    Detected in brain cortex (at protein level). Detected in blood platelets.1 Publication

    Gene expression databases

    ArrayExpressiP28223.
    BgeeiP28223.
    CleanExiHS_HTR2A.
    GenevestigatoriP28223.

    Organism-specific databases

    HPAiHPA014011.

    Interactioni

    Subunit structurei

    Interacts with MPDZ and INADL. May interact with MPP3, PRDX6, DLG4, DLG1, CASK, APBA1 and MAGI2. Interacts with GRM2 and DRD2; this may affect signaling.5 Publications

    Protein-protein interaction databases

    BioGridi109588. 4 interactions.
    DIPiDIP-41844N.
    MINTiMINT-443877.
    STRINGi9606.ENSP00000367959.

    Structurei

    3D structure databases

    ProteinModelPortaliP28223.
    SMRiP28223. Positions 38-406.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7575ExtracellularBy similarityAdd
    BLAST
    Topological domaini100 – 11011CytoplasmicBy similarityAdd
    BLAST
    Topological domaini133 – 14816ExtracellularBy similarityAdd
    BLAST
    Topological domaini172 – 19120CytoplasmicBy similarityAdd
    BLAST
    Topological domaini216 – 23318ExtracellularBy similarityAdd
    BLAST
    Topological domaini255 – 32470CytoplasmicBy similarityAdd
    BLAST
    Topological domaini347 – 36216ExtracellularBy similarityAdd
    BLAST
    Topological domaini385 – 47187CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei76 – 9924Helical; Name=1By similarityAdd
    BLAST
    Transmembranei111 – 13222Helical; Name=2By similarityAdd
    BLAST
    Transmembranei149 – 17123Helical; Name=3By similarityAdd
    BLAST
    Transmembranei192 – 21524Helical; Name=4By similarityAdd
    BLAST
    Transmembranei234 – 25421Helical; Name=5By similarityAdd
    BLAST
    Transmembranei325 – 34622Helical; Name=6By similarityAdd
    BLAST
    Transmembranei363 – 38422Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni155 – 1606Agonist bindingBy similarity
    Regioni336 – 3405Agonist bindingBy similarity

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi172 – 1743DRY motif; important for ligand-induced conformation changesBy similarity
    Motifi376 – 3805NPxxY motif; important for ligand-induced conformation changes and signalingBy similarity
    Motifi469 – 4713PDZ-binding

    Domaini

    The PDZ domain-binding motif is involved in the interaction with INADL, CASK, APBA1, DLG1 and DLG4.

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG247243.
    HOGENOMiHOG000240378.
    HOVERGENiHBG107487.
    InParanoidiP28223.
    KOiK04157.
    OMAiCTMVALG.
    OrthoDBiEOG70ZZN5.
    PhylomeDBiP28223.
    TreeFamiTF316350.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000455. 5HT2A_rcpt.
    IPR002231. 5HT_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24247:SF30. PTHR24247:SF30. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00516. 5HT2ARECEPTR.
    PR01101. 5HTRECEPTOR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P28223-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDILCEENTS LSSTTNSLMQ LNDDTRLYSN DFNSGEANTS DAFNWTVDSE    50
    NRTNLSCEGC LSPSCLSLLH LQEKNWSALL TAVVIILTIA GNILVIMAVS 100
    LEKKLQNATN YFLMSLAIAD MLLGFLVMPV SMLTILYGYR WPLPSKLCAV 150
    WIYLDVLFST ASIMHLCAIS LDRYVAIQNP IHHSRFNSRT KAFLKIIAVW 200
    TISVGISMPI PVFGLQDDSK VFKEGSCLLA DDNFVLIGSF VSFFIPLTIM 250
    VITYFLTIKS LQKEATLCVS DLGTRAKLAS FSFLPQSSLS SEKLFQRSIH 300
    REPGSYTGRR TMQSISNEQK ACKVLGIVFF LFVVMWCPFF ITNIMAVICK 350
    ESCNEDVIGA LLNVFVWIGY LSSAVNPLVY TLFNKTYRSA FSRYIQCQYK 400
    ENKKPLQLIL VNTIPALAYK SSQLQMGQKK NSKQDAKTTD NDCSMVALGK 450
    QHSEEASKDN SDGVNEKVSC V 471
    Length:471
    Mass (Da):52,603
    Last modified:June 1, 1994 - v2
    Checksum:iEF8AAC0BC5379DA2
    GO
    Isoform 2 (identifier: P28223-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-138: MDILCEENTS...PVSMLTILYG → MQFLKSAKQK...ISCVDPEDKW

    Show »
    Length:387
    Mass (Da):43,940
    Checksum:iDA98167A87C1AAB7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Isoform 2 (identifier: P28223-2)
    Sequence conflicti49 – 491D → N in BAG63991. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti25 – 251T → N.2 Publications
    Corresponds to variant rs1805055 [ dbSNP | Ensembl ].
    VAR_003448
    Natural varianti197 – 1971I → V.1 Publication
    Corresponds to variant rs6304 [ dbSNP | Ensembl ].
    VAR_013901
    Natural varianti447 – 4471A → V.1 Publication
    Corresponds to variant rs6308 [ dbSNP | Ensembl ].
    VAR_013902
    Natural varianti452 – 4521H → Y.3 Publications
    Corresponds to variant rs6314 [ dbSNP | Ensembl ].
    VAR_003449

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 138138MDILC…TILYG → MQFLKSAKQKPNYYHIMLVE DQEEGTLHQFNYCERCSESQ NNKCISCVDPEDKW in isoform 2. 1 PublicationVSP_046663Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X57830 mRNA. Translation: CAA40963.1.
    S42168, S42165, S42167 Genomic DNA. Translation: AAB22791.2.
    S71229 mRNA. Translation: AAB31320.1.
    AF498982 mRNA. Translation: AAM21129.1.
    AK302787 mRNA. Translation: BAG63991.1.
    AK314132 mRNA. Translation: BAG36822.1.
    AL160397, AL136958 Genomic DNA. Translation: CAI16877.1.
    AL136958, AL160397 Genomic DNA. Translation: CAI12227.1.
    CH471075 Genomic DNA. Translation: EAX08770.1.
    BC069356 mRNA. Translation: AAH69356.1.
    BC069576 mRNA. Translation: AAH69576.1.
    BC074848 mRNA. Translation: AAH74848.1.
    BC074849 mRNA. Translation: AAH74849.1.
    BC096839 mRNA. Translation: AAH96839.1.
    M86841 mRNA. Translation: AAA58354.1.
    S50130, S49737, S50113 Genomic DNA. Translation: AAB24166.2.
    CCDSiCCDS53867.1. [P28223-2]
    CCDS9405.1. [P28223-1]
    PIRiA43956.
    RefSeqiNP_000612.1. NM_000621.4. [P28223-1]
    NP_001159419.1. NM_001165947.2. [P28223-2]
    UniGeneiHs.72630.

    Genome annotation databases

    EnsembliENST00000378688; ENSP00000367959; ENSG00000102468. [P28223-1]
    ENST00000542664; ENSP00000437737; ENSG00000102468. [P28223-1]
    ENST00000543956; ENSP00000441861; ENSG00000102468. [P28223-2]
    GeneIDi3356.
    KEGGihsa:3356.
    UCSCiuc010acr.4. human. [P28223-1]

    Polymorphism databases

    DMDMi543727.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    SHMPD

    The Singapore human mutation and polymorphism database

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X57830 mRNA. Translation: CAA40963.1 .
    S42168 , S42165 , S42167 Genomic DNA. Translation: AAB22791.2 .
    S71229 mRNA. Translation: AAB31320.1 .
    AF498982 mRNA. Translation: AAM21129.1 .
    AK302787 mRNA. Translation: BAG63991.1 .
    AK314132 mRNA. Translation: BAG36822.1 .
    AL160397 , AL136958 Genomic DNA. Translation: CAI16877.1 .
    AL136958 , AL160397 Genomic DNA. Translation: CAI12227.1 .
    CH471075 Genomic DNA. Translation: EAX08770.1 .
    BC069356 mRNA. Translation: AAH69356.1 .
    BC069576 mRNA. Translation: AAH69576.1 .
    BC074848 mRNA. Translation: AAH74848.1 .
    BC074849 mRNA. Translation: AAH74849.1 .
    BC096839 mRNA. Translation: AAH96839.1 .
    M86841 mRNA. Translation: AAA58354.1 .
    S50130 , S49737 , S50113 Genomic DNA. Translation: AAB24166.2 .
    CCDSi CCDS53867.1. [P28223-2 ]
    CCDS9405.1. [P28223-1 ]
    PIRi A43956.
    RefSeqi NP_000612.1. NM_000621.4. [P28223-1 ]
    NP_001159419.1. NM_001165947.2. [P28223-2 ]
    UniGenei Hs.72630.

    3D structure databases

    ProteinModelPortali P28223.
    SMRi P28223. Positions 38-406.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109588. 4 interactions.
    DIPi DIP-41844N.
    MINTi MINT-443877.
    STRINGi 9606.ENSP00000367959.

    Chemistry

    BindingDBi P28223.
    ChEMBLi CHEMBL2096662.
    DrugBanki DB01238. Aripiprazole.
    DB00477. Chlorpromazine.
    DB01239. Chlorprothixene.
    DB00604. Cisapride.
    DB01242. Clomipramine.
    DB00363. Clozapine.
    DB00924. Cyclobenzaprine.
    DB00434. Cyproheptadine.
    DB00320. Dihydroergotamine.
    DB00843. Donepezil.
    DB00751. Epinastine.
    DB00696. Ergotamine.
    DB00176. Fluvoxamine.
    DB00933. Mesoridazine.
    DB00247. Methysergide.
    DB06148. Mianserin.
    DB00805. Minaprine.
    DB00370. Mirtazapine.
    DB01149. Nefazodone.
    DB00334. Olanzapine.
    DB01267. Paliperidone.
    DB00715. Paroxetine.
    DB00433. Prochlorperazine.
    DB00420. Promazine.
    DB01069. Promethazine.
    DB00777. Propiomazine.
    DB01224. Quetiapine.
    DB00734. Risperidone.
    DB06144. Sertindole.
    DB00372. Thiethylperazine.
    DB00679. Thioridazine.
    DB00752. Tranylcypromine.
    DB00656. Trazodone.
    DB00285. Venlafaxine.
    DB00246. Ziprasidone.
    GuidetoPHARMACOLOGYi 6.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P28223.

    Polymorphism databases

    DMDMi 543727.

    Proteomic databases

    PaxDbi P28223.
    PRIDEi P28223.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000378688 ; ENSP00000367959 ; ENSG00000102468 . [P28223-1 ]
    ENST00000542664 ; ENSP00000437737 ; ENSG00000102468 . [P28223-1 ]
    ENST00000543956 ; ENSP00000441861 ; ENSG00000102468 . [P28223-2 ]
    GeneIDi 3356.
    KEGGi hsa:3356.
    UCSCi uc010acr.4. human. [P28223-1 ]

    Organism-specific databases

    CTDi 3356.
    GeneCardsi GC13M047407.
    HGNCi HGNC:5293. HTR2A.
    HPAi HPA014011.
    MIMi 182135. gene.
    neXtProti NX_P28223.
    PharmGKBi PA193.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG247243.
    HOGENOMi HOG000240378.
    HOVERGENi HBG107487.
    InParanoidi P28223.
    KOi K04157.
    OMAi CTMVALG.
    OrthoDBi EOG70ZZN5.
    PhylomeDBi P28223.
    TreeFami TF316350.

    Enzyme and pathway databases

    Reactomei REACT_17064. Serotonin receptors.
    REACT_18283. G alpha (q) signalling events.
    SignaLinki P28223.

    Miscellaneous databases

    GeneWikii 5-HT2A_receptor.
    GenomeRNAii 3356.
    NextBioi 13270.
    PROi P28223.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P28223.
    Bgeei P28223.
    CleanExi HS_HTR2A.
    Genevestigatori P28223.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000455. 5HT2A_rcpt.
    IPR002231. 5HT_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24247:SF30. PTHR24247:SF30. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00516. 5HT2ARECEPTR.
    PR01101. 5HTRECEPTOR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain stem.
    2. "The human 5-HT2 receptor is encoded by a multiple intron-exon gene."
      Chen K., Yang W., Grimsby J., Shih J.C.
      Brain Res. Mol. Brain Res. 14:20-26(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Primary structure of the human platelet serotonin 5-HT2A receptor: identify with frontal cortex serotonin 5-HT2A receptor."
      Cook E.H. Jr., Fletcher K.E., Wainwright M., Marks N., Yan S.Y., Leventhal B.L.
      J. Neurochem. 63:465-469(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Platelet.
    4. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III, Ikeda S.R., Aronstam R.S.
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Testis and Thalamus.
    6. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung.
    9. "Cloning and nucleotide sequence of the human(5HT) type 2 receptor."
      Tritch R.J., Robinson D.L., Sahagan B.G., Horlick R.A.
      Submitted (MAY-1992) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-464 (ISOFORM 1).
      Tissue: Brain.
    10. "Genomic organization, coding sequence and functional expression of human 5-HT2 and 5-HT1A receptor genes."
      Stam N.J., van Huizen F., van Alebeek C., Brands J., Dijkema R., Tonnaer J.A., Olijve W.
      Eur. J. Pharmacol. 227:153-162(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 105-218, FUNCTION, SUBCELLULAR LOCATION.
    11. "Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1."
      Becamel C., Figge A., Poliak S., Dumuis A., Peles E., Bockaert J., Luebbert H., Ullmer C.
      J. Biol. Chem. 276:12974-12982(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MPDZ.
    12. "The serotonin 5-HT2A and 5-HT2C receptors interact with specific sets of PDZ proteins."
      Becamel C., Gavarini S., Chanrion B., Alonso G., Galeotti N., Dumuis A., Bockaert J., Marin P.
      J. Biol. Chem. 279:20257-20266(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH INADL; MPP3; PRDX6; DLG4; DLG1; CASK; APBA1 AND MAGI2, MUTAGENESIS OF GLY-463; ASN-465; CYS-470 AND VAL-471.
    13. Cited for: REVIEW.
    14. "Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells."
      Cussac D., Boutet-Robinet E., Ailhaud M.C., Newman-Tancredi A., Martel J.C., Danty N., Rauly-Lestienne I.
      Eur. J. Pharmacol. 594:32-38(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    15. Cited for: INTERACTION WITH GRM2, FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    16. "Pharmacological characterization of mitogen-activated protein kinase activation by recombinant human 5-HT2C, 5-HT2A, and 5-HT2B receptors."
      Knauer C.S., Campbell J.E., Chio C.L., Fitzgerald L.W.
      Naunyn Schmiedebergs Arch. Pharmacol. 379:461-471(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    17. "Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptors."
      Albizu L., Holloway T., Gonzalez-Maeso J., Sealfon S.C.
      Neuropharmacology 61:770-777(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DRD2, FUNCTION, SUBCELLULAR LOCATION.
    18. "Serotonin receptors - from molecular biology to clinical applications."
      Pytliak M., Vargova V., Mechirova V., Felsoci M.
      Physiol. Res. 60:15-25(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    19. "Heterocomplex formation of 5-HT2A-mGlu2 and its relevance for cellular signaling cascades."
      Delille H.K., Becker J.M., Burkhardt S., Bleher B., Terstappen G.C., Schmidt M., Meyer A.H., Unger L., Marek G.J., Mezler M.
      Neuropharmacology 62:2184-2191(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GRM2, FUNCTION, SUBCELLULAR LOCATION.
    20. "Systematic screening for mutations in the human serotonin-2A (5-HT2A) receptor gene: identification of two naturally occurring receptor variants and association analysis in schizophrenia."
      Erdmann J., Shimron-Abarbanell D., Rietschel M., Albus M., Maier W., Koerner J., Bondy B., Chen K., Shih J.C., Knapp M., Propping P., Noethen M.M.
      Hum. Genet. 97:614-619(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS ASN-25 AND TYR-452.
    21. "Unified approach to the analysis of genetic variation in serotonergic pathways."
      Marshall S.E., Bird T.G., Hart K., Welsh K.I.
      Am. J. Med. Genet. 88:621-627(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS ASN-25 AND TYR-452.
    22. Cited for: VARIANTS VAL-197; VAL-447 AND TYR-452.

    Entry informationi

    Entry namei5HT2A_HUMAN
    AccessioniPrimary (citable) accession number: P28223
    Secondary accession number(s): B2RAC5
    , B4DZ79, F5GWE8, Q5T8C0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 150 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3