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P28223

- 5HT2A_HUMAN

UniProt

P28223 - 5HT2A_HUMAN

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Protein

5-hydroxytryptamine receptor 2A

Gene

HTR2A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca2+ ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.6 Publications

GO - Molecular functioni

  1. 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding Source: UniProtKB
  2. drug binding Source: UniProtKB
  3. serotonin binding Source: UniProtKB
  4. serotonin receptor activity Source: UniProtKB

GO - Biological processi

  1. activation of phospholipase C activity Source: UniProtKB
  2. aging Source: Ensembl
  3. artery smooth muscle contraction Source: Ensembl
  4. behavioral response to cocaine Source: Ensembl
  5. cell death Source: Ensembl
  6. cellular calcium ion homeostasis Source: UniProtKB
  7. detection of mechanical stimulus involved in sensory perception of pain Source: Ensembl
  8. detection of temperature stimulus involved in sensory perception of pain Source: Ensembl
  9. memory Source: Ensembl
  10. negative regulation of potassium ion transport Source: Ensembl
  11. negative regulation of synaptic transmission, glutamatergic Source: Ensembl
  12. phosphatidylinositol 3-kinase signaling Source: UniProtKB
  13. phospholipase C-activating serotonin receptor signaling pathway Source: Ensembl
  14. positive regulation of cell proliferation Source: Ensembl
  15. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
  16. positive regulation of glycolytic process Source: Ensembl
  17. positive regulation of MAP kinase activity Source: Ensembl
  18. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  19. positive regulation of phosphatidylinositol biosynthetic process Source: UniProtKB
  20. positive regulation of vasoconstriction Source: Ensembl
  21. protein localization to cytoskeleton Source: Ensembl
  22. regulation of behavior Source: InterPro
  23. regulation of dopamine secretion Source: Ensembl
  24. regulation of hormone secretion Source: InterPro
  25. release of sequestered calcium ion into cytosol Source: UniProtKB
  26. response to drug Source: UniProtKB
  27. serotonin receptor signaling pathway Source: UniProtKB
  28. sleep Source: Ensembl
  29. synaptic transmission Source: ProtInc
  30. temperature homeostasis Source: Ensembl
  31. urinary bladder smooth muscle contraction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Behavior

Enzyme and pathway databases

ReactomeiREACT_17064. Serotonin receptors.
REACT_18283. G alpha (q) signalling events.
SignaLinkiP28223.

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 2A
Short name:
5-HT-2
Short name:
5-HT-2A
Alternative name(s):
Serotonin receptor 2A
Gene namesi
Name:HTR2A
Synonyms:HTR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:5293. HTR2A.

Subcellular locationi

Cell membrane; Multi-pass membrane protein. Cell projectiondendrite By similarity. Cell projectionaxon By similarity. Cytoplasmic vesicle By similarity. Membranecaveola By similarity
Note: Localizes to the postsynaptic thickening of axo-dendritic synapses.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7575ExtracellularBy similarityAdd
BLAST
Transmembranei76 – 9924Helical; Name=1By similarityAdd
BLAST
Topological domaini100 – 11011CytoplasmicBy similarityAdd
BLAST
Transmembranei111 – 13222Helical; Name=2By similarityAdd
BLAST
Topological domaini133 – 14816ExtracellularBy similarityAdd
BLAST
Transmembranei149 – 17123Helical; Name=3By similarityAdd
BLAST
Topological domaini172 – 19120CytoplasmicBy similarityAdd
BLAST
Transmembranei192 – 21524Helical; Name=4By similarityAdd
BLAST
Topological domaini216 – 23318ExtracellularBy similarityAdd
BLAST
Transmembranei234 – 25421Helical; Name=5By similarityAdd
BLAST
Topological domaini255 – 32470CytoplasmicBy similarityAdd
BLAST
Transmembranei325 – 34622Helical; Name=6By similarityAdd
BLAST
Topological domaini347 – 36216ExtracellularBy similarityAdd
BLAST
Transmembranei363 – 38422Helical; Name=7By similarityAdd
BLAST
Topological domaini385 – 47187CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  1. cell body fiber Source: Ensembl
  2. cytoplasmic vesicle Source: UniProtKB-KW
  3. cytosol Source: Ensembl
  4. dendritic shaft Source: Ensembl
  5. integral component of plasma membrane Source: ProtInc
  6. neuronal cell body Source: Ensembl
  7. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi280 – 2801S → A: Increased ability of hallucinogens to desensitize the receptor. 1 Publication
Mutagenesisi280 – 2801S → D: Reduced receptor desensitization by nonhallucinogenic agonists. 1 Publication
Mutagenesisi463 – 4631G → V: Loss of interaction with INADL. 1 Publication
Mutagenesisi465 – 4651N → S: No effect on interaction with INADL. Acquires the binding properties of HTR2C; when associated with S-470. 1 Publication
Mutagenesisi470 – 4701C → S: No effect on interaction with INADL. Acquires the binding properties of HTR2C; when associated with S-465. 1 Publication
Mutagenesisi471 – 4711V → A: Loss of interaction with INADL, CASK, APBA1, DLG1 and DLG4. 1 Publication

Organism-specific databases

PharmGKBiPA193.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4714715-hydroxytryptamine receptor 2APRO_0000068946Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi8 – 81N-linked (GlcNAc...)Sequence Analysis
Glycosylationi38 – 381N-linked (GlcNAc...)Sequence Analysis
Glycosylationi44 – 441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi51 – 511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi54 – 541N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi148 ↔ 227PROSITE-ProRule annotation
Modified residuei280 – 2801Phosphoserine1 Publication
Disulfide bondi349 ↔ 353PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP28223.
PRIDEiP28223.

PTM databases

PhosphoSiteiP28223.

Expressioni

Tissue specificityi

Detected in brain cortex (at protein level). Detected in blood platelets.1 Publication

Gene expression databases

BgeeiP28223.
CleanExiHS_HTR2A.
ExpressionAtlasiP28223. baseline and differential.
GenevestigatoriP28223.

Organism-specific databases

HPAiHPA014011.

Interactioni

Subunit structurei

Interacts with MPDZ and INADL. May interact with MPP3, PRDX6, DLG4, DLG1, CASK, APBA1 and MAGI2. Interacts with GRM2 and DRD2; this may affect signaling.5 Publications

Protein-protein interaction databases

BioGridi109588. 4 interactions.
DIPiDIP-41844N.
MINTiMINT-443877.
STRINGi9606.ENSP00000367959.

Structurei

3D structure databases

ProteinModelPortaliP28223.
SMRiP28223. Positions 38-406.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni155 – 1606Agonist bindingBy similarity
Regioni336 – 3405Agonist bindingBy similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi172 – 1743DRY motif; important for ligand-induced conformation changesBy similarity
Motifi376 – 3805NPxxY motif; important for ligand-induced conformation changes and signalingBy similarity
Motifi469 – 4713PDZ-binding

Domaini

The PDZ domain-binding motif is involved in the interaction with INADL, CASK, APBA1, DLG1 and DLG4.

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG247243.
GeneTreeiENSGT00770000120457.
HOGENOMiHOG000240378.
HOVERGENiHBG107487.
InParanoidiP28223.
KOiK04157.
OMAiCTMVALG.
OrthoDBiEOG70ZZN5.
PhylomeDBiP28223.
TreeFamiTF316350.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000455. 5HT2A_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24247:SF30. PTHR24247:SF30. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00516. 5HT2ARECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P28223-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDILCEENTS LSSTTNSLMQ LNDDTRLYSN DFNSGEANTS DAFNWTVDSE
60 70 80 90 100
NRTNLSCEGC LSPSCLSLLH LQEKNWSALL TAVVIILTIA GNILVIMAVS
110 120 130 140 150
LEKKLQNATN YFLMSLAIAD MLLGFLVMPV SMLTILYGYR WPLPSKLCAV
160 170 180 190 200
WIYLDVLFST ASIMHLCAIS LDRYVAIQNP IHHSRFNSRT KAFLKIIAVW
210 220 230 240 250
TISVGISMPI PVFGLQDDSK VFKEGSCLLA DDNFVLIGSF VSFFIPLTIM
260 270 280 290 300
VITYFLTIKS LQKEATLCVS DLGTRAKLAS FSFLPQSSLS SEKLFQRSIH
310 320 330 340 350
REPGSYTGRR TMQSISNEQK ACKVLGIVFF LFVVMWCPFF ITNIMAVICK
360 370 380 390 400
ESCNEDVIGA LLNVFVWIGY LSSAVNPLVY TLFNKTYRSA FSRYIQCQYK
410 420 430 440 450
ENKKPLQLIL VNTIPALAYK SSQLQMGQKK NSKQDAKTTD NDCSMVALGK
460 470
QHSEEASKDN SDGVNEKVSC V
Length:471
Mass (Da):52,603
Last modified:June 1, 1994 - v2
Checksum:iEF8AAC0BC5379DA2
GO
Isoform 2 (identifier: P28223-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-138: MDILCEENTS...PVSMLTILYG → MQFLKSAKQK...ISCVDPEDKW

Show »
Length:387
Mass (Da):43,940
Checksum:iDA98167A87C1AAB7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Isoform 2 (identifier: P28223-2)
Sequence conflicti49 – 491D → N in BAG63991. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti25 – 251T → N.2 Publications
Corresponds to variant rs1805055 [ dbSNP | Ensembl ].
VAR_003448
Natural varianti197 – 1971I → V.1 Publication
Corresponds to variant rs6304 [ dbSNP | Ensembl ].
VAR_013901
Natural varianti447 – 4471A → V.1 Publication
Corresponds to variant rs6308 [ dbSNP | Ensembl ].
VAR_013902
Natural varianti452 – 4521H → Y.3 Publications
Corresponds to variant rs6314 [ dbSNP | Ensembl ].
VAR_003449

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 138138MDILC…TILYG → MQFLKSAKQKPNYYHIMLVE DQEEGTLHQFNYCERCSESQ NNKCISCVDPEDKW in isoform 2. 1 PublicationVSP_046663Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57830 mRNA. Translation: CAA40963.1.
S42168, S42165, S42167 Genomic DNA. Translation: AAB22791.2.
S71229 mRNA. Translation: AAB31320.1.
AF498982 mRNA. Translation: AAM21129.1.
AK302787 mRNA. Translation: BAG63991.1.
AK314132 mRNA. Translation: BAG36822.1.
AL160397, AL136958 Genomic DNA. Translation: CAI16877.1.
AL136958, AL160397 Genomic DNA. Translation: CAI12227.1.
CH471075 Genomic DNA. Translation: EAX08770.1.
BC069356 mRNA. Translation: AAH69356.1.
BC069576 mRNA. Translation: AAH69576.1.
BC074848 mRNA. Translation: AAH74848.1.
BC074849 mRNA. Translation: AAH74849.1.
BC096839 mRNA. Translation: AAH96839.1.
M86841 mRNA. Translation: AAA58354.1.
S50130, S49737, S50113 Genomic DNA. Translation: AAB24166.2.
CCDSiCCDS53867.1. [P28223-2]
CCDS9405.1. [P28223-1]
PIRiA43956.
RefSeqiNP_000612.1. NM_000621.4. [P28223-1]
NP_001159419.1. NM_001165947.2. [P28223-2]
UniGeneiHs.72630.

Genome annotation databases

EnsembliENST00000378688; ENSP00000367959; ENSG00000102468. [P28223-1]
ENST00000542664; ENSP00000437737; ENSG00000102468. [P28223-1]
ENST00000543956; ENSP00000441861; ENSG00000102468. [P28223-2]
GeneIDi3356.
KEGGihsa:3356.
UCSCiuc010acr.4. human. [P28223-1]

Polymorphism databases

DMDMi543727.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57830 mRNA. Translation: CAA40963.1 .
S42168 , S42165 , S42167 Genomic DNA. Translation: AAB22791.2 .
S71229 mRNA. Translation: AAB31320.1 .
AF498982 mRNA. Translation: AAM21129.1 .
AK302787 mRNA. Translation: BAG63991.1 .
AK314132 mRNA. Translation: BAG36822.1 .
AL160397 , AL136958 Genomic DNA. Translation: CAI16877.1 .
AL136958 , AL160397 Genomic DNA. Translation: CAI12227.1 .
CH471075 Genomic DNA. Translation: EAX08770.1 .
BC069356 mRNA. Translation: AAH69356.1 .
BC069576 mRNA. Translation: AAH69576.1 .
BC074848 mRNA. Translation: AAH74848.1 .
BC074849 mRNA. Translation: AAH74849.1 .
BC096839 mRNA. Translation: AAH96839.1 .
M86841 mRNA. Translation: AAA58354.1 .
S50130 , S49737 , S50113 Genomic DNA. Translation: AAB24166.2 .
CCDSi CCDS53867.1. [P28223-2 ]
CCDS9405.1. [P28223-1 ]
PIRi A43956.
RefSeqi NP_000612.1. NM_000621.4. [P28223-1 ]
NP_001159419.1. NM_001165947.2. [P28223-2 ]
UniGenei Hs.72630.

3D structure databases

ProteinModelPortali P28223.
SMRi P28223. Positions 38-406.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109588. 4 interactions.
DIPi DIP-41844N.
MINTi MINT-443877.
STRINGi 9606.ENSP00000367959.

Chemistry

BindingDBi P28223.
ChEMBLi CHEMBL2095200.
DrugBanki DB01614. Acepromazine.
DB06288. Amisulpride.
DB00321. Amitriptyline.
DB00543. Amoxapine.
DB00714. Apomorphine.
DB01238. Aripiprazole.
DB06216. Asenapine.
DB01200. Bromocriptine.
DB00248. Cabergoline.
DB00477. Chlorpromazine.
DB01239. Chlorprothixene.
DB08810. Cinitapride.
DB00604. Cisapride.
DB01242. Clomipramine.
DB00363. Clozapine.
DB00924. Cyclobenzaprine.
DB00434. Cyproheptadine.
DB01151. Desipramine.
DB00843. Donepezil.
DB01142. Doxepin.
DB00751. Epinastine.
DB01049. Ergoloid mesylate.
DB00696. Ergotamine.
DB00875. Flupentixol.
DB04842. Fluspirilene.
DB00502. Haloperidol.
DB04946. Iloperidone.
DB00458. Imipramine.
DB01221. Ketamine.
DB00589. Lisuride.
DB00408. Loxapine.
DB08815. Lurasidone.
DB00934. Maprotiline.
DB00933. Mesoridazine.
DB01403. Methotrimeprazine.
DB00247. Methysergide.
DB06148. Mianserin.
DB00805. Minaprine.
DB00370. Mirtazapine.
DB01618. Molindone.
DB01149. Nefazodone.
DB00540. Nortriptyline.
DB00334. Olanzapine.
DB01267. Paliperidone.
DB00715. Paroxetine.
DB01186. Pergolide.
DB01621. Pipotiazine.
DB00413. Pramipexole.
DB00420. Promazine.
DB01069. Promethazine.
DB00777. Propiomazine.
DB01224. Quetiapine.
DB00409. Remoxipride.
DB00734. Risperidone.
DB00268. Ropinirole.
DB06144. Sertindole.
DB01622. Thioproperazine.
DB00679. Thioridazine.
DB01623. Thiothixene.
DB00656. Trazodone.
DB00726. Trimipramine.
DB01392. Yohimbine.
DB00246. Ziprasidone.
GuidetoPHARMACOLOGYi 6.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P28223.

Polymorphism databases

DMDMi 543727.

Proteomic databases

PaxDbi P28223.
PRIDEi P28223.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000378688 ; ENSP00000367959 ; ENSG00000102468 . [P28223-1 ]
ENST00000542664 ; ENSP00000437737 ; ENSG00000102468 . [P28223-1 ]
ENST00000543956 ; ENSP00000441861 ; ENSG00000102468 . [P28223-2 ]
GeneIDi 3356.
KEGGi hsa:3356.
UCSCi uc010acr.4. human. [P28223-1 ]

Organism-specific databases

CTDi 3356.
GeneCardsi GC13M047407.
HGNCi HGNC:5293. HTR2A.
HPAi HPA014011.
MIMi 182135. gene.
neXtProti NX_P28223.
PharmGKBi PA193.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG247243.
GeneTreei ENSGT00770000120457.
HOGENOMi HOG000240378.
HOVERGENi HBG107487.
InParanoidi P28223.
KOi K04157.
OMAi CTMVALG.
OrthoDBi EOG70ZZN5.
PhylomeDBi P28223.
TreeFami TF316350.

Enzyme and pathway databases

Reactomei REACT_17064. Serotonin receptors.
REACT_18283. G alpha (q) signalling events.
SignaLinki P28223.

Miscellaneous databases

GeneWikii 5-HT2A_receptor.
GenomeRNAii 3356.
NextBioi 13270.
PROi P28223.
SOURCEi Search...

Gene expression databases

Bgeei P28223.
CleanExi HS_HTR2A.
ExpressionAtlasi P28223. baseline and differential.
Genevestigatori P28223.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000455. 5HT2A_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24247:SF30. PTHR24247:SF30. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00516. 5HT2ARECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain stem.
  2. "The human 5-HT2 receptor is encoded by a multiple intron-exon gene."
    Chen K., Yang W., Grimsby J., Shih J.C.
    Brain Res. Mol. Brain Res. 14:20-26(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Primary structure of the human platelet serotonin 5-HT2A receptor: identify with frontal cortex serotonin 5-HT2A receptor."
    Cook E.H. Jr., Fletcher K.E., Wainwright M., Marks N., Yan S.Y., Leventhal B.L.
    J. Neurochem. 63:465-469(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Platelet.
  4. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Testis and Thalamus.
  6. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  9. "Cloning and nucleotide sequence of the human(5HT) type 2 receptor."
    Tritch R.J., Robinson D.L., Sahagan B.G., Horlick R.A.
    Submitted (MAY-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-464 (ISOFORM 1).
    Tissue: Brain.
  10. "Genomic organization, coding sequence and functional expression of human 5-HT2 and 5-HT1A receptor genes."
    Stam N.J., van Huizen F., van Alebeek C., Brands J., Dijkema R., Tonnaer J.A., Olijve W.
    Eur. J. Pharmacol. 227:153-162(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 105-218, FUNCTION, SUBCELLULAR LOCATION.
  11. "Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1."
    Becamel C., Figge A., Poliak S., Dumuis A., Peles E., Bockaert J., Luebbert H., Ullmer C.
    J. Biol. Chem. 276:12974-12982(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MPDZ.
  12. "The serotonin 5-HT2A and 5-HT2C receptors interact with specific sets of PDZ proteins."
    Becamel C., Gavarini S., Chanrion B., Alonso G., Galeotti N., Dumuis A., Bockaert J., Marin P.
    J. Biol. Chem. 279:20257-20266(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH INADL; MPP3; PRDX6; DLG4; DLG1; CASK; APBA1 AND MAGI2, MUTAGENESIS OF GLY-463; ASN-465; CYS-470 AND VAL-471.
  13. Cited for: REVIEW.
  14. "Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells."
    Cussac D., Boutet-Robinet E., Ailhaud M.C., Newman-Tancredi A., Martel J.C., Danty N., Rauly-Lestienne I.
    Eur. J. Pharmacol. 594:32-38(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  15. Cited for: INTERACTION WITH GRM2, FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  16. "Pharmacological characterization of mitogen-activated protein kinase activation by recombinant human 5-HT2C, 5-HT2A, and 5-HT2B receptors."
    Knauer C.S., Campbell J.E., Chio C.L., Fitzgerald L.W.
    Naunyn Schmiedebergs Arch. Pharmacol. 379:461-471(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  17. "Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptors."
    Albizu L., Holloway T., Gonzalez-Maeso J., Sealfon S.C.
    Neuropharmacology 61:770-777(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DRD2, FUNCTION, SUBCELLULAR LOCATION.
  18. "Serotonin receptors - from molecular biology to clinical applications."
    Pytliak M., Vargova V., Mechirova V., Felsoci M.
    Physiol. Res. 60:15-25(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  19. "Heterocomplex formation of 5-HT2A-mGlu2 and its relevance for cellular signaling cascades."
    Delille H.K., Becker J.M., Burkhardt S., Bleher B., Terstappen G.C., Schmidt M., Meyer A.H., Unger L., Marek G.J., Mezler M.
    Neuropharmacology 62:2184-2191(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GRM2, FUNCTION, SUBCELLULAR LOCATION.
  20. "Quantitative phosphoproteomics unravels biased phosphorylation of serotonin 2A receptor at Ser280 by hallucinogenic versus nonhallucinogenic agonists."
    Karaki S., Becamel C., Murat S., Mannoury la Cour C., Millan M.J., Prezeau L., Bockaert J., Marin P., Vandermoere F.
    Mol. Cell. Proteomics 13:1273-1285(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-280, MUTAGENESIS OF SER-280.
  21. "Systematic screening for mutations in the human serotonin-2A (5-HT2A) receptor gene: identification of two naturally occurring receptor variants and association analysis in schizophrenia."
    Erdmann J., Shimron-Abarbanell D., Rietschel M., Albus M., Maier W., Koerner J., Bondy B., Chen K., Shih J.C., Knapp M., Propping P., Noethen M.M.
    Hum. Genet. 97:614-619(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS ASN-25 AND TYR-452.
  22. "Unified approach to the analysis of genetic variation in serotonergic pathways."
    Marshall S.E., Bird T.G., Hart K., Welsh K.I.
    Am. J. Med. Genet. 88:621-627(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS ASN-25 AND TYR-452.
  23. Cited for: VARIANTS VAL-197; VAL-447 AND TYR-452.

Entry informationi

Entry namei5HT2A_HUMAN
AccessioniPrimary (citable) accession number: P28223
Secondary accession number(s): B2RAC5
, B4DZ79, F5GWE8, Q5T8C0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: June 1, 1994
Last modified: November 26, 2014
This is version 152 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3