Reviewed,
UniProtKB/Swiss-Prot P28222 (5HT1B_HUMAN)
Last modified
July 7, 2009.
Version 90.
History...
Clusters with 100%,
90%,
50% identity |
Documents (7) |
Third-party data |
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Names and origin
| Protein names | Recommended name: 5-hydroxytryptamine receptor 1B Alternative name(s): 5-HT-1D-beta Short name=5-HT-1B Short name=5-HT1B Serotonin receptor 1B Serotonin 1D beta receptor S12 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 390 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. |
| Subcellular location | |
| Post-translational modification | Phosphorylated. Desensitization of the receptor may be mediated by its phosphorylation. Ref.12 Palmitoylated. Ref.12 |
| Sequence similarities | Belongs to the G-protein coupled receptor 1 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cell membrane Membrane |
| Coding sequence diversity | Polymorphism |
| Domain | Transmembrane |
| Molecular function | G-protein coupled receptor Receptor Transducer |
| PTM | Disulfide bond Glycoprotein Lipoprotein Palmitate Phosphoprotein |
| Technical term | 3D-structure Complete proteome |
| Gene Ontology (GO) | |
| Biological process | G-protein signaling, coupled to cyclic nucleotide second messenger Ref.4 Traceable author statement. Source: ProtInc synaptic transmission Ref.6Traceable author statement. Source: ProtInc |
| Cellular component | integral to plasma membrane Ref.4 Traceable author statement. Source: ProtInc |
| Molecular function | protein binding Inferred from physical interaction. Source: IntAct serotonin receptor activity Ref.1Traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| GSTK1 | Q9Y2Q3 | 1 | EBI-1056863,EBI-1053767 | |
| NME2 | P22392 | 1 | EBI-1056863,EBI-713693 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 390 | 390 | 5-hydroxytryptamine receptor 1B | PRO_0000068916 | |||||||
Regions | |||||||||||
| Topological domain | 1 – 49 | 49 | Extracellular By similarity | ||||||||
| Transmembrane | 50 – 73 | 24 | 1 By similarity | ||||||||
| Topological domain | 74 – 86 | 13 | Cytoplasmic By similarity | ||||||||
| Transmembrane | 87 – 109 | 23 | 2 By similarity | ||||||||
| Topological domain | 110 – 119 | 10 | Extracellular By similarity | ||||||||
| Transmembrane | 120 – 145 | 26 | 3 By similarity | ||||||||
| Topological domain | 146 – 165 | 20 | Cytoplasmic By similarity | ||||||||
| Transmembrane | 166 – 187 | 22 | 4 By similarity | ||||||||
| Topological domain | 188 – 205 | 18 | Extracellular By similarity | ||||||||
| Transmembrane | 206 – 229 | 24 | 5 By similarity | ||||||||
| Topological domain | 230 – 315 | 86 | Cytoplasmic By similarity | ||||||||
| Transmembrane | 316 – 340 | 25 | 6 By similarity | ||||||||
| Topological domain | 341 – 347 | 7 | Extracellular By similarity | ||||||||
| Transmembrane | 348 – 373 | 26 | 7 By similarity | ||||||||
| Topological domain | 374 – 390 | 17 | Cytoplasmic By similarity | ||||||||
Amino acid modifications | |||||||||||
| Lipidation | 388 | 1 | S-palmitoyl cysteine Potential | ||||||||
| Glycosylation | 24 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 32 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 122 ↔ 199 | By similarity | |||||||||
Natural variations | |||||||||||
| Natural variant | 124 | 1 | F → C: dbSNP rs130060. Ref.13 | VAR_011715 | |||||||
| Natural variant | 219 | 1 | F → L: dbSNP rs130061. | VAR_011831 | |||||||
| Natural variant | 367 | 1 | I → V: dbSNP rs130063. | VAR_011832 | |||||||
| Natural variant | 374 | 1 | E → K: dbSNP rs130064. | VAR_011833 | |||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: a homologue of the rat 5-HT1B receptor with 5-HT1D-like pharmacological specificity." Hamblin M.W., Metcalf M.A., McGuffin R.W., Karpells S. Biochem. Biophys. Res. Commun. 184:752-759(1992) [PubMed: 1315531] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "Cloning and expression of the human 5-HT1B-type receptor gene." Mochizuki D., Yuyama Y., Tsujita R., Komaki H., Sagai H. Biochem. Biophys. Res. Commun. 185:517-523(1992) [PubMed: 1610347] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "Characterization of the human 5-hydroxytryptamine1B receptor." Jin H., Oksenberg D., Ashkenazi A., Peroutka S.J., Duncan A.M.V., Rozmahel R., Yang Y., Mengod G., Palacios J.M., O'Dowd B.F. J. Biol. Chem. 267:5735-5738(1992) [PubMed: 1348246] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [4] | "Molecular cloning of a human serotonin receptor (S12) with a pharmacological profile resembling that of the 5-HT1D subtype." Levy F.O., Gudermann T., Perez-Reyes E., Birnbaumer M., Kaumann A.J., Birnbaumer L. J. Biol. Chem. 267:7553-7562(1992) [PubMed: 1559993] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [5] | "Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta." Weinshank R.L., Zgombick J.M., Macchi M.J., Branchek T.A., Hartig P.R. Proc. Natl. Acad. Sci. U.S.A. 89:3630-3634(1992) [PubMed: 1565658] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta. |
| [6] | "A human serotonin 1D receptor variant (5HT1D beta) encoded by an intronless gene on chromosome 6." Demchyshyn L., Sunahara R.K., Miller K., Teitler M., Hoffman B.J., Kennedy J.L., Seeman P., van Tol H.H.M., Niznik H.B. Proc. Natl. Acad. Sci. U.S.A. 89:5522-5526(1992) [PubMed: 1351684] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [7] | "Cloning and pharmacological characterization of a novel human 5-hydroxytryptamine1D receptor subtype." Veldman S.A., Bienkowski M.J. Mol. Pharmacol. 42:439-444(1992) [PubMed: 1328844] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [8] | "Human-specific amino acid changes found in 103 protein-coding genes." Kitano T., Liu Y.-H., Ueda S., Saitou N. Mol. Biol. Evol. 21:936-944(2004) [PubMed: 15014171] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [9] | "Isolation of complete coding sequence for 5-hydroxytryptamine (serotonin) receptor 1B (HTR1B)." Kopatz S.A., Aronstam R.S., Sharma S.V. Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [10] | "The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. Beck S.Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [11] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [12] | "Human serotonin1B receptor expression in Sf9 cells: phosphorylation, palmitoylation, and adenylyl cyclase inhibition." Ng G.Y.K., George S.R., Zastawny R.L., Caron M., Bouvier M., Dennis M., O'Dowd B.F. Biochemistry 32:11727-11733(1993) [PubMed: 8218242] [Abstract] Cited for: PALMITOYLATION, PHOSPHORYLATION. |
| [13] | "Identification of genetic variation in the human serotonin 1D beta receptor gene." Nothen M.M., Erdmann J., Shimron-Abarbanell D., Propping P. Biochem. Biophys. Res. Commun. 205:1194-1200(1994) [PubMed: 7802650] [Abstract] Cited for: VARIANT CYS-124. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| M89478 Genomic DNA. No translation available. D10995 Genomic DNA. Translation: BAA01763.1. M83180 Genomic DNA. Translation: AAA36029.1. L09732 Genomic DNA. Translation: AAA36030.1. M81590 mRNA. Translation: AAA60316.1. M75128 Genomic DNA. Translation: AAA58675.1. AB041370 Genomic DNA. Translation: BAA94455.1. AY225227 Genomic DNA. Translation: AAO67712.1. AL049595 Genomic DNA. Translation: CAB51537.1. BC069065 mRNA. Translation: AAH69065.1. BC096206 mRNA. Translation: AAH96206.1. BC096207 mRNA. Translation: AAH96207.1. BC096208 mRNA. Translation: AAH96208.1. | |||||||||||||
| IPI | IPI00002184. | ||||||||||||
| PIR | JN0268. | ||||||||||||
| RefSeq | NP_000854.1. | ||||||||||||
| UniGene | Hs.123016 | ||||||||||||
3D structure databases | |||||||||||||
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| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| IntAct | P28222. 2 interactions. | ||||||||||||
Protein family/group databases | |||||||||||||
| GPCRDB | Search... | ||||||||||||
Proteomic databases | |||||||||||||
| PRIDE | P28222. | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENSG00000135312. Homo sapiens. [Contig view] | ||||||||||||
| GeneID | 3351. | ||||||||||||
| KEGG | hsa:3351. | ||||||||||||
| UCSC | uc003pil.1. human. | ||||||||||||
Organism-specific databases | |||||||||||||
| GeneCards | GC06M078228. | ||||||||||||
| H-InvDB | HIX0032923. | ||||||||||||
| HGNC | HGNC:5287. HTR1B. | ||||||||||||
| MIM | 182131. gene. | ||||||||||||
| PharmGKB | PA29549. | ||||||||||||
| GenAtlas | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| HOGENOM | P28222. | ||||||||||||
| HOVERGEN | P28222. | ||||||||||||
| OMA | P28222. APSHNCS. | ||||||||||||
Enzyme and pathway databases | |||||||||||||
| Reactome | REACT_14797. Signaling by GPCR. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | P28222. | ||||||||||||
| Bgee | P28222. | ||||||||||||
| CleanEx | HS_HTR1B. | ||||||||||||
| GermOnline | ENSG00000135312. Homo sapiens. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR002147. 5HT1B_rcpt. IPR002231. 5HT_rcpt. IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view] | ||||||||||||
| PANTHER | PTHR19266:SF67. 5HT1B_rcpt. 1 hit. | ||||||||||||
| Pfam | PF00001. 7tm_1. 1 hit. [Graphical view] | ||||||||||||
| PRINTS | PR00513. 5HT1BRECEPTR. PR01101. 5HTRECEPTOR. PR00237. GPCRRHODOPSN. | ||||||||||||
| PROSITE | PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other Resources | |||||||||||||
| DrugBank | DB00918. Almotriptan. DB01191. Dexfenfluramine. DB00320. Dihydroergotamine. DB00216. Eletriptan. DB00696. Ergotamine. DB00998. Frovatriptan. DB00952. Naratriptan. DB00960. Pindolol. DB00571. Propranolol. DB00953. Rizatriptan. DB00669. Sumatriptan. DB00285. Venlafaxine. DB00315. Zolmitriptan. | ||||||||||||
| NextBio | 13252. | ||||||||||||
| SOURCE | Search... | ||||||||||||
Entry information
| Entry name | 5HT1B_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P28222 Secondary accession number(s): Q4VAY7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| 7-transmembrane G-linked receptors List of 7-transmembrane G-linked receptor entries |
| Human chromosome 6 Human chromosome 6: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


