P28221 (5HT1D_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
5-hydroxytryptamine receptor 1D
Short name=5-HT-1D
Short name=5-HT1D

Alternative name(s):
Serotonin 1D alpha receptor
Short name=5-HT-1D-alpha
Serotonin receptor 1D

Gene names

Name:	HTR1D
Synonyms:	HTR1DA, HTRL

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	377 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Traceable author statement Ref.2. Source: ProtInc intestine smooth muscle contraction Inferred from mutant phenotype PubMed 9186750. Source: UniProtKB response to toxin Inferred from electronic annotation. Source: Compara synaptic transmission Traceable author statement Ref.2. Source: ProtInc
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	serotonin binding Inferred from electronic annotation. Source: Compara serotonin receptor activity Traceable author statement Ref.2. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 377	377	5-hydroxytryptamine receptor 1D		PRO_0000068927
Regions
	Topological domain	1 – 38	38	Extracellular By similarity
	Transmembrane	39 – 62	24	Helical; Name=1; By similarity
	Topological domain	63 – 75	13	Cytoplasmic By similarity
	Transmembrane	76 – 98	23	Helical; Name=2; By similarity
	Topological domain	99 – 108	10	Extracellular By similarity
	Transmembrane	109 – 134	26	Helical; Name=3; By similarity
	Topological domain	135 – 154	20	Cytoplasmic By similarity
	Transmembrane	155 – 176	22	Helical; Name=4; By similarity
	Topological domain	177 – 194	18	Extracellular By similarity
	Transmembrane	195 – 218	24	Helical; Name=5; By similarity
	Topological domain	219 – 302	84	Cytoplasmic By similarity
	Transmembrane	303 – 326	24	Helical; Name=6; By similarity
	Topological domain	327 – 335	9	Extracellular By similarity
	Transmembrane	336 – 360	25	Helical; Name=7; By similarity
	Topological domain	361 – 377	17	Cytoplasmic By similarity
Amino acid modifications
	Glycosylation	5	1	N-linked (GlcNAc...) Potential
	Glycosylation	17	1	N-linked (GlcNAc...) Potential
	Glycosylation	21	1	N-linked (GlcNAc...) Potential
	Disulfide bond	111 ↔ 188		By similarity
Natural variations
	Natural variant	265	1	S → L. Ref.7 Corresponds to variant rs6299 [ dbSNP | Ensembl ].		VAR_011834

Sequences

	Sequence		Length	Mass (Da)
	P28221 [UniParc]. Last modified December 1, 1992. Version 1. Checksum: 0A4FCF81FFE2322A	FASTA	377	41,907
	10 20 30 40 50 60 MSPLNQSAEG LPQEASNRSL NATETSEAWD PRTLQALKIS LAVVLSVITL ATVLSNAFVL 70 80 90 100 110 120 TTILLTRKLH TPANYLIGSL ATTDLLVSIL VMPISIAYTI THTWNFGQIL CDIWLSSDIT 130 140 150 160 170 180 CCTASILHLC VIALDRYWAI TDALEYSKRR TAGHAATMIA IVWAISICIS IPPLFWRQAK 190 200 210 220 230 240 AQEEMSDCLV NTSQISYTIY STCGAFYIPS VLLIILYGRI YRAARNRILN PPSLYGKRFT 250 260 270 280 290 300 TAHLITGSAG SSLCSLNSSL HEGHSHSAGS PLFFNHVKIK LADSALERKR ISAARERKAT 310 320 330 340 350 360 KILGIILGAF IICWLPFFVV SLVLPICRDS CWIHPALFDF FTWLGYLNSL INPIIYTVFN 370 EEFRQAFQKI VPFRKAS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor." Hamblin M.W., Metcalf M.A. Mol. Pharmacol. 40:143-148(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta." Weinshank R.L., Zgombick J.M., Macchi M.J., Branchek T.A., Hartig P.R. Proc. Natl. Acad. Sci. U.S.A. 89:3630-3634(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[3]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Puhl H.L. III, Ikeda S.R., Aronstam R.S. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
[7]	"Characterization of single-nucleotide polymorphisms in coding regions of human genes." Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S. Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT LEU-265.
[8]	Erratum Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S. Nat. Genet. 23:373-373(1999)
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M89955 Genomic DNA. Translation: AAA35491.1. M81589 mRNA. Translation: AAA60315.1. AF498979 mRNA. Translation: AAM21126.1. BT007027 mRNA. Translation: AAP35673.1. AL049576 Genomic DNA. Translation: CAB81617.1. BC007720 mRNA. Translation: AAH07720.1.
IPI	IPI00002183.
PIR	A53279.
RefSeq	NP_000855.1. NM_000864.4.
UniGene	Hs.121482.
3D structure databases
ProteinModelPortal	P28221.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000313661.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P28221.
Polymorphism databases
DMDM	112819.
Proteomic databases
PRIDE	P28221.
Protocols and materials databases
DNASU	3352.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000314113; ENSP00000313661; ENSG00000179546. ENST00000374619; ENSP00000363748; ENSG00000179546.
GeneID	3352.
KEGG	hsa:3352.
UCSC	uc001bgn.3. human.
Organism-specific databases
CTD	3352.
GeneCards	GC01M023517.
HGNC	HGNC:5289. HTR1D.
MIM	182133. gene.
neXtProt	NX_P28221.
PharmGKB	PA29550.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG249628.
HOGENOM	HOG000239242.
HOVERGEN	HBG106962.
InParanoid	P28221.
KO	K04153.
OMA	CRDSCWI.
OrthoDB	EOG4R7VB6.
PhylomeDB	P28221.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	P28221.
CleanEx	HS_HTR1D.
Genevestigator	P28221.
GermOnline	ENSG00000179546. Homo sapiens.
Family and domain databases
InterPro	IPR000505. 5HT1D_rcpt. IPR002231. 5HT_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00514. 5HT1DRECEPTR. PR01101. 5HTRECEPTOR. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P28221.
ChEMBL	CHEMBL1983.
DrugBank	DB00918. Almotriptan. DB00320. Dihydroergotamine. DB00216. Eletriptan. DB00696. Ergotamine. DB00998. Frovatriptan. DB00952. Naratriptan. DB00953. Rizatriptan. DB00669. Sumatriptan. DB01079. Tegaserod. DB00246. Ziprasidone. DB00315. Zolmitriptan.
GenomeRNAi	3352.
NextBio	13256.
SOURCE	Search...

Entry information

Entry name

5HT1D_HUMAN

Accession

Primary (citable) accession number: P28221

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	December 1, 1992
Last modified:	May 1, 2013
This is version 127 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.