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P28192

- PTP4_CAEEL

UniProt

P28192 - PTP4_CAEEL

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Protein
Tyrosine-protein phosphatase 4
Gene
ptp-4, K04D7.4
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei844 – 8441Phosphocysteine intermediate By similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

SignaLinkiP28192.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase 4 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine phosphatase 4
Gene namesi
Name:ptp-4
ORF Names:K04D7.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome IV

Organism-specific databases

WormBaseiK04D7.4a; CE40655; WBGene00010558; ptp-4.
K04D7.4b; CE44709; WBGene00010558; ptp-4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 564543Extracellular Reviewed prediction
Add
BLAST
Transmembranei565 – 58521Helical; Reviewed prediction
Add
BLAST
Topological domaini586 – 1159574Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 11591138Tyrosine-protein phosphatase 4
PRO_0000094884Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi28 – 281N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi36 ↔ 115 By similarity
Glycosylationi153 – 1531N-linked (GlcNAc...) Reviewed prediction
Glycosylationi194 – 1941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi248 – 2481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi279 – 2791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi362 – 3621N-linked (GlcNAc...) Reviewed prediction
Glycosylationi480 – 4801N-linked (GlcNAc...) Reviewed prediction
Glycosylationi488 – 4881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi519 – 5191N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP28192.

Interactioni

Protein-protein interaction databases

STRINGi6239.K04D7.4.

Structurei

3D structure databases

ProteinModelPortaliP28192.
SMRiP28192. Positions 62-440, 596-1148.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 135114Ig-like C2-type
Add
BLAST
Domaini142 – 23594Fibronectin type-III 1
Add
BLAST
Domaini240 – 33596Fibronectin type-III 2
Add
BLAST
Domaini337 – 438102Fibronectin type-III 3
Add
BLAST
Domaini439 – 538100Fibronectin type-III 4
Add
BLAST
Domaini643 – 903261Tyrosine-protein phosphatase 1
Add
BLAST
Domaini888 – 1153266Tyrosine-protein phosphatase 2
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00750000117483.
HOGENOMiHOG000017135.
InParanoidiP28192.
OMAiCNERNAY.
OrthoDBiEOG7DJSQX.
PhylomeDBiP28192.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
3.90.190.10. 1 hit.
InterProiIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF00047. ig. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform a (identifier: P28192-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPRKHFIFLI FLFWKFDSAE SISVTSKNAT EALLRCPPAE NFIRTHMAPD     50
FETPRLVRRL DWFQDDSLVA SYQQDILADS SRQWWVSDGR YQLIRPFYTL 100
RVSPVTPEDS GTYRCRLETD PLFSSPQSTA TQELAVMVKP VAPSSPEIKT 150
FTNRSITLVW THNAARAHRP ILRFSVSVRT VSDNTRFVMA APSNATTVIV 200
DNLSPYTLYA FSVRAENSAG SSDFGPETTF RTLGESPNRP PQIQKIRNIT 250
SECVEVTITP PDEMNGELDK YLVLIQAVNE TIPRKMTFDK PTSTPLTICA 300
LSPSTDYALA IEADNGFGTS PQATLVFHTE DSVPNWSPST ITTLPVVGKP 350
EITVLWPAPP LNATEKVIKY HLYYKAKNED QWKIEHLNVS PNGVKSKLFK 400
YRLVDLNPNT QYRIRVSAST IKGEGAQSAD SVAQTDVGEP GTVTFKDLNF 450
DCKNGVKLRW NYEPSVNSKK SPTFTVKVTN QTTSLQFNTT MLSLDIIDLS 500
LYDEYTLRII VLERSTIDNS TILIGKYSDS HQFILKDKCS YQSSFCSPGE 550
KCAKLTSSAG NPRYISVLIV IFAIIIFAFI CFVIVHFARG SMNFKHLLKK 600
KEKCVYLEEI SPLVYDSAGQ EDIPVELFYG YVEDLNRNDS LKFKTQFQIL 650
ESQTSGIDSV DSGESNSSSD ENSQKNRYNN IGAIEATRIR LNSPTGNDYI 700
NANYVDSCNE RNAYIATQAP LPSTFSDFWS MIWQERSNII VCITNMVEDG 750
KRKCDQYWPS QQDSPQTFGN YQVTLVSEST NAHFSHRILD LKIAKAVPAV 800
ERKVHQLHFM GWPDHGVPSS VFPLLSFVHY TSDIHSTGPV VVHCSAGVGR 850
SGSYILVDSM RRHLISFRRL NVQGHLTHMR RQRAKLVQTL EQYIFCHEAI 900
RQLIRHGITR VHSDLFMRYL HYLSEENLNG KTRMQLQFED ICDCKHQPRC 950
LIESDVITLP GYHRSDEFMV GSWGNECEDL WRLTWQQKVQ TIVILNQRDS 1000
FWRKLPSCIY DGEIQLQHGD NFVLLQKDDQ QLCVRIVNVS RADLDTDFWR 1050
EIENVQKQRI TYHDAPLLIL AHKYPPSVPS PTDSTSTLSL SILFNDDTAL 1100
AFSICAATTL ACQLETTGCV DVVQVLSSYT EIQCGIFASK QEIEIIYEKM 1150
SQLVGGTRV 1159
Length:1,159
Mass (Da):131,423
Last modified:July 10, 2007 - v3
Checksum:i0F6EEEF312799E16
GO
Isoform b (identifier: P28192-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: Missing.

Note: No experimental confirmation available.

Show »
Length:1,113
Mass (Da):126,030
Checksum:i9D42E1BD625A272E
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4646Missing in isoform b.
VSP_047522Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti836 – 8361S → T in AAA28128. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z69664 Genomic DNA. Translation: CAA93513.2.
Z69664 Genomic DNA. Translation: CBK19459.1.
M38014 mRNA. Translation: AAA28128.1.
PIRiT23308.
RefSeqiNP_001255470.1. NM_001268541.1. [P28192-1]
NP_001255471.1. NM_001268542.1. [P28192-2]
UniGeneiCel.12674.

Genome annotation databases

EnsemblMetazoaiK04D7.4a; K04D7.4a; WBGene00010558. [P28192-1]
GeneIDi177898.
KEGGicel:CELE_K04D7.4.
UCSCiF59G1.5.1. c. elegans. [P28192-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z69664 Genomic DNA. Translation: CAA93513.2 .
Z69664 Genomic DNA. Translation: CBK19459.1 .
M38014 mRNA. Translation: AAA28128.1 .
PIRi T23308.
RefSeqi NP_001255470.1. NM_001268541.1. [P28192-1 ]
NP_001255471.1. NM_001268542.1. [P28192-2 ]
UniGenei Cel.12674.

3D structure databases

ProteinModelPortali P28192.
SMRi P28192. Positions 62-440, 596-1148.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.K04D7.4.

Proteomic databases

PaxDbi P28192.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai K04D7.4a ; K04D7.4a ; WBGene00010558 . [P28192-1 ]
GeneIDi 177898.
KEGGi cel:CELE_K04D7.4.
UCSCi F59G1.5.1. c. elegans. [P28192-1 ]

Organism-specific databases

CTDi 177898.
WormBasei K04D7.4a ; CE40655 ; WBGene00010558 ; ptp-4.
K04D7.4b ; CE44709 ; WBGene00010558 ; ptp-4.

Phylogenomic databases

eggNOGi COG5599.
GeneTreei ENSGT00750000117483.
HOGENOMi HOG000017135.
InParanoidi P28192.
OMAi CNERNAY.
OrthoDBi EOG7DJSQX.
PhylomeDBi P28192.

Enzyme and pathway databases

SignaLinki P28192.

Miscellaneous databases

NextBioi 898850.

Family and domain databases

Gene3Di 2.60.40.10. 4 hits.
3.90.190.10. 1 hit.
InterProi IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00041. fn3. 3 hits.
PF00047. ig. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
SSF52799. SSF52799. 2 hits.
PROSITEi PS50853. FN3. 4 hits.
PS50835. IG_LIKE. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.
  2. "Protein tyrosine phosphatase domains from the protochordate Styela plicata."
    Matthews R.J., Flores E., Thomas M.L.
    Immunogenetics 33:33-41(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 735-842.

Entry informationi

Entry nameiPTP4_CAEEL
AccessioniPrimary (citable) accession number: P28192
Secondary accession number(s): D3YT39, Q21214
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: July 10, 2007
Last modified: June 11, 2014
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi