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Protein

Tyrosine-protein phosphatase 4

Gene

ptp-4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei844Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

SignaLinkiP28192

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase 4 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine phosphatase 4
Gene namesi
Name:ptp-4
ORF Names:K04D7.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiK04D7.4a ; CE40655 ; WBGene00010558 ; ptp-4
K04D7.4b ; CE44709 ; WBGene00010558 ; ptp-4

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 564ExtracellularSequence analysisAdd BLAST543
Transmembranei565 – 585HelicalSequence analysisAdd BLAST21
Topological domaini586 – 1159CytoplasmicSequence analysisAdd BLAST574

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000009488422 – 1159Tyrosine-protein phosphatase 4Add BLAST1138

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi28N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi36 ↔ 115PROSITE-ProRule annotation
Glycosylationi153N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi194N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi248N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi279N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi362N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi480N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi488N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi519N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP28192
PRIDEiP28192

Expressioni

Gene expression databases

BgeeiWBGene00010558

Interactioni

Protein-protein interaction databases

STRINGi6239.K04D7.4a

Structurei

3D structure databases

ProteinModelPortaliP28192
SMRiP28192
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 135Ig-like C2-typeAdd BLAST114
Domaini142 – 235Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST94
Domaini240 – 335Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini337 – 438Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST102
Domaini439 – 538Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST100
Domaini643 – 903Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST261
Domaini888 – 1153Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST266

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0789 Eukaryota
COG5599 LUCA
GeneTreeiENSGT00900000140785
HOGENOMiHOG000017135
InParanoidiP28192
OMAiPMTHTIK
OrthoDBiEOG091G0104
PhylomeDBiP28192

Family and domain databases

CDDicd00063 FN3, 3 hits
Gene3Di2.60.40.10, 4 hits
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00041 fn3, 3 hits
PF00102 Y_phosphatase, 1 hit
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00060 FN3, 3 hits
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF49265 SSF49265, 2 hits
SSF52799 SSF52799, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 4 hits
PS50835 IG_LIKE, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 2 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: P28192-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPRKHFIFLI FLFWKFDSAE SISVTSKNAT EALLRCPPAE NFIRTHMAPD
60 70 80 90 100
FETPRLVRRL DWFQDDSLVA SYQQDILADS SRQWWVSDGR YQLIRPFYTL
110 120 130 140 150
RVSPVTPEDS GTYRCRLETD PLFSSPQSTA TQELAVMVKP VAPSSPEIKT
160 170 180 190 200
FTNRSITLVW THNAARAHRP ILRFSVSVRT VSDNTRFVMA APSNATTVIV
210 220 230 240 250
DNLSPYTLYA FSVRAENSAG SSDFGPETTF RTLGESPNRP PQIQKIRNIT
260 270 280 290 300
SECVEVTITP PDEMNGELDK YLVLIQAVNE TIPRKMTFDK PTSTPLTICA
310 320 330 340 350
LSPSTDYALA IEADNGFGTS PQATLVFHTE DSVPNWSPST ITTLPVVGKP
360 370 380 390 400
EITVLWPAPP LNATEKVIKY HLYYKAKNED QWKIEHLNVS PNGVKSKLFK
410 420 430 440 450
YRLVDLNPNT QYRIRVSAST IKGEGAQSAD SVAQTDVGEP GTVTFKDLNF
460 470 480 490 500
DCKNGVKLRW NYEPSVNSKK SPTFTVKVTN QTTSLQFNTT MLSLDIIDLS
510 520 530 540 550
LYDEYTLRII VLERSTIDNS TILIGKYSDS HQFILKDKCS YQSSFCSPGE
560 570 580 590 600
KCAKLTSSAG NPRYISVLIV IFAIIIFAFI CFVIVHFARG SMNFKHLLKK
610 620 630 640 650
KEKCVYLEEI SPLVYDSAGQ EDIPVELFYG YVEDLNRNDS LKFKTQFQIL
660 670 680 690 700
ESQTSGIDSV DSGESNSSSD ENSQKNRYNN IGAIEATRIR LNSPTGNDYI
710 720 730 740 750
NANYVDSCNE RNAYIATQAP LPSTFSDFWS MIWQERSNII VCITNMVEDG
760 770 780 790 800
KRKCDQYWPS QQDSPQTFGN YQVTLVSEST NAHFSHRILD LKIAKAVPAV
810 820 830 840 850
ERKVHQLHFM GWPDHGVPSS VFPLLSFVHY TSDIHSTGPV VVHCSAGVGR
860 870 880 890 900
SGSYILVDSM RRHLISFRRL NVQGHLTHMR RQRAKLVQTL EQYIFCHEAI
910 920 930 940 950
RQLIRHGITR VHSDLFMRYL HYLSEENLNG KTRMQLQFED ICDCKHQPRC
960 970 980 990 1000
LIESDVITLP GYHRSDEFMV GSWGNECEDL WRLTWQQKVQ TIVILNQRDS
1010 1020 1030 1040 1050
FWRKLPSCIY DGEIQLQHGD NFVLLQKDDQ QLCVRIVNVS RADLDTDFWR
1060 1070 1080 1090 1100
EIENVQKQRI TYHDAPLLIL AHKYPPSVPS PTDSTSTLSL SILFNDDTAL
1110 1120 1130 1140 1150
AFSICAATTL ACQLETTGCV DVVQVLSSYT EIQCGIFASK QEIEIIYEKM

SQLVGGTRV
Length:1,159
Mass (Da):131,423
Last modified:July 10, 2007 - v3
Checksum:i0F6EEEF312799E16
GO
Isoform b (identifier: P28192-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: Missing.

Note: No experimental confirmation available.
Show »
Length:1,113
Mass (Da):126,030
Checksum:i9D42E1BD625A272E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti836S → T in AAA28128 (PubMed:1704870).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0475221 – 46Missing in isoform b. CuratedAdd BLAST46

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z69664 Genomic DNA Translation: CAA93513.2
Z69664 Genomic DNA Translation: CBK19459.1
M38014 mRNA Translation: AAA28128.1
PIRiT23308
RefSeqiNP_001255470.1, NM_001268541.1 [P28192-1]
NP_001255471.1, NM_001268542.1 [P28192-2]
UniGeneiCel.12674

Genome annotation databases

EnsemblMetazoaiK04D7.4a; K04D7.4a; WBGene00010558 [P28192-1]
GeneIDi177898
KEGGicel:CELE_K04D7.4
UCSCiF59G1.5.1 c. elegans [P28192-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPTP4_CAEEL
AccessioniPrimary (citable) accession number: P28192
Secondary accession number(s): D3YT39, Q21214
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: July 10, 2007
Last modified: February 28, 2018
This is version 127 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

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