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P28192

- PTP4_CAEEL

UniProt

P28192 - PTP4_CAEEL

Protein

Tyrosine-protein phosphatase 4

Gene

ptp-4

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 3 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei844 – 8441Phosphocysteine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. protein tyrosine phosphatase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Enzyme and pathway databases

    SignaLinkiP28192.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein phosphatase 4 (EC:3.1.3.48)
    Alternative name(s):
    Protein-tyrosine phosphatase 4
    Gene namesi
    Name:ptp-4
    ORF Names:K04D7.4
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome IV

    Organism-specific databases

    WormBaseiK04D7.4a; CE40655; WBGene00010558; ptp-4.
    K04D7.4b; CE44709; WBGene00010558; ptp-4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 11591138Tyrosine-protein phosphatase 4PRO_0000094884Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi28 – 281N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi36 ↔ 115PROSITE-ProRule annotation
    Glycosylationi153 – 1531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi194 – 1941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi248 – 2481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi279 – 2791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi362 – 3621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi480 – 4801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi488 – 4881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi519 – 5191N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP28192.

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.K04D7.4.

    Structurei

    3D structure databases

    ProteinModelPortaliP28192.
    SMRiP28192. Positions 62-440, 596-1148.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 564543ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini586 – 1159574CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei565 – 58521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini22 – 135114Ig-like C2-typeAdd
    BLAST
    Domaini142 – 23594Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini240 – 33596Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini337 – 438102Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini439 – 538100Fibronectin type-III 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini643 – 903261Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini888 – 1153266Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation
    Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5599.
    GeneTreeiENSGT00750000117483.
    HOGENOMiHOG000017135.
    InParanoidiP28192.
    OMAiCNERNAY.
    OrthoDBiEOG7DJSQX.
    PhylomeDBiP28192.

    Family and domain databases

    Gene3Di2.60.40.10. 4 hits.
    3.90.190.10. 1 hit.
    InterProiIPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013151. Immunoglobulin.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF00041. fn3. 3 hits.
    PF00047. ig. 1 hit.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view]
    PRINTSiPR00700. PRTYPHPHTASE.
    SMARTiSM00060. FN3. 3 hits.
    SM00409. IG. 1 hit.
    SM00194. PTPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 2 hits.
    SSF52799. SSF52799. 2 hits.
    PROSITEiPS50853. FN3. 4 hits.
    PS50835. IG_LIKE. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform a (identifier: P28192-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPRKHFIFLI FLFWKFDSAE SISVTSKNAT EALLRCPPAE NFIRTHMAPD     50
    FETPRLVRRL DWFQDDSLVA SYQQDILADS SRQWWVSDGR YQLIRPFYTL 100
    RVSPVTPEDS GTYRCRLETD PLFSSPQSTA TQELAVMVKP VAPSSPEIKT 150
    FTNRSITLVW THNAARAHRP ILRFSVSVRT VSDNTRFVMA APSNATTVIV 200
    DNLSPYTLYA FSVRAENSAG SSDFGPETTF RTLGESPNRP PQIQKIRNIT 250
    SECVEVTITP PDEMNGELDK YLVLIQAVNE TIPRKMTFDK PTSTPLTICA 300
    LSPSTDYALA IEADNGFGTS PQATLVFHTE DSVPNWSPST ITTLPVVGKP 350
    EITVLWPAPP LNATEKVIKY HLYYKAKNED QWKIEHLNVS PNGVKSKLFK 400
    YRLVDLNPNT QYRIRVSAST IKGEGAQSAD SVAQTDVGEP GTVTFKDLNF 450
    DCKNGVKLRW NYEPSVNSKK SPTFTVKVTN QTTSLQFNTT MLSLDIIDLS 500
    LYDEYTLRII VLERSTIDNS TILIGKYSDS HQFILKDKCS YQSSFCSPGE 550
    KCAKLTSSAG NPRYISVLIV IFAIIIFAFI CFVIVHFARG SMNFKHLLKK 600
    KEKCVYLEEI SPLVYDSAGQ EDIPVELFYG YVEDLNRNDS LKFKTQFQIL 650
    ESQTSGIDSV DSGESNSSSD ENSQKNRYNN IGAIEATRIR LNSPTGNDYI 700
    NANYVDSCNE RNAYIATQAP LPSTFSDFWS MIWQERSNII VCITNMVEDG 750
    KRKCDQYWPS QQDSPQTFGN YQVTLVSEST NAHFSHRILD LKIAKAVPAV 800
    ERKVHQLHFM GWPDHGVPSS VFPLLSFVHY TSDIHSTGPV VVHCSAGVGR 850
    SGSYILVDSM RRHLISFRRL NVQGHLTHMR RQRAKLVQTL EQYIFCHEAI 900
    RQLIRHGITR VHSDLFMRYL HYLSEENLNG KTRMQLQFED ICDCKHQPRC 950
    LIESDVITLP GYHRSDEFMV GSWGNECEDL WRLTWQQKVQ TIVILNQRDS 1000
    FWRKLPSCIY DGEIQLQHGD NFVLLQKDDQ QLCVRIVNVS RADLDTDFWR 1050
    EIENVQKQRI TYHDAPLLIL AHKYPPSVPS PTDSTSTLSL SILFNDDTAL 1100
    AFSICAATTL ACQLETTGCV DVVQVLSSYT EIQCGIFASK QEIEIIYEKM 1150
    SQLVGGTRV 1159
    Length:1,159
    Mass (Da):131,423
    Last modified:July 10, 2007 - v3
    Checksum:i0F6EEEF312799E16
    GO
    Isoform b (identifier: P28192-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-46: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,113
    Mass (Da):126,030
    Checksum:i9D42E1BD625A272E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti836 – 8361S → T in AAA28128. (PubMed:1704870)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 4646Missing in isoform b. CuratedVSP_047522Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z69664 Genomic DNA. Translation: CAA93513.2.
    Z69664 Genomic DNA. Translation: CBK19459.1.
    M38014 mRNA. Translation: AAA28128.1.
    PIRiT23308.
    RefSeqiNP_001255470.1. NM_001268541.1. [P28192-1]
    NP_001255471.1. NM_001268542.1. [P28192-2]
    UniGeneiCel.12674.

    Genome annotation databases

    EnsemblMetazoaiK04D7.4a; K04D7.4a; WBGene00010558. [P28192-1]
    GeneIDi177898.
    KEGGicel:CELE_K04D7.4.
    UCSCiF59G1.5.1. c. elegans. [P28192-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z69664 Genomic DNA. Translation: CAA93513.2 .
    Z69664 Genomic DNA. Translation: CBK19459.1 .
    M38014 mRNA. Translation: AAA28128.1 .
    PIRi T23308.
    RefSeqi NP_001255470.1. NM_001268541.1. [P28192-1 ]
    NP_001255471.1. NM_001268542.1. [P28192-2 ]
    UniGenei Cel.12674.

    3D structure databases

    ProteinModelPortali P28192.
    SMRi P28192. Positions 62-440, 596-1148.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.K04D7.4.

    Proteomic databases

    PaxDbi P28192.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai K04D7.4a ; K04D7.4a ; WBGene00010558 . [P28192-1 ]
    GeneIDi 177898.
    KEGGi cel:CELE_K04D7.4.
    UCSCi F59G1.5.1. c. elegans. [P28192-1 ]

    Organism-specific databases

    CTDi 177898.
    WormBasei K04D7.4a ; CE40655 ; WBGene00010558 ; ptp-4.
    K04D7.4b ; CE44709 ; WBGene00010558 ; ptp-4.

    Phylogenomic databases

    eggNOGi COG5599.
    GeneTreei ENSGT00750000117483.
    HOGENOMi HOG000017135.
    InParanoidi P28192.
    OMAi CNERNAY.
    OrthoDBi EOG7DJSQX.
    PhylomeDBi P28192.

    Enzyme and pathway databases

    SignaLinki P28192.

    Miscellaneous databases

    NextBioi 898850.

    Family and domain databases

    Gene3Di 2.60.40.10. 4 hits.
    3.90.190.10. 1 hit.
    InterProi IPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013151. Immunoglobulin.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF00041. fn3. 3 hits.
    PF00047. ig. 1 hit.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view ]
    PRINTSi PR00700. PRTYPHPHTASE.
    SMARTi SM00060. FN3. 3 hits.
    SM00409. IG. 1 hit.
    SM00194. PTPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 2 hits.
    SSF52799. SSF52799. 2 hits.
    PROSITEi PS50853. FN3. 4 hits.
    PS50835. IG_LIKE. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
      Strain: Bristol N2.
    2. "Protein tyrosine phosphatase domains from the protochordate Styela plicata."
      Matthews R.J., Flores E., Thomas M.L.
      Immunogenetics 33:33-41(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 735-842.

    Entry informationi

    Entry nameiPTP4_CAEEL
    AccessioniPrimary (citable) accession number: P28192
    Secondary accession number(s): D3YT39, Q21214
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 106 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3