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P28192

- PTP4_CAEEL

UniProt

P28192 - PTP4_CAEEL

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Protein

Tyrosine-protein phosphatase 4

Gene

ptp-4

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei844 – 8441Phosphocysteine intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

SignaLinkiP28192.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase 4 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine phosphatase 4
Gene namesi
Name:ptp-4
ORF Names:K04D7.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome IV

Organism-specific databases

WormBaseiK04D7.4a; CE40655; WBGene00010558; ptp-4.
K04D7.4b; CE44709; WBGene00010558; ptp-4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 564543ExtracellularSequence AnalysisAdd
BLAST
Transmembranei565 – 58521HelicalSequence AnalysisAdd
BLAST
Topological domaini586 – 1159574CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 11591138Tyrosine-protein phosphatase 4PRO_0000094884Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi28 – 281N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi36 ↔ 115PROSITE-ProRule annotation
Glycosylationi153 – 1531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi194 – 1941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi248 – 2481N-linked (GlcNAc...)Sequence Analysis
Glycosylationi279 – 2791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi362 – 3621N-linked (GlcNAc...)Sequence Analysis
Glycosylationi480 – 4801N-linked (GlcNAc...)Sequence Analysis
Glycosylationi488 – 4881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi519 – 5191N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP28192.

Interactioni

Protein-protein interaction databases

STRINGi6239.K04D7.4.

Structurei

3D structure databases

ProteinModelPortaliP28192.
SMRiP28192. Positions 62-440, 596-1148.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 135114Ig-like C2-typeAdd
BLAST
Domaini142 – 23594Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini240 – 33596Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini337 – 438102Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini439 – 538100Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST
Domaini643 – 903261Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd
BLAST
Domaini888 – 1153266Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00770000120452.
HOGENOMiHOG000017135.
InParanoidiP28192.
OMAiCNERNAY.
OrthoDBiEOG7DJSQX.
PhylomeDBiP28192.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
3.90.190.10. 1 hit.
InterProiIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF00047. ig. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform a (identifier: P28192-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPRKHFIFLI FLFWKFDSAE SISVTSKNAT EALLRCPPAE NFIRTHMAPD
60 70 80 90 100
FETPRLVRRL DWFQDDSLVA SYQQDILADS SRQWWVSDGR YQLIRPFYTL
110 120 130 140 150
RVSPVTPEDS GTYRCRLETD PLFSSPQSTA TQELAVMVKP VAPSSPEIKT
160 170 180 190 200
FTNRSITLVW THNAARAHRP ILRFSVSVRT VSDNTRFVMA APSNATTVIV
210 220 230 240 250
DNLSPYTLYA FSVRAENSAG SSDFGPETTF RTLGESPNRP PQIQKIRNIT
260 270 280 290 300
SECVEVTITP PDEMNGELDK YLVLIQAVNE TIPRKMTFDK PTSTPLTICA
310 320 330 340 350
LSPSTDYALA IEADNGFGTS PQATLVFHTE DSVPNWSPST ITTLPVVGKP
360 370 380 390 400
EITVLWPAPP LNATEKVIKY HLYYKAKNED QWKIEHLNVS PNGVKSKLFK
410 420 430 440 450
YRLVDLNPNT QYRIRVSAST IKGEGAQSAD SVAQTDVGEP GTVTFKDLNF
460 470 480 490 500
DCKNGVKLRW NYEPSVNSKK SPTFTVKVTN QTTSLQFNTT MLSLDIIDLS
510 520 530 540 550
LYDEYTLRII VLERSTIDNS TILIGKYSDS HQFILKDKCS YQSSFCSPGE
560 570 580 590 600
KCAKLTSSAG NPRYISVLIV IFAIIIFAFI CFVIVHFARG SMNFKHLLKK
610 620 630 640 650
KEKCVYLEEI SPLVYDSAGQ EDIPVELFYG YVEDLNRNDS LKFKTQFQIL
660 670 680 690 700
ESQTSGIDSV DSGESNSSSD ENSQKNRYNN IGAIEATRIR LNSPTGNDYI
710 720 730 740 750
NANYVDSCNE RNAYIATQAP LPSTFSDFWS MIWQERSNII VCITNMVEDG
760 770 780 790 800
KRKCDQYWPS QQDSPQTFGN YQVTLVSEST NAHFSHRILD LKIAKAVPAV
810 820 830 840 850
ERKVHQLHFM GWPDHGVPSS VFPLLSFVHY TSDIHSTGPV VVHCSAGVGR
860 870 880 890 900
SGSYILVDSM RRHLISFRRL NVQGHLTHMR RQRAKLVQTL EQYIFCHEAI
910 920 930 940 950
RQLIRHGITR VHSDLFMRYL HYLSEENLNG KTRMQLQFED ICDCKHQPRC
960 970 980 990 1000
LIESDVITLP GYHRSDEFMV GSWGNECEDL WRLTWQQKVQ TIVILNQRDS
1010 1020 1030 1040 1050
FWRKLPSCIY DGEIQLQHGD NFVLLQKDDQ QLCVRIVNVS RADLDTDFWR
1060 1070 1080 1090 1100
EIENVQKQRI TYHDAPLLIL AHKYPPSVPS PTDSTSTLSL SILFNDDTAL
1110 1120 1130 1140 1150
AFSICAATTL ACQLETTGCV DVVQVLSSYT EIQCGIFASK QEIEIIYEKM

SQLVGGTRV
Length:1,159
Mass (Da):131,423
Last modified:July 10, 2007 - v3
Checksum:i0F6EEEF312799E16
GO
Isoform b (identifier: P28192-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: Missing.

Note: No experimental confirmation available.

Show »
Length:1,113
Mass (Da):126,030
Checksum:i9D42E1BD625A272E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti836 – 8361S → T in AAA28128. (PubMed:1704870)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4646Missing in isoform b. CuratedVSP_047522Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z69664 Genomic DNA. Translation: CAA93513.2.
Z69664 Genomic DNA. Translation: CBK19459.1.
M38014 mRNA. Translation: AAA28128.1.
PIRiT23308.
RefSeqiNP_001255470.1. NM_001268541.1. [P28192-1]
NP_001255471.1. NM_001268542.1. [P28192-2]
UniGeneiCel.12674.

Genome annotation databases

EnsemblMetazoaiK04D7.4a; K04D7.4a; WBGene00010558. [P28192-1]
GeneIDi177898.
KEGGicel:CELE_K04D7.4.
UCSCiF59G1.5.1. c. elegans. [P28192-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z69664 Genomic DNA. Translation: CAA93513.2 .
Z69664 Genomic DNA. Translation: CBK19459.1 .
M38014 mRNA. Translation: AAA28128.1 .
PIRi T23308.
RefSeqi NP_001255470.1. NM_001268541.1. [P28192-1 ]
NP_001255471.1. NM_001268542.1. [P28192-2 ]
UniGenei Cel.12674.

3D structure databases

ProteinModelPortali P28192.
SMRi P28192. Positions 62-440, 596-1148.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.K04D7.4.

Proteomic databases

PaxDbi P28192.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai K04D7.4a ; K04D7.4a ; WBGene00010558 . [P28192-1 ]
GeneIDi 177898.
KEGGi cel:CELE_K04D7.4.
UCSCi F59G1.5.1. c. elegans. [P28192-1 ]

Organism-specific databases

CTDi 177898.
WormBasei K04D7.4a ; CE40655 ; WBGene00010558 ; ptp-4.
K04D7.4b ; CE44709 ; WBGene00010558 ; ptp-4.

Phylogenomic databases

eggNOGi COG5599.
GeneTreei ENSGT00770000120452.
HOGENOMi HOG000017135.
InParanoidi P28192.
OMAi CNERNAY.
OrthoDBi EOG7DJSQX.
PhylomeDBi P28192.

Enzyme and pathway databases

SignaLinki P28192.

Miscellaneous databases

NextBioi 898850.

Family and domain databases

Gene3Di 2.60.40.10. 4 hits.
3.90.190.10. 1 hit.
InterProi IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00041. fn3. 3 hits.
PF00047. ig. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
SSF52799. SSF52799. 2 hits.
PROSITEi PS50853. FN3. 4 hits.
PS50835. IG_LIKE. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.
  2. "Protein tyrosine phosphatase domains from the protochordate Styela plicata."
    Matthews R.J., Flores E., Thomas M.L.
    Immunogenetics 33:33-41(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 735-842.

Entry informationi

Entry nameiPTP4_CAEEL
AccessioniPrimary (citable) accession number: P28192
Secondary accession number(s): D3YT39, Q21214
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: July 10, 2007
Last modified: November 26, 2014
This is version 108 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3