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P28192 (PTP4_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein phosphatase 4

EC=3.1.3.48
Alternative name(s):
Protein-tyrosine phosphatase 4
Gene names
Name:ptp-4
ORF Names:K04D7.4
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length1159 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subcellular location

Membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Receptor class subfamily.

Contains 4 fibronectin type-III domains.

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Contains 2 tyrosine-protein phosphatase domains.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainRepeat
Signal
Transmembrane
Transmembrane helix
   Molecular functionHydrolase
Protein phosphatase
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionprotein tyrosine phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform a (identifier: P28192-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform b (identifier: P28192-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 11591138Tyrosine-protein phosphatase 4
PRO_0000094884

Regions

Topological domain22 – 564543Extracellular Potential
Transmembrane565 – 58521Helical; Potential
Topological domain586 – 1159574Cytoplasmic Potential
Domain22 – 135114Ig-like C2-type
Domain142 – 23594Fibronectin type-III 1
Domain240 – 33596Fibronectin type-III 2
Domain337 – 438102Fibronectin type-III 3
Domain439 – 538100Fibronectin type-III 4
Domain643 – 903261Tyrosine-protein phosphatase 1
Domain888 – 1153266Tyrosine-protein phosphatase 2

Sites

Active site8441Phosphocysteine intermediate By similarity

Amino acid modifications

Glycosylation281N-linked (GlcNAc...) Potential
Glycosylation1531N-linked (GlcNAc...) Potential
Glycosylation1941N-linked (GlcNAc...) Potential
Glycosylation2481N-linked (GlcNAc...) Potential
Glycosylation2791N-linked (GlcNAc...) Potential
Glycosylation3621N-linked (GlcNAc...) Potential
Glycosylation4801N-linked (GlcNAc...) Potential
Glycosylation4881N-linked (GlcNAc...) Potential
Glycosylation5191N-linked (GlcNAc...) Potential
Disulfide bond36 ↔ 115 By similarity

Natural variations

Alternative sequence1 – 4646Missing in isoform b.
VSP_047522

Experimental info

Sequence conflict8361S → T in AAA28128. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform a [UniParc].

Last modified July 10, 2007. Version 3.
Checksum: 0F6EEEF312799E16

FASTA1,159131,423
        10         20         30         40         50         60 
MPRKHFIFLI FLFWKFDSAE SISVTSKNAT EALLRCPPAE NFIRTHMAPD FETPRLVRRL 

        70         80         90        100        110        120 
DWFQDDSLVA SYQQDILADS SRQWWVSDGR YQLIRPFYTL RVSPVTPEDS GTYRCRLETD 

       130        140        150        160        170        180 
PLFSSPQSTA TQELAVMVKP VAPSSPEIKT FTNRSITLVW THNAARAHRP ILRFSVSVRT 

       190        200        210        220        230        240 
VSDNTRFVMA APSNATTVIV DNLSPYTLYA FSVRAENSAG SSDFGPETTF RTLGESPNRP 

       250        260        270        280        290        300 
PQIQKIRNIT SECVEVTITP PDEMNGELDK YLVLIQAVNE TIPRKMTFDK PTSTPLTICA 

       310        320        330        340        350        360 
LSPSTDYALA IEADNGFGTS PQATLVFHTE DSVPNWSPST ITTLPVVGKP EITVLWPAPP 

       370        380        390        400        410        420 
LNATEKVIKY HLYYKAKNED QWKIEHLNVS PNGVKSKLFK YRLVDLNPNT QYRIRVSAST 

       430        440        450        460        470        480 
IKGEGAQSAD SVAQTDVGEP GTVTFKDLNF DCKNGVKLRW NYEPSVNSKK SPTFTVKVTN 

       490        500        510        520        530        540 
QTTSLQFNTT MLSLDIIDLS LYDEYTLRII VLERSTIDNS TILIGKYSDS HQFILKDKCS 

       550        560        570        580        590        600 
YQSSFCSPGE KCAKLTSSAG NPRYISVLIV IFAIIIFAFI CFVIVHFARG SMNFKHLLKK 

       610        620        630        640        650        660 
KEKCVYLEEI SPLVYDSAGQ EDIPVELFYG YVEDLNRNDS LKFKTQFQIL ESQTSGIDSV 

       670        680        690        700        710        720 
DSGESNSSSD ENSQKNRYNN IGAIEATRIR LNSPTGNDYI NANYVDSCNE RNAYIATQAP 

       730        740        750        760        770        780 
LPSTFSDFWS MIWQERSNII VCITNMVEDG KRKCDQYWPS QQDSPQTFGN YQVTLVSEST 

       790        800        810        820        830        840 
NAHFSHRILD LKIAKAVPAV ERKVHQLHFM GWPDHGVPSS VFPLLSFVHY TSDIHSTGPV 

       850        860        870        880        890        900 
VVHCSAGVGR SGSYILVDSM RRHLISFRRL NVQGHLTHMR RQRAKLVQTL EQYIFCHEAI 

       910        920        930        940        950        960 
RQLIRHGITR VHSDLFMRYL HYLSEENLNG KTRMQLQFED ICDCKHQPRC LIESDVITLP 

       970        980        990       1000       1010       1020 
GYHRSDEFMV GSWGNECEDL WRLTWQQKVQ TIVILNQRDS FWRKLPSCIY DGEIQLQHGD 

      1030       1040       1050       1060       1070       1080 
NFVLLQKDDQ QLCVRIVNVS RADLDTDFWR EIENVQKQRI TYHDAPLLIL AHKYPPSVPS 

      1090       1100       1110       1120       1130       1140 
PTDSTSTLSL SILFNDDTAL AFSICAATTL ACQLETTGCV DVVQVLSSYT EIQCGIFASK 

      1150 
QEIEIIYEKM SQLVGGTRV 

« Hide

Isoform b [UniParc].

Checksum: 9D42E1BD625A272E
Show »

FASTA1,113126,030

References

« Hide 'large scale' references
[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
Strain: Bristol N2.
[2]"Protein tyrosine phosphatase domains from the protochordate Styela plicata."
Matthews R.J., Flores E., Thomas M.L.
Immunogenetics 33:33-41(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 735-842.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z69664 Genomic DNA. Translation: CAA93513.2.
Z69664 Genomic DNA. Translation: CBK19459.1.
M38014 mRNA. Translation: AAA28128.1.
PIRT23308.
RefSeqNP_001255470.1. NM_001268541.1. [P28192-1]
NP_001255471.1. NM_001268542.1. [P28192-2]
UniGeneCel.12674.

3D structure databases

ProteinModelPortalP28192.
SMRP28192. Positions 62-440, 596-1148.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6239.K04D7.4.

Proteomic databases

PaxDbP28192.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaK04D7.4a; K04D7.4a; WBGene00010558. [P28192-1]
GeneID177898.
KEGGcel:CELE_K04D7.4.
UCSCF59G1.5.1. c. elegans. [P28192-1]

Organism-specific databases

CTD177898.
WormBaseK04D7.4a; CE40655; WBGene00010558; ptp-4.
K04D7.4b; CE44709; WBGene00010558; ptp-4.

Phylogenomic databases

eggNOGCOG5599.
GeneTreeENSGT00750000117483.
HOGENOMHOG000017135.
InParanoidP28192.
OMACNERNAY.
OrthoDBEOG7DJSQX.
PhylomeDBP28192.

Enzyme and pathway databases

SignaLinkP28192.

Family and domain databases

Gene3D2.60.40.10. 4 hits.
3.90.190.10. 1 hit.
InterProIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamPF00041. fn3. 3 hits.
PF00047. ig. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSPR00700. PRTYPHPHTASE.
SMARTSM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMSSF49265. SSF49265. 2 hits.
SSF52799. SSF52799. 2 hits.
PROSITEPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio898850.

Entry information

Entry namePTP4_CAEEL
AccessionPrimary (citable) accession number: P28192
Secondary accession number(s): D3YT39, Q21214
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: July 10, 2007
Last modified: June 11, 2014
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase