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P28191

- PTP1_CAEEL

UniProt

P28191 - PTP1_CAEEL

Protein

Tyrosine-protein phosphatase 1

Gene

ptp-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 3 (30 May 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei920 – 9201SubstrateBy similarity
    Active sitei952 – 9521Phosphocysteine intermediatePROSITE-ProRule annotation
    Binding sitei996 – 9961SubstrateBy similarity

    GO - Molecular functioni

    1. protein tyrosine phosphatase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein phosphatase 1 (EC:3.1.3.48)
    Alternative name(s):
    Protein-tyrosine phosphatase 1
    Gene namesi
    Name:ptp-1
    ORF Names:C48D5.2
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiC48D5.2a; CE17578; WBGene00004213; ptp-1.
    C48D5.2b; CE23603; WBGene00004213; ptp-1.
    C48D5.2c; CE31450; WBGene00004213; ptp-1.

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity

    GO - Cellular componenti

    1. cytoskeleton Source: UniProtKB-SubCell
    2. sarcoplasmic reticulum Source: WormBase

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10261026Tyrosine-protein phosphatase 1PRO_0000219442Add
    BLAST

    Proteomic databases

    PaxDbiP28191.
    PRIDEiP28191.

    Structurei

    3D structure databases

    ProteinModelPortaliP28191.
    SMRiP28191. Positions 29-313, 613-1012.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini29 – 315287FERMPROSITE-ProRule annotationAdd
    BLAST
    Domaini617 – 68973PDZPROSITE-ProRule annotationAdd
    BLAST
    Domaini753 – 1011259Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni952 – 9587Substrate bindingBy similarity

    Sequence similaritiesi

    Contains 1 FERM domain.PROSITE-ProRule annotation
    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
    Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5599.
    GeneTreeiENSGT00750000117342.
    HOGENOMiHOG000007048.
    InParanoidiP28191.
    KOiK18037.
    OMAiHTCTDFW.
    OrthoDBiEOG76HQ1B.
    PhylomeDBiP28191.

    Family and domain databases

    Gene3Di1.20.80.10. 1 hit.
    2.30.29.30. 1 hit.
    2.30.42.10. 1 hit.
    3.90.190.10. 1 hit.
    InterProiIPR019749. Band_41_domain.
    IPR019750. Band_41_fam.
    IPR014847. FERM-adjacent.
    IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
    IPR019748. FERM_central.
    IPR019747. FERM_CS.
    IPR000299. FERM_domain.
    IPR018979. FERM_N.
    IPR018980. FERM_PH-like_C.
    IPR001478. PDZ.
    IPR011993. PH_like_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR012151. Tyr_Pase_non-rcpt_typ-3/4.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF08736. FA. 1 hit.
    PF09380. FERM_C. 1 hit.
    PF00373. FERM_M. 1 hit.
    PF09379. FERM_N. 1 hit.
    PF00595. PDZ. 1 hit.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000927. Tyr-Ptase_nr3. 1 hit.
    PRINTSiPR00935. BAND41.
    PR00700. PRTYPHPHTASE.
    SMARTiSM00295. B41. 1 hit.
    SM00228. PDZ. 1 hit.
    SM00194. PTPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF47031. SSF47031. 1 hit.
    SSF50156. SSF50156. 1 hit.
    SSF52799. SSF52799. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS00660. FERM_1. 1 hit.
    PS00661. FERM_2. 1 hit.
    PS50057. FERM_3. 1 hit.
    PS50106. PDZ. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform a (identifier: P28191-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRLGSNSYDV QRTEAIGQTP VKTPPPNQIR CTVTFLDSTS YHFEIEKNSL     50
    GIVLLEKVFN YLEIIEKDYF GLVFIAVDNS SAQQKKWLDP SKNLRKQMIC 100
    PPYHLFFRVK FYVRDPNRLR DEFTRFQFYQ QVRQNLEEGR LPCNEGSLAL 150
    LASYVVQAEV GDFEEKTHGM SRTCLCYKIQ FATLPDDFSD RVAELHQLHI 200
    GQTPDVAEQN FLDHARRLEM YGMDVYDGVD ANHLPIEIGV GAVGIKVFHE 250
    GIKMNEYAWV RIRKLSFKKK QFQVLVANED GVSETIMIFN IMSAKICKLL 300
    WKCCIEQHTF FRLKTPPKTP QRKVFNFGSK FRYSGRTEYQ TLEENEHRKS 350
    AGHRNFHRSL SKSSFLRSTF SGNTQSIDSS RYTNTTTTDS PELPSSGQLL 400
    ARRLLSAARH DTDSSDALGY ASDGAVVCAP LTTPLSPRRT RDYATDSESS 450
    APSLRQQRLS KEAIYYGTQE SCDEKSWTPS MACTSTSPGI HASTASVRPV 500
    SSGSTPNGAS RKSANSGYSG YGYATQTQQP TSTTNASYSP YLNGTISRSS 550
    GAAVAKAAAR GLPPTNQQAY NTSSPRNSVA SYSSFASAGI GGSPPRSKRS 600
    PQSNKSSSPV GEDQVVTIKM RPDRHGRFGF NVKGGADQNY PVIVSRVAPG 650
    SSADKCQPRL NEGDQVLFID GRDVSTMSHD HVVQFIRSAR SGLNGGELHL 700
    TIRPNVYRLG EEVDEPDSTM VPEPARVADS VPNSDKLSKS LQLLADSLNS 750
    GKVVDHFEML YRKKPGMSMN ICRLTANLAK NRYRDVCPYD DTRVTLQASP 800
    SGDYINANYV NMEIPSSGIV NRYIACQGPL AHTSSDFWVM VWEQHCTTIV 850
    MLTTITERGR VKCHQYWPRV FETQEYGRLM IKCIKDKQTT NCCYREFSIR 900
    DRNSSEERRV TQMQYIAWPD HGVPDDPKHF IQFVDEVRKA RQGSVDPIVV 950
    HCSAGIGRTG VLILMETAAC LVESNEPVYP LDIVRTMRDQ RAMLIQTPGQ 1000
    YTFVCESILR AYHDGTIKPL AEYSKR 1026

    Note: No experimental confirmation available.

    Length:1,026
    Mass (Da):115,094
    Last modified:May 30, 2000 - v3
    Checksum:i2F43F7A614EDBC59
    GO
    Isoform b (identifier: P28191-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-45: MRLGSNSYDV...LDSTSYHFEI → MEVPAFVGKA...DEKLPPRAFR
         46-447: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:624
    Mass (Da):68,783
    Checksum:i04DD488377E2E8B0
    GO
    Isoform c (identifier: P28191-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         3-9: LGSNSYD → RRRTART
         10-446: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:589
    Mass (Da):65,125
    Checksum:i1DD1659D73A8BC75
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 4545MRLGS…YHFEI → MEVPAFVGKACLKLKGLCVN VWTATVATCQENAEIDEKLP PRAFR in isoform b. CuratedVSP_020641Add
    BLAST
    Alternative sequencei3 – 97LGSNSYD → RRRTART in isoform c. CuratedVSP_020642
    Alternative sequencei10 – 446437Missing in isoform c. CuratedVSP_020643Add
    BLAST
    Alternative sequencei46 – 447402Missing in isoform b. CuratedVSP_020644Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z36237, Z48241 Genomic DNA. Translation: CAA85272.1.
    Z36237, Z48241 Genomic DNA. Translation: CAD44107.1.
    Z48241 Genomic DNA. Translation: CAB54194.1.
    M38013 mRNA. Translation: AAA28127.1.
    PIRiT19630.
    T19631.
    RefSeqiNP_497732.1. NM_065331.3. [P28191-1]
    NP_497733.1. NM_065332.3. [P28191-2]
    NP_741112.1. NM_171099.3. [P28191-3]
    UniGeneiCel.17439.

    Genome annotation databases

    EnsemblMetazoaiC48D5.2a; C48D5.2a; WBGene00004213. [P28191-1]
    GeneIDi13188983.
    175463.
    KEGGicel:CELE_C48D5.2.
    cel:CELE_C48D5.2a.
    UCSCiC48D5.2a. c. elegans. [P28191-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z36237 , Z48241 Genomic DNA. Translation: CAA85272.1 .
    Z36237 , Z48241 Genomic DNA. Translation: CAD44107.1 .
    Z48241 Genomic DNA. Translation: CAB54194.1 .
    M38013 mRNA. Translation: AAA28127.1 .
    PIRi T19630.
    T19631.
    RefSeqi NP_497732.1. NM_065331.3. [P28191-1 ]
    NP_497733.1. NM_065332.3. [P28191-2 ]
    NP_741112.1. NM_171099.3. [P28191-3 ]
    UniGenei Cel.17439.

    3D structure databases

    ProteinModelPortali P28191.
    SMRi P28191. Positions 29-313, 613-1012.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi P28191.
    PRIDEi P28191.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai C48D5.2a ; C48D5.2a ; WBGene00004213 . [P28191-1 ]
    GeneIDi 13188983.
    175463.
    KEGGi cel:CELE_C48D5.2.
    cel:CELE_C48D5.2a.
    UCSCi C48D5.2a. c. elegans. [P28191-1 ]

    Organism-specific databases

    CTDi 175463.
    WormBasei C48D5.2a ; CE17578 ; WBGene00004213 ; ptp-1.
    C48D5.2b ; CE23603 ; WBGene00004213 ; ptp-1.
    C48D5.2c ; CE31450 ; WBGene00004213 ; ptp-1.

    Phylogenomic databases

    eggNOGi COG5599.
    GeneTreei ENSGT00750000117342.
    HOGENOMi HOG000007048.
    InParanoidi P28191.
    KOi K18037.
    OMAi HTCTDFW.
    OrthoDBi EOG76HQ1B.
    PhylomeDBi P28191.

    Miscellaneous databases

    NextBioi 888262.
    PROi P28191.

    Family and domain databases

    Gene3Di 1.20.80.10. 1 hit.
    2.30.29.30. 1 hit.
    2.30.42.10. 1 hit.
    3.90.190.10. 1 hit.
    InterProi IPR019749. Band_41_domain.
    IPR019750. Band_41_fam.
    IPR014847. FERM-adjacent.
    IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
    IPR019748. FERM_central.
    IPR019747. FERM_CS.
    IPR000299. FERM_domain.
    IPR018979. FERM_N.
    IPR018980. FERM_PH-like_C.
    IPR001478. PDZ.
    IPR011993. PH_like_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR012151. Tyr_Pase_non-rcpt_typ-3/4.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF08736. FA. 1 hit.
    PF09380. FERM_C. 1 hit.
    PF00373. FERM_M. 1 hit.
    PF09379. FERM_N. 1 hit.
    PF00595. PDZ. 1 hit.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000927. Tyr-Ptase_nr3. 1 hit.
    PRINTSi PR00935. BAND41.
    PR00700. PRTYPHPHTASE.
    SMARTi SM00295. B41. 1 hit.
    SM00228. PDZ. 1 hit.
    SM00194. PTPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47031. SSF47031. 1 hit.
    SSF50156. SSF50156. 1 hit.
    SSF52799. SSF52799. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS00660. FERM_1. 1 hit.
    PS00661. FERM_2. 1 hit.
    PS50057. FERM_3. 1 hit.
    PS50106. PDZ. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
      Strain: Bristol N2.
    2. "Protein tyrosine phosphatase domains from the protochordate Styela plicata."
      Matthews R.J., Flores E., Thomas M.L.
      Immunogenetics 33:33-41(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 844-950.

    Entry informationi

    Entry nameiPTP1_CAEEL
    AccessioniPrimary (citable) accession number: P28191
    Secondary accession number(s): P45449, Q8MM81, Q9U3N7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 116 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3