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P28191

- PTP1_CAEEL

UniProt

P28191 - PTP1_CAEEL

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Protein
Tyrosine-protein phosphatase 1
Gene
ptp-1, C48D5.2
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei920 – 9201Substrate By similarity
Active sitei952 – 9521Phosphocysteine intermediate By similarity
Binding sitei996 – 9961Substrate By similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase 1 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine phosphatase 1
Gene namesi
Name:ptp-1
ORF Names:C48D5.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiC48D5.2a; CE17578; WBGene00004213; ptp-1.
C48D5.2b; CE23603; WBGene00004213; ptp-1.
C48D5.2c; CE31450; WBGene00004213; ptp-1.

Subcellular locationi

Cytoplasmcytoskeleton By similarity

GO - Cellular componenti

  1. cytoskeleton Source: UniProtKB-SubCell
  2. sarcoplasmic reticulum Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10261026Tyrosine-protein phosphatase 1
PRO_0000219442Add
BLAST

Proteomic databases

PaxDbiP28191.
PRIDEiP28191.

Structurei

3D structure databases

ProteinModelPortaliP28191.
SMRiP28191. Positions 29-313, 613-1012.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 315287FERM
Add
BLAST
Domaini617 – 68973PDZ
Add
BLAST
Domaini753 – 1011259Tyrosine-protein phosphatase
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni952 – 9587Substrate binding By similarity

Sequence similaritiesi

Contains 1 FERM domain.
Contains 1 PDZ (DHR) domain.

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00750000117342.
HOGENOMiHOG000007048.
InParanoidiP28191.
KOiK18037.
OMAiHTCTDFW.
OrthoDBiEOG76HQ1B.
PhylomeDBiP28191.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR019750. Band_41_fam.
IPR014847. FERM-adjacent.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR001478. PDZ.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR012151. Tyr_Pase_non-rcpt_typ-3/4.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF08736. FA. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00595. PDZ. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFiPIRSF000927. Tyr-Ptase_nr3. 1 hit.
PRINTSiPR00935. BAND41.
PR00700. PRTYPHPHTASE.
SMARTiSM00295. B41. 1 hit.
SM00228. PDZ. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS50106. PDZ. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform a (identifier: P28191-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRLGSNSYDV QRTEAIGQTP VKTPPPNQIR CTVTFLDSTS YHFEIEKNSL     50
GIVLLEKVFN YLEIIEKDYF GLVFIAVDNS SAQQKKWLDP SKNLRKQMIC 100
PPYHLFFRVK FYVRDPNRLR DEFTRFQFYQ QVRQNLEEGR LPCNEGSLAL 150
LASYVVQAEV GDFEEKTHGM SRTCLCYKIQ FATLPDDFSD RVAELHQLHI 200
GQTPDVAEQN FLDHARRLEM YGMDVYDGVD ANHLPIEIGV GAVGIKVFHE 250
GIKMNEYAWV RIRKLSFKKK QFQVLVANED GVSETIMIFN IMSAKICKLL 300
WKCCIEQHTF FRLKTPPKTP QRKVFNFGSK FRYSGRTEYQ TLEENEHRKS 350
AGHRNFHRSL SKSSFLRSTF SGNTQSIDSS RYTNTTTTDS PELPSSGQLL 400
ARRLLSAARH DTDSSDALGY ASDGAVVCAP LTTPLSPRRT RDYATDSESS 450
APSLRQQRLS KEAIYYGTQE SCDEKSWTPS MACTSTSPGI HASTASVRPV 500
SSGSTPNGAS RKSANSGYSG YGYATQTQQP TSTTNASYSP YLNGTISRSS 550
GAAVAKAAAR GLPPTNQQAY NTSSPRNSVA SYSSFASAGI GGSPPRSKRS 600
PQSNKSSSPV GEDQVVTIKM RPDRHGRFGF NVKGGADQNY PVIVSRVAPG 650
SSADKCQPRL NEGDQVLFID GRDVSTMSHD HVVQFIRSAR SGLNGGELHL 700
TIRPNVYRLG EEVDEPDSTM VPEPARVADS VPNSDKLSKS LQLLADSLNS 750
GKVVDHFEML YRKKPGMSMN ICRLTANLAK NRYRDVCPYD DTRVTLQASP 800
SGDYINANYV NMEIPSSGIV NRYIACQGPL AHTSSDFWVM VWEQHCTTIV 850
MLTTITERGR VKCHQYWPRV FETQEYGRLM IKCIKDKQTT NCCYREFSIR 900
DRNSSEERRV TQMQYIAWPD HGVPDDPKHF IQFVDEVRKA RQGSVDPIVV 950
HCSAGIGRTG VLILMETAAC LVESNEPVYP LDIVRTMRDQ RAMLIQTPGQ 1000
YTFVCESILR AYHDGTIKPL AEYSKR 1026

Note: No experimental confirmation available.

Length:1,026
Mass (Da):115,094
Last modified:May 30, 2000 - v3
Checksum:i2F43F7A614EDBC59
GO
Isoform b (identifier: P28191-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-45: MRLGSNSYDV...LDSTSYHFEI → MEVPAFVGKA...DEKLPPRAFR
     46-447: Missing.

Note: No experimental confirmation available.

Show »
Length:624
Mass (Da):68,783
Checksum:i04DD488377E2E8B0
GO
Isoform c (identifier: P28191-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     3-9: LGSNSYD → RRRTART
     10-446: Missing.

Note: No experimental confirmation available.

Show »
Length:589
Mass (Da):65,125
Checksum:i1DD1659D73A8BC75
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4545MRLGS…YHFEI → MEVPAFVGKACLKLKGLCVN VWTATVATCQENAEIDEKLP PRAFR in isoform b.
VSP_020641Add
BLAST
Alternative sequencei3 – 97LGSNSYD → RRRTART in isoform c.
VSP_020642
Alternative sequencei10 – 446437Missing in isoform c.
VSP_020643Add
BLAST
Alternative sequencei46 – 447402Missing in isoform b.
VSP_020644Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z36237, Z48241 Genomic DNA. Translation: CAA85272.1.
Z36237, Z48241 Genomic DNA. Translation: CAD44107.1.
Z48241 Genomic DNA. Translation: CAB54194.1.
M38013 mRNA. Translation: AAA28127.1.
PIRiT19630.
T19631.
RefSeqiNP_497732.1. NM_065331.3. [P28191-1]
NP_497733.1. NM_065332.3. [P28191-2]
NP_741112.1. NM_171099.3. [P28191-3]
UniGeneiCel.17439.

Genome annotation databases

EnsemblMetazoaiC48D5.2a; C48D5.2a; WBGene00004213. [P28191-1]
GeneIDi13188983.
175463.
KEGGicel:CELE_C48D5.2.
cel:CELE_C48D5.2a.
UCSCiC48D5.2a. c. elegans. [P28191-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z36237 , Z48241 Genomic DNA. Translation: CAA85272.1 .
Z36237 , Z48241 Genomic DNA. Translation: CAD44107.1 .
Z48241 Genomic DNA. Translation: CAB54194.1 .
M38013 mRNA. Translation: AAA28127.1 .
PIRi T19630.
T19631.
RefSeqi NP_497732.1. NM_065331.3. [P28191-1 ]
NP_497733.1. NM_065332.3. [P28191-2 ]
NP_741112.1. NM_171099.3. [P28191-3 ]
UniGenei Cel.17439.

3D structure databases

ProteinModelPortali P28191.
SMRi P28191. Positions 29-313, 613-1012.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi P28191.
PRIDEi P28191.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai C48D5.2a ; C48D5.2a ; WBGene00004213 . [P28191-1 ]
GeneIDi 13188983.
175463.
KEGGi cel:CELE_C48D5.2.
cel:CELE_C48D5.2a.
UCSCi C48D5.2a. c. elegans. [P28191-1 ]

Organism-specific databases

CTDi 175463.
WormBasei C48D5.2a ; CE17578 ; WBGene00004213 ; ptp-1.
C48D5.2b ; CE23603 ; WBGene00004213 ; ptp-1.
C48D5.2c ; CE31450 ; WBGene00004213 ; ptp-1.

Phylogenomic databases

eggNOGi COG5599.
GeneTreei ENSGT00750000117342.
HOGENOMi HOG000007048.
InParanoidi P28191.
KOi K18037.
OMAi HTCTDFW.
OrthoDBi EOG76HQ1B.
PhylomeDBi P28191.

Miscellaneous databases

NextBioi 888262.
PROi P28191.

Family and domain databases

Gene3Di 1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
3.90.190.10. 1 hit.
InterProi IPR019749. Band_41_domain.
IPR019750. Band_41_fam.
IPR014847. FERM-adjacent.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR001478. PDZ.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR012151. Tyr_Pase_non-rcpt_typ-3/4.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF08736. FA. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00595. PDZ. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000927. Tyr-Ptase_nr3. 1 hit.
PRINTSi PR00935. BAND41.
PR00700. PRTYPHPHTASE.
SMARTi SM00295. B41. 1 hit.
SM00228. PDZ. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF47031. SSF47031. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS50106. PDZ. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.
  2. "Protein tyrosine phosphatase domains from the protochordate Styela plicata."
    Matthews R.J., Flores E., Thomas M.L.
    Immunogenetics 33:33-41(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 844-950.

Entry informationi

Entry nameiPTP1_CAEEL
AccessioniPrimary (citable) accession number: P28191
Secondary accession number(s): P45449, Q8MM81, Q9U3N7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: May 30, 2000
Last modified: June 11, 2014
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi