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P28191 (PTP1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein phosphatase 1

EC=3.1.3.48
Alternative name(s):
Protein-tyrosine phosphatase 1
Gene names
Name:ptp-1
ORF Names:C48D5.2
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length1026 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subcellular location

Cytoplasmcytoskeleton By similarity.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.

Contains 1 FERM domain.

Contains 1 PDZ (DHR) domain.

Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
   Coding sequence diversityAlternative splicing
   Molecular functionHydrolase
Protein phosphatase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoskeleton

Inferred from electronic annotation. Source: UniProtKB-SubCell

sarcoplasmic reticulum

Inferred from direct assay PubMed 21611156. Source: WormBase

   Molecular_functionprotein tyrosine phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform a (identifier: P28191-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform b (identifier: P28191-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-45: MRLGSNSYDV...LDSTSYHFEI → MEVPAFVGKA...DEKLPPRAFR
     46-447: Missing.
Note: No experimental confirmation available.
Isoform c (identifier: P28191-3)

The sequence of this isoform differs from the canonical sequence as follows:
     3-9: LGSNSYD → RRRTART
     10-446: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10261026Tyrosine-protein phosphatase 1
PRO_0000219442

Regions

Domain29 – 315287FERM
Domain617 – 68973PDZ
Domain753 – 1011259Tyrosine-protein phosphatase
Region952 – 9587Substrate binding By similarity

Sites

Active site9521Phosphocysteine intermediate By similarity
Binding site9201Substrate By similarity
Binding site9961Substrate By similarity

Natural variations

Alternative sequence1 – 4545MRLGS…YHFEI → MEVPAFVGKACLKLKGLCVN VWTATVATCQENAEIDEKLP PRAFR in isoform b.
VSP_020641
Alternative sequence3 – 97LGSNSYD → RRRTART in isoform c.
VSP_020642
Alternative sequence10 – 446437Missing in isoform c.
VSP_020643
Alternative sequence46 – 447402Missing in isoform b.
VSP_020644

Sequences

Sequence LengthMass (Da)Tools
Isoform a [UniParc].

Last modified May 30, 2000. Version 3.
Checksum: 2F43F7A614EDBC59

FASTA1,026115,094
        10         20         30         40         50         60 
MRLGSNSYDV QRTEAIGQTP VKTPPPNQIR CTVTFLDSTS YHFEIEKNSL GIVLLEKVFN 

        70         80         90        100        110        120 
YLEIIEKDYF GLVFIAVDNS SAQQKKWLDP SKNLRKQMIC PPYHLFFRVK FYVRDPNRLR 

       130        140        150        160        170        180 
DEFTRFQFYQ QVRQNLEEGR LPCNEGSLAL LASYVVQAEV GDFEEKTHGM SRTCLCYKIQ 

       190        200        210        220        230        240 
FATLPDDFSD RVAELHQLHI GQTPDVAEQN FLDHARRLEM YGMDVYDGVD ANHLPIEIGV 

       250        260        270        280        290        300 
GAVGIKVFHE GIKMNEYAWV RIRKLSFKKK QFQVLVANED GVSETIMIFN IMSAKICKLL 

       310        320        330        340        350        360 
WKCCIEQHTF FRLKTPPKTP QRKVFNFGSK FRYSGRTEYQ TLEENEHRKS AGHRNFHRSL 

       370        380        390        400        410        420 
SKSSFLRSTF SGNTQSIDSS RYTNTTTTDS PELPSSGQLL ARRLLSAARH DTDSSDALGY 

       430        440        450        460        470        480 
ASDGAVVCAP LTTPLSPRRT RDYATDSESS APSLRQQRLS KEAIYYGTQE SCDEKSWTPS 

       490        500        510        520        530        540 
MACTSTSPGI HASTASVRPV SSGSTPNGAS RKSANSGYSG YGYATQTQQP TSTTNASYSP 

       550        560        570        580        590        600 
YLNGTISRSS GAAVAKAAAR GLPPTNQQAY NTSSPRNSVA SYSSFASAGI GGSPPRSKRS 

       610        620        630        640        650        660 
PQSNKSSSPV GEDQVVTIKM RPDRHGRFGF NVKGGADQNY PVIVSRVAPG SSADKCQPRL 

       670        680        690        700        710        720 
NEGDQVLFID GRDVSTMSHD HVVQFIRSAR SGLNGGELHL TIRPNVYRLG EEVDEPDSTM 

       730        740        750        760        770        780 
VPEPARVADS VPNSDKLSKS LQLLADSLNS GKVVDHFEML YRKKPGMSMN ICRLTANLAK 

       790        800        810        820        830        840 
NRYRDVCPYD DTRVTLQASP SGDYINANYV NMEIPSSGIV NRYIACQGPL AHTSSDFWVM 

       850        860        870        880        890        900 
VWEQHCTTIV MLTTITERGR VKCHQYWPRV FETQEYGRLM IKCIKDKQTT NCCYREFSIR 

       910        920        930        940        950        960 
DRNSSEERRV TQMQYIAWPD HGVPDDPKHF IQFVDEVRKA RQGSVDPIVV HCSAGIGRTG 

       970        980        990       1000       1010       1020 
VLILMETAAC LVESNEPVYP LDIVRTMRDQ RAMLIQTPGQ YTFVCESILR AYHDGTIKPL 


AEYSKR 

« Hide

Isoform b [UniParc].

Checksum: 04DD488377E2E8B0
Show »

FASTA62468,783
Isoform c [UniParc].

Checksum: 1DD1659D73A8BC75
Show »

FASTA58965,125

References

« Hide 'large scale' references
[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
Strain: Bristol N2.
[2]"Protein tyrosine phosphatase domains from the protochordate Styela plicata."
Matthews R.J., Flores E., Thomas M.L.
Immunogenetics 33:33-41(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 844-950.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z36237, Z48241 Genomic DNA. Translation: CAA85272.1.
Z36237, Z48241 Genomic DNA. Translation: CAD44107.1.
Z48241 Genomic DNA. Translation: CAB54194.1.
M38013 mRNA. Translation: AAA28127.1.
PIRT19630.
T19631.
RefSeqNP_497732.1. NM_065331.3.
NP_497733.1. NM_065332.3.
NP_741112.1. NM_171099.3.
UniGeneCel.17439.

3D structure databases

ProteinModelPortalP28191.
SMRP28191. Positions 26-335, 613-1012.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbP28191.
PRIDEP28191.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaC48D5.2a; C48D5.2a; C48D5.2. [P28191-1]
GeneID13188983.
175463.
KEGGcel:CELE_C48D5.2.
cel:CELE_C48D5.2a.
UCSCC48D5.2a. c. elegans. [P28191-1]

Organism-specific databases

CTD175463.
WormBaseC48D5.2a; CE17578; WBGene00004213; ptp-1.
C48D5.2b; CE23603; WBGene00004213; ptp-1.
C48D5.2c; CE31450; WBGene00004213; ptp-1.

Phylogenomic databases

eggNOGCOG5599.
HOGENOMHOG000007048.
InParanoidP28191.
KOK18037.
OMAHTCTDFW.
OrthoDBEOG76HQ1B.
PhylomeDBP28191.

Family and domain databases

Gene3D1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
InterProIPR019749. Band_41_domain.
IPR019750. Band_41_fam.
IPR014847. FERM-adjacent.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR001478. PDZ.
IPR011993. PH_like_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR012151. Tyr_Pase_non-rcpt_typ-3/4.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamPF08736. FA. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00595. PDZ. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFPIRSF000927. Tyr-Ptase_nr3. 1 hit.
PRINTSPR00935. BAND41.
PR00700. PRTYPHPHTASE.
SMARTSM00295. B41. 1 hit.
SM00228. PDZ. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMSSF47031. SSF47031. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEPS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS50106. PDZ. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio888262.
PROP28191.

Entry information

Entry namePTP1_CAEEL
AccessionPrimary (citable) accession number: P28191
Secondary accession number(s): P45449, Q8MM81, Q9U3N7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: May 30, 2000
Last modified: April 16, 2014
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase