Tyrosine-protein phosphatase 1 - Caenorhabditis elegans

Contribute

Send feedback

Read comments (?) or add your own

P28191 (PTP1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 105. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

text xml rdf/xml gff fasta

Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Tyrosine-protein phosphatase 1
EC=3.1.3.48

Alternative name(s):
Protein-tyrosine phosphatase 1

Gene names

Name:	ptp-1
ORF Names:	C48D5.2

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	1026 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity

Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate.

Subcellular location

Cytoplasm › cytoskeleton By similarity.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.

Contains 1 FERM domain.

Contains 1 PDZ (DHR) domain.

Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Coding sequence diversity	Alternative splicing
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC
Cellular_component	cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell sarcoplasmic reticulum Inferred from direct assay PubMed 21611156. Source: WormBase
Molecular_function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform a (identifier: P28191-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.

Isoform b (identifier: P28191-2) The sequence of this isoform differs from the canonical sequence as follows: 1-45: MRLGSNSYDV...LDSTSYHFEI → MEVPAFVGKA...DEKLPPRAFR 46-447: Missing.
Note: No experimental confirmation available.

Isoform c (identifier: P28191-3) The sequence of this isoform differs from the canonical sequence as follows: 3-9: LGSNSYD → RRRTART 10-446: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1026

1026

Tyrosine-protein phosphatase 1

PRO_0000219442

Regions

Domain

29 – 315

287

FERM

Domain

617 – 689

PDZ

Domain

753 – 1011

259

Tyrosine-protein phosphatase

Region

952 – 958

Substrate binding By similarity

Sites

Active site

952

Phosphocysteine intermediate By similarity

Binding site

920

Substrate By similarity

Binding site

996

Substrate By similarity

Natural variations

Alternative sequence

1 – 45

MRLGS…YHFEI → MEVPAFVGKACLKLKGLCVN VWTATVATCQENAEIDEKLP PRAFR in isoform b.

VSP_020641

Alternative sequence

3 – 9

LGSNSYD → RRRTART in isoform c.

VSP_020642

Alternative sequence

10 – 446

437

Missing in isoform c.

VSP_020643

Alternative sequence

46 – 447

402

Missing in isoform b.

VSP_020644

Sequences

Sequence		Length	Mass (Da)
Isoform a [UniParc]. Last modified May 30, 2000. Version 3. Checksum: 2F43F7A614EDBC59 Show »	FASTA	1,026	115,094
10 20 30 40 50 60 MRLGSNSYDV QRTEAIGQTP VKTPPPNQIR CTVTFLDSTS YHFEIEKNSL GIVLLEKVFN 70 80 90 100 110 120 YLEIIEKDYF GLVFIAVDNS SAQQKKWLDP SKNLRKQMIC PPYHLFFRVK FYVRDPNRLR 130 140 150 160 170 180 DEFTRFQFYQ QVRQNLEEGR LPCNEGSLAL LASYVVQAEV GDFEEKTHGM SRTCLCYKIQ 190 200 210 220 230 240 FATLPDDFSD RVAELHQLHI GQTPDVAEQN FLDHARRLEM YGMDVYDGVD ANHLPIEIGV 250 260 270 280 290 300 GAVGIKVFHE GIKMNEYAWV RIRKLSFKKK QFQVLVANED GVSETIMIFN IMSAKICKLL 310 320 330 340 350 360 WKCCIEQHTF FRLKTPPKTP QRKVFNFGSK FRYSGRTEYQ TLEENEHRKS AGHRNFHRSL 370 380 390 400 410 420 SKSSFLRSTF SGNTQSIDSS RYTNTTTTDS PELPSSGQLL ARRLLSAARH DTDSSDALGY 430 440 450 460 470 480 ASDGAVVCAP LTTPLSPRRT RDYATDSESS APSLRQQRLS KEAIYYGTQE SCDEKSWTPS 490 500 510 520 530 540 MACTSTSPGI HASTASVRPV SSGSTPNGAS RKSANSGYSG YGYATQTQQP TSTTNASYSP 550 560 570 580 590 600 YLNGTISRSS GAAVAKAAAR GLPPTNQQAY NTSSPRNSVA SYSSFASAGI GGSPPRSKRS 610 620 630 640 650 660 PQSNKSSSPV GEDQVVTIKM RPDRHGRFGF NVKGGADQNY PVIVSRVAPG SSADKCQPRL 670 680 690 700 710 720 NEGDQVLFID GRDVSTMSHD HVVQFIRSAR SGLNGGELHL TIRPNVYRLG EEVDEPDSTM 730 740 750 760 770 780 VPEPARVADS VPNSDKLSKS LQLLADSLNS GKVVDHFEML YRKKPGMSMN ICRLTANLAK 790 800 810 820 830 840 NRYRDVCPYD DTRVTLQASP SGDYINANYV NMEIPSSGIV NRYIACQGPL AHTSSDFWVM 850 860 870 880 890 900 VWEQHCTTIV MLTTITERGR VKCHQYWPRV FETQEYGRLM IKCIKDKQTT NCCYREFSIR 910 920 930 940 950 960 DRNSSEERRV TQMQYIAWPD HGVPDDPKHF IQFVDEVRKA RQGSVDPIVV HCSAGIGRTG 970 980 990 1000 1010 1020 VLILMETAAC LVESNEPVYP LDIVRTMRDQ RAMLIQTPGQ YTFVCESILR AYHDGTIKPL AEYSKR « Hide
Isoform b [UniParc]. Checksum: 04DD488377E2E8B0 Show »	FASTA	624	68,783
10 20 30 40 50 60 MEVPAFVGKA CLKLKGLCVN VWTATVATCQ ENAEIDEKLP PRAFRESSAP SLRQQRLSKE 70 80 90 100 110 120 AIYYGTQESC DEKSWTPSMA CTSTSPGIHA STASVRPVSS GSTPNGASRK SANSGYSGYG 130 140 150 160 170 180 YATQTQQPTS TTNASYSPYL NGTISRSSGA AVAKAAARGL PPTNQQAYNT SSPRNSVASY 190 200 210 220 230 240 SSFASAGIGG SPPRSKRSPQ SNKSSSPVGE DQVVTIKMRP DRHGRFGFNV KGGADQNYPV 250 260 270 280 290 300 IVSRVAPGSS ADKCQPRLNE GDQVLFIDGR DVSTMSHDHV VQFIRSARSG LNGGELHLTI 310 320 330 340 350 360 RPNVYRLGEE VDEPDSTMVP EPARVADSVP NSDKLSKSLQ LLADSLNSGK VVDHFEMLYR 370 380 390 400 410 420 KKPGMSMNIC RLTANLAKNR YRDVCPYDDT RVTLQASPSG DYINANYVNM EIPSSGIVNR 430 440 450 460 470 480 YIACQGPLAH TSSDFWVMVW EQHCTTIVML TTITERGRVK CHQYWPRVFE TQEYGRLMIK 490 500 510 520 530 540 CIKDKQTTNC CYREFSIRDR NSSEERRVTQ MQYIAWPDHG VPDDPKHFIQ FVDEVRKARQ 550 560 570 580 590 600 GSVDPIVVHC SAGIGRTGVL ILMETAACLV ESNEPVYPLD IVRTMRDQRA MLIQTPGQYT 610 620 FVCESILRAY HDGTIKPLAE YSKR « Hide
Isoform c [UniParc]. Checksum: 1DD1659D73A8BC75 Show »	FASTA	589	65,125
10 20 30 40 50 60 MRRRRTARTS ESSAPSLRQQ RLSKEAIYYG TQESCDEKSW TPSMACTSTS PGIHASTASV 70 80 90 100 110 120 RPVSSGSTPN GASRKSANSG YSGYGYATQT QQPTSTTNAS YSPYLNGTIS RSSGAAVAKA 130 140 150 160 170 180 AARGLPPTNQ QAYNTSSPRN SVASYSSFAS AGIGGSPPRS KRSPQSNKSS SPVGEDQVVT 190 200 210 220 230 240 IKMRPDRHGR FGFNVKGGAD QNYPVIVSRV APGSSADKCQ PRLNEGDQVL FIDGRDVSTM 250 260 270 280 290 300 SHDHVVQFIR SARSGLNGGE LHLTIRPNVY RLGEEVDEPD STMVPEPARV ADSVPNSDKL 310 320 330 340 350 360 SKSLQLLADS LNSGKVVDHF EMLYRKKPGM SMNICRLTAN LAKNRYRDVC PYDDTRVTLQ 370 380 390 400 410 420 ASPSGDYINA NYVNMEIPSS GIVNRYIACQ GPLAHTSSDF WVMVWEQHCT TIVMLTTITE 430 440 450 460 470 480 RGRVKCHQYW PRVFETQEYG RLMIKCIKDK QTTNCCYREF SIRDRNSSEE RRVTQMQYIA 490 500 510 520 530 540 WPDHGVPDDP KHFIQFVDEV RKARQGSVDP IVVHCSAGIG RTGVLILMET AACLVESNEP 550 560 570 580 VYPLDIVRTM RDQRAMLIQT PGQYTFVCES ILRAYHDGTI KPLAEYSKR « Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING. Strain: Bristol N2.
[2]	"Protein tyrosine phosphatase domains from the protochordate Styela plicata." Matthews R.J., Flores E., Thomas M.L. Immunogenetics 33:33-41(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 844-950.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z36237, Z48241 Genomic DNA. Translation: CAA85272.1. Z36237, Z48241 Genomic DNA. Translation: CAD44107.1. Z48241, Z36237 Genomic DNA. Translation: CAA88287.1. Z48241 Genomic DNA. Translation: CAB54194.1. Z48241, Z36237 Genomic DNA. Translation: CAD44101.1. M38013 mRNA. Translation: AAA28127.1.
PIR	T19630. T19631.
RefSeq	NP_497732.1. NM_065331.3. NP_497733.1. NM_065332.3. NP_741112.1. NM_171099.3.
3D structure databases
ProteinModelPortal	P28191.
SMR	P28191. Positions 29-313, 613-705, 737-1012.
ModBase	Search...
Proteomic databases
PaxDb	P28191.
PRIDE	P28191.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	C48D5.2a; C48D5.2a; C48D5.2.
GeneID	13188983. 175463.
KEGG	cel:CELE_C48D5.2. cel:CELE_C48D5.2a.
UCSC	C48D5.2a. c. elegans.
Organism-specific databases
CTD	175463.
WormBase	C48D5.2a; CE17578; WBGene00004213; ptp-1. C48D5.2b; CE23603; WBGene00004213; ptp-1. C48D5.2c; CE31450; WBGene00004213; ptp-1.
Phylogenomic databases
eggNOG	COG5599.
GeneTree	ENSGT00700000104092.
HOGENOM	HOG000007048.
InParanoid	P28191.
KO	K01104.
OMA	HTCTDFW.
Family and domain databases
Gene3D	1.20.80.10. 1 hit. 2.30.29.30. 1 hit.
InterPro	IPR019749. Band_41_domain. IPR019750. Band_41_fam. IPR014847. FERM-adjacent. IPR014352. FERM/acyl-CoA-bd_prot_3-hlx. IPR019748. FERM_central. IPR019747. FERM_CS. IPR000299. FERM_domain. IPR018979. FERM_N. IPR018980. FERM_PH-like_C. IPR001478. PDZ. IPR011993. PH_like_dom. IPR000387. Tyr/Dual-sp_Pase. IPR016130. Tyr_Pase_AS. IPR012151. Tyr_Pase_non-rcpt_typ-3/4. IPR000242. Tyr_Pase_rcpt/non-rcpt. [Graphical view]
Pfam	PF08736. FA. 1 hit. PF09380. FERM_C. 1 hit. PF00373. FERM_M. 1 hit. PF09379. FERM_N. 1 hit. PF00595. PDZ. 1 hit. PF00102. Y_phosphatase. 1 hit. [Graphical view]
PIRSF	PIRSF000927. Tyr-Ptase_nr3. 1 hit.
PRINTS	PR00935. BAND41. PR00700. PRTYPHPHTASE.
SMART	SM00295. B41. 1 hit. SM00228. PDZ. 1 hit. SM00194. PTPc. 1 hit. [Graphical view]
SUPFAM	SSF47031. FERM_3-hlx. 1 hit. SSF50156. PDZ. 1 hit.
PROSITE	PS00660. FERM_1. 1 hit. PS00661. FERM_2. 1 hit. PS50057. FERM_3. 1 hit. PS50106. PDZ. 1 hit. PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50055. TYR_PHOSPHATASE_PTP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	888262.

Entry information

Entry name

PTP1_CAEEL

Accession

Primary (citable) accession number: P28191
Secondary accession number(s): P45449, Q8MM81, Q9U3N7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	May 30, 2000
Last modified:	May 1, 2013
This is version 105 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project

Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Sites

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Other

Entry information

Relevant documents