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P28191

- PTP1_CAEEL

UniProt

P28191 - PTP1_CAEEL

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Protein

Tyrosine-protein phosphatase 1

Gene

ptp-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei920 – 9201SubstrateBy similarity
Active sitei952 – 9521Phosphocysteine intermediatePROSITE-ProRule annotation
Binding sitei996 – 9961SubstrateBy similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase 1 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine phosphatase 1
Gene namesi
Name:ptp-1
ORF Names:C48D5.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiC48D5.2a; CE17578; WBGene00004213; ptp-1.
C48D5.2b; CE23603; WBGene00004213; ptp-1.
C48D5.2c; CE31450; WBGene00004213; ptp-1.

Subcellular locationi

Cytoplasmcytoskeleton By similarity

GO - Cellular componenti

  1. cytoskeleton Source: UniProtKB-KW
  2. sarcoplasmic reticulum Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10261026Tyrosine-protein phosphatase 1PRO_0000219442Add
BLAST

Proteomic databases

PaxDbiP28191.
PRIDEiP28191.

Structurei

3D structure databases

ProteinModelPortaliP28191.
SMRiP28191. Positions 29-313, 613-1012.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 315287FERMPROSITE-ProRule annotationAdd
BLAST
Domaini617 – 68973PDZPROSITE-ProRule annotationAdd
BLAST
Domaini753 – 1011259Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni952 – 9587Substrate bindingBy similarity

Sequence similaritiesi

Contains 1 FERM domain.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00760000118823.
HOGENOMiHOG000007048.
InParanoidiP28191.
KOiK18037.
OMAiHTCTDFW.
OrthoDBiEOG76HQ1B.
PhylomeDBiP28191.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR019750. Band_41_fam.
IPR014847. FERM-adjacent.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR001478. PDZ.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR012151. Tyr_Pase_non-rcpt_typ-3/4.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF08736. FA. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00595. PDZ. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFiPIRSF000927. Tyr-Ptase_nr3. 1 hit.
PRINTSiPR00935. BAND41.
PR00700. PRTYPHPHTASE.
SMARTiSM00295. B41. 1 hit.
SM00228. PDZ. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS50106. PDZ. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform a (identifier: P28191) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLGSNSYDV QRTEAIGQTP VKTPPPNQIR CTVTFLDSTS YHFEIEKNSL
60 70 80 90 100
GIVLLEKVFN YLEIIEKDYF GLVFIAVDNS SAQQKKWLDP SKNLRKQMIC
110 120 130 140 150
PPYHLFFRVK FYVRDPNRLR DEFTRFQFYQ QVRQNLEEGR LPCNEGSLAL
160 170 180 190 200
LASYVVQAEV GDFEEKTHGM SRTCLCYKIQ FATLPDDFSD RVAELHQLHI
210 220 230 240 250
GQTPDVAEQN FLDHARRLEM YGMDVYDGVD ANHLPIEIGV GAVGIKVFHE
260 270 280 290 300
GIKMNEYAWV RIRKLSFKKK QFQVLVANED GVSETIMIFN IMSAKICKLL
310 320 330 340 350
WKCCIEQHTF FRLKTPPKTP QRKVFNFGSK FRYSGRTEYQ TLEENEHRKS
360 370 380 390 400
AGHRNFHRSL SKSSFLRSTF SGNTQSIDSS RYTNTTTTDS PELPSSGQLL
410 420 430 440 450
ARRLLSAARH DTDSSDALGY ASDGAVVCAP LTTPLSPRRT RDYATDSESS
460 470 480 490 500
APSLRQQRLS KEAIYYGTQE SCDEKSWTPS MACTSTSPGI HASTASVRPV
510 520 530 540 550
SSGSTPNGAS RKSANSGYSG YGYATQTQQP TSTTNASYSP YLNGTISRSS
560 570 580 590 600
GAAVAKAAAR GLPPTNQQAY NTSSPRNSVA SYSSFASAGI GGSPPRSKRS
610 620 630 640 650
PQSNKSSSPV GEDQVVTIKM RPDRHGRFGF NVKGGADQNY PVIVSRVAPG
660 670 680 690 700
SSADKCQPRL NEGDQVLFID GRDVSTMSHD HVVQFIRSAR SGLNGGELHL
710 720 730 740 750
TIRPNVYRLG EEVDEPDSTM VPEPARVADS VPNSDKLSKS LQLLADSLNS
760 770 780 790 800
GKVVDHFEML YRKKPGMSMN ICRLTANLAK NRYRDVCPYD DTRVTLQASP
810 820 830 840 850
SGDYINANYV NMEIPSSGIV NRYIACQGPL AHTSSDFWVM VWEQHCTTIV
860 870 880 890 900
MLTTITERGR VKCHQYWPRV FETQEYGRLM IKCIKDKQTT NCCYREFSIR
910 920 930 940 950
DRNSSEERRV TQMQYIAWPD HGVPDDPKHF IQFVDEVRKA RQGSVDPIVV
960 970 980 990 1000
HCSAGIGRTG VLILMETAAC LVESNEPVYP LDIVRTMRDQ RAMLIQTPGQ
1010 1020
YTFVCESILR AYHDGTIKPL AEYSKR

Note: No experimental confirmation available.

Length:1,026
Mass (Da):115,094
Last modified:May 30, 2000 - v3
Checksum:i2F43F7A614EDBC59
GO
Isoform b (identifier: P28191-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-45: MRLGSNSYDV...LDSTSYHFEI → MEVPAFVGKA...DEKLPPRAFR
     46-447: Missing.

Note: No experimental confirmation available.

Show »
Length:624
Mass (Da):68,783
Checksum:i04DD488377E2E8B0
GO
Isoform c (identifier: P28191-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     3-9: LGSNSYD → RRRTART
     10-446: Missing.

Note: No experimental confirmation available.

Show »
Length:589
Mass (Da):65,125
Checksum:i1DD1659D73A8BC75
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4545MRLGS…YHFEI → MEVPAFVGKACLKLKGLCVN VWTATVATCQENAEIDEKLP PRAFR in isoform b. CuratedVSP_020641Add
BLAST
Alternative sequencei3 – 97LGSNSYD → RRRTART in isoform c. CuratedVSP_020642
Alternative sequencei10 – 446437Missing in isoform c. CuratedVSP_020643Add
BLAST
Alternative sequencei46 – 447402Missing in isoform b. CuratedVSP_020644Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z36237, Z48241 Genomic DNA. Translation: CAA85272.1.
Z36237, Z48241 Genomic DNA. Translation: CAD44107.1.
Z48241 Genomic DNA. Translation: CAB54194.1.
M38013 mRNA. Translation: AAA28127.1.
PIRiT19630.
T19631.
RefSeqiNP_497732.1. NM_065331.3. [P28191-1]
NP_497733.1. NM_065332.3. [P28191-2]
NP_741112.1. NM_171099.3. [P28191-3]
UniGeneiCel.17439.

Genome annotation databases

EnsemblMetazoaiC48D5.2a; C48D5.2a; WBGene00004213. [P28191-1]
GeneIDi13188983.
175463.
KEGGicel:CELE_C48D5.2.
cel:CELE_C48D5.2a.
UCSCiC48D5.2a. c. elegans. [P28191-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z36237 , Z48241 Genomic DNA. Translation: CAA85272.1 .
Z36237 , Z48241 Genomic DNA. Translation: CAD44107.1 .
Z48241 Genomic DNA. Translation: CAB54194.1 .
M38013 mRNA. Translation: AAA28127.1 .
PIRi T19630.
T19631.
RefSeqi NP_497732.1. NM_065331.3. [P28191-1 ]
NP_497733.1. NM_065332.3. [P28191-2 ]
NP_741112.1. NM_171099.3. [P28191-3 ]
UniGenei Cel.17439.

3D structure databases

ProteinModelPortali P28191.
SMRi P28191. Positions 29-313, 613-1012.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi P28191.
PRIDEi P28191.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai C48D5.2a ; C48D5.2a ; WBGene00004213 . [P28191-1 ]
GeneIDi 13188983.
175463.
KEGGi cel:CELE_C48D5.2.
cel:CELE_C48D5.2a.
UCSCi C48D5.2a. c. elegans. [P28191-1 ]

Organism-specific databases

CTDi 175463.
WormBasei C48D5.2a ; CE17578 ; WBGene00004213 ; ptp-1.
C48D5.2b ; CE23603 ; WBGene00004213 ; ptp-1.
C48D5.2c ; CE31450 ; WBGene00004213 ; ptp-1.

Phylogenomic databases

eggNOGi COG5599.
GeneTreei ENSGT00760000118823.
HOGENOMi HOG000007048.
InParanoidi P28191.
KOi K18037.
OMAi HTCTDFW.
OrthoDBi EOG76HQ1B.
PhylomeDBi P28191.

Miscellaneous databases

NextBioi 888262.
PROi P28191.

Family and domain databases

Gene3Di 1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
3.90.190.10. 1 hit.
InterProi IPR019749. Band_41_domain.
IPR019750. Band_41_fam.
IPR014847. FERM-adjacent.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR001478. PDZ.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR012151. Tyr_Pase_non-rcpt_typ-3/4.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF08736. FA. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00595. PDZ. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000927. Tyr-Ptase_nr3. 1 hit.
PRINTSi PR00935. BAND41.
PR00700. PRTYPHPHTASE.
SMARTi SM00295. B41. 1 hit.
SM00228. PDZ. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF47031. SSF47031. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS50106. PDZ. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.
  2. "Protein tyrosine phosphatase domains from the protochordate Styela plicata."
    Matthews R.J., Flores E., Thomas M.L.
    Immunogenetics 33:33-41(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 844-950.

Entry informationi

Entry nameiPTP1_CAEEL
AccessioniPrimary (citable) accession number: P28191
Secondary accession number(s): P45449, Q8MM81, Q9U3N7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: May 30, 2000
Last modified: October 29, 2014
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3