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Protein

Tyrosine-protein phosphatase 1

Gene

ptp-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei920SubstrateBy similarity1
Active sitei952Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei996SubstrateBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

ReactomeiR-CEL-166016. Toll Like Receptor 4 (TLR4) Cascade.
R-CEL-182971. EGFR downregulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase 1 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine phosphatase 1
Gene namesi
Name:ptp-1
ORF Names:C48D5.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiC48D5.2a; CE17578; WBGene00004213; ptp-1.
C48D5.2b; CE23603; WBGene00004213; ptp-1.
C48D5.2c; CE31450; WBGene00004213; ptp-1.

Subcellular locationi

GO - Cellular componenti

  • cytoskeleton Source: UniProtKB-SubCell
  • sarcoplasmic reticulum Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002194421 – 1026Tyrosine-protein phosphatase 1Add BLAST1026

Proteomic databases

EPDiP28191.
PaxDbiP28191.
PeptideAtlasiP28191.

PTM databases

iPTMnetiP28191.

Expressioni

Gene expression databases

BgeeiWBGene00004213.

Interactioni

Protein-protein interaction databases

STRINGi6239.C48D5.2a.

Structurei

3D structure databases

ProteinModelPortaliP28191.
SMRiP28191.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 315FERMPROSITE-ProRule annotationAdd BLAST287
Domaini617 – 689PDZPROSITE-ProRule annotationAdd BLAST73
Domaini753 – 1011Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST259

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni952 – 958Substrate bindingBy similarity7

Sequence similaritiesi

Contains 1 FERM domain.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410KDUQ. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00760000118823.
HOGENOMiHOG000007048.
InParanoidiP28191.
KOiK18037.
OMAiRKLMDWE.
OrthoDBiEOG091G016K.
PhylomeDBiP28191.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR014847. FERM-adjacent.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR001478. PDZ.
IPR011993. PH_dom-like.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR012151. Tyr_Pase_non-rcpt_typ-3/4.
IPR000387. TYR_PHOSPHATASE_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF08736. FA. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00595. PDZ. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFiPIRSF000927. Tyr-Ptase_nr3. 1 hit.
PRINTSiPR00935. BAND41.
PR00700. PRTYPHPHTASE.
SMARTiSM00295. B41. 1 hit.
SM01195. FA. 1 hit.
SM01196. FERM_C. 1 hit.
SM00228. PDZ. 1 hit.
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS50106. PDZ. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: P28191-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLGSNSYDV QRTEAIGQTP VKTPPPNQIR CTVTFLDSTS YHFEIEKNSL
60 70 80 90 100
GIVLLEKVFN YLEIIEKDYF GLVFIAVDNS SAQQKKWLDP SKNLRKQMIC
110 120 130 140 150
PPYHLFFRVK FYVRDPNRLR DEFTRFQFYQ QVRQNLEEGR LPCNEGSLAL
160 170 180 190 200
LASYVVQAEV GDFEEKTHGM SRTCLCYKIQ FATLPDDFSD RVAELHQLHI
210 220 230 240 250
GQTPDVAEQN FLDHARRLEM YGMDVYDGVD ANHLPIEIGV GAVGIKVFHE
260 270 280 290 300
GIKMNEYAWV RIRKLSFKKK QFQVLVANED GVSETIMIFN IMSAKICKLL
310 320 330 340 350
WKCCIEQHTF FRLKTPPKTP QRKVFNFGSK FRYSGRTEYQ TLEENEHRKS
360 370 380 390 400
AGHRNFHRSL SKSSFLRSTF SGNTQSIDSS RYTNTTTTDS PELPSSGQLL
410 420 430 440 450
ARRLLSAARH DTDSSDALGY ASDGAVVCAP LTTPLSPRRT RDYATDSESS
460 470 480 490 500
APSLRQQRLS KEAIYYGTQE SCDEKSWTPS MACTSTSPGI HASTASVRPV
510 520 530 540 550
SSGSTPNGAS RKSANSGYSG YGYATQTQQP TSTTNASYSP YLNGTISRSS
560 570 580 590 600
GAAVAKAAAR GLPPTNQQAY NTSSPRNSVA SYSSFASAGI GGSPPRSKRS
610 620 630 640 650
PQSNKSSSPV GEDQVVTIKM RPDRHGRFGF NVKGGADQNY PVIVSRVAPG
660 670 680 690 700
SSADKCQPRL NEGDQVLFID GRDVSTMSHD HVVQFIRSAR SGLNGGELHL
710 720 730 740 750
TIRPNVYRLG EEVDEPDSTM VPEPARVADS VPNSDKLSKS LQLLADSLNS
760 770 780 790 800
GKVVDHFEML YRKKPGMSMN ICRLTANLAK NRYRDVCPYD DTRVTLQASP
810 820 830 840 850
SGDYINANYV NMEIPSSGIV NRYIACQGPL AHTSSDFWVM VWEQHCTTIV
860 870 880 890 900
MLTTITERGR VKCHQYWPRV FETQEYGRLM IKCIKDKQTT NCCYREFSIR
910 920 930 940 950
DRNSSEERRV TQMQYIAWPD HGVPDDPKHF IQFVDEVRKA RQGSVDPIVV
960 970 980 990 1000
HCSAGIGRTG VLILMETAAC LVESNEPVYP LDIVRTMRDQ RAMLIQTPGQ
1010 1020
YTFVCESILR AYHDGTIKPL AEYSKR
Note: No experimental confirmation available.
Length:1,026
Mass (Da):115,094
Last modified:May 30, 2000 - v3
Checksum:i2F43F7A614EDBC59
GO
Isoform b (identifier: P28191-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-45: MRLGSNSYDV...LDSTSYHFEI → MEVPAFVGKA...DEKLPPRAFR
     46-447: Missing.

Note: No experimental confirmation available.
Show »
Length:624
Mass (Da):68,783
Checksum:i04DD488377E2E8B0
GO
Isoform c (identifier: P28191-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3-9: LGSNSYD → RRRTART
     10-446: Missing.

Note: No experimental confirmation available.
Show »
Length:589
Mass (Da):65,125
Checksum:i1DD1659D73A8BC75
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0206411 – 45MRLGS…YHFEI → MEVPAFVGKACLKLKGLCVN VWTATVATCQENAEIDEKLP PRAFR in isoform b. CuratedAdd BLAST45
Alternative sequenceiVSP_0206423 – 9LGSNSYD → RRRTART in isoform c. Curated7
Alternative sequenceiVSP_02064310 – 446Missing in isoform c. CuratedAdd BLAST437
Alternative sequenceiVSP_02064446 – 447Missing in isoform b. CuratedAdd BLAST402

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36237, Z48241 Genomic DNA. Translation: CAA85272.1.
Z36237, Z48241 Genomic DNA. Translation: CAD44107.1.
Z48241 Genomic DNA. Translation: CAB54194.1.
M38013 mRNA. Translation: AAA28127.1.
PIRiT19630.
T19631.
RefSeqiNP_497732.1. NM_065331.3. [P28191-1]
NP_497733.1. NM_065332.3. [P28191-2]
NP_741112.1. NM_171099.3. [P28191-3]
UniGeneiCel.17439.

Genome annotation databases

EnsemblMetazoaiC48D5.2a.1; C48D5.2a.1; WBGene00004213. [P28191-1]
C48D5.2a.2; C48D5.2a.2; WBGene00004213. [P28191-1]
GeneIDi175463.
KEGGicel:CELE_C48D5.2.
UCSCiC48D5.2a. c. elegans. [P28191-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36237, Z48241 Genomic DNA. Translation: CAA85272.1.
Z36237, Z48241 Genomic DNA. Translation: CAD44107.1.
Z48241 Genomic DNA. Translation: CAB54194.1.
M38013 mRNA. Translation: AAA28127.1.
PIRiT19630.
T19631.
RefSeqiNP_497732.1. NM_065331.3. [P28191-1]
NP_497733.1. NM_065332.3. [P28191-2]
NP_741112.1. NM_171099.3. [P28191-3]
UniGeneiCel.17439.

3D structure databases

ProteinModelPortaliP28191.
SMRiP28191.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C48D5.2a.

PTM databases

iPTMnetiP28191.

Proteomic databases

EPDiP28191.
PaxDbiP28191.
PeptideAtlasiP28191.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC48D5.2a.1; C48D5.2a.1; WBGene00004213. [P28191-1]
C48D5.2a.2; C48D5.2a.2; WBGene00004213. [P28191-1]
GeneIDi175463.
KEGGicel:CELE_C48D5.2.
UCSCiC48D5.2a. c. elegans. [P28191-1]

Organism-specific databases

CTDi175463.
WormBaseiC48D5.2a; CE17578; WBGene00004213; ptp-1.
C48D5.2b; CE23603; WBGene00004213; ptp-1.
C48D5.2c; CE31450; WBGene00004213; ptp-1.

Phylogenomic databases

eggNOGiENOG410KDUQ. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00760000118823.
HOGENOMiHOG000007048.
InParanoidiP28191.
KOiK18037.
OMAiRKLMDWE.
OrthoDBiEOG091G016K.
PhylomeDBiP28191.

Enzyme and pathway databases

ReactomeiR-CEL-166016. Toll Like Receptor 4 (TLR4) Cascade.
R-CEL-182971. EGFR downregulation.

Miscellaneous databases

PROiP28191.

Gene expression databases

BgeeiWBGene00004213.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR014847. FERM-adjacent.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR001478. PDZ.
IPR011993. PH_dom-like.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR012151. Tyr_Pase_non-rcpt_typ-3/4.
IPR000387. TYR_PHOSPHATASE_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF08736. FA. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00595. PDZ. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFiPIRSF000927. Tyr-Ptase_nr3. 1 hit.
PRINTSiPR00935. BAND41.
PR00700. PRTYPHPHTASE.
SMARTiSM00295. B41. 1 hit.
SM01195. FA. 1 hit.
SM01196. FERM_C. 1 hit.
SM00228. PDZ. 1 hit.
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS50106. PDZ. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTP1_CAEEL
AccessioniPrimary (citable) accession number: P28191
Secondary accession number(s): P45449, Q8MM81, Q9U3N7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: May 30, 2000
Last modified: November 30, 2016
This is version 134 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.