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P28190

- AA1R_BOVIN

UniProt

P28190 - AA1R_BOVIN

Protein

Adenosine receptor A1

Gene

ADORA1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 3 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

    GO - Molecular functioni

    1. G-protein coupled adenosine receptor activity Source: InterPro

    GO - Biological processi

    1. negative regulation of inflammatory response Source: Ensembl
    2. negative regulation of leukocyte migration Source: Ensembl
    3. negative regulation of mucus secretion Source: Ensembl
    4. regulation of excitatory postsynaptic membrane potential Source: Ensembl
    5. regulation of glomerular filtration Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_210568. G alpha (i) signalling events.
    REACT_217608. Adenosine P1 receptors.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenosine receptor A1
    Gene namesi
    Name:ADORA1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 16

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 326326Adenosine receptor A1PRO_0000068988Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi80 ↔ 169PROSITE-ProRule annotation
    Glycosylationi148 – 1481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence Analysis
    Lipidationi309 – 3091S-palmitoyl cysteineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PRIDEiP28190.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000045778.

    Structurei

    3D structure databases

    ProteinModelPortaliP28190.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1010ExtracellularSequence Analysis
    Topological domaini34 – 4613CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini70 – 8011ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini103 – 12321CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini147 – 17630ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini202 – 23534CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini260 – 2678ExtracellularSequence Analysis
    Topological domaini293 – 32634CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3323Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei47 – 6923Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei81 – 10222Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei124 – 14623Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei177 – 20125Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei236 – 25924Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei268 – 29225Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG284456.
    GeneTreeiENSGT00550000074524.
    HOGENOMiHOG000015770.
    HOVERGENiHBG106962.
    InParanoidiP28190.
    KOiK04265.
    OMAiIPLRYKM.
    OrthoDBiEOG79SDXQ.
    TreeFamiTF325296.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR001068. Adeno_A1_rcpt.
    IPR001634. Adenosn_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00552. ADENOSINEA1R.
    PR00424. ADENOSINER.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P28190-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPPSISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVS    50
    LAVADVAVGA LVIPLAILIN IGPRTYFHTC LKVACPVLIL TQSSILALLA 100
    IAVDRYLRVK IPLRYKTVVT PRRAVVAITG CWILSFVVGL TPMFGWNNLS 150
    AVERDWLANG SVGEPVIECQ FEKVISMEYM VYFNFFVWVL PPLLLMVLIY 200
    MEVFYLIRKQ LNKKVSASSG DPQKYYGKEL KIAKSLALIL FLFALSWLPL 250
    HILNCITLFC PSCHMPRILI YIAIFLSHGN SAMNPIVYAF RIQKFRVTFL 300
    KIWNDHFRCQ PAPPVDEDAP AERPDD 326
    Length:326
    Mass (Da):36,593
    Last modified:November 13, 2007 - v3
    Checksum:i6F4557FCEFEBC66E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti212 – 2121N → S in CAA45135. (PubMed:1551415)Curated
    Sequence conflicti212 – 2121N → S in AAA30350. (PubMed:1587851)Curated
    Sequence conflicti315 – 3151V → I in CAA45135. (PubMed:1551415)Curated
    Sequence conflicti315 – 3151V → I in AAA30350. (PubMed:1587851)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X63592 mRNA. Translation: CAA45135.1.
    M86261 mRNA. Translation: AAA30350.1.
    BT021759 mRNA. Translation: AAX46606.1.
    BC142208 mRNA. Translation: AAI42209.1.
    BC142265 mRNA. Translation: AAI42266.1.
    PIRiA38144.
    RefSeqiNP_776922.2. NM_174497.3.
    XP_005216709.1. XM_005216652.1.
    XP_005216710.1. XM_005216653.1.
    UniGeneiBt.76442.

    Genome annotation databases

    EnsembliENSBTAT00000015230; ENSBTAP00000015230; ENSBTAG00000011461.
    GeneIDi282133.
    KEGGibta:282133.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X63592 mRNA. Translation: CAA45135.1 .
    M86261 mRNA. Translation: AAA30350.1 .
    BT021759 mRNA. Translation: AAX46606.1 .
    BC142208 mRNA. Translation: AAI42209.1 .
    BC142265 mRNA. Translation: AAI42266.1 .
    PIRi A38144.
    RefSeqi NP_776922.2. NM_174497.3.
    XP_005216709.1. XM_005216652.1.
    XP_005216710.1. XM_005216653.1.
    UniGenei Bt.76442.

    3D structure databases

    ProteinModelPortali P28190.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000045778.

    Chemistry

    BindingDBi P28190.
    ChEMBLi CHEMBL4975.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PRIDEi P28190.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000015230 ; ENSBTAP00000015230 ; ENSBTAG00000011461 .
    GeneIDi 282133.
    KEGGi bta:282133.

    Organism-specific databases

    CTDi 134.

    Phylogenomic databases

    eggNOGi NOG284456.
    GeneTreei ENSGT00550000074524.
    HOGENOMi HOG000015770.
    HOVERGENi HBG106962.
    InParanoidi P28190.
    KOi K04265.
    OMAi IPLRYKM.
    OrthoDBi EOG79SDXQ.
    TreeFami TF325296.

    Enzyme and pathway databases

    Reactomei REACT_210568. G alpha (i) signalling events.
    REACT_217608. Adenosine P1 receptors.

    Miscellaneous databases

    NextBioi 20805968.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR001068. Adeno_A1_rcpt.
    IPR001634. Adenosn_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00552. ADENOSINEA1R.
    PR00424. ADENOSINER.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of a bovine adenosine A1 receptor cDNA."
      Tucker A.L., Linden J., Robeva A.S., D'Angelo D.D., Lynch K.R.
      FEBS Lett. 297:107-111(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "Cloning, expression, and characterization of the unique bovine A1 adenosine receptor. Studies on the ligand binding site by site-directed mutagenesis."
      Olah M.E., Ren H., Ostrowski J., Jacobson K., Stiles G.L.
      J. Biol. Chem. 267:10764-10770(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Fetal pons and Hippocampus.

    Entry informationi

    Entry nameiAA1R_BOVIN
    AccessioniPrimary (citable) accession number: P28190
    Secondary accession number(s): A5PJR1, Q58D38
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 106 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3