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P28190

- AA1R_BOVIN

UniProt

P28190 - AA1R_BOVIN

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Protein

Adenosine receptor A1

Gene
ADORA1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

GO - Molecular functioni

  1. G-protein coupled adenosine receptor activity Source: InterPro

GO - Biological processi

  1. negative regulation of inflammatory response Source: Ensembl
  2. negative regulation of leukocyte migration Source: Ensembl
  3. negative regulation of mucus secretion Source: Ensembl
  4. regulation of excitatory postsynaptic membrane potential Source: Ensembl
  5. regulation of glomerular filtration Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_210568. G alpha (i) signalling events.
REACT_217608. Adenosine P1 receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine receptor A1
Gene namesi
Name:ADORA1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 16

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010Extracellular Reviewed prediction
Transmembranei11 – 3323Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini34 – 4613Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei47 – 6923Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini70 – 8011Extracellular Reviewed predictionAdd
BLAST
Transmembranei81 – 10222Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini103 – 12321Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei124 – 14623Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini147 – 17630Extracellular Reviewed predictionAdd
BLAST
Transmembranei177 – 20125Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini202 – 23534Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei236 – 25924Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini260 – 2678Extracellular Reviewed prediction
Transmembranei268 – 29225Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini293 – 32634Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Adenosine receptor A1PRO_0000068988Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi80 ↔ 169 By similarity
Glycosylationi148 – 1481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi159 – 1591N-linked (GlcNAc...) Reviewed prediction
Lipidationi309 – 3091S-palmitoyl cysteine Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiP28190.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000045778.

Structurei

3D structure databases

ProteinModelPortaliP28190.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG284456.
GeneTreeiENSGT00550000074524.
HOGENOMiHOG000015770.
HOVERGENiHBG106962.
InParanoidiP28190.
KOiK04265.
OMAiIPLRYKM.
OrthoDBiEOG79SDXQ.
TreeFamiTF325296.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR001068. Adeno_A1_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00552. ADENOSINEA1R.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28190-1 [UniParc]FASTAAdd to Basket

« Hide

MPPSISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVS    50
LAVADVAVGA LVIPLAILIN IGPRTYFHTC LKVACPVLIL TQSSILALLA 100
IAVDRYLRVK IPLRYKTVVT PRRAVVAITG CWILSFVVGL TPMFGWNNLS 150
AVERDWLANG SVGEPVIECQ FEKVISMEYM VYFNFFVWVL PPLLLMVLIY 200
MEVFYLIRKQ LNKKVSASSG DPQKYYGKEL KIAKSLALIL FLFALSWLPL 250
HILNCITLFC PSCHMPRILI YIAIFLSHGN SAMNPIVYAF RIQKFRVTFL 300
KIWNDHFRCQ PAPPVDEDAP AERPDD 326
Length:326
Mass (Da):36,593
Last modified:November 13, 2007 - v3
Checksum:i6F4557FCEFEBC66E
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti212 – 2121N → S in CAA45135. 1 Publication
Sequence conflicti212 – 2121N → S in AAA30350. 1 Publication
Sequence conflicti315 – 3151V → I in CAA45135. 1 Publication
Sequence conflicti315 – 3151V → I in AAA30350. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X63592 mRNA. Translation: CAA45135.1.
M86261 mRNA. Translation: AAA30350.1.
BT021759 mRNA. Translation: AAX46606.1.
BC142208 mRNA. Translation: AAI42209.1.
BC142265 mRNA. Translation: AAI42266.1.
PIRiA38144.
RefSeqiNP_776922.2. NM_174497.3.
XP_005216709.1. XM_005216652.1.
XP_005216710.1. XM_005216653.1.
UniGeneiBt.76442.

Genome annotation databases

EnsembliENSBTAT00000015230; ENSBTAP00000015230; ENSBTAG00000011461.
GeneIDi282133.
KEGGibta:282133.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X63592 mRNA. Translation: CAA45135.1 .
M86261 mRNA. Translation: AAA30350.1 .
BT021759 mRNA. Translation: AAX46606.1 .
BC142208 mRNA. Translation: AAI42209.1 .
BC142265 mRNA. Translation: AAI42266.1 .
PIRi A38144.
RefSeqi NP_776922.2. NM_174497.3.
XP_005216709.1. XM_005216652.1.
XP_005216710.1. XM_005216653.1.
UniGenei Bt.76442.

3D structure databases

ProteinModelPortali P28190.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000045778.

Chemistry

BindingDBi P28190.
ChEMBLi CHEMBL4975.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PRIDEi P28190.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000015230 ; ENSBTAP00000015230 ; ENSBTAG00000011461 .
GeneIDi 282133.
KEGGi bta:282133.

Organism-specific databases

CTDi 134.

Phylogenomic databases

eggNOGi NOG284456.
GeneTreei ENSGT00550000074524.
HOGENOMi HOG000015770.
HOVERGENi HBG106962.
InParanoidi P28190.
KOi K04265.
OMAi IPLRYKM.
OrthoDBi EOG79SDXQ.
TreeFami TF325296.

Enzyme and pathway databases

Reactomei REACT_210568. G alpha (i) signalling events.
REACT_217608. Adenosine P1 receptors.

Miscellaneous databases

NextBioi 20805968.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR001068. Adeno_A1_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00552. ADENOSINEA1R.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of a bovine adenosine A1 receptor cDNA."
    Tucker A.L., Linden J., Robeva A.S., D'Angelo D.D., Lynch K.R.
    FEBS Lett. 297:107-111(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Cloning, expression, and characterization of the unique bovine A1 adenosine receptor. Studies on the ligand binding site by site-directed mutagenesis."
    Olah M.E., Ren H., Ostrowski J., Jacobson K., Stiles G.L.
    J. Biol. Chem. 267:10764-10770(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal pons and Hippocampus.

Entry informationi

Entry nameiAA1R_BOVIN
AccessioniPrimary (citable) accession number: P28190
Secondary accession number(s): A5PJR1, Q58D38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: November 13, 2007
Last modified: September 3, 2014
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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