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P28190 (AA1R_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Adenosine receptor A1
Gene names
Name:ADORA1
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length326 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 326326Adenosine receptor A1
PRO_0000068988

Regions

Topological domain1 – 1010Extracellular Potential
Transmembrane11 – 3323Helical; Name=1; Potential
Topological domain34 – 4613Cytoplasmic Potential
Transmembrane47 – 6923Helical; Name=2; Potential
Topological domain70 – 8011Extracellular Potential
Transmembrane81 – 10222Helical; Name=3; Potential
Topological domain103 – 12321Cytoplasmic Potential
Transmembrane124 – 14623Helical; Name=4; Potential
Topological domain147 – 17630Extracellular Potential
Transmembrane177 – 20125Helical; Name=5; Potential
Topological domain202 – 23534Cytoplasmic Potential
Transmembrane236 – 25924Helical; Name=6; Potential
Topological domain260 – 2678Extracellular Potential
Transmembrane268 – 29225Helical; Name=7; Potential
Topological domain293 – 32634Cytoplasmic Potential

Amino acid modifications

Lipidation3091S-palmitoyl cysteine Potential
Glycosylation1481N-linked (GlcNAc...) Potential
Glycosylation1591N-linked (GlcNAc...) Potential
Disulfide bond80 ↔ 169 By similarity

Experimental info

Sequence conflict2121N → S in CAA45135. Ref.1
Sequence conflict2121N → S in AAA30350. Ref.2
Sequence conflict3151V → I in CAA45135. Ref.1
Sequence conflict3151V → I in AAA30350. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P28190 [UniParc].

Last modified November 13, 2007. Version 3.
Checksum: 6F4557FCEFEBC66E

FASTA32636,593
        10         20         30         40         50         60 
MPPSISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVS LAVADVAVGA 

        70         80         90        100        110        120 
LVIPLAILIN IGPRTYFHTC LKVACPVLIL TQSSILALLA IAVDRYLRVK IPLRYKTVVT 

       130        140        150        160        170        180 
PRRAVVAITG CWILSFVVGL TPMFGWNNLS AVERDWLANG SVGEPVIECQ FEKVISMEYM 

       190        200        210        220        230        240 
VYFNFFVWVL PPLLLMVLIY MEVFYLIRKQ LNKKVSASSG DPQKYYGKEL KIAKSLALIL 

       250        260        270        280        290        300 
FLFALSWLPL HILNCITLFC PSCHMPRILI YIAIFLSHGN SAMNPIVYAF RIQKFRVTFL 

       310        320 
KIWNDHFRCQ PAPPVDEDAP AERPDD 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and expression of a bovine adenosine A1 receptor cDNA."
Tucker A.L., Linden J., Robeva A.S., D'Angelo D.D., Lynch K.R.
FEBS Lett. 297:107-111(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"Cloning, expression, and characterization of the unique bovine A1 adenosine receptor. Studies on the ligand binding site by site-directed mutagenesis."
Olah M.E., Ren H., Ostrowski J., Jacobson K., Stiles G.L.
J. Biol. Chem. 267:10764-10770(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Characterization of 954 bovine full-CDS cDNA sequences."
Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.
BMC Genomics 6:166-166(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal pons and Hippocampus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X63592 mRNA. Translation: CAA45135.1.
M86261 mRNA. Translation: AAA30350.1.
BT021759 mRNA. Translation: AAX46606.1.
BC142208 mRNA. Translation: AAI42209.1.
BC142265 mRNA. Translation: AAI42266.1.
PIRA38144.
RefSeqNP_776922.2. NM_174497.3.
XP_005216709.1. XM_005216652.1.
XP_005216710.1. XM_005216653.1.
UniGeneBt.76442.

3D structure databases

ProteinModelPortalP28190.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000045778.

Chemistry

BindingDBP28190.
ChEMBLCHEMBL4975.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEP28190.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000015230; ENSBTAP00000015230; ENSBTAG00000011461.
GeneID282133.
KEGGbta:282133.

Organism-specific databases

CTD134.

Phylogenomic databases

eggNOGNOG284456.
GeneTreeENSGT00550000074524.
HOGENOMHOG000015770.
HOVERGENHBG106962.
InParanoidP28190.
KOK04265.
OMAIPLRYKM.
OrthoDBEOG79SDXQ.
TreeFamTF325296.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR001068. Adeno_A1_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00552. ADENOSINEA1R.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20805968.

Entry information

Entry nameAA1R_BOVIN
AccessionPrimary (citable) accession number: P28190
Secondary accession number(s): A5PJR1, Q58D38
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: November 13, 2007
Last modified: April 16, 2014
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries