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Protein

Adenosine receptor A1

Gene

ADORA1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-BTA-417973. Adenosine P1 receptors.
R-BTA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine receptor A1
Gene namesi
Name:ADORA1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 16

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10ExtracellularSequence analysis10
Transmembranei11 – 33Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini34 – 46CytoplasmicSequence analysisAdd BLAST13
Transmembranei47 – 69Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini70 – 80ExtracellularSequence analysisAdd BLAST11
Transmembranei81 – 102Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini103 – 123CytoplasmicSequence analysisAdd BLAST21
Transmembranei124 – 146Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini147 – 176ExtracellularSequence analysisAdd BLAST30
Transmembranei177 – 201Helical; Name=5Sequence analysisAdd BLAST25
Topological domaini202 – 235CytoplasmicSequence analysisAdd BLAST34
Transmembranei236 – 259Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini260 – 267ExtracellularSequence analysis8
Transmembranei268 – 292Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini293 – 326CytoplasmicSequence analysisAdd BLAST34

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4975.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000689881 – 326Adenosine receptor A1Add BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi80 ↔ 169PROSITE-ProRule annotation
Glycosylationi148N-linked (GlcNAc...)Sequence analysis1
Glycosylationi159N-linked (GlcNAc...)Sequence analysis1
Lipidationi309S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP28190.
PRIDEiP28190.

Expressioni

Gene expression databases

BgeeiENSBTAG00000011461.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015230.

Chemistry databases

BindingDBiP28190.

Structurei

3D structure databases

ProteinModelPortaliP28190.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00550000074524.
HOGENOMiHOG000015770.
HOVERGENiHBG106962.
InParanoidiP28190.
KOiK04265.
OMAiVYAFRIH.
OrthoDBiEOG091G0I3U.
TreeFamiTF325296.

Family and domain databases

InterProiIPR001068. Adeno_A1_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00552. ADENOSINEA1R.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28190-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPSISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVS
60 70 80 90 100
LAVADVAVGA LVIPLAILIN IGPRTYFHTC LKVACPVLIL TQSSILALLA
110 120 130 140 150
IAVDRYLRVK IPLRYKTVVT PRRAVVAITG CWILSFVVGL TPMFGWNNLS
160 170 180 190 200
AVERDWLANG SVGEPVIECQ FEKVISMEYM VYFNFFVWVL PPLLLMVLIY
210 220 230 240 250
MEVFYLIRKQ LNKKVSASSG DPQKYYGKEL KIAKSLALIL FLFALSWLPL
260 270 280 290 300
HILNCITLFC PSCHMPRILI YIAIFLSHGN SAMNPIVYAF RIQKFRVTFL
310 320
KIWNDHFRCQ PAPPVDEDAP AERPDD
Length:326
Mass (Da):36,593
Last modified:November 13, 2007 - v3
Checksum:i6F4557FCEFEBC66E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti212N → S in CAA45135 (PubMed:1551415).Curated1
Sequence conflicti212N → S in AAA30350 (PubMed:1587851).Curated1
Sequence conflicti315V → I in CAA45135 (PubMed:1551415).Curated1
Sequence conflicti315V → I in AAA30350 (PubMed:1587851).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63592 mRNA. Translation: CAA45135.1.
M86261 mRNA. Translation: AAA30350.1.
BT021759 mRNA. Translation: AAX46606.1.
BC142208 mRNA. Translation: AAI42209.1.
BC142265 mRNA. Translation: AAI42266.1.
PIRiA38144.
RefSeqiNP_776922.2. NM_174497.3.
XP_005216709.1. XM_005216652.3.
XP_005216710.1. XM_005216653.3.
XP_010811315.1. XM_010813013.2.
UniGeneiBt.76442.

Genome annotation databases

EnsembliENSBTAT00000015230; ENSBTAP00000015230; ENSBTAG00000011461.
GeneIDi282133.
KEGGibta:282133.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63592 mRNA. Translation: CAA45135.1.
M86261 mRNA. Translation: AAA30350.1.
BT021759 mRNA. Translation: AAX46606.1.
BC142208 mRNA. Translation: AAI42209.1.
BC142265 mRNA. Translation: AAI42266.1.
PIRiA38144.
RefSeqiNP_776922.2. NM_174497.3.
XP_005216709.1. XM_005216652.3.
XP_005216710.1. XM_005216653.3.
XP_010811315.1. XM_010813013.2.
UniGeneiBt.76442.

3D structure databases

ProteinModelPortaliP28190.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015230.

Chemistry databases

BindingDBiP28190.
ChEMBLiCHEMBL4975.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiP28190.
PRIDEiP28190.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000015230; ENSBTAP00000015230; ENSBTAG00000011461.
GeneIDi282133.
KEGGibta:282133.

Organism-specific databases

CTDi134.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00550000074524.
HOGENOMiHOG000015770.
HOVERGENiHBG106962.
InParanoidiP28190.
KOiK04265.
OMAiVYAFRIH.
OrthoDBiEOG091G0I3U.
TreeFamiTF325296.

Enzyme and pathway databases

ReactomeiR-BTA-417973. Adenosine P1 receptors.
R-BTA-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiP28190.

Gene expression databases

BgeeiENSBTAG00000011461.

Family and domain databases

InterProiIPR001068. Adeno_A1_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00552. ADENOSINEA1R.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAA1R_BOVIN
AccessioniPrimary (citable) accession number: P28190
Secondary accession number(s): A5PJR1, Q58D38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: November 13, 2007
Last modified: September 7, 2016
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.