Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P28188

- RAD2A_ARATH

UniProt

P28188 - RAD2A_ARATH

Protein

Ras-related protein RABD2a

Gene

RABD2A

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 3 (02 Sep 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER).2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi15 – 228GTPBy similarity
    Nucleotide bindingi63 – 675GTPBy similarity
    Nucleotide bindingi121 – 1244GTPBy similarity
    Nucleotide bindingi151 – 1522GTPBy similarity

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW

    GO - Biological processi

    1. ER to Golgi vesicle-mediated transport Source: TAIR
    2. protein transport Source: UniProtKB-KW
    3. response to cadmium ion Source: TAIR
    4. small GTPase mediated signal transduction Source: InterPro

    Keywords - Biological processi

    ER-Golgi transport, Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein RABD2a
    Short name:
    AtRABD2a
    Alternative name(s):
    Ras-related protein Ara-5
    Ras-related protein Rab1B
    Short name:
    AtRab1B
    Gene namesi
    Name:RABD2A
    Synonyms:ARA-5, RAB1B
    Ordered Locus Names:At1g02130
    ORF Names:T7I23.6
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G02130.

    Subcellular locationi

    Golgi apparatustrans-Golgi network membrane 1 Publication. Golgi apparatus membrane 1 Publication; Lipid-anchor 1 Publication

    GO - Cellular componenti

    1. Golgi membrane Source: UniProtKB
    2. plasma membrane Source: TAIR
    3. trans-Golgi network membrane Source: UniProtKB
    4. vacuole Source: TAIR

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi121 – 1211N → I: Inhibits trafficking between the ER and Golgi. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 203202Ras-related protein RABD2aPRO_0000121292Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi200 – 2001S-geranylgeranyl cysteineBy similarity
    Lipidationi201 – 2011S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Prenylation

    Proteomic databases

    PaxDbiP28188.
    PRIDEiP28188.

    Expressioni

    Gene expression databases

    GenevestigatoriP28188.

    Interactioni

    Subunit structurei

    Does not interact with GC5.

    Protein-protein interaction databases

    BioGridi22265. 1 interaction.
    IntActiP28188. 1 interaction.
    STRINGi3702.AT1G02130.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliP28188.
    SMRiP28188. Positions 3-173.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi37 – 459Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    HOGENOMiHOG000233968.
    InParanoidiP28188.
    KOiK07874.
    OMAiVESYIST.
    PhylomeDBiP28188.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00175. RAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P28188-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNPEYDYLFK LLLIGDSGVG KSCLLLRFSD DSYVESYIST IGVDFKIRTV    50
    EQDGKTIKLQ IWDTAGQERF RTITSSYYRG AHGIIIVYDV TDEESFNNVK 100
    QWLSEIDRYA SDNVNKLLVG NKSDLTENRA IPYETAKAFA DEIGIPFMET 150
    SAKDATNVEQ AFMAMSASIK ERMASQPAGN NARPPTVQIR GQPVAQKNGC 200
    CST 203
    Length:203
    Mass (Da):22,648
    Last modified:September 2, 2008 - v3
    Checksum:i85A2870837300B8D
    GO

    Sequence cautioni

    The sequence AAC24370.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U89959 Genomic DNA. Translation: AAC24370.1. Sequence problems.
    CP002684 Genomic DNA. Translation: AEE27387.1.
    AY052333 mRNA. Translation: AAK96526.1.
    AY061905 mRNA. Translation: AAL31232.1.
    D01027 mRNA. Translation: BAA00832.1.
    PIRiB86153.
    PS0279.
    RefSeqiNP_171715.1. NM_100093.3.
    UniGeneiAt.21490.

    Genome annotation databases

    EnsemblPlantsiAT1G02130.1; AT1G02130.1; AT1G02130.
    GeneIDi837023.
    KEGGiath:AT1G02130.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U89959 Genomic DNA. Translation: AAC24370.1 . Sequence problems.
    CP002684 Genomic DNA. Translation: AEE27387.1 .
    AY052333 mRNA. Translation: AAK96526.1 .
    AY061905 mRNA. Translation: AAL31232.1 .
    D01027 mRNA. Translation: BAA00832.1 .
    PIRi B86153.
    PS0279.
    RefSeqi NP_171715.1. NM_100093.3.
    UniGenei At.21490.

    3D structure databases

    ProteinModelPortali P28188.
    SMRi P28188. Positions 3-173.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 22265. 1 interaction.
    IntActi P28188. 1 interaction.
    STRINGi 3702.AT1G02130.1-P.

    Proteomic databases

    PaxDbi P28188.
    PRIDEi P28188.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G02130.1 ; AT1G02130.1 ; AT1G02130 .
    GeneIDi 837023.
    KEGGi ath:AT1G02130.

    Organism-specific databases

    TAIRi AT1G02130.

    Phylogenomic databases

    eggNOGi COG1100.
    HOGENOMi HOG000233968.
    InParanoidi P28188.
    KOi K07874.
    OMAi VESYIST.
    PhylomeDBi P28188.

    Gene expression databases

    Genevestigatori P28188.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00175. RAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Isolation and analysis of cDNAs encoding small GTP-binding proteins of Arabidopsis thaliana."
      Anai T., Hasegawa K., Watanabe Y., Uchimiya H., Ishizaki R., Matsui M.
      Gene 108:259-264(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-203.
      Strain: cv. Columbia, cv. En-1, cv. Est, cv. Landsberg erecta and cv. Lapalmam.
      Tissue: Leaf.
    5. "A rab1 GTPase is required for transport between the endoplasmic reticulum and Golgi apparatus and for normal Golgi movement in plants."
      Batoko H., Zheng H.-Q., Hawes C., Moore I.
      Plant Cell 12:2201-2218(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, MUTAGENESIS OF ASN-121.
    6. "Redistribution of membrane proteins between the Golgi apparatus and endoplasmic reticulum in plants is reversible and not dependent on cytoskeletal networks."
      Saint-Jore C.M., Evins J., Batoko H., Brandizzi F., Moore I., Hawes C.
      Plant J. 29:661-678(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "Analysis of the small GTPase gene superfamily of Arabidopsis."
      Vernoud V., Horton A.C., Yang Z., Nielsen E.
      Plant Physiol. 131:1191-1208(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.
    8. "Localization and domain characterization of Arabidopsis golgin candidates."
      Latijnhouwers M., Gillespie T., Boevink P., Kriechbaumer V., Hawes C., Carvalho C.M.
      J. Exp. Bot. 58:4373-4386(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GC5.
    9. "Genetic evidence that the higher plant Rab-D1 and Rab-D2 GTPases exhibit distinct but overlapping interactions in the early secretory pathway."
      Pinheiro H., Samalova M., Geldner N., Chory J., Martinez A., Moore I.
      J. Cell Sci. 122:3749-3758(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiRAD2A_ARATH
    AccessioniPrimary (citable) accession number: P28188
    Secondary accession number(s): Q940Z7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 116 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3