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P28188 (RAD2A_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ras-related protein RABD2a

Short name=AtRABD2a
Alternative name(s):
Ras-related protein Ara-5
Ras-related protein Rab1B
Short name=AtRab1B
Gene names
Name:RABD2A
Synonyms:ARA-5, RAB1B
Ordered Locus Names:At1g02130
ORF Names:T7I23.6
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length203 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Ref.5 Ref.6

Subunit structure

Does not interact with GC5.

Subcellular location

Golgi apparatustrans-Golgi network membrane. Golgi apparatus membrane; Lipid-anchor Probable Ref.9.

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Sequence caution

The sequence AAC24370.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 203202Ras-related protein RABD2a
PRO_0000121292

Regions

Nucleotide binding15 – 228GTP By similarity
Nucleotide binding63 – 675GTP By similarity
Nucleotide binding121 – 1244GTP By similarity
Nucleotide binding151 – 1522GTP By similarity
Motif37 – 459Effector region By similarity

Amino acid modifications

Lipidation2001S-geranylgeranyl cysteine By similarity
Lipidation2011S-geranylgeranyl cysteine By similarity

Experimental info

Mutagenesis1211N → I: Inhibits trafficking between the ER and Golgi. Ref.5

Sequences

Sequence LengthMass (Da)Tools
P28188 [UniParc].

Last modified September 2, 2008. Version 3.
Checksum: 85A2870837300B8D

FASTA20322,648
        10         20         30         40         50         60 
MNPEYDYLFK LLLIGDSGVG KSCLLLRFSD DSYVESYIST IGVDFKIRTV EQDGKTIKLQ 

        70         80         90        100        110        120 
IWDTAGQERF RTITSSYYRG AHGIIIVYDV TDEESFNNVK QWLSEIDRYA SDNVNKLLVG 

       130        140        150        160        170        180 
NKSDLTENRA IPYETAKAFA DEIGIPFMET SAKDATNVEQ AFMAMSASIK ERMASQPAGN 

       190        200 
NARPPTVQIR GQPVAQKNGC CST 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. expand/collapse author list , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[4]"Isolation and analysis of cDNAs encoding small GTP-binding proteins of Arabidopsis thaliana."
Anai T., Hasegawa K., Watanabe Y., Uchimiya H., Ishizaki R., Matsui M.
Gene 108:259-264(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-203.
Strain: cv. Columbia, cv. En-1, cv. Est, cv. Landsberg erecta and cv. Lapalmam.
Tissue: Leaf.
[5]"A rab1 GTPase is required for transport between the endoplasmic reticulum and Golgi apparatus and for normal Golgi movement in plants."
Batoko H., Zheng H.-Q., Hawes C., Moore I.
Plant Cell 12:2201-2218(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, MUTAGENESIS OF ASN-121.
[6]"Redistribution of membrane proteins between the Golgi apparatus and endoplasmic reticulum in plants is reversible and not dependent on cytoskeletal networks."
Saint-Jore C.M., Evins J., Batoko H., Brandizzi F., Moore I., Hawes C.
Plant J. 29:661-678(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[7]"Analysis of the small GTPase gene superfamily of Arabidopsis."
Vernoud V., Horton A.C., Yang Z., Nielsen E.
Plant Physiol. 131:1191-1208(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.
[8]"Localization and domain characterization of Arabidopsis golgin candidates."
Latijnhouwers M., Gillespie T., Boevink P., Kriechbaumer V., Hawes C., Carvalho C.M.
J. Exp. Bot. 58:4373-4386(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH GC5.
[9]"Genetic evidence that the higher plant Rab-D1 and Rab-D2 GTPases exhibit distinct but overlapping interactions in the early secretory pathway."
Pinheiro H., Samalova M., Geldner N., Chory J., Martinez A., Moore I.
J. Cell Sci. 122:3749-3758(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U89959 Genomic DNA. Translation: AAC24370.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE27387.1.
AY052333 mRNA. Translation: AAK96526.1.
AY061905 mRNA. Translation: AAL31232.1.
D01027 mRNA. Translation: BAA00832.1.
PIRB86153.
PS0279.
RefSeqNP_171715.1. NM_100093.3.
UniGeneAt.21490.

3D structure databases

ProteinModelPortalP28188.
SMRP28188. Positions 3-173.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid22265. 1 interaction.
IntActP28188. 1 interaction.
STRING3702.AT1G02130.1-P.

Proteomic databases

PaxDbP28188.
PRIDEP28188.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT1G02130.1; AT1G02130.1; AT1G02130.
GeneID837023.
KEGGath:AT1G02130.

Organism-specific databases

TAIRAT1G02130.

Phylogenomic databases

eggNOGCOG1100.
HOGENOMHOG000233968.
InParanoidP28188.
KOK07874.
OMAVESYIST.
PhylomeDBP28188.

Gene expression databases

GenevestigatorP28188.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRAD2A_ARATH
AccessionPrimary (citable) accession number: P28188
Secondary accession number(s): Q940Z7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: September 2, 2008
Last modified: May 14, 2014
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names