Metallothionein-3 - Mus musculus (Mouse)

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P28184 (MT3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 103. History...

Clusters with 100%, 90%, 50% identity |

Documents (4) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Metallothionein-3
Short name=MT-3

Alternative name(s):
Growth inhibitory factor
Short name=GIF
Metallothionein-III
Short name=MT-III

Gene names

Name:

Mt3

Organism

Mus musculus (Mouse)

Taxonomic identifier

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	68 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro By similarity.
Tissue specificity	Brain.
Sequence similarities	Belongs to the metallothionein superfamily. Type 1 family.

Ontologies

Keywords
Ligand	Copper Metal-binding Metal-thiolate cluster Zinc
PTM	Acetylation
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cellular metal ion homeostasis Inferred from direct assay. Source: MGI negative regulation of neurogenesis Inferred from direct assay. Source: MGI removal of superoxide radicals Inferred from sequence or structural similarity. Source: UniProtKB response to hypoxia Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	synaptic vesicle Inferred from direct assay. Source: UniProtKB
Molecular function	zinc ion binding Inferred from direct assay. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

68

Metallothionein-3

PRO_0000197251

Regions

Region

30

Beta

Region

38

Alpha

Sites

Metal binding

1

Divalent metal cation; cluster B By similarity

Metal binding

1

Divalent metal cation; cluster B By similarity

Metal binding

1

Divalent metal cation; cluster B By similarity

Metal binding

1

Divalent metal cation; cluster B By similarity

Metal binding

1

Divalent metal cation; cluster B By similarity

Metal binding

1

Divalent metal cation; cluster B By similarity

Metal binding

1

Divalent metal cation; cluster B By similarity

Metal binding

1

Divalent metal cation; cluster B By similarity

Metal binding

1

Divalent metal cation; cluster B By similarity

Metal binding

1

Divalent metal cation; cluster A By similarity

Metal binding

1

Divalent metal cation; cluster A By similarity

Metal binding

1

Divalent metal cation; cluster A By similarity

Metal binding

1

Divalent metal cation; cluster A By similarity

Metal binding

1

Divalent metal cation; cluster A By similarity

Metal binding

1

Divalent metal cation; cluster A By similarity

Metal binding

1

Divalent metal cation; cluster A By similarity

Metal binding

1

Divalent metal cation; cluster A By similarity

Metal binding

1

Divalent metal cation; cluster A By similarity

Metal binding

1

Divalent metal cation; cluster A By similarity

Metal binding

1

Divalent metal cation; cluster A By similarity

Amino acid modifications

Modified residue

1

N-acetylmethionine By similarity

Secondary structure

1

.

.

.

.

.

68

Helix Strand Turn

Sequences

Sequence

Length

Mass (Da)

Tools

P28184 [UniParc].

Last modified December 1, 1992. Version 1.
Checksum: 791AF60E38FED3CA
Show »

68

7,009

        10         20         30         40         50         60 
MDPETCPCPT GGSCTCSDKC KCKGCKCTNC KKSCCSCCPA GCEKCAKDCV CKGEEGAKAE 


AEKCSCCQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"MT-III, a brain-specific member of the metallothionein gene family." Palmiter R.D., Findley S.D., Whitmore T.E., Durnam D.M. Proc. Natl. Acad. Sci. U.S.A. 89:6333-6337(1992) [PubMed: 1631128] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Brain.
[2]	"Structures of the human and mouse growth inhibitory factor-encoding genes." Naruse S., Igarashi S., Furuya T., Kobayashi H., Miyatake T., Tsuji S. Gene 144:283-287(1994) [PubMed: 8039715] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"Three-dimensional structure and dynamics of a brain specific growth inhibitory factor: metallothionein-3." Oz G., Zangger K., Armitage I.M. Biochemistry 40:11433-11441(2001) [PubMed: 11560491] [Abstract] Cited for: STRUCTURE BY NMR OF 32-68.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M93310 Genomic DNA. Translation: AAA39529.1.
S72046 Genomic DNA. Translation: AAB31397.1.
BC059725 mRNA. Translation: AAH59725.1.

IPI

PIR

RefSeq

NP_038631.1. NM_013603.2.

UniGene

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1JI9	NMR	-	A	32-68	[»]

ProteinModelPortal

SMR

P28184. Positions 32-68.

ModBase

PTM databases

PhosphoSite

Proteomic databases

PRIDE

Protocols and materials databases

StructuralBiologyKnowledgebase

Genome annotation databases

Ensembl

ENSMUST00000034211; ENSMUSP00000034211; ENSMUSG00000031760.

GeneID

KEGG

Organism-specific databases

CTD

MGI

MGI:97173. Mt3.

Phylogenomic databases

HOVERGEN

InParanoid

OMA

Gene expression databases

ArrayExpress

Bgee

CleanEx

Genevestigator

GermOnline

ENSMUSG00000031760. Mus musculus.

Family and domain databases

InterPro

IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]

Gene3D

G3DSA:4.10.10.10. Metallothionein_vert. 1 hit.

KO

PANTHER

PTHR23299. Metallothionein_vert. 1 hit.

Pfam

PF00131. Metallothio. 1 hit.
[Graphical view]

PRINTS

PR00860. MTVERTEBRATE.

SUPFAM

SSF57868. Metallothionein_sfam. 1 hit.

PROSITE

PS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]

ProtoNet

Other

NextBio

SOURCE

Entry information

Entry name

MT3_MOUSE

Accession

Primary (citable) accession number: P28184

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	December 1, 1992
Last modified:	November 16, 2011
This is version 103 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

Metallothioneins

Classification of metallothioneins and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents