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Protein

Interferon tau-11

Gene

IFNT11

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium. This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity. This, and a possible direct effect of IFN-tau on prostaglandin synthesis, leads in turn to continued ovarian progesterone secretion, which stimulates the secretion by the endometrium of the nutrients required for the growth of the conceptus. In summary, displays particularly high antiviral and antiproliferative potency concurrently with particular weak cytotoxicity, high antiluteolytic activity and immunomodulatory properties. In contrast with other IFNs, IFN-tau is not virally inducible.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Hormone

Keywords - Biological processi

Antiviral defense, Pregnancy

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon tau-11
Short name:
IFN-tau-11
Alternative name(s):
Antiluteolysin
P4
S4
Trophoblast antiluteolytic protein
Trophoblast protein 1
Short name:
TP-1
Trophoblastin
Gene namesi
Name:IFNT11
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Unplaced

Subcellular locationi

  • Secreted

  • Note: Secreted into the uterine lumen.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi166 – 1661I → T: 20-fold reduction in receptor binding activity, greatly reduces antiviral and almost abolishes antiproliferative activity.
Mutagenesisi183 – 1831Missing : Little effect on receptor binding activity but greatly reduces antiviral and almost abolishes antiproliferative activity.
Mutagenesisi185 – 19511Missing : Little effect on receptor binding activity but greatly reduces antiviral and almost abolishes antiproliferative activity. Add
BLAST

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 195172Interferon tau-11PRO_0000016422Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 ↔ 122By similarity
Disulfide bondi52 ↔ 162By similarity
Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Constitutively and exclusively expressed in the mononuclear cells of the extraembryonic trophectoderm.

Developmental stagei

Major secretory product synthesized by the sheep conceptus between days 13 and 21 of pregnancy.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OVImodel-A24-195[»]
ProteinModelPortaliP28169.
SMRiP28169. Positions 24-187.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG052086.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28169-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFVLSLLMA LVLVSYGPGG SLGCYLSQRL MLDARENLRL LDRMNRLSPH
60 70 80 90 100
SCLQDRKDFG LPQEMVEGDQ LQEAQAFCVL YEMLQQSFNL FHTERSSAAW
110 120 130 140 150
NTTLLEQLCT GLQQQLEDLD TCRGPVMGEK DSELGKMDPI VTVKKYFQGI
160 170 180 190
HFYLKEKEYS DCAWEIVRVE MMRALSSSTS LQERLRKMGG DLNSP
Length:195
Mass (Da):22,244
Last modified:November 1, 1996 - v1
Checksum:iDC6321E42BDF948A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73241 Genomic DNA. Translation: AAA31573.1.
PIRiI47097.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73241 Genomic DNA. Translation: AAA31573.1.
PIRiI47097.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OVImodel-A24-195[»]
ProteinModelPortaliP28169.
SMRiP28169. Positions 24-187.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG052086.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genes for the trophoblast interferons in sheep, goat, and musk ox and distribution of related genes among mammals."
    Leaman D.W., Roberts R.M.
    J. Interferon Res. 12:1-11(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Ovine interferon tau suppresses transcription of the estrogen receptor and oxytocin receptor genes in the ovine endometrium."
    Spencer T.E., Bazer F.W.
    Endocrinology 137:1144-1147(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  3. Cited for: CIRCULAR DICHROISM ANALYSIS, 3D-STRUCTURE MODELING.
  4. "A three-dimensional model of interferon-tau."
    Senda T., Saitoh S., Mitsui Y., Li J., Roberts R.M.
    J. Interferon Cytokine Res. 15:1053-1060(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING.
  5. "Structure-function relationships in the interferon-tau (IFN-tau). Changes in receptor binding and in antiviral and antiproliferative activities resulting from site-directed mutagenesis performed near the carboxyl terminus."
    Li J., Roberts R.M.
    J. Biol. Chem. 269:24826-24833(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS.
  6. "Effect of variants of interferon-tau with mutations near the carboxyl terminus on luteal life span in sheep."
    Niswender K.D., Li J., Powell M.R., Loos K.R., Roberts R.M., Keisler D.H., Smith M.F.
    Biol. Reprod. 56:214-220(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS.
  7. "IFN-tau: a novel subtype I IFN1. Structural characteristics, non-ubiquitous expression, structure-function relationships, a pregnancy hormonal embryonic signal and cross-species therapeutic potentialities."
    Martal J.L., Chene N.M., Huynh L.P., L'Haridon R.M., Reinaud P.B., Guillomot M.W., Charlier M.A., Charpigny S.Y.
    Biochimie 80:755-777(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiIFNTB_SHEEP
AccessioniPrimary (citable) accession number: P28169
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: October 14, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

IFN-tau genes are intronless. They evolved from IFN-omega genes in the ruminantia suborder and have continued to duplicate independently in different lineages of the ruminantia. They code for proteins very similar in sequence but with different biological potency and pattern of expression.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.