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P28159

- SUH_DROME

UniProt

P28159 - SUH_DROME

Protein

Suppressor of hairless protein

Gene

Su(H)

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 145 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Binds directly the 5'-GTGRGAR-3' DNA consensus sequence, which is present in the regulatory region of several genes. Required for neurogenesis in imaginal disks. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some Notch protein, it acts as a transcriptional activator that activates transcription of Notch target genes. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Required for transcription of Sim. Also functions independently of Notch pathway, in the development of the bristle sensory organ precursor cell.3 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi132 – 1398By similarity
    DNA bindingi266 – 27510By similarity
    DNA bindingi339 – 37133By similarityAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. protein binding Source: IntAct
    3. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: InterPro
    4. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: FlyBase
    5. RNA polymerase II distal enhancer sequence-specific DNA binding Source: FlyBase
    6. sequence-specific DNA binding Source: FlyBase

    GO - Biological processi

    1. asymmetric cell division Source: FlyBase
    2. cell fate determination Source: FlyBase
    3. crystal cell differentiation Source: FlyBase
    4. hemopoiesis Source: FlyBase
    5. I-kappaB phosphorylation Source: FlyBase
    6. imaginal disc-derived wing vein morphogenesis Source: FlyBase
    7. lateral inhibition Source: FlyBase
    8. long-term memory Source: FlyBase
    9. negative regulation of compound eye cone cell fate specification Source: FlyBase
    10. negative regulation of transcription, DNA-templated Source: FlyBase
    11. negative regulation of transcription from RNA polymerase II promoter Source: FlyBase
    12. Notch signaling pathway Source: UniProtKB
    13. positive regulation of G1/S transition of mitotic cell cycle Source: FlyBase
    14. positive regulation of transcription, DNA-templated Source: FlyBase
    15. positive regulation of transcription from RNA polymerase II promoter Source: FlyBase
    16. sensory organ precursor cell fate determination Source: UniProtKB
    17. wing disc dorsal/ventral pattern formation Source: FlyBase

    Keywords - Molecular functioni

    Activator, Developmental protein, Repressor

    Keywords - Biological processi

    Notch signaling pathway, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    SignaLinkiP28159.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Suppressor of hairless protein
    Alternative name(s):
    J kappa-recombination signal-binding protein
    RBP-J kappa
    Gene namesi
    Name:Su(H)
    Synonyms:dRBP-JK
    ORF Names:CG3497
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2L

    Organism-specific databases

    FlyBaseiFBgn0004837. Su(H).

    Subcellular locationi

    Nucleus 1 Publication. Cytoplasm 1 Publication
    Note: In imaginal disk, at the onset of differentiation of socket cell, it is also present in the cytoplasm.

    GO - Cellular componenti

    1. cytoplasm Source: FlyBase
    2. nucleus Source: FlyBase
    3. polytene chromosome Source: FlyBase
    4. protein complex Source: FlyBase
    5. transcriptional repressor complex Source: FlyBase

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi315 – 3151Y → F: No effect. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 594594Suppressor of hairless proteinPRO_0000208572Add
    BLAST

    Proteomic databases

    PaxDbiP28159.
    PRIDEiP28159.

    Expressioni

    Gene expression databases

    BgeeiP28159.

    Interactioni

    Subunit structurei

    Interacts with activated cleaved Notch. Interacts with Hairless, this interaction preventing its DNA-binding activity.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    insvQ9VQD53EBI-92180,EBI-192407
    NP072074EBI-92180,EBI-103438
    Notch1Q017053EBI-92180,EBI-1392707From a different organism.

    Protein-protein interaction databases

    BioGridi60899. 39 interactions.
    DIPiDIP-177N.
    IntActiP28159. 11 interactions.
    MINTiMINT-335544.

    Structurei

    3D structure databases

    ProteinModelPortaliP28159.
    SMRiP28159. Positions 103-522.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini429 – 51991IPT/TIGAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi35 – 428Gln-rich
    Compositional biasi58 – 8831Gln-richAdd
    BLAST
    Compositional biasi541 – 55818Asn-richAdd
    BLAST
    Compositional biasi569 – 5768Gln-rich

    Sequence similaritiesi

    Belongs to the Su(H) family.Curated
    Contains 1 IPT/TIG domain.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG295376.
    GeneTreeiENSGT00390000005197.
    InParanoidiP28159.
    KOiK06053.
    OMAiMGPVHAP.
    OrthoDBiEOG7BP826.
    PhylomeDBiP28159.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    2.60.40.1450. 1 hit.
    InterProiIPR015350. Beta-trefoil_DNA-bd_dom.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002909. IPT.
    IPR015351. LAG1_DNA-bd.
    IPR008967. p53-like_TF_DNA-bd.
    [Graphical view]
    PfamiPF09270. BTD. 1 hit.
    PF09271. LAG1-DNAbind. 1 hit.
    PF01833. TIG. 1 hit.
    [Graphical view]
    SUPFAMiSSF110217. SSF110217. 1 hit.
    SSF49417. SSF49417. 1 hit.
    SSF81296. SSF81296. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P28159-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSYSQFNLN AAAPPAIAYE TTVVNPNGSP LDPHQQQQQQ SQDMPHFGLP    50
    GPQPPSSQQQ QQQLQVHHQQ QQQQQQQQQQ QQHQQQMQMS LLPGPYRPHI 100
    EEKKLTRDAM EKYMRERNDM VIVILHAKVA QKSYGNEKRF FCPPPCIYLF 150
    GSGWRRRYEE MLQQGEGEQG AQLCAFIGIG SSDQDMQQLD LNGKQYCAAK 200
    TLFISDSDKR KHFMLSVKMF YGNGHDIGVF NSKRIKVISK PSKKKQSLKN 250
    ADLCIASGTN VALFNRLRSQ TVSTRYLHVE NGHFHASSTQ WGAFTIHLLD 300
    DNESESEEFQ VRDGYIHYGA TVKLVCSVTG MALPRLIIRK VDKQMALLEA 350
    DDPVSQLHKC AFYMKDTDRM YLCLSQEKII QFQATPCPKE PNKEMINDGA 400
    CWTIISTDKA EYQFYEGMGP VASPVTPVPI VNSLNLNGGG DVAMLELSGD 450
    NFTPHLQVWF GDVEAETMYR CTETLLCVVP EISQFRGEWL WVRQPTQVPI 500
    SLVRNDGIIY ATGLTFTYTP EPGPRPHCNT QAEDVMRARQ NNNNNNITSI 550
    SNNNNSNNAG SPAAGGGLQQ QQQQHQALPS ISEVQWNSHG SGLS 594
    Length:594
    Mass (Da):66,924
    Last modified:July 1, 1993 - v1
    Checksum:i145144F336CD8F4C
    GO

    Sequence cautioni

    The sequence AAA06211.1 differs from that shown. Reason: Frameshift at position 6.
    The sequence CAA41282.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti116 – 1172ER → DG in AAA06211. (PubMed:1744127)Curated
    Sequence conflicti116 – 1172ER → DG in CAA41282. (PubMed:1744127)Curated
    Sequence conflicti492 – 4921V → A in AAA06211. (PubMed:1744127)Curated
    Sequence conflicti492 – 4921V → A in CAA41282. (PubMed:1744127)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti80 – 823Missing in strain: LAMTO 3, LAMTO 4, LAMTO 12, LAMTO 18, LAMTO 19, LAMTO 21, LAMTO 31, LAMTO 35, LAMTO 101 and LAMTO 111.
    Natural varianti81 – 822Missing in strain: LAMTO 13, LAMTO 37 and LAMTO 134.
    Natural varianti82 – 821Missing in strain: LAMTO 124.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S69213 Genomic DNA. Translation: AAA06211.1. Frameshift.
    X58393 mRNA. Translation: CAA41282.1. Different initiation.
    M94383 mRNA. Translation: AAA28919.1.
    AE014134 Genomic DNA. Translation: AAF53434.1.
    AY069091 mRNA. Translation: AAL39236.1.
    AF088255 Genomic DNA. Translation: AAD39698.1.
    AF088256 Genomic DNA. Translation: AAD39699.1.
    AF088257 Genomic DNA. Translation: AAD39700.1.
    AF088258 Genomic DNA. Translation: AAD39701.1.
    AF088259 Genomic DNA. Translation: AAD39702.1.
    AF088260 Genomic DNA. Translation: AAD39703.1.
    AF088261 Genomic DNA. Translation: AAD39704.1.
    AF088262 Genomic DNA. Translation: AAD39705.1.
    AF088263 Genomic DNA. Translation: AAD39706.1.
    AF088264 Genomic DNA. Translation: AAD39707.1.
    AF088265 Genomic DNA. Translation: AAD39708.1.
    AF088266 Genomic DNA. Translation: AAD39709.1.
    AF088267 Genomic DNA. Translation: AAD39710.1.
    AF088268 Genomic DNA. Translation: AAD39711.1.
    AF088269 Genomic DNA. Translation: AAD39712.1.
    AF088270 Genomic DNA. Translation: AAD39713.1.
    AF088271 Genomic DNA. Translation: AAD39714.1.
    AF088272 Genomic DNA. Translation: AAD39715.1.
    AF088273 Genomic DNA. Translation: AAD39716.1.
    AF088274 Genomic DNA. Translation: AAD39717.1.
    PIRiA41585.
    A42770.
    RefSeqiNP_476868.1. NM_057520.3.
    UniGeneiDm.2288.

    Genome annotation databases

    EnsemblMetazoaiFBtr0080700; FBpp0080261; FBgn0004837.
    GeneIDi34881.
    KEGGidme:Dmel_CG3497.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S69213 Genomic DNA. Translation: AAA06211.1 . Frameshift.
    X58393 mRNA. Translation: CAA41282.1 . Different initiation.
    M94383 mRNA. Translation: AAA28919.1 .
    AE014134 Genomic DNA. Translation: AAF53434.1 .
    AY069091 mRNA. Translation: AAL39236.1 .
    AF088255 Genomic DNA. Translation: AAD39698.1 .
    AF088256 Genomic DNA. Translation: AAD39699.1 .
    AF088257 Genomic DNA. Translation: AAD39700.1 .
    AF088258 Genomic DNA. Translation: AAD39701.1 .
    AF088259 Genomic DNA. Translation: AAD39702.1 .
    AF088260 Genomic DNA. Translation: AAD39703.1 .
    AF088261 Genomic DNA. Translation: AAD39704.1 .
    AF088262 Genomic DNA. Translation: AAD39705.1 .
    AF088263 Genomic DNA. Translation: AAD39706.1 .
    AF088264 Genomic DNA. Translation: AAD39707.1 .
    AF088265 Genomic DNA. Translation: AAD39708.1 .
    AF088266 Genomic DNA. Translation: AAD39709.1 .
    AF088267 Genomic DNA. Translation: AAD39710.1 .
    AF088268 Genomic DNA. Translation: AAD39711.1 .
    AF088269 Genomic DNA. Translation: AAD39712.1 .
    AF088270 Genomic DNA. Translation: AAD39713.1 .
    AF088271 Genomic DNA. Translation: AAD39714.1 .
    AF088272 Genomic DNA. Translation: AAD39715.1 .
    AF088273 Genomic DNA. Translation: AAD39716.1 .
    AF088274 Genomic DNA. Translation: AAD39717.1 .
    PIRi A41585.
    A42770.
    RefSeqi NP_476868.1. NM_057520.3.
    UniGenei Dm.2288.

    3D structure databases

    ProteinModelPortali P28159.
    SMRi P28159. Positions 103-522.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 60899. 39 interactions.
    DIPi DIP-177N.
    IntActi P28159. 11 interactions.
    MINTi MINT-335544.

    Proteomic databases

    PaxDbi P28159.
    PRIDEi P28159.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0080700 ; FBpp0080261 ; FBgn0004837 .
    GeneIDi 34881.
    KEGGi dme:Dmel_CG3497.

    Organism-specific databases

    CTDi 34881.
    FlyBasei FBgn0004837. Su(H).

    Phylogenomic databases

    eggNOGi NOG295376.
    GeneTreei ENSGT00390000005197.
    InParanoidi P28159.
    KOi K06053.
    OMAi MGPVHAP.
    OrthoDBi EOG7BP826.
    PhylomeDBi P28159.

    Enzyme and pathway databases

    SignaLinki P28159.

    Miscellaneous databases

    GenomeRNAii 34881.
    NextBioi 790672.
    PROi P28159.

    Gene expression databases

    Bgeei P28159.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    2.60.40.1450. 1 hit.
    InterProi IPR015350. Beta-trefoil_DNA-bd_dom.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002909. IPT.
    IPR015351. LAG1_DNA-bd.
    IPR008967. p53-like_TF_DNA-bd.
    [Graphical view ]
    Pfami PF09270. BTD. 1 hit.
    PF09271. LAG1-DNAbind. 1 hit.
    PF01833. TIG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF110217. SSF110217. 1 hit.
    SSF49417. SSF49417. 1 hit.
    SSF81296. SSF81296. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The Drosophila RBP-J kappa gene encodes the binding protein for the immunoglobulin J kappa recombination signal sequence."
      Furukawa T., Kawaichi M., Matsunami N., Ryo H., Nishida Y., Honjo T.
      J. Biol. Chem. 266:23334-23340(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Tissue: Embryo.
    2. "Suppressor of Hairless, the Drosophila homolog of the mouse recombination signal-binding protein gene, controls sensory organ cell fates."
      Schweisguth F., Posakony J.W.
      Cell 69:1199-1212(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
      Tissue: Imaginal disk.
    3. "An exploration of the sequence of a 2.9-Mb region of the genome of Drosophila melanogaster: the Adh region."
      Ashburner M., Misra S., Roote J., Lewis S.E., Blazej R.G., Davis T., Doyle C., Galle R.F., George R.A., Harris N.L., Hartzell G., Harvey D.A., Hong L., Houston K.A., Hoskins R.A., Johnson G., Martin C., Moshrefi A.R.
      , Palazzolo M., Reese M.G., Spradling A.C., Tsang G., Wan K.H., Whitelaw K., Celniker S.E., Rubin G.M.
      Genetics 153:179-219(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    4. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    5. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.
      Tissue: Head.
    7. "Selective sweep at the Drosophila melanogaster Suppressor of Hairless locus and its association with the In(2L)t inversion polymorphism."
      Depaulis F., Brazier L., Veuille M.
      Genetics 152:1017-1024(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-128.
      Strain: LAMTO 101, LAMTO 106, LAMTO 111, LAMTO 12, LAMTO 120, LAMTO 124, LAMTO 13, LAMTO 134, LAMTO 19, LAMTO 21, LAMTO 27, LAMTO 28, LAMTO 3, LAMTO 31, LAMTO 33, LAMTO 35, LAMTO 37, LAMTO 4, LAMTO 5 and LAMTP 18.
    8. "The Drosophila homolog of the immunoglobulin recombination signal-binding protein regulates peripheral nervous system development."
      Furukawa T., Maruyama S., Kawaichi M., Honjo T.
      Cell 69:1191-1197(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    9. "The sequence similarity of the Drosophila suppressor of hairless protein to the integrase domain has no functional significance in vivo."
      Schweisguth F., Nero P., Posakony J.W.
      Dev. Biol. 166:812-814(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, MUTAGENESIS OF TYR-315.
    10. "Inhibition of the DNA-binding activity of Drosophila suppressor of hairless and of its human homolog, KBF2/RBP-J kappa, by direct protein-protein interaction with Drosophila hairless."
      Brou C., Logeat F., Lecourtois M., Vandekerckhove J., Kourilsky P., Schweisguth F., Israel A.
      Genes Dev. 8:2491-2503(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HAIRLESS.
    11. "Subcellular localization of Suppressor of Hairless in Drosophila sense organ cells during Notch signalling."
      Gho M., Lecourtois M., Geraud G., Posakony J.W., Schweisguth F.
      Development 122:1673-1682(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    12. "Repression by suppressor of hairless and activation by Notch are required to define a single row of single-minded expressing cells in the Drosophila embryo."
      Morel V., Schweisguth F.
      Genes Dev. 14:377-388(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DNA-BINDING.
    13. "A Notch-independent function of Suppressor of Hairless during the development of the bristle sensory organ precursor cell of Drosophila."
      Koelzer S., Klein T.
      Development 130:1973-1988(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiSUH_DROME
    AccessioniPrimary (citable) accession number: P28159
    Secondary accession number(s): Q3S1M8
    , Q9TVK8, Q9TVY7, Q9TW34, Q9U8F9, Q9V446
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 145 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Caution

    Despite some similarity with the "phage" integrase family, PubMed:7958912 showed that it has no recombinase activity.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3