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Protein

Protein Wnt-10b

Gene

WNT-10B

Organism
Plethodon jordani (Red-cheeked salamander)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Involved in neurogenesis. Performs a partially redundant function with wnt1 in the formation of the midbrain-hindbrain boundary (MHB) organizer.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-10b
Gene namesi
Name:WNT-10B
OrganismiPlethodon jordani (Red-cheeked salamander)
Taxonomic identifieri8336 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaCaudataSalamandroideaPlethodontidaePlethodontinaePlethodon

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000200666‹1 – ›117Protein Wnt-10bAdd BLAST›117

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi1O-palmitoleoyl serine; by PORCNBy similarity1
Disulfide bondi83 ↔ 98By similarity
Glycosylationi84N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiP28132.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Phylogenomic databases

HOVERGENiHBG001595.

Family and domain databases

InterProiView protein in InterPro
IPR005817. Wnt.
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiView protein in Pfam
PF00110. wnt. 1 hit.
SMARTiView protein in SMART
SM00097. WNT1. 1 hit.

Sequencei

Sequence statusi: Fragment.

P28132-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SGSCQFKTCW HVTPEFRLVS SVLKEKFQRA TFINSHNKNT GVFHPRRLKK
60 70 80 90 100
KRLAKELVYF EKSPDFCERD TKVDSPGTQG RVCNKTSHQM DSCGNLCCGR
110
GHNILMQTPS ERCNCRF
Length:117
Mass (Da):13,486
Last modified:November 1, 1995 - v2
Checksum:i0314FA6F60182D41
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei1171

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91289 Genomic DNA. Translation: AAA49457.1.

Similar proteinsi

Entry informationi

Entry nameiWN10B_PLEJO
AccessioniPrimary (citable) accession number: P28132
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: November 1, 1995
Last modified: October 25, 2017
This is version 73 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families