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Protein

Protein Wnt-4

Gene

WNT4

Organism
Meleagris gallopavo (Common turkey)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-4
Gene namesi
Name:WNT4
OrganismiMeleagris gallopavo (Common turkey)
Taxonomic identifieri9103 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaeMeleagridinaeMeleagris
Proteomesi
  • UP000001645 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000200624‹1 – ›119Protein Wnt-4Add BLAST›119

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi1O-palmitoleoyl serine; by PORCNBy similarity1
Disulfide bondi85 ↔ 100By similarity
Glycosylationi86N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9103.ENSMGAP00000006855.

Structurei

3D structure databases

SMRiP28127.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Phylogenomic databases

eggNOGiKOG3913. Eukaryota.
ENOG410XQZ1. LUCA.
HOVERGENiHBG001595.
InParanoidiP28127.

Family and domain databases

InterProiView protein in InterPro
IPR005817. Wnt.
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiView protein in Pfam
PF00110. wnt. 1 hit.
SMARTiView protein in SMART
SM00097. WNT1. 1 hit.

Sequencei

Sequence statusi: Fragment.

P28127-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SGSCEFKTCW KAMPPFRKVG NVLKEKFDGA TEVEQSEIGS TKVLVPKNSQ
60 70 80 90 100
FKPHTDEDLV YLDSSPDFCD HDLKNGVLGT SGRQCNKTSK AIDGCELMCC
110
GRGFHTDEVE VVERCSCKF
Length:119
Mass (Da):13,188
Last modified:December 1, 1992 - v1
Checksum:i4312D822F2200356
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei1191

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91283 Genomic DNA. Translation: AAA49632.1.

Similar proteinsi

Entry informationi

Entry nameiWNT4_MELGA
AccessioniPrimary (citable) accession number: P28127
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: October 25, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families