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Protein

Protein Wnt-5(III)

Gene

WNT-5(III)

Organism
Eptatretus stoutii (Pacific hagfish)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-5(III)
Gene namesi
Name:WNT-5(III)
OrganismiEptatretus stoutii (Pacific hagfish)
Taxonomic identifieri7765 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataCyclostomataHyperotretiMyxiniformesMyxinidaeEptatretinaeEptatretus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000200637‹1 – ›116Protein Wnt-5(III)Add BLAST›116

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi1O-palmitoleoyl serine; by PORCNBy similarity1
Glycosylationi69N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi82 ↔ 97By similarity

Post-translational modificationi

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiP28121.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Phylogenomic databases

HOVERGENiHBG001595.

Family and domain databases

InterProiView protein in InterPro
IPR005817. Wnt.
IPR026537. Wnt5b.
PANTHERiPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF87. PTHR12027:SF87. 1 hit.
PfamiView protein in Pfam
PF00110. wnt. 1 hit.
SMARTiView protein in SMART
SM00097. WNT1. 1 hit.

Sequencei

Sequence statusi: Fragment.

P28121-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SGSCSLKTCW LQLADFRSVG TQLKERYDLA KVVRVTRKSR LEPRNRKLGT
60 70 80 90 100
PTPTDLVHLE SSPDYCARNG SSGSLGTIGR ECDKRSAGMD GCQLMCCGRG
110
YDHFKVTVTQ RCNCKF
Length:116
Mass (Da):12,897
Last modified:December 1, 1992 - v1
Checksum:i5BC4409D692BA4A4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei1161

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91268 Genomic DNA. Translation: AAA49249.1.

Similar proteinsi

Entry informationi

Entry nameiWNT53_EPTST
AccessioniPrimary (citable) accession number: P28121
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: October 25, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families