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Protein

Protein Wnt-5a

Gene

WNT-5A

Organism
Plestiodon skiltonianus (Western skink) (Eumeces skiltonianus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. Required during embryogenesis for extension of the primary anterior-posterior axis.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-5a
Gene namesi
Name:WNT-5A
OrganismiPlestiodon skiltonianus (Western skink) (Eumeces skiltonianus)
Taxonomic identifieri463545 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataScinciformataScincidaeScincinaePlestiodon

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000200630‹1 – ›116Protein Wnt-5aAdd BLAST›116

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi1O-palmitoleoyl serine; by PORCNBy similarity1
Glycosylationi69N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi82 ↔ 97By similarity
Glycosylationi83N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiP28117
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Phylogenomic databases

HOVERGENiHBG001595

Family and domain databases

InterProiView protein in InterPro
IPR005817 Wnt
IPR026538 Wnt5a
PANTHERiPTHR12027 PTHR12027, 1 hit
PTHR12027:SF33 PTHR12027:SF33, 1 hit
PfamiView protein in Pfam
PF00110 wnt, 1 hit
SMARTiView protein in SMART
SM00097 WNT1, 1 hit

Sequencei

Sequence statusi: Fragment.

P28117-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SGSCSLKTCW LQLADFRKVG DALKEKYDSA AAMKLNPRGK LVQVNSRFNA
60 70 80 90 100
PTIHDLVYID PSPDYCVRNE STGSLGTQGR LCNKTSEGMD GCELMCCGRG
110
YDQFKTVQTE RCHCKF
Length:116
Mass (Da):12,896
Last modified:December 1, 1992 - v1
Checksum:iF6178E1E8B5134D6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei1161

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91279 Genomic DNA Translation: AAA49257.1

Similar proteinsi

Entry informationi

Entry nameiWNT5A_PLESK
AccessioniPrimary (citable) accession number: P28117
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: May 23, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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