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Protein

Protein Wnt-1

Gene

WNT-1

Organism
Plestiodon skiltonianus (Western skink) (Eumeces skiltonianus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-1
Gene namesi
Name:WNT-1
OrganismiPlestiodon skiltonianus (Western skink) (Eumeces skiltonianus)
Taxonomic identifieri463545 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataScinciformataScincidaeScincinaePlestiodon

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000200603‹1 – ›126Protein Wnt-1Add BLAST›126

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi1O-palmitoleoyl serine; by PORCNBy similarity1
Disulfide bondi92 ↔ 107By similarity
Glycosylationi93N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi123N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Palmitoleoylation is required for efficient binding to frizzled receptors. Palmitoleoylation is necessary for proper trafficking to cell surface (By similarity). Depalmitoleoylated by NOTUM, leading to inhibit Wnt signaling pathway (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiP28113.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Phylogenomic databases

HOVERGENiHBG001595.

Family and domain databases

InterProiView protein in InterPro
IPR005817. Wnt.
IPR009139. Wnt1.
PANTHERiPTHR12027. PTHR12027. 2 hits.
PfamiView protein in Pfam
PF00110. wnt. 1 hit.
PRINTSiPR01841. WNT1PROTEIN.
SMARTiView protein in SMART
SM00097. WNT1. 1 hit.

Sequencei

Sequence statusi: Fragment.

P28113-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SGSCTVKTCW MRLPTFRTVG DFLKDRFDGA SRVIYGNKGS NRASRVELHH
60 70 80 90 100
LEPENPAHKP PSPHDLVYFE KSPNFCTYSG KTGTAGTAGR SCNSSSPALD
110 120
GCELLCCGRG YRTRTQRVTE RCNCTF
Length:126
Mass (Da):13,914
Last modified:December 1, 1992 - v1
Checksum:i1C4FECD85805D8B2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei1261

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91277 Genomic DNA. Translation: AAA49255.1.

Similar proteinsi

Entry informationi

Entry nameiWNT1_PLESK
AccessioniPrimary (citable) accession number: P28113
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: October 25, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families