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Protein

Protein Wnt-10

Gene

WNT-10

Organism
Eptatretus stoutii (Pacific hagfish)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-10
Gene namesi
Name:WNT-10
OrganismiEptatretus stoutii (Pacific hagfish)
Taxonomic identifieri7765 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataCyclostomataHyperotretiMyxiniformesMyxinidaeEptatretinaeEptatretus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000200662‹1 – ›113Protein Wnt-10Add BLAST›113

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi1O-palmitoleoyl serine; by PORCNBy similarity1
Disulfide bondi79 ↔ 94By similarity

Post-translational modificationi

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Lipoprotein

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiP28112.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Phylogenomic databases

HOVERGENiHBG001595.

Family and domain databases

InterProiView protein in InterPro
IPR005817. Wnt.
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiView protein in Pfam
PF00110. wnt. 1 hit.
SMARTiView protein in SMART
SM00097. WNT1. 1 hit.

Sequencei

Sequence statusi: Fragment.

P28112-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SGSCQLKTCW QVSPDFRSVG DTLREKFQSA LFLPLHNGHG GIGGLLVPRD
60 70 80 90 100
TQLVYFERSP TFCEQEDDIG SPGTRGRLCE RTEQGFSGCS SMCCGRGHNV
110
VRETRVERCN CKF
Length:113
Mass (Da):12,563
Last modified:December 1, 1992 - v1
Checksum:i921724E791B33DA8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei1131

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91263 Genomic DNA. Translation: AAA49245.1.

Similar proteinsi

Entry informationi

Entry nameiWNT10_EPTST
AccessioniPrimary (citable) accession number: P28112
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: October 25, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families