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Protein

Protein Wnt-5b

Gene

WNT-5B

Organism
Alopias vulpinus (Thresher shark) (Squalus vulpinus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-5b
Gene namesi
Name:WNT-5B
OrganismiAlopias vulpinus (Thresher shark) (Squalus vulpinus)
Taxonomic identifieri7852 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataChondrichthyesElasmobranchiiGaleomorphiiGaleoideaLamniformesAlopiidaeAlopias

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000200632‹1 – ›116Protein Wnt-5bAdd BLAST›116

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi1O-palmitoleoyl serine; by PORCNBy similarity1
Glycosylationi69N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi82 ↔ 97By similarity
Glycosylationi83N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiP28104.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Phylogenomic databases

HOVERGENiHBG001595.

Family and domain databases

InterProiView protein in InterPro
IPR005817. Wnt.
IPR026538. Wnt5a.
PANTHERiPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF33. PTHR12027:SF33. 1 hit.
PfamiView protein in Pfam
PF00110. wnt. 1 hit.
SMARTiView protein in SMART
SM00097. WNT1. 1 hit.

Sequencei

Sequence statusi: Fragment.

P28104-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SGSCSLKTCW LQLADFRKVG DLLKEKYDSA AAMKITRKGK LELVNSRFNP
60 70 80 90 100
PTPDDLVYLD QSPDYCVKNK STGSLGTMGR LCNKTSEGMD GCELMCCGRG
110
YDQFKTVQVE RCHCKF
Length:116
Mass (Da):12,962
Last modified:December 1, 1992 - v1
Checksum:i1C2F17C5F4705B8B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei1161

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91255 Genomic DNA. Translation: AAA48541.1.

Similar proteinsi

Entry informationi

Entry nameiWNT5B_ALOVU
AccessioniPrimary (citable) accession number: P28104
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: October 25, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families