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P28088

- EDNRB_BOVIN

UniProt

P28088 - EDNRB_BOVIN

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Protein
Endothelin B receptor
Gene
EDNRB
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  1. endothelin receptor activity Source: Ensembl
  2. peptide hormone binding Source: Ensembl

GO - Biological processi

  1. enteric nervous system development Source: Ensembl
  2. enteric smooth muscle cell differentiation Source: Ensembl
  3. macrophage chemotaxis Source: Ensembl
  4. melanocyte differentiation Source: Ensembl
  5. negative regulation of cellular protein metabolic process Source: Ensembl
  6. negative regulation of neuron maturation Source: Ensembl
  7. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  8. neural crest cell migration Source: Ensembl
  9. peripheral nervous system development Source: Ensembl
  10. posterior midgut development Source: Ensembl
  11. regulation of blood pressure Source: Ensembl
  12. regulation of pH Source: Ensembl
  13. vein smooth muscle contraction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_209521. G alpha (q) signalling events.
REACT_219025. Peptide ligand-binding receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin B receptor
Short name:
ET-B
Short name:
ET-BR
Alternative name(s):
Endothelin receptor non-selective type
Gene namesi
Name:EDNRB
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 12

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 10074Extracellular Reviewed prediction
Add
BLAST
Transmembranei101 – 12525Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini126 – 13611Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei137 – 16226Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini163 – 17412Extracellular Reviewed prediction
Add
BLAST
Transmembranei175 – 19622Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini197 – 21721Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei218 – 24225Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini243 – 27028Extracellular Reviewed prediction
Add
BLAST
Transmembranei271 – 29525Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini296 – 32328Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei324 – 34926Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini350 – 36112Extracellular Reviewed prediction
Add
BLAST
Transmembranei362 – 38827Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini389 – 44153Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 26262 Publications
Add
BLAST
Chaini27 – 441415Endothelin B receptor
PRO_0000012726Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi173 ↔ 254 By similarity
Modified residuei304 – 3041Phosphoserine1 Publication
Lipidationi402 – 4021S-palmitoyl cysteine1 Publication
Lipidationi404 – 4041S-palmitoyl cysteine1 Publication
Modified residuei418 – 4181Phosphoserine1 Publication
Modified residuei434 – 4341Phosphoserine Inferred
Modified residuei435 – 4351Phosphoserine Inferred
Modified residuei438 – 4381Phosphotyrosine1 Publication
Modified residuei439 – 4391Phosphoserine1 Publication
Modified residuei440 – 4401Phosphoserine1 Publication
Modified residuei441 – 4411Phosphoserine1 Publication

Post-translational modificationi

It is not sure whether phosphorylation is on Ser-434 or Ser-435.

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PRIDEiP28088.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000043840.

Structurei

3D structure databases

ProteinModelPortaliP28088.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG278704.
GeneTreeiENSGT00690000101856.
HOGENOMiHOG000272623.
HOVERGENiHBG051443.
InParanoidiP28088.
KOiK04198.
OMAiLHIVIDI.
OrthoDBiEOG7HHWS4.
TreeFamiTF331292.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000499. Endthln_rcpt.
IPR001112. ETB_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00571. ENDOTHELINBR.
PR00366. ENDOTHELINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28088-1 [UniParc]FASTAAdd to Basket

« Hide

MQPLPSLCGR ALVALILACG VAGIQAEERE FPPAGATQPL PGTGEMMETP    50
TETSWPGRSN ASDPRSSATP QIPRGGRMAG IPPRTPPPCD GPIEIKETFK 100
YINTVVSCLV FVLGIIGNST LLRIIYKNKC MRNGPNILIA SLALGDLLHI 150
IIDIPINTYK LLAKDWPFGV EMCKLVPFIQ KASVGITVLS LCALSIDRYR 200
AVASWSRIKG IGVPKWTAVE IVLIWVVSVV LAVPEAVGFD IITSDHIGNK 250
LRICLLHPTQ KTAFMQFYKT AKDWWLFSFY FCLPLAITAL FYTLMTCEML 300
RKKSGMQIAL NDHLKQRREV AKTVFCLVLV FALCWLPLHL SRILKLTLYD 350
QHDPRRCEFL SFLLVLDYIG INMASLNSCI NPIALYLVSK RFKNCFKSCL 400
CCWCQSFEEK QSLEEKQSCL KFKANDHGYD NFRSSNKYSS S 441
Length:441
Mass (Da):49,371
Last modified:August 1, 1992 - v1
Checksum:iF634462C544DB0D2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D10994 Genomic DNA. Translation: BAA01762.1.
D90456 mRNA. Translation: BAA14422.1.
BC120256 mRNA. Translation: AAI20257.1.
PIRiA41591.
RefSeqiNP_776734.1. NM_174309.2.
XP_005213931.1. XM_005213874.1.
UniGeneiBt.487.

Genome annotation databases

EnsembliENSBTAT00000006979; ENSBTAP00000006979; ENSBTAG00000005299.
GeneIDi281750.
KEGGibta:281750.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D10994 Genomic DNA. Translation: BAA01762.1 .
D90456 mRNA. Translation: BAA14422.1 .
BC120256 mRNA. Translation: AAI20257.1 .
PIRi A41591.
RefSeqi NP_776734.1. NM_174309.2.
XP_005213931.1. XM_005213874.1.
UniGenei Bt.487.

3D structure databases

ProteinModelPortali P28088.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000043840.

Chemistry

BindingDBi P28088.
ChEMBLi CHEMBL4401.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PRIDEi P28088.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000006979 ; ENSBTAP00000006979 ; ENSBTAG00000005299 .
GeneIDi 281750.
KEGGi bta:281750.

Organism-specific databases

CTDi 1910.

Phylogenomic databases

eggNOGi NOG278704.
GeneTreei ENSGT00690000101856.
HOGENOMi HOG000272623.
HOVERGENi HBG051443.
InParanoidi P28088.
KOi K04198.
OMAi LHIVIDI.
OrthoDBi EOG7HHWS4.
TreeFami TF331292.

Enzyme and pathway databases

Reactomei REACT_209521. G alpha (q) signalling events.
REACT_219025. Peptide ligand-binding receptors.

Miscellaneous databases

NextBioi 20805669.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000499. Endthln_rcpt.
IPR001112. ETB_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00571. ENDOTHELINBR.
PR00366. ENDOTHELINR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure of bovine endothelin ETB receptor and identification of signal peptidase and metal proteinase cleavage sites."
    Saito Y., Mizuno T., Itakura M., Suzuki Y., Ito T., Hagiwara H., Hirose S.
    J. Biol. Chem. 266:23433-23437(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], PARTIAL PROTEIN SEQUENCE.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Thymus.
  3. "Purification and characterization of bovine lung endothelin receptor."
    Kozuka M., Ito T., Hirose S., Lodhi K.M., Hagiwara H.
    J. Biol. Chem. 266:16892-16896(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 124-127; 262-269; 304-315; 417-421 AND 424-432.
    Tissue: Lung.
  4. "Isolation of the endothelin B receptor from bovine lung. Structure, signal sequence, and binding site."
    Hick S., Heidemann I., Soskic V., Muller-Esterl W., Godovac-Zimmermann J.
    Eur. J. Biochem. 234:251-257(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE.
    Tissue: Lung.
  5. "Post-translational modifications of endothelin receptor B from bovine lungs analyzed by mass spectrometry."
    Roos M., Soskic V., Poznanovic S., Godovac-Zimmermann J.
    J. Biol. Chem. 273:924-931(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 27-32, PALMITOYLATION AT CYS-402 AND CYS-404, PHOSPHORYLATION AT SER-304; SER-418; TYR-438; SER-439; SER-440 AND SER-441, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Lung.

Entry informationi

Entry nameiEDNRB_BOVIN
AccessioniPrimary (citable) accession number: P28088
Secondary accession number(s): Q0VCB3, Q9TSB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: September 3, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

N-terminal sequencing (1 Publication) indicates the presence of a signal peptide but an unprocessed form where the signal sequence is not cleaved has also been detected (1 Publication). It is unclear if this exists in vivo.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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