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P28088

- EDNRB_BOVIN

UniProt

P28088 - EDNRB_BOVIN

Protein

Endothelin B receptor

Gene

EDNRB

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Aug 1992)
      Previous versions | rss
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    Functioni

    Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

    GO - Molecular functioni

    1. endothelin receptor activity Source: Ensembl
    2. peptide hormone binding Source: Ensembl

    GO - Biological processi

    1. enteric nervous system development Source: Ensembl
    2. enteric smooth muscle cell differentiation Source: Ensembl
    3. macrophage chemotaxis Source: Ensembl
    4. melanocyte differentiation Source: Ensembl
    5. negative regulation of cellular protein metabolic process Source: Ensembl
    6. negative regulation of neuron maturation Source: Ensembl
    7. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    8. neural crest cell migration Source: Ensembl
    9. peripheral nervous system development Source: Ensembl
    10. posterior midgut development Source: Ensembl
    11. regulation of blood pressure Source: Ensembl
    12. regulation of pH Source: Ensembl
    13. vein smooth muscle contraction Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_209521. G alpha (q) signalling events.
    REACT_219025. Peptide ligand-binding receptors.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endothelin B receptor
    Short name:
    ET-B
    Short name:
    ET-BR
    Alternative name(s):
    Endothelin receptor non-selective type
    Gene namesi
    Name:EDNRB
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 12

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 26262 PublicationsAdd
    BLAST
    Chaini27 – 441415Endothelin B receptorPRO_0000012726Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi173 ↔ 254PROSITE-ProRule annotation
    Modified residuei304 – 3041Phosphoserine1 Publication
    Lipidationi402 – 4021S-palmitoyl cysteine1 Publication
    Lipidationi404 – 4041S-palmitoyl cysteine1 Publication
    Modified residuei418 – 4181Phosphoserine1 Publication
    Modified residuei434 – 4341PhosphoserineCurated
    Modified residuei435 – 4351PhosphoserineCurated
    Modified residuei438 – 4381Phosphotyrosine1 Publication
    Modified residuei439 – 4391Phosphoserine1 Publication
    Modified residuei440 – 4401Phosphoserine1 Publication
    Modified residuei441 – 4411Phosphoserine1 Publication

    Post-translational modificationi

    It is not sure whether phosphorylation is on Ser-434 or Ser-435.1 Publication

    Keywords - PTMi

    Disulfide bond, Lipoprotein, Palmitate, Phosphoprotein

    Proteomic databases

    PRIDEiP28088.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000043840.

    Structurei

    3D structure databases

    ProteinModelPortaliP28088.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini27 – 10074ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini126 – 13611CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini163 – 17412ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini197 – 21721CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini243 – 27028ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini296 – 32328CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini350 – 36112ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini389 – 44153CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei101 – 12525Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei137 – 16226Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei175 – 19622Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei218 – 24225Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei271 – 29525Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei324 – 34926Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei362 – 38827Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG278704.
    GeneTreeiENSGT00690000101856.
    HOGENOMiHOG000272623.
    HOVERGENiHBG051443.
    InParanoidiP28088.
    KOiK04198.
    OMAiLHIVIDI.
    OrthoDBiEOG7HHWS4.
    TreeFamiTF331292.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000499. Endthln_rcpt.
    IPR001112. ETB_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00571. ENDOTHELINBR.
    PR00366. ENDOTHELINR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P28088-1 [UniParc]FASTAAdd to Basket

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    MQPLPSLCGR ALVALILACG VAGIQAEERE FPPAGATQPL PGTGEMMETP    50
    TETSWPGRSN ASDPRSSATP QIPRGGRMAG IPPRTPPPCD GPIEIKETFK 100
    YINTVVSCLV FVLGIIGNST LLRIIYKNKC MRNGPNILIA SLALGDLLHI 150
    IIDIPINTYK LLAKDWPFGV EMCKLVPFIQ KASVGITVLS LCALSIDRYR 200
    AVASWSRIKG IGVPKWTAVE IVLIWVVSVV LAVPEAVGFD IITSDHIGNK 250
    LRICLLHPTQ KTAFMQFYKT AKDWWLFSFY FCLPLAITAL FYTLMTCEML 300
    RKKSGMQIAL NDHLKQRREV AKTVFCLVLV FALCWLPLHL SRILKLTLYD 350
    QHDPRRCEFL SFLLVLDYIG INMASLNSCI NPIALYLVSK RFKNCFKSCL 400
    CCWCQSFEEK QSLEEKQSCL KFKANDHGYD NFRSSNKYSS S 441
    Length:441
    Mass (Da):49,371
    Last modified:August 1, 1992 - v1
    Checksum:iF634462C544DB0D2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10994 Genomic DNA. Translation: BAA01762.1.
    D90456 mRNA. Translation: BAA14422.1.
    BC120256 mRNA. Translation: AAI20257.1.
    PIRiA41591.
    RefSeqiNP_776734.1. NM_174309.2.
    XP_005213931.1. XM_005213874.1.
    UniGeneiBt.487.

    Genome annotation databases

    EnsembliENSBTAT00000006979; ENSBTAP00000006979; ENSBTAG00000005299.
    GeneIDi281750.
    KEGGibta:281750.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10994 Genomic DNA. Translation: BAA01762.1 .
    D90456 mRNA. Translation: BAA14422.1 .
    BC120256 mRNA. Translation: AAI20257.1 .
    PIRi A41591.
    RefSeqi NP_776734.1. NM_174309.2.
    XP_005213931.1. XM_005213874.1.
    UniGenei Bt.487.

    3D structure databases

    ProteinModelPortali P28088.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000043840.

    Chemistry

    BindingDBi P28088.
    ChEMBLi CHEMBL4401.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PRIDEi P28088.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000006979 ; ENSBTAP00000006979 ; ENSBTAG00000005299 .
    GeneIDi 281750.
    KEGGi bta:281750.

    Organism-specific databases

    CTDi 1910.

    Phylogenomic databases

    eggNOGi NOG278704.
    GeneTreei ENSGT00690000101856.
    HOGENOMi HOG000272623.
    HOVERGENi HBG051443.
    InParanoidi P28088.
    KOi K04198.
    OMAi LHIVIDI.
    OrthoDBi EOG7HHWS4.
    TreeFami TF331292.

    Enzyme and pathway databases

    Reactomei REACT_209521. G alpha (q) signalling events.
    REACT_219025. Peptide ligand-binding receptors.

    Miscellaneous databases

    NextBioi 20805669.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000499. Endthln_rcpt.
    IPR001112. ETB_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00571. ENDOTHELINBR.
    PR00366. ENDOTHELINR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure of bovine endothelin ETB receptor and identification of signal peptidase and metal proteinase cleavage sites."
      Saito Y., Mizuno T., Itakura M., Suzuki Y., Ito T., Hagiwara H., Hirose S.
      J. Biol. Chem. 266:23433-23437(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], PARTIAL PROTEIN SEQUENCE.
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Thymus.
    3. "Purification and characterization of bovine lung endothelin receptor."
      Kozuka M., Ito T., Hirose S., Lodhi K.M., Hagiwara H.
      J. Biol. Chem. 266:16892-16896(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 124-127; 262-269; 304-315; 417-421 AND 424-432.
      Tissue: Lung.
    4. "Isolation of the endothelin B receptor from bovine lung. Structure, signal sequence, and binding site."
      Hick S., Heidemann I., Soskic V., Muller-Esterl W., Godovac-Zimmermann J.
      Eur. J. Biochem. 234:251-257(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL PROTEIN SEQUENCE.
      Tissue: Lung.
    5. "Post-translational modifications of endothelin receptor B from bovine lungs analyzed by mass spectrometry."
      Roos M., Soskic V., Poznanovic S., Godovac-Zimmermann J.
      J. Biol. Chem. 273:924-931(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 27-32, PALMITOYLATION AT CYS-402 AND CYS-404, PHOSPHORYLATION AT SER-304; SER-418; TYR-438; SER-439; SER-440 AND SER-441, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Lung.

    Entry informationi

    Entry nameiEDNRB_BOVIN
    AccessioniPrimary (citable) accession number: P28088
    Secondary accession number(s): Q0VCB3, Q9TSB9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    N-terminal sequencing (PubMed:9422751) indicates the presence of a signal peptide but an unprocessed form where the signal sequence is not cleaved has also been detected (PubMed:8529649). It is unclear if this exists in vivo.2 Publications

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3