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Protein

Endothelin B receptor

Gene

EDNRB

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-BTA-375276. Peptide ligand-binding receptors.
R-BTA-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin B receptor
Short name:
ET-B
Short name:
ET-BR
Alternative name(s):
Endothelin receptor non-selective type
Gene namesi
Name:EDNRB
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 12

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 100ExtracellularSequence analysisAdd BLAST74
Transmembranei101 – 125Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini126 – 136CytoplasmicSequence analysisAdd BLAST11
Transmembranei137 – 162Helical; Name=2Sequence analysisAdd BLAST26
Topological domaini163 – 174ExtracellularSequence analysisAdd BLAST12
Transmembranei175 – 196Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini197 – 217CytoplasmicSequence analysisAdd BLAST21
Transmembranei218 – 242Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini243 – 270ExtracellularSequence analysisAdd BLAST28
Transmembranei271 – 295Helical; Name=5Sequence analysisAdd BLAST25
Topological domaini296 – 323CytoplasmicSequence analysisAdd BLAST28
Transmembranei324 – 349Helical; Name=6Sequence analysisAdd BLAST26
Topological domaini350 – 361ExtracellularSequence analysisAdd BLAST12
Transmembranei362 – 388Helical; Name=7Sequence analysisAdd BLAST27
Topological domaini389 – 441CytoplasmicSequence analysisAdd BLAST53

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4401.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 262 PublicationsAdd BLAST26
ChainiPRO_000001272627 – 441Endothelin B receptorAdd BLAST415

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi173 ↔ 254PROSITE-ProRule annotation
Modified residuei304Phosphoserine1 Publication1
Lipidationi402S-palmitoyl cysteine1 Publication1
Lipidationi404S-palmitoyl cysteine1 Publication1
Modified residuei418Phosphoserine1 Publication1
Modified residuei434PhosphoserineCurated1
Modified residuei435PhosphoserineCurated1
Modified residuei438Phosphotyrosine1 Publication1
Modified residuei439Phosphoserine1 Publication1
Modified residuei440Phosphoserine1 Publication1
Modified residuei441Phosphoserine1 Publication1

Post-translational modificationi

It is not sure whether phosphorylation is on Ser-434 or Ser-435.1 Publication

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP28088.
PRIDEiP28088.

PTM databases

iPTMnetiP28088.

Expressioni

Gene expression databases

BgeeiENSBTAG00000005299.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000006979.

Chemistry databases

BindingDBiP28088.

Structurei

3D structure databases

ProteinModelPortaliP28088.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119177.
HOGENOMiHOG000272623.
HOVERGENiHBG051443.
InParanoidiP28088.
KOiK04198.
OMAiTAEIMTP.
OrthoDBiEOG091G0CJV.
TreeFamiTF331292.

Family and domain databases

InterProiIPR000499. Endthln_rcpt.
IPR001112. ETB_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00571. ENDOTHELINBR.
PR00366. ENDOTHELINR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28088-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPLPSLCGR ALVALILACG VAGIQAEERE FPPAGATQPL PGTGEMMETP
60 70 80 90 100
TETSWPGRSN ASDPRSSATP QIPRGGRMAG IPPRTPPPCD GPIEIKETFK
110 120 130 140 150
YINTVVSCLV FVLGIIGNST LLRIIYKNKC MRNGPNILIA SLALGDLLHI
160 170 180 190 200
IIDIPINTYK LLAKDWPFGV EMCKLVPFIQ KASVGITVLS LCALSIDRYR
210 220 230 240 250
AVASWSRIKG IGVPKWTAVE IVLIWVVSVV LAVPEAVGFD IITSDHIGNK
260 270 280 290 300
LRICLLHPTQ KTAFMQFYKT AKDWWLFSFY FCLPLAITAL FYTLMTCEML
310 320 330 340 350
RKKSGMQIAL NDHLKQRREV AKTVFCLVLV FALCWLPLHL SRILKLTLYD
360 370 380 390 400
QHDPRRCEFL SFLLVLDYIG INMASLNSCI NPIALYLVSK RFKNCFKSCL
410 420 430 440
CCWCQSFEEK QSLEEKQSCL KFKANDHGYD NFRSSNKYSS S
Length:441
Mass (Da):49,371
Last modified:August 1, 1992 - v1
Checksum:iF634462C544DB0D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10994 Genomic DNA. Translation: BAA01762.1.
D90456 mRNA. Translation: BAA14422.1.
BC120256 mRNA. Translation: AAI20257.1.
PIRiA41591.
RefSeqiNP_776734.1. NM_174309.2.
XP_005213931.1. XM_005213874.3.
UniGeneiBt.487.

Genome annotation databases

EnsembliENSBTAT00000006979; ENSBTAP00000006979; ENSBTAG00000005299.
GeneIDi281750.
KEGGibta:281750.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10994 Genomic DNA. Translation: BAA01762.1.
D90456 mRNA. Translation: BAA14422.1.
BC120256 mRNA. Translation: AAI20257.1.
PIRiA41591.
RefSeqiNP_776734.1. NM_174309.2.
XP_005213931.1. XM_005213874.3.
UniGeneiBt.487.

3D structure databases

ProteinModelPortaliP28088.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000006979.

Chemistry databases

BindingDBiP28088.
ChEMBLiCHEMBL4401.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP28088.

Proteomic databases

PaxDbiP28088.
PRIDEiP28088.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000006979; ENSBTAP00000006979; ENSBTAG00000005299.
GeneIDi281750.
KEGGibta:281750.

Organism-specific databases

CTDi1910.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119177.
HOGENOMiHOG000272623.
HOVERGENiHBG051443.
InParanoidiP28088.
KOiK04198.
OMAiTAEIMTP.
OrthoDBiEOG091G0CJV.
TreeFamiTF331292.

Enzyme and pathway databases

ReactomeiR-BTA-375276. Peptide ligand-binding receptors.
R-BTA-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiP28088.

Gene expression databases

BgeeiENSBTAG00000005299.

Family and domain databases

InterProiIPR000499. Endthln_rcpt.
IPR001112. ETB_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00571. ENDOTHELINBR.
PR00366. ENDOTHELINR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEDNRB_BOVIN
AccessioniPrimary (citable) accession number: P28088
Secondary accession number(s): Q0VCB3, Q9TSB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: September 7, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

N-terminal sequencing (PubMed:9422751) indicates the presence of a signal peptide but an unprocessed form where the signal sequence is not cleaved has also been detected (PubMed:8529649). It is unclear if this exists in vivo.2 Publications

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.