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Protein

Endothelin receptor type B

Gene

EDNRB

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Caution

N-terminal sequencing (PubMed:9422751) indicates the presence of a signal peptide but an unprocessed form where the signal sequence is not cleaved has also been detected (PubMed:8529649). It is unclear if this exists in vivo.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-BTA-375276 Peptide ligand-binding receptors
R-BTA-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin receptor type BCurated
Short name:
ET-B
Short name:
ET-BR
Alternative name(s):
Endothelin receptor non-selective type
Gene namesi
Name:EDNRB
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 12

Organism-specific databases

VGNCiVGNC:28330 EDNRB

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 100ExtracellularSequence analysisAdd BLAST74
Transmembranei101 – 125Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini126 – 136CytoplasmicSequence analysisAdd BLAST11
Transmembranei137 – 162Helical; Name=2Sequence analysisAdd BLAST26
Topological domaini163 – 174ExtracellularSequence analysisAdd BLAST12
Transmembranei175 – 196Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini197 – 217CytoplasmicSequence analysisAdd BLAST21
Transmembranei218 – 242Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini243 – 270ExtracellularSequence analysisAdd BLAST28
Transmembranei271 – 295Helical; Name=5Sequence analysisAdd BLAST25
Topological domaini296 – 323CytoplasmicSequence analysisAdd BLAST28
Transmembranei324 – 349Helical; Name=6Sequence analysisAdd BLAST26
Topological domaini350 – 361ExtracellularSequence analysisAdd BLAST12
Transmembranei362 – 388Helical; Name=7Sequence analysisAdd BLAST27
Topological domaini389 – 441CytoplasmicSequence analysisAdd BLAST53

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4401

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 262 PublicationsAdd BLAST26
ChainiPRO_000001272627 – 441Endothelin receptor type BAdd BLAST415

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi173 ↔ 254PROSITE-ProRule annotation
Modified residuei304Phosphoserine1 Publication1
Lipidationi402S-palmitoyl cysteine1 Publication1
Lipidationi404S-palmitoyl cysteine1 Publication1
Modified residuei418Phosphoserine1 Publication1
Modified residuei434PhosphoserineCurated1
Modified residuei435PhosphoserineCurated1
Modified residuei438Phosphotyrosine1 Publication1
Modified residuei439Phosphoserine1 Publication1
Modified residuei440Phosphoserine1 Publication1
Modified residuei441Phosphoserine1 Publication1

Post-translational modificationi

It is not sure whether phosphorylation is on Ser-434 or Ser-435.1 Publication

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP28088
PRIDEiP28088

PTM databases

iPTMnetiP28088

Expressioni

Gene expression databases

BgeeiENSBTAG00000005299

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000006979

Chemistry databases

BindingDBiP28088

Structurei

3D structure databases

ProteinModelPortaliP28088
SMRiP28088
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119177
HOGENOMiHOG000272623
HOVERGENiHBG051443
InParanoidiP28088
KOiK04198
OMAiTAEIMTP
OrthoDBiEOG091G0CJV
TreeFamiTF331292

Family and domain databases

InterProiView protein in InterPro
IPR000499 Endthln_rcpt
IPR001112 ETB_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00571 ENDOTHELINBR
PR00366 ENDOTHELINR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28088-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPLPSLCGR ALVALILACG VAGIQAEERE FPPAGATQPL PGTGEMMETP
60 70 80 90 100
TETSWPGRSN ASDPRSSATP QIPRGGRMAG IPPRTPPPCD GPIEIKETFK
110 120 130 140 150
YINTVVSCLV FVLGIIGNST LLRIIYKNKC MRNGPNILIA SLALGDLLHI
160 170 180 190 200
IIDIPINTYK LLAKDWPFGV EMCKLVPFIQ KASVGITVLS LCALSIDRYR
210 220 230 240 250
AVASWSRIKG IGVPKWTAVE IVLIWVVSVV LAVPEAVGFD IITSDHIGNK
260 270 280 290 300
LRICLLHPTQ KTAFMQFYKT AKDWWLFSFY FCLPLAITAL FYTLMTCEML
310 320 330 340 350
RKKSGMQIAL NDHLKQRREV AKTVFCLVLV FALCWLPLHL SRILKLTLYD
360 370 380 390 400
QHDPRRCEFL SFLLVLDYIG INMASLNSCI NPIALYLVSK RFKNCFKSCL
410 420 430 440
CCWCQSFEEK QSLEEKQSCL KFKANDHGYD NFRSSNKYSS S
Length:441
Mass (Da):49,371
Last modified:August 1, 1992 - v1
Checksum:iF634462C544DB0D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10994 Genomic DNA Translation: BAA01762.1
D90456 mRNA Translation: BAA14422.1
BC120256 mRNA Translation: AAI20257.1
PIRiA41591
RefSeqiNP_776734.1, NM_174309.2
XP_005213931.1, XM_005213874.3
UniGeneiBt.487

Genome annotation databases

EnsembliENSBTAT00000006979; ENSBTAP00000006979; ENSBTAG00000005299
GeneIDi281750
KEGGibta:281750

Similar proteinsi

Entry informationi

Entry nameiEDNRB_BOVIN
AccessioniPrimary (citable) accession number: P28088
Secondary accession number(s): Q0VCB3, Q9TSB9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: March 28, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome