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Protein

Class II histocompatibility antigen, M alpha chain

Gene

H2-DMa

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a critical role in catalyzing the release of class II HLA-associated invariant chain-derived peptides (CLIP) from newly synthesized class II HLA molecules and freeing the peptide binding site for acquisition of antigenic peptides.

GO - Molecular functioni

GO - Biological processi

  • antigen processing and presentation Source: MGI
  • antigen processing and presentation of exogenous peptide antigen via MHC class II Source: MGI
  • chaperone mediated protein folding requiring cofactor Source: MGI
  • immunoglobulin mediated immune response Source: MGI
  • inner ear development Source: MGI
  • peptide antigen assembly with MHC class II protein complex Source: MGI
  • positive regulation of germinal center formation Source: BHF-UCL
  • positive regulation of humoral immune response Source: BHF-UCL
  • positive regulation of immune response Source: MGI
  • positive regulation of T cell differentiation Source: MGI
  • positive thymic T cell selection Source: MGI
  • protein complex assembly Source: MGI
  • protein transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Class II histocompatibility antigen, M alpha chain
Gene namesi
Name:H2-DMa
Synonyms:H2-Ma, Ma
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:95921. H2-DMa.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 231205LumenalSequence analysisAdd
BLAST
Transmembranei232 – 25221HelicalSequence analysisAdd
BLAST
Topological domaini253 – 2619CytoplasmicSequence analysis

GO - Cellular componenti

  • cell surface Source: MGI
  • endosome membrane Source: MGI
  • extracellular exosome Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • intracellular Source: MGI
  • late endosome Source: MGI
  • late endosome membrane Source: UniProtKB-SubCell
  • lysosomal membrane Source: MGI
  • lysosome Source: MGI
  • membrane Source: MGI
  • MHC class II protein complex Source: MGI
  • multivesicular body Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Lysosome, Membrane, MHC II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 261235Class II histocompatibility antigen, M alpha chainPRO_0000018959Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi41 – 411N-linked (GlcNAc...)1 Publication
Disulfide bondi50 ↔ 105PROSITE-ProRule annotation1 Publication
Disulfide bondi147 ↔ 202PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP28078.
PRIDEiP28078.

PTM databases

PhosphoSiteiP28078.

Expressioni

Gene expression databases

CleanExiMM_H2-DMA.

Interactioni

Subunit structurei

Heterodimer of an alpha chain (DMA) and a beta chain (DMB).1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiP28078. 1 interaction.
STRINGi10090.ENSMUSP00000037088.

Structurei

Secondary structure

1
261
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi41 – 6323Combined sources
Beta strandi66 – 727Combined sources
Turni73 – 764Combined sources
Beta strandi77 – 826Combined sources
Turni83 – 864Combined sources
Helixi87 – 904Combined sources
Helixi95 – 11016Combined sources
Helixi112 – 1165Combined sources
Beta strandi128 – 1358Combined sources
Beta strandi143 – 15513Combined sources
Beta strandi157 – 1637Combined sources
Beta strandi166 – 1683Combined sources
Beta strandi175 – 1795Combined sources
Turni180 – 1823Combined sources
Beta strandi183 – 19210Combined sources
Beta strandi200 – 2067Combined sources
Turni207 – 2093Combined sources
Beta strandi212 – 2176Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K8IX-ray3.10A30-220[»]
ProteinModelPortaliP28078.
SMRiP28078. Positions 40-220.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP28078.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini114 – 215102Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni27 – 12498Alpha-1Add
BLAST
Regioni125 – 21793Alpha-2Add
BLAST
Regioni218 – 23114Connecting peptideSequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IR26. Eukaryota.
ENOG410YJDD. LUCA.
HOGENOMiHOG000126882.
HOVERGENiHBG001688.
InParanoidiP28078.
PhylomeDBiP28078.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28078-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHEQKSGAV LLRLLRLLWL LPHSWAVLEA STPVLWDDPQ NHTFRHTLFC
60 70 80 90 100
QDGIPNIGLS ETYDEDELFS FDFSQNTRVP RLPDFAEWAQ GQGDASAIAF
110 120 130 140 150
GKSFCEMLMR EVSPKLEGQI PVSRGLSVAE VFTLKPLEFG KPNTLVCFIS
160 170 180 190 200
NLFPPTLTVN WQLHSAPVEG ASPTSISAVD GLTFQAFSYL NFTPEPFDLY
210 220 230 240 250
SCTVTHEIDR YTAIAYWVPQ NALPSDLLEN ALCGVAFALG VLGTIIGIVF
260
FLCSQRPCSG D
Length:261
Mass (Da):28,950
Last modified:August 1, 1992 - v1
Checksum:iC8403C76CB54A55C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62742 mRNA. Translation: CAA44604.1.
CCDSiCCDS37579.1.
PIRiS17888.
UniGeneiMm.16373.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62742 mRNA. Translation: CAA44604.1.
CCDSiCCDS37579.1.
PIRiS17888.
UniGeneiMm.16373.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K8IX-ray3.10A30-220[»]
ProteinModelPortaliP28078.
SMRiP28078. Positions 40-220.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP28078. 1 interaction.
STRINGi10090.ENSMUSP00000037088.

PTM databases

PhosphoSiteiP28078.

Proteomic databases

PaxDbiP28078.
PRIDEiP28078.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:95921. H2-DMa.

Phylogenomic databases

eggNOGiENOG410IR26. Eukaryota.
ENOG410YJDD. LUCA.
HOGENOMiHOG000126882.
HOVERGENiHBG001688.
InParanoidiP28078.
PhylomeDBiP28078.

Miscellaneous databases

ChiTaRSiH2-DMa. mouse.
EvolutionaryTraceiP28078.
PROiP28078.
SOURCEiSearch...

Gene expression databases

CleanExiMM_H2-DMA.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDMA_MOUSE
AccessioniPrimary (citable) accession number: P28078
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: November 11, 2015
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.