UniProtKB - P28068 (DMB_HUMAN)
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Protein
HLA class II histocompatibility antigen, DM beta chain
Gene
HLA-DMB
Organism
Homo sapiens (Human)
Status
Functioni
Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.3 Publications
GO - Molecular functioni
- MHC class II protein complex binding Source: UniProtKB
GO - Biological processi
- antigen processing and presentation of exogenous peptide antigen via MHC class II Source: UniProtKB
- immune response Source: InterPro
- MHC class II protein complex assembly Source: UniProtKB
- peptide antigen assembly with MHC class II protein complex Source: UniProtKB
- positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell Source: UniProtKB
- positive regulation of T cell proliferation Source: UniProtKB
Keywordsi
Biological process | Immunity |
Enzyme and pathway databases
Reactomei | R-HSA-2132295. MHC class II antigen presentation. |
SIGNORi | P28068. |
Names & Taxonomyi
Protein namesi | Recommended name: HLA class II histocompatibility antigen, DM beta chainAlternative name(s): MHC class II antigen DMB Really interesting new gene 7 protein |
Gene namesi | Name:HLA-DMB Synonyms:DMB, RING7 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000242574.8. |
HGNCi | HGNC:4935. HLA-DMB. |
MIMi | 142856. gene. |
neXtProti | NX_P28068. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 19 – 218 | LumenalSequence analysisAdd BLAST | 200 | |
Transmembranei | 219 – 239 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 240 – 263 | CytoplasmicSequence analysisAdd BLAST | 24 |
Keywords - Cellular componenti
Endosome, Lysosome, Membrane, MHC IIPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 248 | Y → A: Abolishes targeting to endosomes and results in relocalization to the cell membrane. 1 Publication | 1 | |
Mutagenesisi | 251 | L → A: Abolishes targeting to endosomes and results in relocalization to the cell membrane. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 3109. |
PharmGKBi | PA35059. |
Polymorphism and mutation databases
BioMutai | HLA-DMB. |
DMDMi | 133160. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_0000018960 | 19 – 263 | HLA class II histocompatibility antigen, DM beta chainAdd BLAST | 245 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 29 ↔ 97 | |||
Glycosylationi | 110 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 135 ↔ 192 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P28068. |
PeptideAtlasi | P28068. |
PRIDEi | P28068. |
PTM databases
iPTMneti | P28068. |
PhosphoSitePlusi | P28068. |
Expressioni
Gene expression databases
Bgeei | ENSG00000242574. |
CleanExi | HS_HLA-DMB. |
ExpressionAtlasi | P28068. baseline and differential. |
Genevisiblei | P28068. HS. |
Organism-specific databases
HPAi | HPA012298. |
Interactioni
Subunit structurei
Heterodimer of an alpha chain (DMA) and a beta chain (DMB).2 Publications
Binary interactionsi
GO - Molecular functioni
- MHC class II protein complex binding Source: UniProtKB
Protein-protein interaction databases
BioGridi | 109354. 11 interactors. |
DIPi | DIP-6185N. |
IntActi | P28068. 10 interactors. |
MINTi | P28068. |
STRINGi | 9606.ENSP00000398890. |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Beta strandi | 22 – 32 | Combined sources | 11 | |
Beta strandi | 33 – 35 | Combined sources | 3 | |
Beta strandi | 37 – 46 | Combined sources | 10 | |
Beta strandi | 49 – 55 | Combined sources | 7 | |
Turni | 56 – 59 | Combined sources | 4 | |
Beta strandi | 60 – 63 | Combined sources | 4 | |
Beta strandi | 67 – 69 | Combined sources | 3 | |
Helixi | 70 – 81 | Combined sources | 12 | |
Helixi | 84 – 91 | Combined sources | 8 | |
Helixi | 93 – 109 | Combined sources | 17 | |
Beta strandi | 116 – 121 | Combined sources | 6 | |
Beta strandi | 128 – 143 | Combined sources | 16 | |
Beta strandi | 146 – 151 | Combined sources | 6 | |
Beta strandi | 154 – 156 | Combined sources | 3 | |
Beta strandi | 170 – 172 | Combined sources | 3 | |
Beta strandi | 174 – 182 | Combined sources | 9 | |
Beta strandi | 190 – 195 | Combined sources | 6 | |
Beta strandi | 199 – 201 | Combined sources | 3 | |
Beta strandi | 203 – 207 | Combined sources | 5 | |
Helixi | 212 – 214 | Combined sources | 3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1HDM | X-ray | 2.50 | B | 19-218 | [»] | |
2BC4 | X-ray | 2.27 | B/D | 19-218 | [»] | |
4FQX | X-ray | 2.60 | D | 19-211 | [»] | |
4GBX | X-ray | 3.00 | D | 19-211 | [»] | |
4I0P | X-ray | 3.20 | B/F | 21-211 | [»] | |
ProteinModelPortali | P28068. | |||||
SMRi | P28068. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P28068. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 114 – 208 | Ig-like C1-typeAdd BLAST | 95 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 19 – 112 | Beta-1Add BLAST | 94 | |
Regioni | 113 – 207 | Beta-2Add BLAST | 95 | |
Regioni | 208 – 218 | Connecting peptideSequence analysisAdd BLAST | 11 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 248 – 251 | YXXZ motif | 4 |
Domaini
The YXXZ (Tyr-Xaa-Xaa-Zaa, where Zaa is a hydrophobic residue) motif mediates the targeting to the lysosomal compartments.
Sequence similaritiesi
Belongs to the MHC class II family.Curated
Keywords - Domaini
Immunoglobulin domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IFNH. Eukaryota. ENOG410YU9X. LUCA. |
HOVERGENi | HBG007327. |
InParanoidi | P28068. |
KOi | K06752. |
OrthoDBi | EOG091G0G84. |
PhylomeDBi | P28068. |
TreeFami | TF335727. |
Family and domain databases
Gene3Di | 2.60.40.10. 1 hit. 3.10.320.10. 1 hit. |
InterProi | View protein in InterPro IPR007110. Ig-like_dom. IPR036179. Ig-like_dom_sf. IPR013783. Ig-like_fold. IPR003006. Ig/MHC_CS. IPR003597. Ig_C1-set. IPR011162. MHC_I/II-like_Ag-recog. IPR014745. MHC_II_a/b_N. IPR000353. MHC_II_b_N. |
Pfami | View protein in Pfam PF07654. C1-set. 1 hit. PF00969. MHC_II_beta. 1 hit. |
SMARTi | View protein in SMART SM00407. IGc1. 1 hit. SM00921. MHC_II_beta. 1 hit. |
SUPFAMi | SSF48726. SSF48726. 1 hit. SSF54452. SSF54452. 1 hit. |
PROSITEi | View protein in PROSITE PS50835. IG_LIKE. 1 hit. PS00290. IG_MHC. 1 hit. |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P28068-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MITFLPLLLG LSLGCTGAGG FVAHVESTCL LDDAGTPKDF TYCISFNKDL
60 70 80 90 100
LTCWDPEENK MAPCEFGVLN SLANVLSQHL NQKDTLMQRL RNGLQNCATH
110 120 130 140 150
TQPFWGSLTN RTRPPSVQVA KTTPFNTREP VMLACYVWGF YPAEVTITWR
160 170 180 190 200
KNGKLVMPHS SAHKTAQPNG DWTYQTLSHL ALTPSYGDTY TCVVEHIGAP
210 220 230 240 250
EPILRDWTPG LSPMQTLKVS VSAVTLGLGL IIFSLGVISW RRAGHSSYTP
260
LPGSNYSEGW HIS
Polymorphismi
The following alleles of DMB are known: DMB*01:01, DMB*01:02, DMB*01:03, DMB*01:04 (DMB3.4), DMB*01:05, DMB*01:06, and DMB*01:07. The sequence shown is that of DMB*01:01.
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050360 | 28 | T → A in allele DMB*01:07. Corresponds to variant dbSNP:rs17583782Ensembl. | 1 | |
Natural variantiVAR_016752 | 45 | S → F in allele DMB*01:06. Corresponds to variant dbSNP:rs41560814Ensembl. | 1 | |
Natural variantiVAR_050361 | 49 | D → V in allele DMB*01:07. Corresponds to variant dbSNP:rs17617333Ensembl. | 1 | |
Natural variantiVAR_050362 | 71 | S → N in allele DMB*01:07. Corresponds to variant dbSNP:rs17617321Ensembl. | 1 | |
Natural variantiVAR_016753 | 162 | A → E in allele DMB*01:02 and allele DMB*01:06. Corresponds to variant dbSNP:rs2071555Ensembl. | 1 | |
Natural variantiVAR_016754 | 162 | A → V in allele DMB*01:04 and allele DMB*01:05. Corresponds to variant dbSNP:rs2071555Ensembl. | 1 | |
Natural variantiVAR_016755 | 197 | I → T in allele DMB*01:03, allele DMB*01:04 and allele DMB*01:06. 1 PublicationCorresponds to variant dbSNP:rs1042337Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z23139 mRNA. Translation: CAA80670.1. U15085 mRNA. Translation: AAB60387.1. X76776 Genomic DNA. Translation: CAA54171.1. X87344 Genomic DNA. Translation: CAA60782.1. AY645722 mRNA. Translation: AAV97947.1. AL662845 Genomic DNA. No translation available. AL645941 Genomic DNA. No translation available. AL935042 Genomic DNA. No translation available. BX088556 Genomic DNA. No translation available. BX927138 Genomic DNA. No translation available. CR936913 Genomic DNA. No translation available. CR759798 Genomic DNA. No translation available. CR752645 Genomic DNA. No translation available. CH471081 Genomic DNA. Translation: EAX03657.1. BC027175 mRNA. Translation: AAH27175.1. Z24750 Genomic DNA. No translation available. Z24751 Genomic DNA. No translation available. U00700 Genomic DNA. Translation: AAA03296.1. U16762 Genomic DNA. Translation: AAC50514.1. AF134890 Genomic DNA. Translation: AAD30279.1. AF072680 Genomic DNA. Translation: AAC26112.1. |
CCDSi | CCDS4760.1. |
PIRi | I37533. |
RefSeqi | NP_002109.2. NM_002118.4. |
UniGenei | Hs.351279. |
Genome annotation databases
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Entry informationi
Entry namei | DMB_HUMAN | |
Accessioni | P28068Primary (citable) accession number: P28068 Secondary accession number(s): O77936 Q9XRX2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1992 |
Last sequence update: | August 1, 1992 | |
Last modified: | March 28, 2018 | |
This is version 175 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |