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Protein

HLA class II histocompatibility antigen, DM alpha chain

Gene

HLA-DMA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.3 Publications

GO - Molecular functioni

  • MHC class II protein complex binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processImmunity

Enzyme and pathway databases

ReactomeiR-HSA-2132295. MHC class II antigen presentation.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class II histocompatibility antigen, DM alpha chain
Alternative name(s):
MHC class II antigen DMA
Really interesting new gene 6 protein
Gene namesi
Name:HLA-DMA
Synonyms:DMA, RING6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000204257.14.
HGNCiHGNC:4934. HLA-DMA.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 233LumenalSequence analysisAdd BLAST207
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Topological domaini255 – 261CytoplasmicSequence analysis7

Keywords - Cellular componenti

Endosome, Lysosome, Membrane, MHC II

Pathology & Biotechi

Organism-specific databases

DisGeNETi3108.

Polymorphism and mutation databases

DMDMi133158.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000001895827 – 261HLA class II histocompatibility antigen, DM alpha chainAdd BLAST235

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi41N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi50 ↔ 105
Disulfide bondi147 ↔ 202

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP28067.
PaxDbiP28067.
PeptideAtlasiP28067.
PRIDEiP28067.

PTM databases

iPTMnetiP28067.
PhosphoSitePlusiP28067.

Expressioni

Gene expression databases

BgeeiENSG00000204257.
CleanExiHS_HLA-DMA.
ExpressionAtlasiP28067. baseline and differential.
GenevisibleiP28067. HS.

Organism-specific databases

HPAiHPA012750.
HPA017295.

Interactioni

Subunit structurei

Heterodimer of an alpha chain (DMA) and a beta chain (DMB).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HLA-DMBP2806817EBI-3865396,EBI-2877138

GO - Molecular functioni

  • MHC class II protein complex binding Source: UniProtKB

Protein-protein interaction databases

DIPiDIP-6184N.
IntActiP28067. 7 interactors.
MINTiMINT-1539780.
STRINGi9606.ENSP00000363976.

Structurei

Secondary structure

1261
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi41 – 63Combined sources23
Beta strandi66 – 72Combined sources7
Turni73 – 76Combined sources4
Beta strandi77 – 82Combined sources6
Helixi83 – 85Combined sources3
Helixi87 – 89Combined sources3
Helixi95 – 110Combined sources16
Turni114 – 116Combined sources3
Turni117 – 119Combined sources3
Beta strandi122 – 124Combined sources3
Beta strandi128 – 135Combined sources8
Beta strandi143 – 155Combined sources13
Beta strandi157 – 163Combined sources7
Beta strandi166 – 168Combined sources3
Beta strandi175 – 179Combined sources5
Turni180 – 182Combined sources3
Beta strandi183 – 192Combined sources10
Beta strandi200 – 206Combined sources7
Turni207 – 210Combined sources4
Beta strandi211 – 217Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HDMX-ray2.50A27-230[»]
2BC4X-ray2.27A/C27-229[»]
4FQXX-ray2.60C27-225[»]
4GBXX-ray3.00C27-225[»]
ProteinModelPortaliP28067.
SMRiP28067.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP28067.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini121 – 215Ig-like C1-typeAdd BLAST95

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni27 – 124Alpha-1Add BLAST98
Regioni125 – 217Alpha-2Add BLAST93
Regioni218 – 233Connecting peptideSequence analysisAdd BLAST16

Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IR26. Eukaryota.
ENOG410YJDD. LUCA.
HOGENOMiHOG000126882.
HOVERGENiHBG001688.
InParanoidiP28067.
OrthoDBiEOG091G0LMN.
PhylomeDBiP28067.
TreeFamiTF333797.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
PfamiView protein in Pfam
PF07654. C1-set. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
SMARTiView protein in SMART
SM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28067-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGHEQNQGAA LLQMLPLLWL LPHSWAVPEA PTPMWPDDLQ NHTFLHTVYC
60 70 80 90 100
QDGSPSVGLS EAYDEDQLFF FDFSQNTRVP RLPEFADWAQ EQGDAPAILF
110 120 130 140 150
DKEFCEWMIQ QIGPKLDGKI PVSRGFPIAE VFTLKPLEFG KPNTLVCFVS
160 170 180 190 200
NLFPPMLTVN WHDHSVPVEG FGPTFVSAVD GLSFQAFSYL NFTPEPSDIF
210 220 230 240 250
SCIVTHEIDR YTAIAYWVPR NALPSDLLEN VLCGVAFGLG VLGIIVGIVL
260
IIYFRKPCSG D
Length:261
Mass (Da):29,194
Last modified:August 1, 1992 - v1
Checksum:i1986C3C1989F02E9
GO

Polymorphismi

The following alleles of DMA are known: DMA*01:01, DMA*01:02, DMA*01:03 (DMA3.2) and DMA*01:04 (DMA3.4). The sequence shown is that of DMA*01:01.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_016746162H → Q in allele DMA*01:03 and allele DMA*01:04. 1
Natural variantiVAR_016747163D → H in allele DMA*01:03 and allele DMA*01:04. 1
Natural variantiVAR_016748166V → I in allele DMA*01:02 and allele DMA*01:04. Corresponds to variant dbSNP:rs1063478Ensembl.1
Natural variantiVAR_016749181G → A in allele DMA*01:03. Corresponds to variant dbSNP:rs6926628Ensembl.1
Natural variantiVAR_016750210R → C in allele DMA*01:04. Corresponds to variant dbSNP:rs17214044Ensembl.1
Natural variantiVAR_016751210R → H in allele DMA*01:03. Corresponds to variant dbSNP:rs41555121Ensembl.1
Natural variantiVAR_056544235V → M. Corresponds to variant dbSNP:rs9469319Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62744 mRNA. Translation: CAA44606.1.
AL935042 Genomic DNA. No translation available.
Z24753 Genomic DNA. No translation available.
U04878 Genomic DNA. Translation: AAA56994.1.
U04877 Genomic DNA. Translation: AAA56993.1.
CCDSiCCDS4761.1.
PIRiI38490.
S17886.
UniGeneiHs.728759.

Genome annotation databases

EnsembliENST00000374843; ENSP00000363976; ENSG00000204257.
ENST00000383230; ENSP00000372717; ENSG00000243215.
ENST00000434337; ENSP00000407198; ENSG00000242361.
ENST00000441375; ENSP00000410591; ENSG00000239463.
ENST00000450601; ENSP00000392842; ENSG00000242685.
ENST00000452615; ENSP00000395349; ENSG00000243189.
ENST00000453490; ENSP00000404018; ENSG00000243719.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDMA_HUMAN
AccessioniPrimary (citable) accession number: P28067
Secondary accession number(s): Q29639, Q29640
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: September 27, 2017
This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families