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Protein

Proteasome subunit beta type-8

Gene

PSMB8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes.4 Publications

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei73NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Keywords - Biological processi

Differentiation, Host-virus interaction, Immunity

Enzyme and pathway databases

BioCyciZFISH:HS09748-MONOMER.
ReactomeiR-HSA-1169091. Activation of NF-kappaB in B cells.
R-HSA-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-HSA-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-HSA-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-HSA-174154. APC/C:Cdc20 mediated degradation of Securin.
R-HSA-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-HSA-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-HSA-180534. Vpu mediated degradation of CD4.
R-HSA-180585. Vif-mediated degradation of APOBEC3G.
R-HSA-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-HSA-195253. Degradation of beta-catenin by the destruction complex.
R-HSA-202424. Downstream TCR signaling.
R-HSA-211733. Regulation of activated PAK-2p34 by proteasome mediated degradation.
R-HSA-2467813. Separation of Sister Chromatids.
R-HSA-2871837. FCERI mediated NF-kB activation.
R-HSA-349425. Autodegradation of the E3 ubiquitin ligase COP1.
R-HSA-350562. Regulation of ornithine decarboxylase (ODC).
R-HSA-382556. ABC-family proteins mediated transport.
R-HSA-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-HSA-4608870. Asymmetric localization of PCP proteins.
R-HSA-4641257. Degradation of AXIN.
R-HSA-4641258. Degradation of DVL.
R-HSA-5358346. Hedgehog ligand biogenesis.
R-HSA-5362768. Hh mutants that don't undergo autocatalytic processing are degraded by ERAD.
R-HSA-5607761. Dectin-1 mediated noncanonical NF-kB signaling.
R-HSA-5607764. CLEC7A (Dectin-1) signaling.
R-HSA-5610780. Degradation of GLI1 by the proteasome.
R-HSA-5610783. Degradation of GLI2 by the proteasome.
R-HSA-5610785. GLI3 is processed to GLI3R by the proteasome.
R-HSA-5632684. Hedgehog 'on' state.
R-HSA-5658442. Regulation of RAS by GAPs.
R-HSA-5668541. TNFR2 non-canonical NF-kB pathway.
R-HSA-5676590. NIK-->noncanonical NF-kB signaling.
R-HSA-5678895. Defective CFTR causes cystic fibrosis.
R-HSA-5687128. MAPK6/MAPK4 signaling.
R-HSA-5689603. UCH proteinases.
R-HSA-5689880. Ub-specific processing proteases.
R-HSA-68827. CDT1 association with the CDC6:ORC:origin complex.
R-HSA-68949. Orc1 removal from chromatin.
R-HSA-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-HSA-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-HSA-69481. G2/M Checkpoints.
R-HSA-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-HSA-8852276. The role of GTSE1 in G2/M progression after G2 checkpoint.
R-HSA-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Protein family/group databases

MEROPSiT01.015.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit beta type-8 (EC:3.4.25.1)
Alternative name(s):
Low molecular mass protein 7
Macropain subunit C13
Multicatalytic endopeptidase complex subunit C13
Proteasome component C13
Proteasome subunit beta-5i
Really interesting new gene 10 protein
Gene namesi
Name:PSMB8
Synonyms:LMP7, PSMB5i, RING10, Y2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:9545. PSMB8.

Subcellular locationi

  • Cytoplasm PROSITE-ProRule annotation
  • Nucleus By similarity

GO - Cellular componenti

  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • nucleoplasm Source: Reactome
  • proteasome complex Source: UniProtKB
  • proteasome core complex Source: UniProtKB
  • spermatoproteasome complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

Pathology & Biotechi

Involvement in diseasei

Nakajo syndrome (NKJO)6 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive autoinflammatory disorder characterized by early childhood onset of recurrent fever, joint stiffness and severe contractures of the hands and feet, and erythematous skin lesions with subsequent development of lipodystrophy and laboratory evidence of immune dysregulation. Accompanying features may include muscle weakness and atrophy, hepatosplenomegaly, and microcytic anemia.
See also OMIM:256040
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06529175T → M in NKJO; markedly decreased chymotrypsin-like activity consistent with a decrease in proteasomal activity and loss of function; some patients are heterozygotes for this mutation and also carry a mutation in PSMA3; patients' cells show reduction of proteasome content and endopeptidase activity of the proteasome. 2 PublicationsCorresponds to variant rs748082671dbSNPEnsembl.1
Natural variantiVAR_07525694A → P in NKJO; unknown pathological significance. 1 Publication1
Natural variantiVAR_075257105K → Q in NKJO; some patients are heterozygotes for this mutation and also carry a mutation in PSMB4. 1 Publication1
Natural variantiVAR_066449201G → V in NKJO; affects immunoproteasome assembly; reduced proteasome levels; reduced chymotrypsin-like activity consistent with a decrease in proteasomal activity. 2 PublicationsCorresponds to variant rs387906680dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi5696.
MalaCardsiPSMB8.
MIMi256040. phenotype.
OpenTargetsiENSG00000204264.
ENSG00000206298.
ENSG00000226201.
ENSG00000230034.
ENSG00000230669.
ENSG00000231631.
ENSG00000235715.
ENSG00000236443.
Orphaneti325004. CANDLE syndrome.
324999. JMP syndrome.
2615. Nakajo-Nishimura syndrome.
PharmGKBiPA33890.

Chemistry databases

ChEMBLiCHEMBL5620.
DrugBankiDB08889. Carfilzomib.
GuidetoPHARMACOLOGYi2408.

Polymorphism and mutation databases

BioMutaiPSMB8.
DMDMi334302881.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000265971 – 72Removed in mature formBy similarityAdd BLAST72
ChainiPRO_000002659873 – 276Proteasome subunit beta type-8Add BLAST204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 2 (identifier: P28062-2)
Modified residuei5PhosphothreonineCombined sources1

Post-translational modificationi

Autocleaved. The resulting N-terminal Thr residue of the mature subunit is responsible for the nucleophile proteolytic activity.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei72 – 73Cleavage; by autolysisBy similarity2

Keywords - PTMi

Phosphoprotein, Zymogen

Proteomic databases

EPDiP28062.
PaxDbiP28062.
PeptideAtlasiP28062.
PRIDEiP28062.

PTM databases

iPTMnetiP28062.
PhosphoSitePlusiP28062.
SwissPalmiP28062.

Expressioni

Developmental stagei

Highly expressed in immature dendritic cells (at protein level).1 Publication

Inductioni

Up-regulated by IFNG/IFN-gamma and IRF1 (at protein level). Up-regulated by TNF (at protein level). Up-regulated by tetrodotoxin (TTX) in glial cells. Up-regulated in Crohn's bowel disease (CD). Down-regulated by the selective inhibitor PR-957. Down-regulated in mature dendritic cells by HSV-1 infection. Up-regulated by heat shock treatment.9 Publications

Gene expression databases

BgeeiENSG00000204264.
CleanExiHS_PSMB8.
ExpressionAtlasiP28062. baseline and differential.
GenevisibleiP28062. HS.

Organism-specific databases

HPAiHPA046995.
HPA050327.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Component of the immunoproteasome, where it displaces the equivalent housekeeping subunit PSMB5. Component of the spermatoproteasome, a form of the proteasome specifically found in testis. Directly interacts with POMP. Interacts with HIV-1 TAT protein. Interacts with TAP1.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
P279584EBI-372294,EBI-3649474From a different organism.

Protein-protein interaction databases

BioGridi111669. 61 interactors.
IntActiP28062. 13 interactors.
MINTiMINT-3010850.
STRINGi9606.ENSP00000364016.

Chemistry databases

BindingDBiP28062.

Structurei

3D structure databases

ProteinModelPortaliP28062.
SMRiP28062.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0175. Eukaryota.
ENOG410XQRP. LUCA.
GeneTreeiENSGT00510000046395.
HOGENOMiHOG000091082.
HOVERGENiHBG108297.
InParanoidiP28062.
KOiK02740.
OMAiATIRVNK.
OrthoDBiEOG091G0BPS.
PhylomeDBiP28062.
TreeFamiTF106223.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR000243. Pept_T1A_subB.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
[Graphical view]
PRINTSiPR00141. PROTEASOME.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: P28062-1) [UniParc]FASTAAdd to basket
Also known as: LMP7B, LMP7-E2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALLDVCGAP RGQRPESALP VAGSGRRSDP GHYSFSMRSP ELALPRGMQP
60 70 80 90 100
TEFFQSLGGD GERNVQIEMA HGTTTLAFKF QHGVIAAVDS RASAGSYISA
110 120 130 140 150
LRVNKVIEIN PYLLGTMSGC AADCQYWERL LAKECRLYYL RNGERISVSA
160 170 180 190 200
ASKLLSNMMC QYRGMGLSMG SMICGWDKKG PGLYYVDEHG TRLSGNMFST
210 220 230 240 250
GSGNTYAYGV MDSGYRPNLS PEEAYDLGRR AIAYATHRDS YSGGVVNMYH
260 270
MKEDGWVKVE STDVSDLLHQ YREANQ
Length:276
Mass (Da):30,354
Last modified:May 31, 2011 - v3
Checksum:i4F689501677DBD44
GO
Isoform 2 (identifier: P28062-2) [UniParc]FASTAAdd to basket
Also known as: LMP7A, LMP7-E1

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: MALLDVCGAP...PELALPRGMQ → MLIGTPTPRD...PVSSGCPGLE

Show »
Length:272
Mass (Da):29,770
Checksum:iE5A903101BE5C0B7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0064888G → R in allele LMP7C. Corresponds to variant rs114772012dbSNPEnsembl.1
Natural variantiVAR_00648930 – 32PGH → RPD in allele LPM7C. 3
Natural variantiVAR_06520449Q → K.1 PublicationCorresponds to variant rs2071543dbSNPEnsembl.1
Natural variantiVAR_05704674T → S.Corresponds to variant rs17220206dbSNPEnsembl.1
Natural variantiVAR_06529175T → M in NKJO; markedly decreased chymotrypsin-like activity consistent with a decrease in proteasomal activity and loss of function; some patients are heterozygotes for this mutation and also carry a mutation in PSMA3; patients' cells show reduction of proteasome content and endopeptidase activity of the proteasome. 2 PublicationsCorresponds to variant rs748082671dbSNPEnsembl.1
Natural variantiVAR_07525694A → P in NKJO; unknown pathological significance. 1 Publication1
Natural variantiVAR_075257105K → Q in NKJO; some patients are heterozygotes for this mutation and also carry a mutation in PSMB4. 1 Publication1
Natural variantiVAR_066449201G → V in NKJO; affects immunoproteasome assembly; reduced proteasome levels; reduced chymotrypsin-like activity consistent with a decrease in proteasomal activity. 2 PublicationsCorresponds to variant rs387906680dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0052871 – 49MALLD…PRGMQ → MLIGTPTPRDTTPSSWLTSS LLVEAAPLDDTTLPTPVSSG CPGLE in isoform 2. 2 PublicationsAdd BLAST49

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66401 Genomic DNA. Translation: CAA47026.1.
X62598 mRNA. Translation: CAA44482.1.
Z14982 Genomic DNA. Translation: CAA78705.1.
Z14982 Genomic DNA. Translation: CAA78706.1.
L11045 Genomic DNA. No translation available.
X87344 Genomic DNA. Translation: CAA60786.1.
X87344 Genomic DNA. Translation: CAA60787.1.
U17496 mRNA. Translation: AAA56777.1.
U17497 mRNA. Translation: AAA56778.1.
AL671681 Genomic DNA. Translation: CAI17712.1.
AL671681 Genomic DNA. Translation: CAI17713.1.
AL669918 Genomic DNA. Translation: CAI18138.1.
AL669918 Genomic DNA. Translation: CAI18139.1.
AL935043 Genomic DNA. Translation: CAI18623.1.
AL935043 Genomic DNA. Translation: CAI18625.1.
BX682530, BX088556 Genomic DNA. Translation: CAM25945.1.
BX682530, BX088556 Genomic DNA. Translation: CAM25947.1.
BX088556, BX682530 Genomic DNA. Translation: CAM26261.1.
BX088556, BX682530 Genomic DNA. Translation: CAM26262.1.
CT009502 Genomic DNA. Translation: CAQ07779.1.
CT009502 Genomic DNA. Translation: CAQ07781.1.
BX927138 Genomic DNA. Translation: CAQ08445.1.
BX927138 Genomic DNA. Translation: CAQ08448.1.
CR762476 Genomic DNA. Translation: CAQ08492.1.
CR762476 Genomic DNA. Translation: CAQ08494.1.
CR753889 Genomic DNA. Translation: CAQ10284.1.
CR753889 Genomic DNA. Translation: CAQ10286.1.
CH471081 Genomic DNA. Translation: EAX03644.1.
CH471081 Genomic DNA. Translation: EAX03645.1.
BC001114 mRNA. Translation: AAH01114.1.
U32863 Genomic DNA. Translation: AAA80235.1.
U32862 Genomic DNA. Translation: AAA80234.1.
CCDSiCCDS4756.1. [P28062-2]
CCDS4757.1. [P28062-1]
PIRiA44324.
C44324.
G01564.
G02018.
RefSeqiNP_004150.1. NM_004159.4. [P28062-2]
NP_683720.2. NM_148919.3. [P28062-1]
UniGeneiHs.180062.

Genome annotation databases

EnsembliENST00000374881; ENSP00000364015; ENSG00000204264. [P28062-2]
ENST00000374882; ENSP00000364016; ENSG00000204264. [P28062-1]
ENST00000383236; ENSP00000372723; ENSG00000206298. [P28062-1]
ENST00000383238; ENSP00000372725; ENSG00000206298. [P28062-2]
ENST00000416134; ENSP00000397057; ENSG00000235715. [P28062-2]
ENST00000416564; ENSP00000408825; ENSG00000226201. [P28062-2]
ENST00000421445; ENSP00000402406; ENSG00000236443. [P28062-1]
ENST00000429645; ENSP00000394155; ENSG00000226201. [P28062-1]
ENST00000435978; ENSP00000414731; ENSG00000231631. [P28062-2]
ENST00000436627; ENSP00000392693; ENSG00000230669. [P28062-2]
ENST00000438442; ENSP00000404585; ENSG00000231631. [P28062-1]
ENST00000441960; ENSP00000407539; ENSG00000230034. [P28062-2]
ENST00000452573; ENSP00000412618; ENSG00000236443. [P28062-2]
ENST00000455660; ENSP00000406797; ENSG00000230669. [P28062-1]
ENST00000457261; ENSP00000414770; ENSG00000235715. [P28062-1]
GeneIDi5696.
KEGGihsa:5696.
UCSCiuc003ocf.4. human. [P28062-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66401 Genomic DNA. Translation: CAA47026.1.
X62598 mRNA. Translation: CAA44482.1.
Z14982 Genomic DNA. Translation: CAA78705.1.
Z14982 Genomic DNA. Translation: CAA78706.1.
L11045 Genomic DNA. No translation available.
X87344 Genomic DNA. Translation: CAA60786.1.
X87344 Genomic DNA. Translation: CAA60787.1.
U17496 mRNA. Translation: AAA56777.1.
U17497 mRNA. Translation: AAA56778.1.
AL671681 Genomic DNA. Translation: CAI17712.1.
AL671681 Genomic DNA. Translation: CAI17713.1.
AL669918 Genomic DNA. Translation: CAI18138.1.
AL669918 Genomic DNA. Translation: CAI18139.1.
AL935043 Genomic DNA. Translation: CAI18623.1.
AL935043 Genomic DNA. Translation: CAI18625.1.
BX682530, BX088556 Genomic DNA. Translation: CAM25945.1.
BX682530, BX088556 Genomic DNA. Translation: CAM25947.1.
BX088556, BX682530 Genomic DNA. Translation: CAM26261.1.
BX088556, BX682530 Genomic DNA. Translation: CAM26262.1.
CT009502 Genomic DNA. Translation: CAQ07779.1.
CT009502 Genomic DNA. Translation: CAQ07781.1.
BX927138 Genomic DNA. Translation: CAQ08445.1.
BX927138 Genomic DNA. Translation: CAQ08448.1.
CR762476 Genomic DNA. Translation: CAQ08492.1.
CR762476 Genomic DNA. Translation: CAQ08494.1.
CR753889 Genomic DNA. Translation: CAQ10284.1.
CR753889 Genomic DNA. Translation: CAQ10286.1.
CH471081 Genomic DNA. Translation: EAX03644.1.
CH471081 Genomic DNA. Translation: EAX03645.1.
BC001114 mRNA. Translation: AAH01114.1.
U32863 Genomic DNA. Translation: AAA80235.1.
U32862 Genomic DNA. Translation: AAA80234.1.
CCDSiCCDS4756.1. [P28062-2]
CCDS4757.1. [P28062-1]
PIRiA44324.
C44324.
G01564.
G02018.
RefSeqiNP_004150.1. NM_004159.4. [P28062-2]
NP_683720.2. NM_148919.3. [P28062-1]
UniGeneiHs.180062.

3D structure databases

ProteinModelPortaliP28062.
SMRiP28062.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111669. 61 interactors.
IntActiP28062. 13 interactors.
MINTiMINT-3010850.
STRINGi9606.ENSP00000364016.

Chemistry databases

BindingDBiP28062.
ChEMBLiCHEMBL5620.
DrugBankiDB08889. Carfilzomib.
GuidetoPHARMACOLOGYi2408.

Protein family/group databases

MEROPSiT01.015.

PTM databases

iPTMnetiP28062.
PhosphoSitePlusiP28062.
SwissPalmiP28062.

Polymorphism and mutation databases

BioMutaiPSMB8.
DMDMi334302881.

Proteomic databases

EPDiP28062.
PaxDbiP28062.
PeptideAtlasiP28062.
PRIDEiP28062.

Protocols and materials databases

DNASUi5696.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374881; ENSP00000364015; ENSG00000204264. [P28062-2]
ENST00000374882; ENSP00000364016; ENSG00000204264. [P28062-1]
ENST00000383236; ENSP00000372723; ENSG00000206298. [P28062-1]
ENST00000383238; ENSP00000372725; ENSG00000206298. [P28062-2]
ENST00000416134; ENSP00000397057; ENSG00000235715. [P28062-2]
ENST00000416564; ENSP00000408825; ENSG00000226201. [P28062-2]
ENST00000421445; ENSP00000402406; ENSG00000236443. [P28062-1]
ENST00000429645; ENSP00000394155; ENSG00000226201. [P28062-1]
ENST00000435978; ENSP00000414731; ENSG00000231631. [P28062-2]
ENST00000436627; ENSP00000392693; ENSG00000230669. [P28062-2]
ENST00000438442; ENSP00000404585; ENSG00000231631. [P28062-1]
ENST00000441960; ENSP00000407539; ENSG00000230034. [P28062-2]
ENST00000452573; ENSP00000412618; ENSG00000236443. [P28062-2]
ENST00000455660; ENSP00000406797; ENSG00000230669. [P28062-1]
ENST00000457261; ENSP00000414770; ENSG00000235715. [P28062-1]
GeneIDi5696.
KEGGihsa:5696.
UCSCiuc003ocf.4. human. [P28062-1]

Organism-specific databases

CTDi5696.
DisGeNETi5696.
GeneCardsiPSMB8.
HGNCiHGNC:9545. PSMB8.
HPAiHPA046995.
HPA050327.
MalaCardsiPSMB8.
MIMi177046. gene.
256040. phenotype.
neXtProtiNX_P28062.
OpenTargetsiENSG00000204264.
ENSG00000206298.
ENSG00000226201.
ENSG00000230034.
ENSG00000230669.
ENSG00000231631.
ENSG00000235715.
ENSG00000236443.
Orphaneti325004. CANDLE syndrome.
324999. JMP syndrome.
2615. Nakajo-Nishimura syndrome.
PharmGKBiPA33890.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0175. Eukaryota.
ENOG410XQRP. LUCA.
GeneTreeiENSGT00510000046395.
HOGENOMiHOG000091082.
HOVERGENiHBG108297.
InParanoidiP28062.
KOiK02740.
OMAiATIRVNK.
OrthoDBiEOG091G0BPS.
PhylomeDBiP28062.
TreeFamiTF106223.

Enzyme and pathway databases

BioCyciZFISH:HS09748-MONOMER.
ReactomeiR-HSA-1169091. Activation of NF-kappaB in B cells.
R-HSA-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-HSA-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-HSA-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-HSA-174154. APC/C:Cdc20 mediated degradation of Securin.
R-HSA-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-HSA-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-HSA-180534. Vpu mediated degradation of CD4.
R-HSA-180585. Vif-mediated degradation of APOBEC3G.
R-HSA-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-HSA-195253. Degradation of beta-catenin by the destruction complex.
R-HSA-202424. Downstream TCR signaling.
R-HSA-211733. Regulation of activated PAK-2p34 by proteasome mediated degradation.
R-HSA-2467813. Separation of Sister Chromatids.
R-HSA-2871837. FCERI mediated NF-kB activation.
R-HSA-349425. Autodegradation of the E3 ubiquitin ligase COP1.
R-HSA-350562. Regulation of ornithine decarboxylase (ODC).
R-HSA-382556. ABC-family proteins mediated transport.
R-HSA-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-HSA-4608870. Asymmetric localization of PCP proteins.
R-HSA-4641257. Degradation of AXIN.
R-HSA-4641258. Degradation of DVL.
R-HSA-5358346. Hedgehog ligand biogenesis.
R-HSA-5362768. Hh mutants that don't undergo autocatalytic processing are degraded by ERAD.
R-HSA-5607761. Dectin-1 mediated noncanonical NF-kB signaling.
R-HSA-5607764. CLEC7A (Dectin-1) signaling.
R-HSA-5610780. Degradation of GLI1 by the proteasome.
R-HSA-5610783. Degradation of GLI2 by the proteasome.
R-HSA-5610785. GLI3 is processed to GLI3R by the proteasome.
R-HSA-5632684. Hedgehog 'on' state.
R-HSA-5658442. Regulation of RAS by GAPs.
R-HSA-5668541. TNFR2 non-canonical NF-kB pathway.
R-HSA-5676590. NIK-->noncanonical NF-kB signaling.
R-HSA-5678895. Defective CFTR causes cystic fibrosis.
R-HSA-5687128. MAPK6/MAPK4 signaling.
R-HSA-5689603. UCH proteinases.
R-HSA-5689880. Ub-specific processing proteases.
R-HSA-68827. CDT1 association with the CDC6:ORC:origin complex.
R-HSA-68949. Orc1 removal from chromatin.
R-HSA-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-HSA-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-HSA-69481. G2/M Checkpoints.
R-HSA-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-HSA-8852276. The role of GTSE1 in G2/M progression after G2 checkpoint.
R-HSA-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

ChiTaRSiPSMB8. human.
GeneWikiiPSMB8.
GenomeRNAii5696.
PROiP28062.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204264.
CleanExiHS_PSMB8.
ExpressionAtlasiP28062. baseline and differential.
GenevisibleiP28062. HS.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR000243. Pept_T1A_subB.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
[Graphical view]
PRINTSiPR00141. PROTEASOME.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPSB8_HUMAN
AccessioniPrimary (citable) accession number: P28062
Secondary accession number(s): B0UZC0
, Q29824, Q5JNW6, Q5QNR8, Q96J48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: May 31, 2011
Last modified: November 30, 2016
This is version 194 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.