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P28049 (LAB_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lupus La protein homolog B
Alternative name(s):
La autoantigen homolog B
La ribonucleoprotein B
Gene names
Name:ssb-b
Synonyms:lab1
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length427 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

La protein plays a role in the transcription of RNA polymerase III. It is most probably a transcription termination factor. Binds to the 3' termini of virtually all nascent polymerase III transcripts By similarity.

Subcellular location

Nucleus Probable.

Developmental stage

Barely detectable in stage I/II oocytes, accumulate in stage III/IV oocytes, then exhibit a roughly constant steady state level in mature oocytes, eggs, and early embryos.

Post-translational modification

Phosphorylated Probable.

Miscellaneous

There are two forms of La, LaA and LaB, in Xenopus.

Sequence similarities

Contains 1 HTH La-type RNA-binding domain.

Contains 1 RRM (RNA recognition motif) domain.

Ontologies

Keywords
   Cellular componentNucleus
   LigandRNA-binding
   PTMPhosphoprotein
Gene Ontology (GO)
   Biological_processRNA processing

Inferred from electronic annotation. Source: InterPro

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

ribonucleoprotein complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 427427Lupus La protein homolog B
PRO_0000207604

Regions

Domain6 – 9893HTH La-type RNA-binding
Domain110 – 20293RRM
Motif315 – 33117Nuclear localization signal Potential

Sequences

Sequence LengthMass (Da)Tools
P28049 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: 45F3146F8934A355

FASTA42748,996
        10         20         30         40         50         60 
MAENGDKEQL DLDTKICEQI EYYFGDHNLP RDKFLKQQVL LDNGWVPLET MIKFNRLSKL 

        70         80         90        100        110        120 
TTDFNIILQA LKKSKTELLE INEEKCKIRR SPAKPLPELN EDYKNSFKHR SVYIKGFPTI 

       130        140        150        160        170        180 
TNLDEIKEWL NDKGPIENIQ MRRTLQREFK GSVFLVFNTE DGAKKFLEDK NLKYKDNDMI 

       190        200        210        220        230        240 
ILSREEYFAK KNEERKLNKS EEKAKSKQEK EEAQKQAEDA ERKLMEERVG CLLKFSGDLD 

       250        260        270        280        290        300 
NMTSREDLHA LFQTHGEIEW IDFSRGAKEG IVLFKMNAKE ALDKAKAANN DNLKLKGKNV 

       310        320        330        340        350        360 
KWELIEGDAE KEALKKIMEG KQESFNKRKG RDGRKFKGKG RGGKGNDSSP RKKIQFQGKK 

       370        380        390        400        410        420 
KTFDSSDDED DMEESESPQK VTIKAKETAG PKNGASAAPG SPKKRALDDK AEDGPAVKQS 


KTEVGDQ 

« Hide

References

[1]"La proteins from Xenopus laevis. cDNA cloning and developmental expression."
Scherly D., Stutz F., Lin-Marq N., Clarkson S.G.
J. Mol. Biol. 231:196-204(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Oocyte.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X68818 mRNA. Translation: CAA48716.1.
PIRS33817.
UniGeneXl.3639.

3D structure databases

ProteinModelPortalP28049.
SMRP28049. Positions 5-191, 225-331.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

XenbaseXB-GENE-866058. ssb.

Phylogenomic databases

HOVERGENHBG001407.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
3.30.70.330. 2 hits.
InterProIPR002344. Lupus_La.
IPR006630. Lupus_La_RNA-bd.
IPR012677. Nucleotide-bd_a/b_plait.
IPR014886. RRM_3.
IPR000504. RRM_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF05383. La. 1 hit.
PF00076. RRM_1. 1 hit.
PF08777. RRM_3. 1 hit.
[Graphical view]
PRINTSPR00302. LUPUSLA.
SMARTSM00715. LA. 1 hit.
SM00360. RRM. 1 hit.
[Graphical view]
PROSITEPS50961. HTH_LA. 1 hit.
PS50102. RRM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLAB_XENLA
AccessionPrimary (citable) accession number: P28049
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: May 1, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families