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Protein

Lupus La protein homolog B

Gene

ssb-b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

La protein plays a role in the transcription of RNA polymerase III. It is most probably a transcription termination factor. Binds to the 3' termini of virtually all nascent polymerase III transcripts (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lupus La protein homolog B
Alternative name(s):
La autoantigen homolog B
La ribonucleoprotein B
Gene namesi
Name:ssb-b
Synonyms:lab1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002076041 – 427Lupus La protein homolog BAdd BLAST427

Post-translational modificationi

Phosphorylated.Curated

Keywords - PTMi

Phosphoprotein

Expressioni

Developmental stagei

Barely detectable in stage I/II oocytes, accumulate in stage III/IV oocytes, then exhibit a roughly constant steady state level in mature oocytes, eggs, and early embryos.

Structurei

3D structure databases

ProteinModelPortaliP28049.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 98HTH La-type RNA-bindingPROSITE-ProRule annotationAdd BLAST93
Domaini110 – 202RRMPROSITE-ProRule annotationAdd BLAST93

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi315 – 331Nuclear localization signalSequence analysisAdd BLAST17

Sequence similaritiesi

Contains 1 HTH La-type RNA-binding domain.PROSITE-ProRule annotation
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG001407.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.70.330. 2 hits.
InterProiIPR014886. La_RRM.
IPR002344. Lupus_La.
IPR006630. Lupus_La_RNA-bd.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF05383. La. 1 hit.
PF00076. RRM_1. 1 hit.
PF08777. RRM_3. 1 hit.
[Graphical view]
PRINTSiPR00302. LUPUSLA.
SMARTiSM00715. LA. 1 hit.
SM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF54928. SSF54928. 2 hits.
PROSITEiPS50961. HTH_LA. 1 hit.
PS50102. RRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28049-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAENGDKEQL DLDTKICEQI EYYFGDHNLP RDKFLKQQVL LDNGWVPLET
60 70 80 90 100
MIKFNRLSKL TTDFNIILQA LKKSKTELLE INEEKCKIRR SPAKPLPELN
110 120 130 140 150
EDYKNSFKHR SVYIKGFPTI TNLDEIKEWL NDKGPIENIQ MRRTLQREFK
160 170 180 190 200
GSVFLVFNTE DGAKKFLEDK NLKYKDNDMI ILSREEYFAK KNEERKLNKS
210 220 230 240 250
EEKAKSKQEK EEAQKQAEDA ERKLMEERVG CLLKFSGDLD NMTSREDLHA
260 270 280 290 300
LFQTHGEIEW IDFSRGAKEG IVLFKMNAKE ALDKAKAANN DNLKLKGKNV
310 320 330 340 350
KWELIEGDAE KEALKKIMEG KQESFNKRKG RDGRKFKGKG RGGKGNDSSP
360 370 380 390 400
RKKIQFQGKK KTFDSSDDED DMEESESPQK VTIKAKETAG PKNGASAAPG
410 420
SPKKRALDDK AEDGPAVKQS KTEVGDQ
Length:427
Mass (Da):48,996
Last modified:August 1, 1992 - v1
Checksum:i45F3146F8934A355
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68818 mRNA. Translation: CAA48716.1.
PIRiS33817.
UniGeneiXl.3639.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68818 mRNA. Translation: CAA48716.1.
PIRiS33817.
UniGeneiXl.3639.

3D structure databases

ProteinModelPortaliP28049.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG001407.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.70.330. 2 hits.
InterProiIPR014886. La_RRM.
IPR002344. Lupus_La.
IPR006630. Lupus_La_RNA-bd.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF05383. La. 1 hit.
PF00076. RRM_1. 1 hit.
PF08777. RRM_3. 1 hit.
[Graphical view]
PRINTSiPR00302. LUPUSLA.
SMARTiSM00715. LA. 1 hit.
SM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF54928. SSF54928. 2 hits.
PROSITEiPS50961. HTH_LA. 1 hit.
PS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLAB_XENLA
AccessioniPrimary (citable) accession number: P28049
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: October 5, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two forms of La, LaA and LaB, in Xenopus.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.