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P28049

- LAB_XENLA

UniProt

P28049 - LAB_XENLA

Protein

Lupus La protein homolog B

Gene

ssb-b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Aug 1992)
      Previous versions | rss
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    Functioni

    La protein plays a role in the transcription of RNA polymerase III. It is most probably a transcription termination factor. Binds to the 3' termini of virtually all nascent polymerase III transcripts By similarity.By similarity

    GO - Molecular functioni

    1. nucleotide binding Source: InterPro
    2. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. RNA processing Source: InterPro

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lupus La protein homolog B
    Alternative name(s):
    La autoantigen homolog B
    La ribonucleoprotein B
    Gene namesi
    Name:ssb-b
    Synonyms:lab1
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-866058. ssb.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. ribonucleoprotein complex Source: InterPro

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 427427Lupus La protein homolog BPRO_0000207604Add
    BLAST

    Post-translational modificationi

    Phosphorylated.Curated

    Keywords - PTMi

    Phosphoprotein

    Expressioni

    Developmental stagei

    Barely detectable in stage I/II oocytes, accumulate in stage III/IV oocytes, then exhibit a roughly constant steady state level in mature oocytes, eggs, and early embryos.

    Structurei

    3D structure databases

    ProteinModelPortaliP28049.
    SMRiP28049. Positions 5-191, 225-331.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 9893HTH La-type RNA-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini110 – 20293RRMPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi315 – 33117Nuclear localization signalSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HTH La-type RNA-binding domain.PROSITE-ProRule annotation
    Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG001407.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    3.30.70.330. 2 hits.
    InterProiIPR002344. Lupus_La.
    IPR006630. Lupus_La_RNA-bd.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR014886. RRM_3.
    IPR000504. RRM_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF05383. La. 1 hit.
    PF00076. RRM_1. 1 hit.
    PF08777. RRM_3. 1 hit.
    [Graphical view]
    PRINTSiPR00302. LUPUSLA.
    SMARTiSM00715. LA. 1 hit.
    SM00360. RRM. 1 hit.
    [Graphical view]
    PROSITEiPS50961. HTH_LA. 1 hit.
    PS50102. RRM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P28049-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAENGDKEQL DLDTKICEQI EYYFGDHNLP RDKFLKQQVL LDNGWVPLET    50
    MIKFNRLSKL TTDFNIILQA LKKSKTELLE INEEKCKIRR SPAKPLPELN 100
    EDYKNSFKHR SVYIKGFPTI TNLDEIKEWL NDKGPIENIQ MRRTLQREFK 150
    GSVFLVFNTE DGAKKFLEDK NLKYKDNDMI ILSREEYFAK KNEERKLNKS 200
    EEKAKSKQEK EEAQKQAEDA ERKLMEERVG CLLKFSGDLD NMTSREDLHA 250
    LFQTHGEIEW IDFSRGAKEG IVLFKMNAKE ALDKAKAANN DNLKLKGKNV 300
    KWELIEGDAE KEALKKIMEG KQESFNKRKG RDGRKFKGKG RGGKGNDSSP 350
    RKKIQFQGKK KTFDSSDDED DMEESESPQK VTIKAKETAG PKNGASAAPG 400
    SPKKRALDDK AEDGPAVKQS KTEVGDQ 427
    Length:427
    Mass (Da):48,996
    Last modified:August 1, 1992 - v1
    Checksum:i45F3146F8934A355
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X68818 mRNA. Translation: CAA48716.1.
    PIRiS33817.
    UniGeneiXl.3639.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X68818 mRNA. Translation: CAA48716.1 .
    PIRi S33817.
    UniGenei Xl.3639.

    3D structure databases

    ProteinModelPortali P28049.
    SMRi P28049. Positions 5-191, 225-331.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    Xenbasei XB-GENE-866058. ssb.

    Phylogenomic databases

    HOVERGENi HBG001407.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    3.30.70.330. 2 hits.
    InterProi IPR002344. Lupus_La.
    IPR006630. Lupus_La_RNA-bd.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR014886. RRM_3.
    IPR000504. RRM_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF05383. La. 1 hit.
    PF00076. RRM_1. 1 hit.
    PF08777. RRM_3. 1 hit.
    [Graphical view ]
    PRINTSi PR00302. LUPUSLA.
    SMARTi SM00715. LA. 1 hit.
    SM00360. RRM. 1 hit.
    [Graphical view ]
    PROSITEi PS50961. HTH_LA. 1 hit.
    PS50102. RRM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "La proteins from Xenopus laevis. cDNA cloning and developmental expression."
      Scherly D., Stutz F., Lin-Marq N., Clarkson S.G.
      J. Mol. Biol. 231:196-204(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Oocyte.

    Entry informationi

    Entry nameiLAB_XENLA
    AccessioniPrimary (citable) accession number: P28049
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    There are two forms of La, LaA and LaB, in Xenopus.

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3