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Protein

Lupus La protein homolog A

Gene

ssb-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

La protein plays a role in the transcription of RNA polymerase III. It is most probably a transcription termination factor. Binds to the 3' termini of virtually all nascent polymerase III transcripts (By similarity).By similarity

Miscellaneous

There are two forms of La, LaA and LaB, in Xenopus.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lupus La protein homolog A
Alternative name(s):
La autoantigen homolog A
La ribonucleoprotein A
Gene namesi
Name:ssb-a
Synonyms:laa1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6254453 ssb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002076031 – 428Lupus La protein homolog AAdd BLAST428

Post-translational modificationi

Phosphorylated.Curated

Keywords - PTMi

Phosphoprotein

Expressioni

Developmental stagei

Barely detectable in stage I/II oocytes, accumulate in stage III/IV oocytes, then exhibit a roughly constant steady state level in mature oocytes, eggs, and early embryos.

Structurei

3D structure databases

ProteinModelPortaliP28048
SMRiP28048
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 99HTH La-type RNA-bindingPROSITE-ProRule annotationAdd BLAST93
Domaini111 – 203RRMPROSITE-ProRule annotationAdd BLAST93

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi196 – 212Nuclear localization signalSequence analysisAdd BLAST17
Motifi316 – 332Nuclear localization signalSequence analysisAdd BLAST17

Phylogenomic databases

HOVERGENiHBG001407
KOiK11090

Family and domain databases

Gene3Di1.10.10.10, 1 hit
3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR006630 La_HTH
IPR014886 La_RRM
IPR002344 Lupus_La
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF05383 La, 1 hit
PF00076 RRM_1, 1 hit
PF08777 RRM_3, 1 hit
PRINTSiPR00302 LUPUSLA
SMARTiView protein in SMART
SM00715 LA, 1 hit
SM00360 RRM, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50961 HTH_LA, 1 hit
PS50102 RRM, 1 hit

Sequencei

Sequence statusi: Complete.

P28048-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAENGDKEQK LDSDTKICEQ IEYYFGDHNL PRDKFLKQQI LLDDGWVPLE
60 70 80 90 100
TMIKFNRLSK LTTDFNTILQ ALKKSKTELL EINEEKCKIR RSPAKPLPEL
110 120 130 140 150
NDEYKNSLKH KSVYIKGFPT SAILDDVKEW LKDKGPIENI QMRRTLQREF
160 170 180 190 200
KGSIFIIFNT DDDAKKFLEN RNLKYKDNDM TVLSREEYHA KKNEERKLNK
210 220 230 240 250
SEEKAKSKQV KKEAQKQAED AERKLVEERV GSLLKFSGDL DNMTSREDLH
260 270 280 290 300
ALFQTHGDIE WIDFSRGAKE GIVLFKMNAK EALDKAKAAN SDNLKLKGKD
310 320 330 340 350
VKWELIEGDT EKEALKKILE GKQESFNKRK GRDGRKFKGK GRGGKGNDSS
360 370 380 390 400
SRKRTQFQGK KKTFDSSDDE DDMEESESPQ KASVKAEESA GTKNGAAAAP
410 420
GSPKKRSLDD KAEDGPAVKQ SKTEVGDQ
Length:428
Mass (Da):48,864
Last modified:August 1, 1992 - v1
Checksum:iAEB3A38B7D2E3EC3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68817 mRNA Translation: CAA48715.1
PIRiS33818
RefSeqiNP_001081021.1, NM_001087552.1
UniGeneiXl.1236

Genome annotation databases

GeneIDi394333
KEGGixla:394333

Similar proteinsi

Entry informationi

Entry nameiLAA_XENLA
AccessioniPrimary (citable) accession number: P28048
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: May 23, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

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