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P28048

- LAA_XENLA

UniProt

P28048 - LAA_XENLA

Protein

Lupus La protein homolog A

Gene

ssb-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Aug 1992)
      Previous versions | rss
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    Functioni

    La protein plays a role in the transcription of RNA polymerase III. It is most probably a transcription termination factor. Binds to the 3' termini of virtually all nascent polymerase III transcripts By similarity.By similarity

    GO - Molecular functioni

    1. nucleotide binding Source: InterPro
    2. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. RNA processing Source: InterPro

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lupus La protein homolog A
    Alternative name(s):
    La autoantigen homolog A
    La ribonucleoprotein A
    Gene namesi
    Name:ssb-a
    Synonyms:laa1
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-6254453. ssb.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. ribonucleoprotein complex Source: InterPro

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 428428Lupus La protein homolog APRO_0000207603Add
    BLAST

    Post-translational modificationi

    Phosphorylated.Curated

    Keywords - PTMi

    Phosphoprotein

    Expressioni

    Developmental stagei

    Barely detectable in stage I/II oocytes, accumulate in stage III/IV oocytes, then exhibit a roughly constant steady state level in mature oocytes, eggs, and early embryos.

    Structurei

    3D structure databases

    ProteinModelPortaliP28048.
    SMRiP28048. Positions 5-192, 226-332.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini7 – 9993HTH La-type RNA-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini111 – 20393RRMPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi196 – 21217Nuclear localization signalSequence AnalysisAdd
    BLAST
    Motifi316 – 33217Nuclear localization signalSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HTH La-type RNA-binding domain.PROSITE-ProRule annotation
    Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG001407.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    3.30.70.330. 2 hits.
    InterProiIPR002344. Lupus_La.
    IPR006630. Lupus_La_RNA-bd.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR014886. RRM_3.
    IPR000504. RRM_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF05383. La. 1 hit.
    PF00076. RRM_1. 1 hit.
    PF08777. RRM_3. 1 hit.
    [Graphical view]
    PRINTSiPR00302. LUPUSLA.
    SMARTiSM00715. LA. 1 hit.
    SM00360. RRM. 1 hit.
    [Graphical view]
    PROSITEiPS50961. HTH_LA. 1 hit.
    PS50102. RRM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P28048-1 [UniParc]FASTAAdd to Basket

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    MAENGDKEQK LDSDTKICEQ IEYYFGDHNL PRDKFLKQQI LLDDGWVPLE    50
    TMIKFNRLSK LTTDFNTILQ ALKKSKTELL EINEEKCKIR RSPAKPLPEL 100
    NDEYKNSLKH KSVYIKGFPT SAILDDVKEW LKDKGPIENI QMRRTLQREF 150
    KGSIFIIFNT DDDAKKFLEN RNLKYKDNDM TVLSREEYHA KKNEERKLNK 200
    SEEKAKSKQV KKEAQKQAED AERKLVEERV GSLLKFSGDL DNMTSREDLH 250
    ALFQTHGDIE WIDFSRGAKE GIVLFKMNAK EALDKAKAAN SDNLKLKGKD 300
    VKWELIEGDT EKEALKKILE GKQESFNKRK GRDGRKFKGK GRGGKGNDSS 350
    SRKRTQFQGK KKTFDSSDDE DDMEESESPQ KASVKAEESA GTKNGAAAAP 400
    GSPKKRSLDD KAEDGPAVKQ SKTEVGDQ 428
    Length:428
    Mass (Da):48,864
    Last modified:August 1, 1992 - v1
    Checksum:iAEB3A38B7D2E3EC3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X68817 mRNA. Translation: CAA48715.1.
    PIRiS33818.
    RefSeqiNP_001081021.1. NM_001087552.1.
    UniGeneiXl.1236.

    Genome annotation databases

    GeneIDi394333.
    KEGGixla:394333.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X68817 mRNA. Translation: CAA48715.1 .
    PIRi S33818.
    RefSeqi NP_001081021.1. NM_001087552.1.
    UniGenei Xl.1236.

    3D structure databases

    ProteinModelPortali P28048.
    SMRi P28048. Positions 5-192, 226-332.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 394333.
    KEGGi xla:394333.

    Organism-specific databases

    CTDi 394333.
    Xenbasei XB-GENE-6254453. ssb.

    Phylogenomic databases

    HOVERGENi HBG001407.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    3.30.70.330. 2 hits.
    InterProi IPR002344. Lupus_La.
    IPR006630. Lupus_La_RNA-bd.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR014886. RRM_3.
    IPR000504. RRM_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF05383. La. 1 hit.
    PF00076. RRM_1. 1 hit.
    PF08777. RRM_3. 1 hit.
    [Graphical view ]
    PRINTSi PR00302. LUPUSLA.
    SMARTi SM00715. LA. 1 hit.
    SM00360. RRM. 1 hit.
    [Graphical view ]
    PROSITEi PS50961. HTH_LA. 1 hit.
    PS50102. RRM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "La proteins from Xenopus laevis. cDNA cloning and developmental expression."
      Scherly D., Stutz F., Lin-Marq N., Clarkson S.G.
      J. Mol. Biol. 231:196-204(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Oocyte.

    Entry informationi

    Entry nameiLAA_XENLA
    AccessioniPrimary (citable) accession number: P28048
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    There are two forms of La, LaA and LaB, in Xenopus.

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3