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P28048 (LAA_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lupus La protein homolog A
Alternative name(s):
La autoantigen homolog A
La ribonucleoprotein A
Gene names
Name:ssb-a
Synonyms:laa1
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length428 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

La protein plays a role in the transcription of RNA polymerase III. It is most probably a transcription termination factor. Binds to the 3' termini of virtually all nascent polymerase III transcripts By similarity.

Subcellular location

Nucleus Probable.

Developmental stage

Barely detectable in stage I/II oocytes, accumulate in stage III/IV oocytes, then exhibit a roughly constant steady state level in mature oocytes, eggs, and early embryos.

Post-translational modification

Phosphorylated Probable.

Miscellaneous

There are two forms of La, LaA and LaB, in Xenopus.

Sequence similarities

Contains 1 HTH La-type RNA-binding domain.

Contains 1 RRM (RNA recognition motif) domain.

Ontologies

Keywords
   Cellular componentNucleus
   LigandRNA-binding
   PTMPhosphoprotein
Gene Ontology (GO)
   Biological_processRNA processing

Inferred from electronic annotation. Source: InterPro

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

ribonucleoprotein complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 428428Lupus La protein homolog A
PRO_0000207603

Regions

Domain7 – 9993HTH La-type RNA-binding
Domain111 – 20393RRM
Motif196 – 21217Nuclear localization signal Potential
Motif316 – 33217Nuclear localization signal Potential

Sequences

Sequence LengthMass (Da)Tools
P28048 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: AEB3A38B7D2E3EC3

FASTA42848,864
        10         20         30         40         50         60 
MAENGDKEQK LDSDTKICEQ IEYYFGDHNL PRDKFLKQQI LLDDGWVPLE TMIKFNRLSK 

        70         80         90        100        110        120 
LTTDFNTILQ ALKKSKTELL EINEEKCKIR RSPAKPLPEL NDEYKNSLKH KSVYIKGFPT 

       130        140        150        160        170        180 
SAILDDVKEW LKDKGPIENI QMRRTLQREF KGSIFIIFNT DDDAKKFLEN RNLKYKDNDM 

       190        200        210        220        230        240 
TVLSREEYHA KKNEERKLNK SEEKAKSKQV KKEAQKQAED AERKLVEERV GSLLKFSGDL 

       250        260        270        280        290        300 
DNMTSREDLH ALFQTHGDIE WIDFSRGAKE GIVLFKMNAK EALDKAKAAN SDNLKLKGKD 

       310        320        330        340        350        360 
VKWELIEGDT EKEALKKILE GKQESFNKRK GRDGRKFKGK GRGGKGNDSS SRKRTQFQGK 

       370        380        390        400        410        420 
KKTFDSSDDE DDMEESESPQ KASVKAEESA GTKNGAAAAP GSPKKRSLDD KAEDGPAVKQ 


SKTEVGDQ 

« Hide

References

[1]"La proteins from Xenopus laevis. cDNA cloning and developmental expression."
Scherly D., Stutz F., Lin-Marq N., Clarkson S.G.
J. Mol. Biol. 231:196-204(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Oocyte.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X68817 mRNA. Translation: CAA48715.1.
PIRS33818.
RefSeqNP_001081021.1. NM_001087552.1.
UniGeneXl.1236.

3D structure databases

ProteinModelPortalP28048.
SMRP28048. Positions 5-192, 226-332.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID394333.
KEGGxla:394333.

Organism-specific databases

CTD394333.
XenbaseXB-GENE-6254453. ssb.

Phylogenomic databases

HOVERGENHBG001407.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
3.30.70.330. 2 hits.
InterProIPR002344. Lupus_La.
IPR006630. Lupus_La_RNA-bd.
IPR012677. Nucleotide-bd_a/b_plait.
IPR014886. RRM_3.
IPR000504. RRM_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF05383. La. 1 hit.
PF00076. RRM_1. 1 hit.
PF08777. RRM_3. 1 hit.
[Graphical view]
PRINTSPR00302. LUPUSLA.
SMARTSM00715. LA. 1 hit.
SM00360. RRM. 1 hit.
[Graphical view]
PROSITEPS50961. HTH_LA. 1 hit.
PS50102. RRM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLAA_XENLA
AccessionPrimary (citable) accession number: P28048
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: May 1, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families