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P28048

- LAA_XENLA

UniProt

P28048 - LAA_XENLA

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Protein
Lupus La protein homolog A
Gene
ssb-a, laa1
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

La protein plays a role in the transcription of RNA polymerase III. It is most probably a transcription termination factor. Binds to the 3' termini of virtually all nascent polymerase III transcripts By similarity.

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
  2. nucleotide binding Source: InterPro

GO - Biological processi

  1. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lupus La protein homolog A
Alternative name(s):
La autoantigen homolog A
La ribonucleoprotein A
Gene namesi
Name:ssb-a
Synonyms:laa1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6254453. ssb.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. ribonucleoprotein complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 428428Lupus La protein homolog A
PRO_0000207603Add
BLAST

Post-translational modificationi

Phosphorylated Inferred.

Keywords - PTMi

Phosphoprotein

Expressioni

Developmental stagei

Barely detectable in stage I/II oocytes, accumulate in stage III/IV oocytes, then exhibit a roughly constant steady state level in mature oocytes, eggs, and early embryos.

Structurei

3D structure databases

ProteinModelPortaliP28048.
SMRiP28048. Positions 5-192, 226-332.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 9993HTH La-type RNA-binding
Add
BLAST
Domaini111 – 20393RRM
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi196 – 21217Nuclear localization signal Reviewed prediction
Add
BLAST
Motifi316 – 33217Nuclear localization signal Reviewed prediction
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG001407.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.70.330. 2 hits.
InterProiIPR002344. Lupus_La.
IPR006630. Lupus_La_RNA-bd.
IPR012677. Nucleotide-bd_a/b_plait.
IPR014886. RRM_3.
IPR000504. RRM_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF05383. La. 1 hit.
PF00076. RRM_1. 1 hit.
PF08777. RRM_3. 1 hit.
[Graphical view]
PRINTSiPR00302. LUPUSLA.
SMARTiSM00715. LA. 1 hit.
SM00360. RRM. 1 hit.
[Graphical view]
PROSITEiPS50961. HTH_LA. 1 hit.
PS50102. RRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28048-1 [UniParc]FASTAAdd to Basket

« Hide

MAENGDKEQK LDSDTKICEQ IEYYFGDHNL PRDKFLKQQI LLDDGWVPLE    50
TMIKFNRLSK LTTDFNTILQ ALKKSKTELL EINEEKCKIR RSPAKPLPEL 100
NDEYKNSLKH KSVYIKGFPT SAILDDVKEW LKDKGPIENI QMRRTLQREF 150
KGSIFIIFNT DDDAKKFLEN RNLKYKDNDM TVLSREEYHA KKNEERKLNK 200
SEEKAKSKQV KKEAQKQAED AERKLVEERV GSLLKFSGDL DNMTSREDLH 250
ALFQTHGDIE WIDFSRGAKE GIVLFKMNAK EALDKAKAAN SDNLKLKGKD 300
VKWELIEGDT EKEALKKILE GKQESFNKRK GRDGRKFKGK GRGGKGNDSS 350
SRKRTQFQGK KKTFDSSDDE DDMEESESPQ KASVKAEESA GTKNGAAAAP 400
GSPKKRSLDD KAEDGPAVKQ SKTEVGDQ 428
Length:428
Mass (Da):48,864
Last modified:August 1, 1992 - v1
Checksum:iAEB3A38B7D2E3EC3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X68817 mRNA. Translation: CAA48715.1.
PIRiS33818.
RefSeqiNP_001081021.1. NM_001087552.1.
UniGeneiXl.1236.

Genome annotation databases

GeneIDi394333.
KEGGixla:394333.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X68817 mRNA. Translation: CAA48715.1 .
PIRi S33818.
RefSeqi NP_001081021.1. NM_001087552.1.
UniGenei Xl.1236.

3D structure databases

ProteinModelPortali P28048.
SMRi P28048. Positions 5-192, 226-332.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 394333.
KEGGi xla:394333.

Organism-specific databases

CTDi 394333.
Xenbasei XB-GENE-6254453. ssb.

Phylogenomic databases

HOVERGENi HBG001407.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
3.30.70.330. 2 hits.
InterProi IPR002344. Lupus_La.
IPR006630. Lupus_La_RNA-bd.
IPR012677. Nucleotide-bd_a/b_plait.
IPR014886. RRM_3.
IPR000504. RRM_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF05383. La. 1 hit.
PF00076. RRM_1. 1 hit.
PF08777. RRM_3. 1 hit.
[Graphical view ]
PRINTSi PR00302. LUPUSLA.
SMARTi SM00715. LA. 1 hit.
SM00360. RRM. 1 hit.
[Graphical view ]
PROSITEi PS50961. HTH_LA. 1 hit.
PS50102. RRM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "La proteins from Xenopus laevis. cDNA cloning and developmental expression."
    Scherly D., Stutz F., Lin-Marq N., Clarkson S.G.
    J. Mol. Biol. 231:196-204(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Oocyte.

Entry informationi

Entry nameiLAA_XENLA
AccessioniPrimary (citable) accession number: P28048
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: May 1, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two forms of La, LaA and LaB, in Xenopus.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi