Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P28047

- WNT7B_MOUSE

UniProt

P28047 - WNT7B_MOUSE

Protein

Protein Wnt-7b

Gene

Wnt7b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 1 (01 Aug 1992)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

    GO - Molecular functioni

    1. frizzled binding Source: MGI
    2. receptor agonist activity Source: BHF-UCL
    3. receptor binding Source: MGI

    GO - Biological processi

    1. anatomical structure regression Source: MGI
    2. apoptotic process involved in patterning of blood vessels Source: MGI
    3. canonical Wnt signaling pathway Source: MGI
    4. cell-cell signaling Source: MGI
    5. cell fate commitment Source: RefGenome
    6. cell proliferation in forebrain Source: BHF-UCL
    7. cellular metabolic process Source: MGI
    8. central nervous system vasculogenesis Source: MGI
    9. chorio-allantoic fusion Source: MGI
    10. developmental growth involved in morphogenesis Source: MGI
    11. embryonic organ development Source: MGI
    12. embryonic placenta morphogenesis Source: MGI
    13. establishment or maintenance of polarity of embryonic epithelium Source: MGI
    14. forebrain regionalization Source: UniProtKB
    15. homeostatic process Source: MGI
    16. inner medullary collecting duct development Source: MGI
    17. in utero embryonic development Source: MGI
    18. lobar bronchus development Source: MGI
    19. lung-associated mesenchyme development Source: MGI
    20. lung development Source: MGI
    21. lung epithelium development Source: MGI
    22. lung morphogenesis Source: MGI
    23. metanephric collecting duct development Source: MGI
    24. metanephric epithelium development Source: MGI
    25. metanephric loop of Henle development Source: MGI
    26. metanephros morphogenesis Source: MGI
    27. negative regulation of neurogenesis Source: BHF-UCL
    28. negative regulation of smoothened signaling pathway Source: MGI
    29. neuron differentiation Source: RefGenome
    30. odontogenesis of dentin-containing tooth Source: MGI
    31. outer medullary collecting duct development Source: MGI
    32. oxygen homeostasis Source: MGI
    33. positive regulation of cell proliferation Source: MGI
    34. positive regulation of gene expression Source: MGI
    35. positive regulation of JNK cascade Source: RefGenome
    36. positive regulation of osteoblast differentiation Source: MGI
    37. renal inner medulla development Source: MGI
    38. renal outer medulla development Source: MGI
    39. signal transduction Source: MGI
    40. smooth muscle cell differentiation Source: MGI
    41. stem cell development Source: BHF-UCL
    42. synapse organization Source: MGI
    43. trachea cartilage morphogenesis Source: MGI
    44. vasculature development Source: MGI
    45. Wnt signaling pathway Source: MGI

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_213918. WNT ligand biogenesis and trafficking.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Wnt-7b
    Gene namesi
    Name:Wnt7b
    Synonyms:Wnt-7b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:98962. Wnt7b.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: BHF-UCL
    2. endoplasmic reticulum lumen Source: Reactome
    3. extracellular space Source: RefGenome
    4. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 349325Protein Wnt-7bPRO_0000041445Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi73 ↔ 84By similarity
    Glycosylationi83 – 831N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi123 ↔ 131By similarity
    Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi133 ↔ 152By similarity
    Disulfide bondi200 ↔ 214By similarity
    Disulfide bondi202 ↔ 209By similarity
    Lipidationi206 – 2061O-palmitoyl serine; by PORCNBy similarity
    Disulfide bondi294 ↔ 309By similarity
    Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi324 ↔ 339By similarity
    Disulfide bondi326 ↔ 336By similarity
    Disulfide bondi331 ↔ 332By similarity

    Post-translational modificationi

    Palmitoylation at Ser-206 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PRIDEiP28047.

    PTM databases

    PhosphoSiteiP28047.

    Expressioni

    Gene expression databases

    ArrayExpressiP28047.
    BgeeiP28047.
    CleanExiMM_WNT7B.
    GenevestigatoriP28047.

    Interactioni

    Subunit structurei

    Interacts with PORCN.1 Publication

    Protein-protein interaction databases

    BioGridi204581. 5 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP28047.
    SMRiP28047. Positions 62-341.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Wnt family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG284879.
    GeneTreeiENSGT00740000115016.
    HOGENOMiHOG000039528.
    HOVERGENiHBG001595.
    KOiK00572.
    OrthoDBiEOG7C8GJ8.
    PhylomeDBiP28047.

    Family and domain databases

    InterProiIPR005817. Wnt.
    IPR013300. Wnt7.
    IPR018161. Wnt_CS.
    [Graphical view]
    PANTHERiPTHR12027. PTHR12027. 1 hit.
    PfamiPF00110. wnt. 1 hit.
    [Graphical view]
    PRINTSiPR01891. WNT7PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTiSM00097. WNT1. 1 hit.
    [Graphical view]
    PROSITEiPS00246. WNT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P28047-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHRNFRKWIF YVFLCFGVLY VKLGALSSVV ALGANIICNK IPGLAPRQRA    50
    ICQSRPDAII VIGEGAQMGI DECQHQFRFG RWNCSALGEK TVFGQELRVG 100
    SREAAFTYAI TAAGVAHAVT AACSQGNLSN CGCDREKQGY YNQAEGWKWG 150
    GCSADVRYGI DFSRRFVDAR EIKKNARRLM NLHNNEAGRK VLEDRMKLEC 200
    KCHGVSGSCT TKTCWTTLPK FREVGHLLKE KYNAAVQVEV VRASRLRQPT 250
    FLRIKQLRSY QKPMETDLVY IEKSPNYCEE DAATGSVGTQ GRLCNRTSPG 300
    ADGCDTMCCG RGYNTHQYTK VWQCNCKFHW CCFVKCNTCS ERTEVFTCK 349
    Length:349
    Mass (Da):39,302
    Last modified:August 1, 1992 - v1
    Checksum:iBDD82AB020DC680E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti33 – 331G → V in AAH52018. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M89802 mRNA. Translation: AAA40571.1.
    BC052018 mRNA. Translation: AAH52018.2.
    CCDSiCCDS37171.1.
    PIRiH36470.
    RefSeqiNP_001157105.1. NM_001163633.1.
    NP_001157106.1. NM_001163634.1.
    NP_033554.3. NM_009528.3.
    UniGeneiMm.306946.

    Genome annotation databases

    EnsembliENSMUST00000023015; ENSMUSP00000023015; ENSMUSG00000022382.
    GeneIDi22422.
    KEGGimmu:22422.
    UCSCiuc007xdf.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M89802 mRNA. Translation: AAA40571.1 .
    BC052018 mRNA. Translation: AAH52018.2 .
    CCDSi CCDS37171.1.
    PIRi H36470.
    RefSeqi NP_001157105.1. NM_001163633.1.
    NP_001157106.1. NM_001163634.1.
    NP_033554.3. NM_009528.3.
    UniGenei Mm.306946.

    3D structure databases

    ProteinModelPortali P28047.
    SMRi P28047. Positions 62-341.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204581. 5 interactions.

    PTM databases

    PhosphoSitei P28047.

    Proteomic databases

    PRIDEi P28047.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023015 ; ENSMUSP00000023015 ; ENSMUSG00000022382 .
    GeneIDi 22422.
    KEGGi mmu:22422.
    UCSCi uc007xdf.2. mouse.

    Organism-specific databases

    CTDi 7477.
    MGIi MGI:98962. Wnt7b.

    Phylogenomic databases

    eggNOGi NOG284879.
    GeneTreei ENSGT00740000115016.
    HOGENOMi HOG000039528.
    HOVERGENi HBG001595.
    KOi K00572.
    OrthoDBi EOG7C8GJ8.
    PhylomeDBi P28047.

    Enzyme and pathway databases

    Reactomei REACT_213918. WNT ligand biogenesis and trafficking.

    Miscellaneous databases

    NextBioi 302857.
    PROi P28047.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P28047.
    Bgeei P28047.
    CleanExi MM_WNT7B.
    Genevestigatori P28047.

    Family and domain databases

    InterProi IPR005817. Wnt.
    IPR013300. Wnt7.
    IPR018161. Wnt_CS.
    [Graphical view ]
    PANTHERi PTHR12027. PTHR12027. 1 hit.
    Pfami PF00110. wnt. 1 hit.
    [Graphical view ]
    PRINTSi PR01891. WNT7PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTi SM00097. WNT1. 1 hit.
    [Graphical view ]
    PROSITEi PS00246. WNT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development."
      Gavin B.J., McMahon J.A., McMahon A.P.
      Genes Dev. 4:2319-2332(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
    3. "The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family."
      Tanaka K., Okabayashi H., Asashima M., Perrimon N., Kadowaki T.
      Eur. J. Biochem. 267:4300-4311(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PORCN.

    Entry informationi

    Entry nameiWNT7B_MOUSE
    AccessioniPrimary (citable) accession number: P28047
    Secondary accession number(s): Q80US5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 124 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3