Reviewed,
UniProtKB/Swiss-Prot P28047 (WNT7B_MOUSE)
Last modified
June 16, 2009.
Version 76.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Protein Wnt-7b | ||||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 349 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. |
| Subunit structure | Interacts with PORCN. Ref.3 |
| Subcellular location | |
| Sequence similarities | Belongs to the Wnt family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Wnt signaling pathway |
| Cellular component | Extracellular matrix Secreted |
| Domain | Signal |
| Molecular function | Developmental protein |
| PTM | Glycoprotein |
| Gene Ontology (GO) | |
| Biological process | Wnt receptor signaling pathway, calcium modulating pathway Inferred from electronic annotation. Source: InterPro cell-cell signalingTraceable author statement. Source: MGI organ morphogenesisInferred from mutant phenotype. Source: MGI positive regulation of osteoblast differentiationInferred from direct assay. Source: MGI synapse organizationInferred from genetic interaction. Source: MGI |
| Cellular component | extracellular space Inferred from electronic annotation. Source: UniProtKB-SubCell proteinaceous extracellular matrixInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | receptor binding Traceable author statement. Source: MGI signal transducer activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 31 | 31 | Potential | ||||||
| Chain | 32 – 349 | 318 | Protein Wnt-7b | PRO_0000041445 | |||||
Amino acid modifications | |||||||||
| Glycosylation | 83 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 127 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 295 | 1 | N-linked (GlcNAc...) Potential | ||||||
Experimental info | |||||||||
| Sequence conflict | 33 | 1 | G → V in AAH52018. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development." Gavin B.J., McMahon J.A., McMahon A.P. Genes Dev. 4:2319-2332(1990) [PubMed: 2279700] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. |
| [3] | "The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family." Tanaka K., Okabayashi H., Asashima M., Perrimon N., Kadowaki T. Eur. J. Biochem. 267:4300-4311(2000) [PubMed: 10866835] [Abstract] Cited for: INTERACTION WITH PORCN. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| M89802 mRNA. Translation: AAA40571.1. BC052018 mRNA. Translation: AAH52018.2. | |
| IPI | IPI00116644. |
| PIR | H36470. |
| RefSeq | NP_033554.2. |
| UniGene | Mm.306946 |
3D structure databases | |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | P28047. |
Proteomic databases | |
| PRIDE | P28047. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000022382. Mus musculus. [Contig view] |
| GeneID | 22422. |
| KEGG | mmu:22422. |
Organism-specific databases | |
| MGI | MGI:98962. Wnt7b. |
Phylogenomic databases | |
| HOVERGEN | P28047. |
Gene expression databases | |
| ArrayExpress | P28047. |
| Bgee | P28047. |
| CleanEx | MM_WNT7B. |
Family and domain databases | |
| InterPro | IPR013300. Wnt7. IPR005816. Wnt_grthfactor. IPR018161. Wnt_grthfactor_CS. IPR005817. Wnt_SF. [Graphical view] |
| PANTHER | PTHR12027. Wnt. 1 hit. |
| Pfam | PF00110. wnt. 1 hit. [Graphical view] |
| PRINTS | PR01891. WNT7PROTEIN. PR01349. WNTPROTEIN. |
| SMART | SM00097. WNT1. 1 hit. [Graphical view] |
| PROSITE | PS00246. WNT1. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 302857. |
| SOURCE | Search... |
Entry information
| Entry name | WNT7B_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P28047 Secondary accession number(s): Q80US5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


