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P28047 (WNT7B_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein Wnt-7b
Gene names
Name:Wnt7b
Synonyms:Wnt-7b
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length349 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

Subunit structure

Interacts with PORCN. Ref.3

Subcellular location

Secretedextracellular spaceextracellular matrix.

Post-translational modification

Palmitoylation at Ser-206 is required for efficient binding to frizzled receptors. It is also required for subsequent palmitoylation at Cys-73. Palmitoylation is necessary for proper trafficking to cell surface By similarity.

Sequence similarities

Belongs to the Wnt family.

Ontologies

Keywords
   Biological processWnt signaling pathway
   Cellular componentExtracellular matrix
Secreted
   DomainSignal
   Molecular functionDevelopmental protein
   PTMGlycoprotein
Lipoprotein
Palmitate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processWnt signaling pathway

Inferred from mutant phenotype PubMed 18367557. Source: MGI

anatomical structure regression

Inferred from mutant phenotype PubMed 16163358. Source: MGI

apoptotic process involved in patterning of blood vessels

Inferred from mutant phenotype PubMed 16163358. Source: MGI

canonical Wnt signaling pathway

Inferred from direct assay PubMed 17804636. Source: MGI

cell fate commitment

Inferred from Biological aspect of Ancestor. Source: RefGenome

cell proliferation in forebrain

Inferred from direct assay PubMed 12843296. Source: BHF-UCL

cell-cell signaling

Traceable author statement PubMed 9889131. Source: MGI

cellular metabolic process

Inferred from mutant phenotype PubMed 18367557. Source: MGI

central nervous system vasculogenesis

Inferred from genetic interaction PubMed 19023080. Source: MGI

chorio-allantoic fusion

Inferred from mutant phenotype PubMed 11543617. Source: MGI

developmental growth involved in morphogenesis

Inferred from mutant phenotype PubMed 19060336. Source: MGI

embryonic organ development

Inferred from mutant phenotype PubMed 18367557. Source: MGI

embryonic placenta morphogenesis

Inferred from mutant phenotype PubMed 11543617. Source: MGI

establishment or maintenance of polarity of embryonic epithelium

Inferred from mutant phenotype PubMed 19060336. Source: MGI

forebrain regionalization

Inferred from expression pattern PubMed 15164427. Source: UniProtKB

homeostatic process

Inferred from mutant phenotype PubMed 18367557. Source: MGI

in utero embryonic development

Inferred from mutant phenotype PubMed 18367557. Source: MGI

inner medullary collecting duct development

Inferred from mutant phenotype PubMed 19060336. Source: MGI

lobar bronchus development

Inferred from mutant phenotype PubMed 18367557. Source: MGI

lung development

Inferred from mutant phenotype PubMed 18343501. Source: MGI

lung epithelium development

Inferred from mutant phenotype PubMed 18367557. Source: MGI

lung morphogenesis

Inferred from mutant phenotype PubMed 18367557. Source: MGI

lung-associated mesenchyme development

Inferred from mutant phenotype PubMed 18367557. Source: MGI

metanephric collecting duct development

Inferred from mutant phenotype PubMed 19060336. Source: MGI

metanephric epithelium development

Inferred from mutant phenotype PubMed 19060336. Source: MGI

metanephric loop of Henle development

Inferred from mutant phenotype PubMed 19060336. Source: MGI

metanephros morphogenesis

Inferred from mutant phenotype PubMed 19060336. Source: MGI

negative regulation of neurogenesis

Inferred from direct assay PubMed 12843296. Source: BHF-UCL

negative regulation of smoothened signaling pathway

Inferred from mutant phenotype PubMed 10781055. Source: MGI

neuron differentiation

Inferred from Biological aspect of Ancestor. Source: RefGenome

odontogenesis of dentin-containing tooth

Inferred from mutant phenotype PubMed 10781055. Source: MGI

outer medullary collecting duct development

Inferred from mutant phenotype PubMed 19060336. Source: MGI

oxygen homeostasis

Inferred from mutant phenotype PubMed 18367557. Source: MGI

positive regulation of JNK cascade

Inferred from Biological aspect of Ancestor. Source: RefGenome

positive regulation of cell proliferation

Inferred from mutant phenotype PubMed 19690384. Source: MGI

positive regulation of gene expression

Inferred from mutant phenotype PubMed 19690384. Source: MGI

positive regulation of osteoblast differentiation

Inferred from direct assay PubMed 15576404. Source: MGI

renal inner medulla development

Inferred from mutant phenotype PubMed 19060336. Source: MGI

renal outer medulla development

Inferred from mutant phenotype PubMed 19060336. Source: MGI

signal transduction

Traceable author statement PubMed 9889131. Source: MGI

smooth muscle cell differentiation

Inferred from mutant phenotype PubMed 19690384. Source: MGI

stem cell development

Inferred from direct assay PubMed 12843296. Source: BHF-UCL

synapse organization

Inferred from genetic interaction PubMed 16818724. Source: MGI

trachea cartilage morphogenesis

Inferred from mutant phenotype PubMed 18367557. Source: MGI

vasculature development

Inferred from mutant phenotype PubMed 16163358. Source: MGI

   Cellular_componentcell surface

Inferred from direct assay PubMed 8167409. Source: BHF-UCL

endoplasmic reticulum lumen

Traceable author statement. Source: Reactome

extracellular space

Inferred from Biological aspect of Ancestor. Source: RefGenome

proteinaceous extracellular matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionfrizzled binding

Inferred from physical interaction PubMed 15923619PubMed 16163358. Source: MGI

receptor agonist activity

Inferred by curator PubMed 16163358. Source: BHF-UCL

receptor binding

Traceable author statement PubMed 9889131. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 349325Protein Wnt-7b
PRO_0000041445

Amino acid modifications

Lipidation731S-palmitoyl cysteine By similarity
Lipidation2061O-palmitoyl serine; by PORCN By similarity
Glycosylation831N-linked (GlcNAc...) Potential
Glycosylation1271N-linked (GlcNAc...) Potential
Glycosylation2951N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict331G → V in AAH52018. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P28047 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: BDD82AB020DC680E

FASTA34939,302
        10         20         30         40         50         60 
MHRNFRKWIF YVFLCFGVLY VKLGALSSVV ALGANIICNK IPGLAPRQRA ICQSRPDAII 

        70         80         90        100        110        120 
VIGEGAQMGI DECQHQFRFG RWNCSALGEK TVFGQELRVG SREAAFTYAI TAAGVAHAVT 

       130        140        150        160        170        180 
AACSQGNLSN CGCDREKQGY YNQAEGWKWG GCSADVRYGI DFSRRFVDAR EIKKNARRLM 

       190        200        210        220        230        240 
NLHNNEAGRK VLEDRMKLEC KCHGVSGSCT TKTCWTTLPK FREVGHLLKE KYNAAVQVEV 

       250        260        270        280        290        300 
VRASRLRQPT FLRIKQLRSY QKPMETDLVY IEKSPNYCEE DAATGSVGTQ GRLCNRTSPG 

       310        320        330        340 
ADGCDTMCCG RGYNTHQYTK VWQCNCKFHW CCFVKCNTCS ERTEVFTCK 

« Hide

References

« Hide 'large scale' references
[1]"Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development."
Gavin B.J., McMahon J.A., McMahon A.P.
Genes Dev. 4:2319-2332(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
[3]"The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family."
Tanaka K., Okabayashi H., Asashima M., Perrimon N., Kadowaki T.
Eur. J. Biochem. 267:4300-4311(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH PORCN.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M89802 mRNA. Translation: AAA40571.1.
BC052018 mRNA. Translation: AAH52018.2.
CCDSCCDS37171.1.
PIRH36470.
RefSeqNP_001157105.1. NM_001163633.1.
NP_001157106.1. NM_001163634.1.
NP_033554.3. NM_009528.3.
UniGeneMm.306946.

3D structure databases

ProteinModelPortalP28047.
SMRP28047. Positions 62-341.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid204581. 5 interactions.

PTM databases

PhosphoSiteP28047.

Proteomic databases

PRIDEP28047.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000023015; ENSMUSP00000023015; ENSMUSG00000022382.
GeneID22422.
KEGGmmu:22422.
UCSCuc007xdf.2. mouse.

Organism-specific databases

CTD7477.
MGIMGI:98962. Wnt7b.

Phylogenomic databases

eggNOGNOG284879.
GeneTreeENSGT00740000115016.
HOGENOMHOG000039528.
HOVERGENHBG001595.
KOK00572.
OrthoDBEOG7C8GJ8.
PhylomeDBP28047.

Enzyme and pathway databases

ReactomeREACT_188257. Signal Transduction.

Gene expression databases

ArrayExpressP28047.
BgeeP28047.
CleanExMM_WNT7B.
GenevestigatorP28047.

Family and domain databases

InterProIPR005817. Wnt.
IPR013300. Wnt7.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERPTHR12027. PTHR12027. 1 hit.
PfamPF00110. wnt. 1 hit.
[Graphical view]
PRINTSPR01891. WNT7PROTEIN.
PR01349. WNTPROTEIN.
SMARTSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio302857.
PROP28047.
SOURCESearch...

Entry information

Entry nameWNT7B_MOUSE
AccessionPrimary (citable) accession number: P28047
Secondary accession number(s): Q80US5
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: July 9, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot