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Protein

Protein Wnt-7b

Gene

Wnt7b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

GO - Molecular functioni

  1. frizzled binding Source: MGI
  2. receptor agonist activity Source: BHF-UCL

GO - Biological processi

  1. anatomical structure regression Source: MGI
  2. angiogenesis Source: MGI
  3. apoptotic process involved in patterning of blood vessels Source: MGI
  4. canonical Wnt signaling pathway Source: MGI
  5. cell fate commitment Source: GO_Central
  6. cell proliferation in forebrain Source: BHF-UCL
  7. cellular metabolic process Source: MGI
  8. central nervous system vasculogenesis Source: MGI
  9. chorio-allantoic fusion Source: MGI
  10. developmental growth involved in morphogenesis Source: MGI
  11. embryonic organ development Source: MGI
  12. embryonic placenta morphogenesis Source: MGI
  13. establishment or maintenance of polarity of embryonic epithelium Source: MGI
  14. forebrain regionalization Source: UniProtKB
  15. homeostatic process Source: MGI
  16. inner medullary collecting duct development Source: MGI
  17. in utero embryonic development Source: MGI
  18. lobar bronchus development Source: MGI
  19. lung-associated mesenchyme development Source: MGI
  20. lung development Source: MGI
  21. lung epithelium development Source: MGI
  22. lung morphogenesis Source: MGI
  23. metanephric collecting duct development Source: MGI
  24. metanephric epithelium development Source: MGI
  25. metanephric loop of Henle development Source: MGI
  26. metanephros morphogenesis Source: MGI
  27. negative regulation of neurogenesis Source: BHF-UCL
  28. negative regulation of smoothened signaling pathway Source: MGI
  29. neuron differentiation Source: GO_Central
  30. odontogenesis of dentin-containing tooth Source: MGI
  31. outer medullary collecting duct development Source: MGI
  32. oxygen homeostasis Source: MGI
  33. positive regulation of cell proliferation Source: MGI
  34. positive regulation of gene expression Source: MGI
  35. positive regulation of JNK cascade Source: GO_Central
  36. positive regulation of osteoblast differentiation Source: MGI
  37. renal inner medulla development Source: MGI
  38. renal outer medulla development Source: MGI
  39. smooth muscle cell differentiation Source: MGI
  40. stem cell development Source: BHF-UCL
  41. synapse organization Source: MGI
  42. trachea cartilage morphogenesis Source: MGI
  43. vasculature development Source: MGI
  44. Wnt signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_295052. WNT ligand biogenesis and trafficking.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-7b
Gene namesi
Name:Wnt7b
Synonyms:Wnt-7b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:98962. Wnt7b.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: BHF-UCL
  2. endoplasmic reticulum lumen Source: Reactome
  3. extracellular space Source: GO_Central
  4. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 349325Protein Wnt-7bPRO_0000041445Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi73 ↔ 84By similarity
Glycosylationi83 – 831N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi123 ↔ 131By similarity
Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi133 ↔ 152By similarity
Disulfide bondi200 ↔ 214By similarity
Disulfide bondi202 ↔ 209By similarity
Lipidationi206 – 2061O-palmitoleyl serine; by PORCNBy similarity
Disulfide bondi294 ↔ 309By similarity
Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi324 ↔ 339By similarity
Disulfide bondi326 ↔ 336By similarity
Disulfide bondi331 ↔ 332By similarity

Post-translational modificationi

Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

MaxQBiP28047.
PRIDEiP28047.

PTM databases

PhosphoSiteiP28047.

Expressioni

Gene expression databases

BgeeiP28047.
CleanExiMM_WNT7B.
ExpressionAtlasiP28047. baseline and differential.
GenevestigatoriP28047.

Interactioni

Subunit structurei

Interacts with PORCN.1 Publication

Protein-protein interaction databases

BioGridi204581. 5 interactions.

Structurei

3D structure databases

ProteinModelPortaliP28047.
SMRiP28047. Positions 62-341.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG284879.
GeneTreeiENSGT00760000118943.
HOGENOMiHOG000039528.
HOVERGENiHBG001595.
InParanoidiP28047.
KOiK00572.
OrthoDBiEOG7C8GJ8.
PhylomeDBiP28047.

Family and domain databases

InterProiIPR005817. Wnt.
IPR013300. Wnt7.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01891. WNT7PROTEIN.
PR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28047-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHRNFRKWIF YVFLCFGVLY VKLGALSSVV ALGANIICNK IPGLAPRQRA
60 70 80 90 100
ICQSRPDAII VIGEGAQMGI DECQHQFRFG RWNCSALGEK TVFGQELRVG
110 120 130 140 150
SREAAFTYAI TAAGVAHAVT AACSQGNLSN CGCDREKQGY YNQAEGWKWG
160 170 180 190 200
GCSADVRYGI DFSRRFVDAR EIKKNARRLM NLHNNEAGRK VLEDRMKLEC
210 220 230 240 250
KCHGVSGSCT TKTCWTTLPK FREVGHLLKE KYNAAVQVEV VRASRLRQPT
260 270 280 290 300
FLRIKQLRSY QKPMETDLVY IEKSPNYCEE DAATGSVGTQ GRLCNRTSPG
310 320 330 340
ADGCDTMCCG RGYNTHQYTK VWQCNCKFHW CCFVKCNTCS ERTEVFTCK
Length:349
Mass (Da):39,302
Last modified:August 1, 1992 - v1
Checksum:iBDD82AB020DC680E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 331G → V in AAH52018 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M89802 mRNA. Translation: AAA40571.1.
BC052018 mRNA. Translation: AAH52018.2.
CCDSiCCDS37171.1.
PIRiH36470.
RefSeqiNP_001157105.1. NM_001163633.1.
NP_001157106.1. NM_001163634.1.
NP_033554.3. NM_009528.3.
UniGeneiMm.306946.

Genome annotation databases

EnsembliENSMUST00000023015; ENSMUSP00000023015; ENSMUSG00000022382.
GeneIDi22422.
KEGGimmu:22422.
UCSCiuc007xdf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M89802 mRNA. Translation: AAA40571.1.
BC052018 mRNA. Translation: AAH52018.2.
CCDSiCCDS37171.1.
PIRiH36470.
RefSeqiNP_001157105.1. NM_001163633.1.
NP_001157106.1. NM_001163634.1.
NP_033554.3. NM_009528.3.
UniGeneiMm.306946.

3D structure databases

ProteinModelPortaliP28047.
SMRiP28047. Positions 62-341.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204581. 5 interactions.

PTM databases

PhosphoSiteiP28047.

Proteomic databases

MaxQBiP28047.
PRIDEiP28047.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023015; ENSMUSP00000023015; ENSMUSG00000022382.
GeneIDi22422.
KEGGimmu:22422.
UCSCiuc007xdf.2. mouse.

Organism-specific databases

CTDi7477.
MGIiMGI:98962. Wnt7b.

Phylogenomic databases

eggNOGiNOG284879.
GeneTreeiENSGT00760000118943.
HOGENOMiHOG000039528.
HOVERGENiHBG001595.
InParanoidiP28047.
KOiK00572.
OrthoDBiEOG7C8GJ8.
PhylomeDBiP28047.

Enzyme and pathway databases

ReactomeiREACT_295052. WNT ligand biogenesis and trafficking.

Miscellaneous databases

NextBioi302857.
PROiP28047.
SOURCEiSearch...

Gene expression databases

BgeeiP28047.
CleanExiMM_WNT7B.
ExpressionAtlasiP28047. baseline and differential.
GenevestigatoriP28047.

Family and domain databases

InterProiIPR005817. Wnt.
IPR013300. Wnt7.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01891. WNT7PROTEIN.
PR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development."
    Gavin B.J., McMahon J.A., McMahon A.P.
    Genes Dev. 4:2319-2332(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
  3. "The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family."
    Tanaka K., Okabayashi H., Asashima M., Perrimon N., Kadowaki T.
    Eur. J. Biochem. 267:4300-4311(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PORCN.

Entry informationi

Entry nameiWNT7B_MOUSE
AccessioniPrimary (citable) accession number: P28047
Secondary accession number(s): Q80US5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: April 29, 2015
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.