Reviewed, UniProtKB/Swiss-Prot P28047 (WNT7B_MOUSE)

Names and origin

Protein names

Recommended name:
    Protein Wnt-7b

Gene names

Name:	Wnt7b
Synonyms:	Wnt-7b

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	349 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.
Subunit structure	Interacts with PORCN. Ref.3
Subcellular location	Secreted › extracellular space › extracellular matrix.
Sequence similarities	Belongs to the Wnt family.

Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Extracellular matrix Secreted
Domain	Signal
Molecular function	Developmental protein
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	Wnt receptor signaling pathway, calcium modulating pathway Inferred from electronic annotation. Source: InterPro cell-cell signaling Traceable author statement. Source: MGI organ morphogenesis Inferred from mutant phenotype. Source: MGI positive regulation of osteoblast differentiation Inferred from direct assay. Source: MGI synapse organization Inferred from genetic interaction. Source: MGI
Cellular component	extracellular space Inferred from electronic annotation. Source: UniProtKB-SubCell proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	receptor binding Traceable author statement. Source: MGI signal transducer activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 31	31	Potential
	Chain	32 – 349	318	Protein Wnt-7b		PRO_0000041445
Amino acid modifications
	Glycosylation	83	1	N-linked (GlcNAc...) Potential
	Glycosylation	127	1	N-linked (GlcNAc...) Potential
	Glycosylation	295	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	33	1	G → V in AAH52018. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P28047-1 [UniParc]. Last modified August 1, 1992. Version 1. Checksum: BDD82AB020DC680E	FASTA	349	39,302
	10 20 30 40 50 60 MHRNFRKWIF YVFLCFGVLY VKLGALSSVV ALGANIICNK IPGLAPRQRA ICQSRPDAII 70 80 90 100 110 120 VIGEGAQMGI DECQHQFRFG RWNCSALGEK TVFGQELRVG SREAAFTYAI TAAGVAHAVT 130 140 150 160 170 180 AACSQGNLSN CGCDREKQGY YNQAEGWKWG GCSADVRYGI DFSRRFVDAR EIKKNARRLM 190 200 210 220 230 240 NLHNNEAGRK VLEDRMKLEC KCHGVSGSCT TKTCWTTLPK FREVGHLLKE KYNAAVQVEV 250 260 270 280 290 300 VRASRLRQPT FLRIKQLRSY QKPMETDLVY IEKSPNYCEE DAATGSVGTQ GRLCNRTSPG 310 320 330 340 ADGCDTMCCG RGYNTHQYTK VWQCNCKFHW CCFVKCNTCS ERTEVFTCK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development." Gavin B.J., McMahon J.A., McMahon A.P. Genes Dev. 4:2319-2332(1990) [PubMed: 2279700] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6.
[3]	"The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family." Tanaka K., Okabayashi H., Asashima M., Perrimon N., Kadowaki T. Eur. J. Biochem. 267:4300-4311(2000) [PubMed: 10866835] [Abstract] Cited for: INTERACTION WITH PORCN.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M89802 mRNA. Translation: AAA40571.1. BC052018 mRNA. Translation: AAH52018.2.
IPI	IPI00116644.
PIR	H36470.
RefSeq	NP_033554.2.
UniGene	Mm.306946
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	P28047.
Proteomic databases
PRIDE	P28047.
Genome annotation databases
Ensembl	ENSMUSG00000022382. Mus musculus. [Contig view]
GeneID	22422.
KEGG	mmu:22422.
Organism-specific databases
MGI	MGI:98962. Wnt7b.
Phylogenomic databases
HOVERGEN	P28047.
Gene expression databases
ArrayExpress	P28047.
Bgee	P28047.
CleanEx	MM_WNT7B.
Family and domain databases
InterPro	IPR013300. Wnt7. IPR005816. Wnt_grthfactor. IPR018161. Wnt_grthfactor_CS. IPR005817. Wnt_SF. [Graphical view]
PANTHER	PTHR12027. Wnt. 1 hit.
Pfam	PF00110. wnt. 1 hit. [Graphical view]
PRINTS	PR01891. WNT7PROTEIN. PR01349. WNTPROTEIN.
SMART	SM00097. WNT1. 1 hit. [Graphical view]
PROSITE	PS00246. WNT1. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	302857.
SOURCE	Search...

Entry information

Entry name

WNT7B_MOUSE

Accession

Primary (citable) accession number: P28047
Secondary accession number(s): Q80US5

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	June 16, 2009
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)