Reviewed,
UniProtKB/Swiss-Prot P28033 (CEBPB_MOUSE)
Last modified
November 3, 2009.
Version 92.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: CCAAT/enhancer-binding protein beta Short name=C/EBP beta Alternative name(s): Interleukin-6-dependent-binding protein Short name=IL-6DBP Liver-enriched transcriptional activator Short name=LAP AGP/EBP | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 296 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Involved in interleukin-6 signal transduction, including the transcriptional activation of acute-phase genes. Functions in brown adipose tissue (BAT) differentiation. Ref.7 |
| Subunit structure | Binds DNA as a dimer and can form stable heterodimers with C/EBP alpha and gamma. Interacts with TRIM28 and PTGES2. Interacts with PRDM16. Interacts with CCDC85B. Ref.7 Ref.4 Ref.5 Ref.6 |
| Subcellular location | |
| Tissue specificity | Abundantly expressed in myoblasts. Enriched in brown adipose tissue (BAT) versus white adipose tissue (WAT). Ref.7 |
| Induction | Up-regulated by cold exposure. Ref.7 |
| Disruption phenotype | Mice die in 24 hours after birth. Embryos display defects in brown fat tissue development. Ref.7 |
| Sequence similarities | Belongs to the bZIP family. C/EBP subfamily. Contains 1 bZIP domain. |
Ontologies
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| ATF4 | P18848 | 1 | EBI-1029979,EBI-492498 | From a different organism. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 296 | 296 | CCAAT/enhancer-binding protein beta | PRO_0000076618 | |||||||
Regions | |||||||||||
| Domain | 257 – 285 | 29 | Leucine-zipper | ||||||||
| DNA binding | 228 – 244 | 17 | Basic motif | ||||||||
| Region | 1 – 22 | 22 | Required for Lys-174 sumoylation By similarity | ||||||||
| Compositional bias | 120 – 129 | 10 | Pro-rich | ||||||||
| Compositional bias | 170 – 191 | 22 | Pro/Ser-rich | ||||||||
Amino acid modifications | |||||||||||
| Cross-link | 133 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) By similarity | |||||||||
Secondary structure | |||||||||||
Helix Strand Turn | |||||||||||
| Helix | 240 – 282 | 43 | |||||||||
Sequences
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References
| [1] | "Molecular cloning of a transcription factor, AGP/EBP, that belongs to members of the C/EBP family." Chang C.J., Chen T.T., Lei H.Y., Chen D.S., Lee S.C. Mol. Cell. Biol. 10:6642-6653(1990) [PubMed: 1701020] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c. Tissue: Liver. |
| [2] | "Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells." Cao Z., Umek R.M., McKnight S.L. Genes Dev. 5:1538-1552(1991) [PubMed: 1840554] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. |
| [3] | "Autoregulated induction of the acute-phase response transcription factor gene, agp/ebp." Chang C.J., Shen B.J., Lee S.C. DNA Cell Biol. 14:529-537(1995) [PubMed: 7598808] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-11. Tissue: Liver. |
| [4] | "Coactivator TIF1beta interacts with transcription factor C/EBPbeta and glucocorticoid receptor to induce alpha1-acid glycoprotein gene expression." Chang C.J., Chen Y.L., Lee S.C. Mol. Cell. Biol. 18:5880-5887(1998) [PubMed: 9742105] [Abstract] Cited for: INTERACTION WITH TRIM28. |
| [5] | "Delta-interacting protein A, a new inhibitory partner of CCAAT/enhancer-binding protein beta, implicated in adipocyte differentiation." Bezy O., Elabd C., Cochet O., Petersen R.K., Kristiansen K., Dani C., Ailhaud G., Amri E.-Z. J. Biol. Chem. 280:11432-11438(2005) [PubMed: 15644333] [Abstract] Cited for: INTERACTION WITH CCDC85B. |
| [6] | "IFN-gamma-stimulated transcriptional activation by IFN-gamma-activated transcriptional element-binding factor 1 occurs via an inducible interaction with CAAAT/enhancer-binding protein-beta." Meng Q., Raha A., Roy S., Hu J., Kalvakolanu D.V. J. Immunol. 174:6203-6211(2005) [PubMed: 15879117] [Abstract] Cited for: INTERACTION WITH PTGES2. |
| [7] | "Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex." Kajimura S., Seale P., Kubota K., Lunsford E., Frangioni J.V., Gygi S.P., Spiegelman B.M. Nature 460:1154-1158(2009) [PubMed: 19641492] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, DISRUPTION PHENOTYPE, INTERACTION WITH PRDM16, INDUCTION BY COLD EXPOSURE, TISSUE SPECIFICITY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| X62600 mRNA. Translation: CAA44484.1. M61007 mRNA. Translation: AAA37192.1. S78572 Genomic DNA. No translation available. | |||||||||||||
| IPI | IPI00116613. | ||||||||||||
| PIR | A36366. | ||||||||||||
| RefSeq | NP_034013.1. | ||||||||||||
| UniGene | Mm.439656 | ||||||||||||
3D structure databases | |||||||||||||
| |||||||||||||
| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| IntAct | P28033. 1 interaction. | ||||||||||||
| STRING | P28033. | ||||||||||||
PTM databases | |||||||||||||
| PhosphoSite | P28033. | ||||||||||||
Proteomic databases | |||||||||||||
| PRIDE | P28033. | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENSMUST00000070642; ENSMUSP00000069850; ENSMUSG00000056501; Mus musculus. [Genome view] | ||||||||||||
| GeneID | 12608. | ||||||||||||
| KEGG | mmu:12608. | ||||||||||||
| UCSC | uc008oaf.1. mouse. | ||||||||||||
Organism-specific databases | |||||||||||||
| CTD | 12608. | ||||||||||||
| MGI | MGI:88373. Cebpb. | ||||||||||||
Phylogenomic databases | |||||||||||||
| HOGENOM | P28033. | ||||||||||||
| HOVERGEN | P28033. | ||||||||||||
| OMA | KAPPAAC. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | P28033. | ||||||||||||
| Bgee | P28033. | ||||||||||||
| CleanEx | MM_CEBPB. | ||||||||||||
| Genevestigator | P28033. | ||||||||||||
| GermOnline | ENSMUSG00000056501. Mus musculus. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR011700. bZIP_2. IPR016468. CCAAT/enhancer-binding. IPR004827. TF_bZIP. [Graphical view] | ||||||||||||
| Pfam | PF07716. bZIP_2. 1 hit. [Graphical view] | ||||||||||||
| PIRSF | PIRSF005879. CCAAT/enhancer-binding. 1 hit. | ||||||||||||
| SMART | SM00338. BRLZ. 1 hit. [Graphical view] | ||||||||||||
| PROSITE | PS50217. BZIP. 1 hit. PS00036. BZIP_BASIC. False negative. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other Resources | |||||||||||||
| NextBio | 281758. | ||||||||||||
| SOURCE | Search... | ||||||||||||
Entry information
| Entry name | CEBPB_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P28033 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


