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Protein

Alcohol dehydrogenase 2

Gene

ADH2

Organism
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.By similarity

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi48Zinc 1; catalyticBy similarity1
Metal bindingi50Zinc 1By similarity1
Binding sitei50NADBy similarity1
Binding sitei50SubstrateBy similarity1
Metal bindingi70Zinc 1; catalyticBy similarity1
Binding sitei70SubstrateBy similarity1
Metal bindingi100Zinc 2By similarity1
Metal bindingi103Zinc 2By similarity1
Metal bindingi106Zinc 2By similarity1
Metal bindingi114Zinc 2By similarity1
Metal bindingi178Zinc 1; catalyticBy similarity1
Binding sitei227NADBy similarity1
Binding sitei232NADBy similarity1
Binding sitei273NAD; via carbonyl oxygenBy similarity1
Binding sitei296NAD; via carbonyl oxygenBy similarity1
Binding sitei323NAD; via amide nitrogenBy similarity1
Binding sitei373NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi203 – 208NADBy similarity6
Nucleotide bindingi296 – 298NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 2 (EC:1.1.1.1By similarity)
Gene namesi
Name:ADH2
OrganismiSolanum lycopersicum (Tomato) (Lycopersicon esculentum)
Taxonomic identifieri4081 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon
Proteomesi
  • UP000004994 Componenti: Unplaced

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607021 – 380Alcohol dehydrogenase 2Add BLAST380

Proteomic databases

PaxDbiP28032.

Interactioni

Subunit structurei

Homodimer (By similarity). Homotetramer.By similarity

Protein-protein interaction databases

STRINGi4081.Solyc06g059740.2.1.

Structurei

3D structure databases

ProteinModelPortaliP28032.
SMRiP28032.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0022. Eukaryota.
COG1062. LUCA.
InParanoidiP28032.
KOiK18857.

Family and domain databases

InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

P28032-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTTVGQVIR CKAAVAWEAG KPLVMEEVDV APPQKMEVRL KILYTSLCHT
60 70 80 90 100
DVYFWEAKGQ NPVFPRILGH EAAGIVESVG EGVTDLAPGD HVLPVFTGEC
110 120 130 140 150
KDCAHCKSEE SNMCSLLRIN TDRGVMLNDG KSRFSINGNP IYHFVGTSTF
160 170 180 190 200
SEYTVVHVGC VAKINPLAPL DKVCVLSCGI STGLGASLNV AKPTKGSSVA
210 220 230 240 250
IFGLGAVGLA AAEGARIAGA SRIIGVDLNA SRFEQAKKFG VTEFVNPKDY
260 270 280 290 300
SKPVQEVIAE MTDGGVDRSV ECTGHIDAMI SAFECVHDGW GVAVLVGVPH
310 320 330 340 350
KEAVFKTHPL NFLNERTLKG TFFGNYKPRS DIPCVVEKYM NKELELEKFI
360 370 380
THTLPFAEIN KAFDLMLKGE GLRCIITMAD
Length:380
Mass (Da):41,040
Last modified:July 1, 1993 - v2
Checksum:iD5B123DF9DE28027
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86724 mRNA. Translation: AAA34133.1.
X77233 Genomic DNA. Translation: CAA54450.1.
X60600 mRNA. Translation: CAA43055.1.
PIRiS51826.
RefSeqiNP_001234099.1. NM_001247170.2.
UniGeneiLes.19427.

Genome annotation databases

GeneIDi544074.
KEGGisly:544074.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86724 mRNA. Translation: AAA34133.1.
X77233 Genomic DNA. Translation: CAA54450.1.
X60600 mRNA. Translation: CAA43055.1.
PIRiS51826.
RefSeqiNP_001234099.1. NM_001247170.2.
UniGeneiLes.19427.

3D structure databases

ProteinModelPortaliP28032.
SMRiP28032.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4081.Solyc06g059740.2.1.

Proteomic databases

PaxDbiP28032.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi544074.
KEGGisly:544074.

Phylogenomic databases

eggNOGiKOG0022. Eukaryota.
COG1062. LUCA.
InParanoidiP28032.
KOiK18857.

Family and domain databases

InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADH2_SOLLC
AccessioniPrimary (citable) accession number: P28032
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: July 1, 1993
Last modified: May 10, 2017
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.