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P28028

- BRAF_MOUSE

UniProt

P28028 - BRAF_MOUSE

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Protein

Serine/threonine-protein kinase B-raf

Gene

Braf

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Zn2+CuratedNote: Binds 2 Zn(2+) ions per subunit.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi219 – 2191Zinc 1By similarity
Metal bindingi232 – 2321Zinc 2By similarity
Metal bindingi235 – 2351Zinc 2By similarity
Metal bindingi245 – 2451Zinc 1By similarity
Metal bindingi248 – 2481Zinc 1By similarity
Metal bindingi253 – 2531Zinc 2By similarity
Metal bindingi256 – 2561Zinc 2By similarity
Metal bindingi264 – 2641Zinc 1By similarity
Binding sitei520 – 5201ATPPROSITE-ProRule annotation
Active sitei613 – 6131Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi500 – 5089ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. calcium ion binding Source: Ensembl
  3. MAP kinase kinase kinase activity Source: Ensembl
  4. protein kinase activity Source: BHF-UCL

GO - Biological processi

  1. alpha-beta T cell differentiation Source: MGI
  2. CD4-positive, alpha-beta T cell differentiation Source: MGI
  3. cell differentiation Source: MGI
  4. cellular response to calcium ion Source: Ensembl
  5. cellular response to drug Source: MGI
  6. long-term synaptic potentiation Source: MGI
  7. myeloid progenitor cell differentiation Source: MGI
  8. negative regulation of endothelial cell apoptotic process Source: MGI
  9. negative regulation of fibroblast migration Source: MGI
  10. negative regulation of neuron apoptotic process Source: MGI
  11. negative regulation of synaptic vesicle exocytosis Source: MGI
  12. positive regulation of ERK1 and ERK2 cascade Source: MGI
  13. positive regulation of gene expression Source: Ensembl
  14. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
  15. positive regulation of stress fiber assembly Source: MGI
  16. positive regulation of substrate adhesion-dependent cell spreading Source: MGI
  17. positive T cell selection Source: MGI
  18. protein heterooligomerization Source: Ensembl
  19. protein phosphorylation Source: BHF-UCL
  20. regulation of cell proliferation Source: MGI
  21. response to cAMP Source: Ensembl
  22. response to epidermal growth factor Source: Ensembl
  23. response to peptide hormone Source: Ensembl
  24. somatic stem cell maintenance Source: MGI
  25. visual learning Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_198246. CREB phosphorylation through the activation of Ras.
REACT_198526. Spry regulation of FGF signaling.
REACT_234035. ARMS-mediated activation.
REACT_252757. Signalling to p38 via RIT and RIN.
REACT_262560. Frs2-mediated activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase B-raf (EC:2.7.11.1)
Alternative name(s):
Proto-oncogene B-Raf
Gene namesi
Name:Braf
Synonyms:B-raf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:88190. Braf.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity. Cell membrane By similarity
Note: Colocalizes with RGS14 and RAF1 in both the cytoplasm and membranes.By similarity

GO - Cellular componenti

  1. cell body Source: MGI
  2. cytoplasm Source: MGI
  3. mitochondrion Source: MGI
  4. neuron projection Source: MGI
  5. nucleus Source: UniProtKB-KW
  6. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Involvement in diseasei

Participates in a chromosomal translocation that produces a Tif1a-BRAF (T18) oncogene originally isolated from a furfural-induced hepatoma.

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 804803Serine/threonine-protein kinase B-rafPRO_0000085666Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei348 – 3481Phosphoserine; by SGK1By similarity
Modified residuei356 – 3561Phosphothreonine; by autocatalysisBy similarity
Modified residuei431 – 4311PhosphothreonineBy similarity
Modified residuei434 – 4341PhosphoserineBy similarity
Modified residuei436 – 4361PhosphothreonineBy similarity
Modified residuei483 – 4831Phosphoserine1 Publication
Modified residuei484 – 4841PhosphoserineBy similarity
Cross-linki615 – 615Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei708 – 7081Omega-N-methylarginine; by PRMT5By similarity
Modified residuei766 – 7661PhosphoserineBy similarity
Modified residuei790 – 7901Phosphothreonine; by MAPK1By similarity

Post-translational modificationi

Phosphorylation at Ser-348 by SGK1 inhibits its activity.By similarity
Methylation by PRMT5 decreases stability and kinase activity.1 Publication
Ubiquitinated by RNF149; which leads to proteasomal degradation. Polyubiquitinated at Lys-615 in response to EGF (By similarity).By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP28028.
PaxDbiP28028.
PRIDEiP28028.

PTM databases

PhosphoSiteiP28028.

Expressioni

Gene expression databases

BgeeiP28028.
CleanExiMM_BRAF.
ExpressionAtlasiP28028. baseline and differential.
GenevestigatoriP28028.

Interactioni

Subunit structurei

Monomer. Homodimer. Heterodimerizes with RAF1, and the heterodimer possesses a highly increased kinase activity compared to the respective homodimers or monomers. Heterodimerization is mitogen-regulated and enhanced by 14-3-3 proteins. MAPK1/ERK2 activation can induce a negative feedback that promotes the dissociation of the heterodimer by phosphorylating BRAF at Thr-790. Found in a complex with at least BRAF, HRAS, MAP2K1, MAPK3 and RGS14. Interacts with RIT1. Interacts (via N-terminus) with RGS14 (via RBD domains); the interaction mediates the formation of a ternary complex with RAF1, a ternary complex inhibited by GNAI1 (By similarity). Interacts with DGKH (By similarity). Interacts with PRMT5 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Raf1Q99N572EBI-2584830,EBI-397757

Protein-protein interaction databases

BioGridi225124. 3 interactions.
DIPiDIP-57050N.
IntActiP28028. 8 interactions.
MINTiMINT-1518176.

Structurei

3D structure databases

ProteinModelPortaliP28028.
SMRiP28028. Positions 133-267, 485-760.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini139 – 21173RBDPROSITE-ProRule annotationAdd
BLAST
Domaini494 – 754261Protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi6 – 3025Poly-GlyAdd
BLAST
Compositional biasi465 – 4695Poly-Ser

Sequence similaritiesi

Contains 1 phorbol-ester/DAG-type zinc finger.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 RBD (Ras-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118807.
HOGENOMiHOG000252972.
HOVERGENiHBG001886.
InParanoidiP28028.
KOiK04365.
OMAiHRTRTSS.
OrthoDBiEOG7F5128.
TreeFamiTF317006.

Family and domain databases

InterProiIPR020454. DAG/PE-bd.
IPR011009. Kinase-like_dom.
IPR002219. PE/DAG-bd.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR003116. Raf-like_ras-bd.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00130. C1_1. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF02196. RBD. 1 hit.
[Graphical view]
PRINTSiPR00008. DAGPEDOMAIN.
SMARTiSM00109. C1. 1 hit.
SM00455. RBD. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50898. RBD. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P28028-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAALSGGGGS SSGGGGGGGG GGGGGDGGGG AEQGQALFNG DMEPEAGAGA
60 70 80 90 100
AASSAADPAI PEEVWNIKQM IKLTQEHIEA LLDKFGGEHN PPSIYLEAYE
110 120 130 140 150
EYTSKLDALQ QREQQLLESL VFQTPTDASR NNPKSPQKPI VRVFLPNKQR
160 170 180 190 200
TVVPARCGVT VRDSLKKALM MRGLIPECCA VYRIQDGEKK PIGWDTDISW
210 220 230 240 250
LTGEELHVEV LENVPLTTHN FVRKTFFTLA FCDFCRKLLF QGFRCQTCGY
260 270 280 290 300
KFHQRCSTEV PLMCVNYDQL DLLFVSKFFE HHPVPQEEAS FPETALPSGS
310 320 330 340 350
SSAPPSDSTG PQILTSPSPS KSIPIPQPFR PADEDHRNQF GQRDRSSSAP
360 370 380 390 400
NVHINTIEPV NIDEKFPEVE LQDQRDLIRD QGFRGDGAPL NQLMRCLRKY
410 420 430 440 450
QSRTPSPLLH SVPSEIVFDF EPGPVFRGST TGLSATPPAS LPGSLTNVKA
460 470 480 490 500
LQKSPGPQRE RKSSSSSSSE DRSRMKTLGR RDSSDDWEIP DGQITVGQRI
510 520 530 540 550
GSGSFGTVYK GKWHGDVAVK MLNVTAPTPQ QLQAFKNEVG VLRKTRHVNI
560 570 580 590 600
LLFMGYSTKP QLAIVTQWCE GSSLYHHLHI IETKFEMIKL IDIARQTAQG
610 620 630 640 650
MDYLHAKSII HRDLKSNNIF LHEDLTVKIG DFGLATVKSR WSGSHQFEQL
660 670 680 690 700
SGSILWMAPE VIRMQDKNPY SFQSDVYAFG IVLYELMTGQ LPYSNINNRD
710 720 730 740 750
QIIFMVGRGY LSPDLSKVRS NCPKAMKRLM AECLKKKRDE RPLFPQILAS
760 770 780 790 800
IELLARSLPK IHRSASEPSL NRAGFQTEDF SLYACASPKT PIQAGGYGEF

AAFK
Length:804
Mass (Da):88,780
Last modified:July 27, 2011 - v3
Checksum:i4C6CC16A2C660A17
GO
Isoform 2 (identifier: P28028-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-474: Missing.
     799-804: EFAAFK → GFPVH

Note: No experimental confirmation available.

Show »
Length:329
Mass (Da):37,118
Checksum:i93913670A27EAB2C
GO

Sequence cautioni

The sequence AAA37320.1 differs from that shown. Reason: Chimeric cDNA.Curated
The sequence AAA37320.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti10 – 112SS → RR in BAE24384. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 474474Missing in isoform 2. 1 PublicationVSP_022169Add
BLAST
Alternative sequencei799 – 8046EFAAFK → GFPVH in isoform 2. 1 PublicationVSP_022170

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK140431 mRNA. Translation: BAE24384.1.
AC122345 Genomic DNA. No translation available.
AC163109 Genomic DNA. No translation available.
M64429 mRNA. Translation: AAA37320.1. Sequence problems.
CCDSiCCDS39463.1. [P28028-1]
PIRiA40951. TVMSBF.
RefSeqiNP_647455.3. NM_139294.5. [P28028-1]
UniGeneiMm.245513.
Mm.489691.

Genome annotation databases

EnsembliENSMUST00000002487; ENSMUSP00000002487; ENSMUSG00000002413. [P28028-1]
GeneIDi109880.
KEGGimmu:109880.
UCSCiuc009bme.2. mouse. [P28028-1]
uc009bmf.1. mouse. [P28028-2]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK140431 mRNA. Translation: BAE24384.1 .
AC122345 Genomic DNA. No translation available.
AC163109 Genomic DNA. No translation available.
M64429 mRNA. Translation: AAA37320.1 . Sequence problems.
CCDSi CCDS39463.1. [P28028-1 ]
PIRi A40951. TVMSBF.
RefSeqi NP_647455.3. NM_139294.5. [P28028-1 ]
UniGenei Mm.245513.
Mm.489691.

3D structure databases

ProteinModelPortali P28028.
SMRi P28028. Positions 133-267, 485-760.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 225124. 3 interactions.
DIPi DIP-57050N.
IntActi P28028. 8 interactions.
MINTi MINT-1518176.

Chemistry

ChEMBLi CHEMBL2331061.

PTM databases

PhosphoSitei P28028.

Proteomic databases

MaxQBi P28028.
PaxDbi P28028.
PRIDEi P28028.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000002487 ; ENSMUSP00000002487 ; ENSMUSG00000002413 . [P28028-1 ]
GeneIDi 109880.
KEGGi mmu:109880.
UCSCi uc009bme.2. mouse. [P28028-1 ]
uc009bmf.1. mouse. [P28028-2 ]

Organism-specific databases

CTDi 673.
MGIi MGI:88190. Braf.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000118807.
HOGENOMi HOG000252972.
HOVERGENi HBG001886.
InParanoidi P28028.
KOi K04365.
OMAi HRTRTSS.
OrthoDBi EOG7F5128.
TreeFami TF317006.

Enzyme and pathway databases

Reactomei REACT_198246. CREB phosphorylation through the activation of Ras.
REACT_198526. Spry regulation of FGF signaling.
REACT_234035. ARMS-mediated activation.
REACT_252757. Signalling to p38 via RIT and RIN.
REACT_262560. Frs2-mediated activation.

Miscellaneous databases

ChiTaRSi Braf. mouse.
NextBioi 362941.
PROi P28028.
SOURCEi Search...

Gene expression databases

Bgeei P28028.
CleanExi MM_BRAF.
ExpressionAtlasi P28028. baseline and differential.
Genevestigatori P28028.

Family and domain databases

InterProi IPR020454. DAG/PE-bd.
IPR011009. Kinase-like_dom.
IPR002219. PE/DAG-bd.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR003116. Raf-like_ras-bd.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF00130. C1_1. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF02196. RBD. 1 hit.
[Graphical view ]
PRINTSi PR00008. DAGPEDOMAIN.
SMARTi SM00109. C1. 1 hit.
SM00455. RBD. 1 hit.
[Graphical view ]
SUPFAMi SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50898. RBD. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Medulla oblongata.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Development of a highly efficient expression cDNA cloning system: application to oncogene isolation."
    Miki T., Fleming T.P., Crescenzi M., Molloy C.J., Blam S.B., Reynolds S.H., Aaronson S.A.
    Proc. Natl. Acad. Sci. U.S.A. 88:5167-5171(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 476-804 (ISOFORM 2).
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-483, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. "Protein arginine methyltransferase 5 regulates ERK1/2 signal transduction amplitude and cell fate through CRAF."
    Andreu-Perez P., Esteve-Puig R., de Torre-Minguela C., Lopez-Fauqued M., Bech-Serra J.J., Tenbaum S., Garcia-Trevijano E.R., Canals F., Merlino G., Avila M.A., Recio J.A.
    Sci. Signal. 4:RA58-RA58(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: METHYLATION.

Entry informationi

Entry nameiBRAF_MOUSE
AccessioniPrimary (citable) accession number: P28028
Secondary accession number(s): E9QNG9, Q3USE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 147 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3