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P28024 (PSB4_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proteasome subunit beta type-4

EC=3.4.25.1
Alternative name(s):
Macropain beta chain
Multicatalytic endopeptidase complex beta chain
Proteasome beta chain
Proteasome chain 3
Gene names
Name:psmb4
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length242 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Catalytic activity

Cleavage of peptide bonds with very broad specificity.

Subunit structure

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

Subcellular location

Cytoplasm. Nucleus.

Sequence similarities

Belongs to the peptidase T1B family.

Sequence caution

The sequence CAA44593.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Propeptide‹1 – 23›23 Potential
PRO_0000026587
Chain24 – 242219Proteasome subunit beta type-4
PRO_0000026588

Sites

Active site241Nucleophile By similarity

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
P28024 [UniParc].

Last modified December 15, 1998. Version 2.
Checksum: DCEB9D1A13C61D3E

FASTA24226,759
        10         20         30         40         50         60 
ESVARGTAPG ELHCFPGAGP VRHTLNPMVT GTSVLGVKFD GGVIIAADML GSYGSLARFR 

        70         80         90        100        110        120 
NISRIMKVNE NTILGASGDY ADYQYLKQVI DQMVIDEELV GDGHNYSPKA IHSWLTRVMY 

       130        140        150        160        170        180 
NRRSKMNPLW NTVVIGGFYN GESFLGYVDK LGVAYEAPTI ATGFGAYLAQ PLLREVTENK 

       190        200        210        220        230        240 
ATLSKEEARQ LVDRCMKVLY YRDARSYNRF EITTVTESGV EVEGPLSSET NWEIAHLISG 


FE 

« Hide

References

[1]"Cloning and sequence analysis of pituitary cDNA encoding the beta-subunit of Xenopus proteasome."
van Riel M.C.H.M., Martens G.J.M.
FEBS Lett. 291:37-40(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Pituitary.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X62709 mRNA. Translation: CAA44593.1. Different initiation.
PIRS17568.
UniGeneXl.4728.

3D structure databases

ProteinModelPortalP28024.
SMRP28024. Positions 24-240.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPST01.987.

Proteomic databases

PRIDEP28024.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

XenbaseXB-GENE-6253413. psmb4.

Phylogenomic databases

HOVERGENHBG018194.

Family and domain databases

Gene3D3.60.20.10. 1 hit.
InterProIPR029055. Ntn_hydrolases_N.
IPR016050. Proteasome_bsu_CS.
IPR016295. Proteasome_endopept_cplx_B.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamPF00227. Proteasome. 1 hit.
[Graphical view]
PIRSFPIRSF001213. Psome_endopept_beta. 1 hit.
SUPFAMSSF56235. SSF56235. 1 hit.
PROSITEPS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePSB4_XENLA
AccessionPrimary (citable) accession number: P28024
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: December 15, 1998
Last modified: June 11, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries