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Protein

Casein kinase II subunit beta

Gene

csnk2b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Participates in Wnt signaling. Plays a complex role in regulating the basal catalytic activity of the alpha subunit (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi109 – 1091Zinc
Metal bindingi114 – 1141Zinc
Metal bindingi137 – 1371Zinc
Metal bindingi140 – 1401Zinc

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Wnt signaling pathway

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Casein kinase II subunit beta
Short name:
CK II beta
Alternative name(s):
Phosvitin
Gene namesi
Name:csnk2b
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-865748. csnk2b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 215215Casein kinase II subunit betaPRO_0000068242Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21Phosphoserine; by autocatalysisCurated

Post-translational modificationi

Phosphorylated by alpha subunit.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Tetramer composed of an alpha subunit, an alpha' subunit and two beta subunits. The beta subunit dimerization is mediated by zinc ions (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
PAPCB5TR113EBI-7614441,EBI-7614422

Protein-protein interaction databases

IntActiP28021. 1 interaction.
MINTiMINT-8329056.

Structurei

Secondary structure

1
215
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi9 – 157Combined sources
Helixi27 – 315Combined sources
Helixi33 – 364Combined sources
Helixi39 – 413Combined sources
Helixi46 – 538Combined sources
Helixi69 – 8719Combined sources
Helixi91 – 10212Combined sources
Turni103 – 1064Combined sources
Helixi112 – 1143Combined sources
Beta strandi120 – 1223Combined sources
Beta strandi134 – 1363Combined sources
Turni138 – 1403Combined sources
Helixi149 – 1513Combined sources
Helixi156 – 1583Combined sources
Helixi163 – 1708Combined sources
Helixi172 – 1743Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1RQFX-ray2.89A/B/D/E/G/H/J/K1-178[»]
ProteinModelPortaliP28021.
SMRiP28021. Positions 2-205.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP28021.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni188 – 1936Interaction with alpha subunitBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi55 – 6410Asp/Glu-rich (acidic)

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG051131.
KOiK03115.

Family and domain databases

Gene3Di1.10.1820.10. 1 hit.
2.20.25.20. 1 hit.
InterProiIPR016149. Casein_kin_II_reg-sub_a-hlx.
IPR016150. Casein_kin_II_reg-sub_b-sht.
IPR000704. Casein_kinase_II_reg-sub.
[Graphical view]
PANTHERiPTHR11740. PTHR11740. 1 hit.
PfamiPF01214. CK_II_beta. 1 hit.
[Graphical view]
PRINTSiPR00472. CASNKINASEII.
SMARTiSM01085. CK_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF57798. SSF57798. 1 hit.
PROSITEiPS01101. CK2_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28021-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSEEVSWI SWFCGLRGNE FFCEVDEDYI QDKFNLTGLN EQVPHYRQAL
60 70 80 90 100
DMILDLEPDE ELEDNPNQSD LIEQAAEMLY GLIHARYILT NRGIAQMLEK
110 120 130 140 150
YQQGDFGYCP RVYCENQPML PIGLSDIPGE AMVKLYCPKC MDVYTPKSSR
160 170 180 190 200
HHHTDGAYFG TGFPHMLFMV HPEYRPKRPA NQFVPRLYGF KIHPMAYQLQ
210
LQAASNFKSP VKTMR
Length:215
Mass (Da):24,960
Last modified:August 1, 1992 - v1
Checksum:iE46371E699B0E0EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62376 mRNA. Translation: CAA44239.1.
BC077212 mRNA. Translation: AAH77212.1.
PIRiS20405.
RefSeqiNP_001084126.1. NM_001090657.1.
UniGeneiXl.43774.

Genome annotation databases

GeneIDi399320.
KEGGixla:399320.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62376 mRNA. Translation: CAA44239.1.
BC077212 mRNA. Translation: AAH77212.1.
PIRiS20405.
RefSeqiNP_001084126.1. NM_001090657.1.
UniGeneiXl.43774.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1RQFX-ray2.89A/B/D/E/G/H/J/K1-178[»]
ProteinModelPortaliP28021.
SMRiP28021. Positions 2-205.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP28021. 1 interaction.
MINTiMINT-8329056.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi399320.
KEGGixla:399320.

Organism-specific databases

CTDi1460.
XenbaseiXB-GENE-865748. csnk2b.

Phylogenomic databases

HOVERGENiHBG051131.
KOiK03115.

Miscellaneous databases

EvolutionaryTraceiP28021.

Family and domain databases

Gene3Di1.10.1820.10. 1 hit.
2.20.25.20. 1 hit.
InterProiIPR016149. Casein_kin_II_reg-sub_a-hlx.
IPR016150. Casein_kin_II_reg-sub_b-sht.
IPR000704. Casein_kinase_II_reg-sub.
[Graphical view]
PANTHERiPTHR11740. PTHR11740. 1 hit.
PfamiPF01214. CK_II_beta. 1 hit.
[Graphical view]
PRINTSiPR00472. CASNKINASEII.
SMARTiSM01085. CK_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF57798. SSF57798. 1 hit.
PROSITEiPS01101. CK2_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The cDNAs coding for the alpha- and beta-subunits of Xenopus laevis casein kinase II."
    Jedlicki A., Hinrichs M.V., Allende C., Allende J.E.
    FEBS Lett. 297:280-284(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovary.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  3. "Structure of the regulatory subunit of CK2 in the presence of a p21WAF1 peptide demonstrates flexibility of the acidic loop."
    Bertrand L., Sayed M.F., Pei X.Y., Parisini E., Dhanaraj V., Bolanos-Garcia V.M., Allende J.E., Blundell T.L.
    Acta Crystallogr. D 60:1698-1704(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.89 ANGSTROMS) OF 1-178 IN COMPLEX WITH CDKN1A PEPTIDE, ZINC-BINDING SITES.

Entry informationi

Entry nameiCSK2B_XENLA
AccessioniPrimary (citable) accession number: P28021
Secondary accession number(s): Q6DEB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: October 14, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.