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P28018

- BLA1_BACMY

UniProt

P28018 - BLA1_BACMY

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Protein

Beta-lactamase 1

Gene

blaCI

Organism
Bacillus mycoides
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

This protein is a beta-lactamase with a substrate specificity for penicillins.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei89 – 891Acyl-ester intermediatePROSITE-ProRule annotation
Active sitei185 – 1851Proton acceptorBy similarity

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC

GO - Biological processi

  1. beta-lactam antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase 1 (EC:3.5.2.6)
Alternative name(s):
Beta-lactamase I
Penicillinase
Gene namesi
Name:blaCI
OrganismiBacillus mycoides
Taxonomic identifieri1405 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4343By similarityAdd
BLAST
Chaini44 – 306263Beta-lactamase 1PRO_0000016972Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP28018.
SMRiP28018. Positions 52-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni251 – 2533Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the class-A beta-lactamase family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28018-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKNKRMLKIG MCVGILGLSV TSLEAFTGGA LQVEAKEKTG QVKHKNQATH
60 70 80 90 100
KEFSQLEKKF DARLGVYAID TGTNQTISYR HNERFAFAST YKALAAGVLL
110 120 130 140 150
QQNSIDTLNE VIKFTKEDLV DYSPVTEKHV DTGMKLGEIA EAAVRSSDNT
160 170 180 190 200
AGNILFHKIG GPKGYEKALR QIGDRVTMSD RFETELNEAI PGDIRDTSTA
210 220 230 240 250
KAIASNLKAF TVGNALPAEK RKILTEWMKG NATGDKLIRA GVPTDWIVGD
260 270 280 290 300
KSGAGSYGTR NDIAIVWPPN RAPIIIAILS SKDEKEATYD NQLIAEAPEV

IVKSLK
Length:306
Mass (Da):33,383
Last modified:August 1, 1992 - v1
Checksum:i849BB01FD499E3BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62244 Genomic DNA. Translation: CAA44161.1.
PIRiS17339.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62244 Genomic DNA. Translation: CAA44161.1 .
PIRi S17339.

3D structure databases

ProteinModelPortali P28018.
SMRi P28018. Positions 52-305.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view ]
PRINTSi PR00118. BLACTAMASEA.
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The beta-lactamase I gene From Bacillus mycoides."
    Groenstad A., Kristensen T., Hornes E., Kolstoe A.-B.
    Submitted (SEP-1991) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: NI10R.

Entry informationi

Entry nameiBLA1_BACMY
AccessioniPrimary (citable) accession number: P28018
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: October 1, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3