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P28018 (BLA1_BACMY) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-lactamase 1

EC=3.5.2.6
Alternative name(s):
Beta-lactamase I
Penicillinase
Gene names
Name:blaCI
OrganismBacillus mycoides
Taxonomic identifier1405 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

Protein attributes

Sequence length306 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

This protein is a beta-lactamase with a substrate specificity for penicillins.

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Sequence similarities

Belongs to the class-A beta-lactamase family.

Ontologies

Keywords
   Biological processAntibiotic resistance
   DomainSignal
   Molecular functionHydrolase
Gene Ontology (GO)
   Biological_processbeta-lactam antibiotic catabolic process

Inferred from electronic annotation. Source: InterPro

response to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionbeta-lactamase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 4343 By similarity
Chain44 – 306263Beta-lactamase 1
PRO_0000016972

Regions

Region251 – 2533Substrate binding By similarity

Sites

Active site891Acyl-ester intermediate By similarity
Active site1851Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
P28018 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: 849BB01FD499E3BB

FASTA30633,383
        10         20         30         40         50         60 
MKNKRMLKIG MCVGILGLSV TSLEAFTGGA LQVEAKEKTG QVKHKNQATH KEFSQLEKKF 

        70         80         90        100        110        120 
DARLGVYAID TGTNQTISYR HNERFAFAST YKALAAGVLL QQNSIDTLNE VIKFTKEDLV 

       130        140        150        160        170        180 
DYSPVTEKHV DTGMKLGEIA EAAVRSSDNT AGNILFHKIG GPKGYEKALR QIGDRVTMSD 

       190        200        210        220        230        240 
RFETELNEAI PGDIRDTSTA KAIASNLKAF TVGNALPAEK RKILTEWMKG NATGDKLIRA 

       250        260        270        280        290        300 
GVPTDWIVGD KSGAGSYGTR NDIAIVWPPN RAPIIIAILS SKDEKEATYD NQLIAEAPEV 


IVKSLK 

« Hide

References

[1]"The beta-lactamase I gene From Bacillus mycoides."
Groenstad A., Kristensen T., Hornes E., Kolstoe A.-B.
Submitted (SEP-1991) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: NI10R.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X62244 Genomic DNA. Translation: CAA44161.1.
PIRS17339.

3D structure databases

ProteinModelPortalP28018.
SMRP28018. Positions 52-305.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.710.10. 1 hit.
InterProIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PRINTSPR00118. BLACTAMASEA.
SUPFAMSSF56601. SSF56601. 1 hit.
PROSITEPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBLA1_BACMY
AccessionPrimary (citable) accession number: P28018
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: October 16, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families