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P28018

- BLA1_BACMY

UniProt

P28018 - BLA1_BACMY

Protein

Beta-lactamase 1

Gene

blaCI

Organism
Bacillus mycoides
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (01 Aug 1992)
      Previous versions | rss
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    • Comment

    Functioni

    This protein is a beta-lactamase with a substrate specificity for penicillins.

    Catalytic activityi

    A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei89 – 891Acyl-ester intermediatePROSITE-ProRule annotation
    Active sitei185 – 1851Proton acceptorBy similarity

    GO - Molecular functioni

    1. beta-lactamase activity Source: UniProtKB-EC

    GO - Biological processi

    1. beta-lactam antibiotic catabolic process Source: InterPro
    2. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-lactamase 1 (EC:3.5.2.6)
    Alternative name(s):
    Beta-lactamase I
    Penicillinase
    Gene namesi
    Name:blaCI
    OrganismiBacillus mycoides
    Taxonomic identifieri1405 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 4343By similarityAdd
    BLAST
    Chaini44 – 306263Beta-lactamase 1PRO_0000016972Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP28018.
    SMRiP28018. Positions 52-305.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni251 – 2533Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the class-A beta-lactamase family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR000871. Beta-lactam_class-A/D.
    IPR023650. Beta-lactam_class-A_AS.
    [Graphical view]
    PRINTSiPR00118. BLACTAMASEA.
    SUPFAMiSSF56601. SSF56601. 1 hit.
    PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P28018-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKNKRMLKIG MCVGILGLSV TSLEAFTGGA LQVEAKEKTG QVKHKNQATH    50
    KEFSQLEKKF DARLGVYAID TGTNQTISYR HNERFAFAST YKALAAGVLL 100
    QQNSIDTLNE VIKFTKEDLV DYSPVTEKHV DTGMKLGEIA EAAVRSSDNT 150
    AGNILFHKIG GPKGYEKALR QIGDRVTMSD RFETELNEAI PGDIRDTSTA 200
    KAIASNLKAF TVGNALPAEK RKILTEWMKG NATGDKLIRA GVPTDWIVGD 250
    KSGAGSYGTR NDIAIVWPPN RAPIIIAILS SKDEKEATYD NQLIAEAPEV 300
    IVKSLK 306
    Length:306
    Mass (Da):33,383
    Last modified:August 1, 1992 - v1
    Checksum:i849BB01FD499E3BB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X62244 Genomic DNA. Translation: CAA44161.1.
    PIRiS17339.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X62244 Genomic DNA. Translation: CAA44161.1 .
    PIRi S17339.

    3D structure databases

    ProteinModelPortali P28018.
    SMRi P28018. Positions 52-305.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR000871. Beta-lactam_class-A/D.
    IPR023650. Beta-lactam_class-A_AS.
    [Graphical view ]
    PRINTSi PR00118. BLACTAMASEA.
    SUPFAMi SSF56601. SSF56601. 1 hit.
    PROSITEi PS00146. BETA_LACTAMASE_A. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The beta-lactamase I gene From Bacillus mycoides."
      Groenstad A., Kristensen T., Hornes E., Kolstoe A.-B.
      Submitted (SEP-1991) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: NI10R.

    Entry informationi

    Entry nameiBLA1_BACMY
    AccessioniPrimary (citable) accession number: P28018
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3