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P28006

- GAC1_YEAST

UniProt

P28006 - GAC1_YEAST

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Protein

Serine/threonine-protein phosphatase 1 regulatory subunit GAC1

Gene
GAC1, YOR178C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Regulates the activity of glycogen synthase. It is most probably a regulatory subunit for protein phosphatase type 1.

GO - Molecular functioni

  1. heat shock protein binding Source: SGD
  2. protein phosphatase type 1 regulator activity Source: SGD
  3. structural molecule activity Source: SGD

GO - Biological processi

  1. glycogen biosynthetic process Source: UniProtKB-KW
  2. glycogen metabolic process Source: SGD
  3. meiotic nuclear division Source: SGD
  4. mitotic spindle assembly checkpoint Source: SGD
  5. negative regulation of transcription from RNA polymerase II promoter Source: SGD
  6. regulation of catalytic activity Source: GOC
  7. response to heat Source: SGD
Complete GO annotation...

Keywords - Biological processi

Glycogen biosynthesis

Enzyme and pathway databases

BioCyciYEAST:G3O-33690-MONOMER.

Protein family/group databases

CAZyiCBM21. Carbohydrate-Binding Module Family 21.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 1 regulatory subunit GAC1
Gene namesi
Name:GAC1
Ordered Locus Names:YOR178C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XV

Organism-specific databases

CYGDiYOR178c.
SGDiS000005704. GAC1.

Subcellular locationi

GO - Cellular componenti

  1. protein phosphatase type 1 complex Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 793793Serine/threonine-protein phosphatase 1 regulatory subunit GAC1PRO_0000071518Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei415 – 4151Phosphoserine1 Publication
Modified residuei424 – 4241Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Expressioni

Gene expression databases

GenevestigatoriP28006.

Interactioni

Protein-protein interaction databases

BioGridi34573. 28 interactions.
DIPiDIP-2375N.
IntActiP28006. 9 interactions.
MINTiMINT-554233.
STRINGi4932.YOR178C.

Structurei

3D structure databases

ProteinModelPortaliP28006.
SMRiP28006. Positions 258-365.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini235 – 360126CBM21Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi500 – 52324Ser-richAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG257148.
GeneTreeiENSGT00530000068231.
OrthoDBiEOG7G7M21.

Family and domain databases

InterProiIPR005036. CBM_21.
[Graphical view]
PfamiPF03370. CBM_21. 1 hit.
[Graphical view]
PROSITEiPS51159. CBM21. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28006-1 [UniParc]FASTAAdd to Basket

« Hide

MVIQTATTLS PAKARPSFPH NDLIKSMSDS LISRPTHPPI RKLKSSLKIS    50
HPEPISRSKS EIFCTSPEKN VRFAIELTTV KRFDKNAEPS SISNENSPTL 100
SPVDSNTAAD DVQLFNNEDC WFNDSSLVTN LLKNEKKFRY MNSLNNMFKL 150
DLYDSEDEDD IDEHINSQAE YGYTYNSLST RGKTSENKSA TSSLATQATN 200
ICDWKLHCTD LVPFKIAPPL FTKTLSASDL QGQLTKYLNG QNVKLHSLTQ 250
LGDDSSKITG LVYVKNLSFE KYLEIKFTFN SWRDIHYVTA NFNRTINSNV 300
DEFKFTIDLN SLKYILLIKR IITMEKNTSS CPLNIELCCR YDVNNETYYD 350
NNNGKNYHLF MTTFKKGGET KEKIPVVVEP ASQTDAAMSP KEMKARFVSS 400
NPTLSRFLPQ SRKFSEDTDY YNTSPLKHLY HNDTTSWVKP KRLNVVLDKL 450
ENATPPPPSS ALANDTARTG KITKDKNNVL APPTASNSID LPILGSQHQS 500
LYSGSSSYSS SSSSISSSLS FASSNNSSTN SSSASCSFPL TELDNFDYAN 550
LYEPNDTFTT ANLFNHSLNS LMPEISTPSF FGGFRNENTI NNNDSKNLVT 600
SLEDSYEDKQ SVITDTTMDE NNKTSTINNS TDTLIKPSKE NGTVKENKSS 650
ANSTSAPSSS QNRASTILND HSNGKSDLKY VNYQSLLDSH CFYNHPSSPN 700
LQSTSFSSAA PFSGISQASD IFDYENEDSD SNQIAGEIDN NSFPPHFYLD 750
EDDKSACLSD DALIDHHRNT NPFINTFSSS PPILSQEVDR WRL 793
Length:793
Mass (Da):88,533
Last modified:November 1, 1997 - v2
Checksum:i1880E966A6480D80
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti228 – 2281S → SS in CAA45371. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X63941 Genomic DNA. Translation: CAA45371.1.
Z75086 Genomic DNA. Translation: CAA99387.1.
BK006948 Genomic DNA. Translation: DAA10950.1.
PIRiS67070.
RefSeqiNP_014821.3. NM_001183597.3.

Genome annotation databases

EnsemblFungiiYOR178C; YOR178C; YOR178C.
GeneIDi854350.
KEGGisce:YOR178C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X63941 Genomic DNA. Translation: CAA45371.1 .
Z75086 Genomic DNA. Translation: CAA99387.1 .
BK006948 Genomic DNA. Translation: DAA10950.1 .
PIRi S67070.
RefSeqi NP_014821.3. NM_001183597.3.

3D structure databases

ProteinModelPortali P28006.
SMRi P28006. Positions 258-365.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34573. 28 interactions.
DIPi DIP-2375N.
IntActi P28006. 9 interactions.
MINTi MINT-554233.
STRINGi 4932.YOR178C.

Protein family/group databases

CAZyi CBM21. Carbohydrate-Binding Module Family 21.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YOR178C ; YOR178C ; YOR178C .
GeneIDi 854350.
KEGGi sce:YOR178C.

Organism-specific databases

CYGDi YOR178c.
SGDi S000005704. GAC1.

Phylogenomic databases

eggNOGi NOG257148.
GeneTreei ENSGT00530000068231.
OrthoDBi EOG7G7M21.

Enzyme and pathway databases

BioCyci YEAST:G3O-33690-MONOMER.

Miscellaneous databases

NextBioi 976437.

Gene expression databases

Genevestigatori P28006.

Family and domain databases

InterProi IPR005036. CBM_21.
[Graphical view ]
Pfami PF03370. CBM_21. 1 hit.
[Graphical view ]
PROSITEi PS51159. CBM21. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "GAC1 may encode a regulatory subunit for protein phosphatase type 1 in Saccharomyces cerevisiae."
    Francois J.M., Thompson-Jaeger S., Skroch J., Zellenka U., Spevak W., Tatchell K.
    EMBO J. 11:87-96(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
    Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
    , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
    Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-415 AND SER-424, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGAC1_YEAST
AccessioniPrimary (citable) accession number: P28006
Secondary accession number(s): D6W2N4, Q08551
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

External Data

Dasty 3

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