P28006 (GAC1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein phosphatase 1 regulatory subunit GAC1

Gene names

Name:	GAC1
Ordered Locus Names:	YOR178C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	793 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Function	Regulates the activity of glycogen synthase. It is most probably a regulatory subunit for protein phosphatase type 1.
Sequence similarities	Contains 1 CBM21 (carbohydrate binding type-21) domain.

Ontologies

Keywords
Biological process	Glycogen biosynthesis
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glycogen biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW glycogen metabolic process Inferred from physical interaction PubMed 8289829. Source: SGD meiosis Inferred from physical interaction PubMed 8754819. Source: SGD mitotic spindle assembly checkpoint Inferred from mutant phenotype PubMed 10072380. Source: SGD negative regulation of transcription from RNA polymerase II promoter Traceable author statement PubMed 8846786. Source: SGD response to heat Inferred from physical interaction PubMed 10207049. Source: SGD
Cellular_component	protein phosphatase type 1 complex Inferred from direct assay PubMed 8289829. Source: SGD
Molecular_function	heat shock protein binding Inferred from direct assay PubMed 10207049. Source: SGD protein phosphatase type 1 regulator activity Traceable author statement PubMed 11412094. Source: SGD structural molecule activity Traceable author statement PubMed 11973298. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 793	793	Serine/threonine-protein phosphatase 1 regulatory subunit GAC1		PRO_0000071518
Regions
	Domain	235 – 360	126	CBM21
	Compositional bias	500 – 523	24	Ser-rich
Experimental info
	Sequence conflict	228	1	S → SS in CAA45371. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P28006 [UniParc]. Last modified November 1, 1997. Version 2. Checksum: 1880E966A6480D80	FASTA	793	88,533
	10 20 30 40 50 60 MVIQTATTLS PAKARPSFPH NDLIKSMSDS LISRPTHPPI RKLKSSLKIS HPEPISRSKS 70 80 90 100 110 120 EIFCTSPEKN VRFAIELTTV KRFDKNAEPS SISNENSPTL SPVDSNTAAD DVQLFNNEDC 130 140 150 160 170 180 WFNDSSLVTN LLKNEKKFRY MNSLNNMFKL DLYDSEDEDD IDEHINSQAE YGYTYNSLST 190 200 210 220 230 240 RGKTSENKSA TSSLATQATN ICDWKLHCTD LVPFKIAPPL FTKTLSASDL QGQLTKYLNG 250 260 270 280 290 300 QNVKLHSLTQ LGDDSSKITG LVYVKNLSFE KYLEIKFTFN SWRDIHYVTA NFNRTINSNV 310 320 330 340 350 360 DEFKFTIDLN SLKYILLIKR IITMEKNTSS CPLNIELCCR YDVNNETYYD NNNGKNYHLF 370 380 390 400 410 420 MTTFKKGGET KEKIPVVVEP ASQTDAAMSP KEMKARFVSS NPTLSRFLPQ SRKFSEDTDY 430 440 450 460 470 480 YNTSPLKHLY HNDTTSWVKP KRLNVVLDKL ENATPPPPSS ALANDTARTG KITKDKNNVL 490 500 510 520 530 540 APPTASNSID LPILGSQHQS LYSGSSSYSS SSSSISSSLS FASSNNSSTN SSSASCSFPL 550 560 570 580 590 600 TELDNFDYAN LYEPNDTFTT ANLFNHSLNS LMPEISTPSF FGGFRNENTI NNNDSKNLVT 610 620 630 640 650 660 SLEDSYEDKQ SVITDTTMDE NNKTSTINNS TDTLIKPSKE NGTVKENKSS ANSTSAPSSS 670 680 690 700 710 720 QNRASTILND HSNGKSDLKY VNYQSLLDSH CFYNHPSSPN LQSTSFSSAA PFSGISQASD 730 740 750 760 770 780 IFDYENEDSD SNQIAGEIDN NSFPPHFYLD EDDKSACLSD DALIDHHRNT NPFINTFSSS 790 PPILSQEVDR WRL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"GAC1 may encode a regulatory subunit for protein phosphatase type 1 in Saccharomyces cerevisiae." Francois J.M., Thompson-Jaeger S., Skroch J., Zellenka U., Spevak W., Tatchell K. EMBO J. 11:87-96(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XV." Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D. , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K. Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X63941 Genomic DNA. Translation: CAA45371.1. Z75086 Genomic DNA. Translation: CAA99387.1. BK006948 Genomic DNA. Translation: DAA10950.1.
PIR	S67070.
RefSeq	NP_014821.3. NM_001183597.3.
3D structure databases
ProteinModelPortal	P28006.
SMR	P28006. Positions 258-365.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-2375N.
IntAct	P28006. 9 interactions.
MINT	MINT-554233.
STRING	4932.YOR178C.
Protein family/group databases
CAZy	CBM21. Carbohydrate-Binding Module Family 21.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YOR178C; YOR178C; YOR178C.
GeneID	854350.
KEGG	sce:YOR178C. sce:YOR180C.
Organism-specific databases
CYGD	YOR178c.
SGD	S000005704. GAC1.
Phylogenomic databases
eggNOG	NOG257148.
GeneTree	ENSGT00530000068231.
OrthoDB	EOG4BK8DC.
Gene expression databases
Genevestigator	P28006.
GermOnline	YOR178C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR005036. CBM_21. [Graphical view]
Pfam	PF03370. CBM_21. 1 hit. [Graphical view]
PROSITE	PS51159. CBM21. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	976437.

Entry information

Entry name

GAC1_YEAST

Accession

Primary (citable) accession number: P28006
Secondary accession number(s): D6W2N4, Q08551

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 94 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program