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P28006

- GAC1_YEAST

UniProt

P28006 - GAC1_YEAST

Protein

Serine/threonine-protein phosphatase 1 regulatory subunit GAC1

Gene

GAC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Regulates the activity of glycogen synthase. It is most probably a regulatory subunit for protein phosphatase type 1.

    GO - Molecular functioni

    1. heat shock protein binding Source: SGD
    2. protein phosphatase type 1 regulator activity Source: SGD
    3. structural molecule activity Source: SGD

    GO - Biological processi

    1. glycogen biosynthetic process Source: UniProtKB-KW
    2. glycogen metabolic process Source: SGD
    3. meiotic nuclear division Source: SGD
    4. mitotic spindle assembly checkpoint Source: SGD
    5. negative regulation of transcription from RNA polymerase II promoter Source: SGD
    6. regulation of catalytic activity Source: GOC
    7. response to heat Source: SGD

    Keywords - Biological processi

    Glycogen biosynthesis

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33690-MONOMER.

    Protein family/group databases

    CAZyiCBM21. Carbohydrate-Binding Module Family 21.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase 1 regulatory subunit GAC1
    Gene namesi
    Name:GAC1
    Ordered Locus Names:YOR178C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XV

    Organism-specific databases

    CYGDiYOR178c.
    SGDiS000005704. GAC1.

    Subcellular locationi

    GO - Cellular componenti

    1. protein phosphatase type 1 complex Source: SGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 793793Serine/threonine-protein phosphatase 1 regulatory subunit GAC1PRO_0000071518Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei415 – 4151Phosphoserine1 Publication
    Modified residuei424 – 4241Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Expressioni

    Gene expression databases

    GenevestigatoriP28006.

    Interactioni

    Protein-protein interaction databases

    BioGridi34573. 28 interactions.
    DIPiDIP-2375N.
    IntActiP28006. 9 interactions.
    MINTiMINT-554233.
    STRINGi4932.YOR178C.

    Structurei

    3D structure databases

    ProteinModelPortaliP28006.
    SMRiP28006. Positions 258-365.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini235 – 360126CBM21PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi500 – 52324Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CBM21 (carbohydrate binding type-21) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG257148.
    GeneTreeiENSGT00530000068231.
    OrthoDBiEOG7G7M21.

    Family and domain databases

    InterProiIPR005036. CBM_21.
    [Graphical view]
    PfamiPF03370. CBM_21. 1 hit.
    [Graphical view]
    PROSITEiPS51159. CBM21. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P28006-1 [UniParc]FASTAAdd to Basket

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    MVIQTATTLS PAKARPSFPH NDLIKSMSDS LISRPTHPPI RKLKSSLKIS    50
    HPEPISRSKS EIFCTSPEKN VRFAIELTTV KRFDKNAEPS SISNENSPTL 100
    SPVDSNTAAD DVQLFNNEDC WFNDSSLVTN LLKNEKKFRY MNSLNNMFKL 150
    DLYDSEDEDD IDEHINSQAE YGYTYNSLST RGKTSENKSA TSSLATQATN 200
    ICDWKLHCTD LVPFKIAPPL FTKTLSASDL QGQLTKYLNG QNVKLHSLTQ 250
    LGDDSSKITG LVYVKNLSFE KYLEIKFTFN SWRDIHYVTA NFNRTINSNV 300
    DEFKFTIDLN SLKYILLIKR IITMEKNTSS CPLNIELCCR YDVNNETYYD 350
    NNNGKNYHLF MTTFKKGGET KEKIPVVVEP ASQTDAAMSP KEMKARFVSS 400
    NPTLSRFLPQ SRKFSEDTDY YNTSPLKHLY HNDTTSWVKP KRLNVVLDKL 450
    ENATPPPPSS ALANDTARTG KITKDKNNVL APPTASNSID LPILGSQHQS 500
    LYSGSSSYSS SSSSISSSLS FASSNNSSTN SSSASCSFPL TELDNFDYAN 550
    LYEPNDTFTT ANLFNHSLNS LMPEISTPSF FGGFRNENTI NNNDSKNLVT 600
    SLEDSYEDKQ SVITDTTMDE NNKTSTINNS TDTLIKPSKE NGTVKENKSS 650
    ANSTSAPSSS QNRASTILND HSNGKSDLKY VNYQSLLDSH CFYNHPSSPN 700
    LQSTSFSSAA PFSGISQASD IFDYENEDSD SNQIAGEIDN NSFPPHFYLD 750
    EDDKSACLSD DALIDHHRNT NPFINTFSSS PPILSQEVDR WRL 793
    Length:793
    Mass (Da):88,533
    Last modified:November 1, 1997 - v2
    Checksum:i1880E966A6480D80
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti228 – 2281S → SS in CAA45371. (PubMed:1310938)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X63941 Genomic DNA. Translation: CAA45371.1.
    Z75086 Genomic DNA. Translation: CAA99387.1.
    BK006948 Genomic DNA. Translation: DAA10950.1.
    PIRiS67070.
    RefSeqiNP_014821.3. NM_001183597.3.

    Genome annotation databases

    EnsemblFungiiYOR178C; YOR178C; YOR178C.
    GeneIDi854350.
    KEGGisce:YOR178C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X63941 Genomic DNA. Translation: CAA45371.1 .
    Z75086 Genomic DNA. Translation: CAA99387.1 .
    BK006948 Genomic DNA. Translation: DAA10950.1 .
    PIRi S67070.
    RefSeqi NP_014821.3. NM_001183597.3.

    3D structure databases

    ProteinModelPortali P28006.
    SMRi P28006. Positions 258-365.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34573. 28 interactions.
    DIPi DIP-2375N.
    IntActi P28006. 9 interactions.
    MINTi MINT-554233.
    STRINGi 4932.YOR178C.

    Protein family/group databases

    CAZyi CBM21. Carbohydrate-Binding Module Family 21.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YOR178C ; YOR178C ; YOR178C .
    GeneIDi 854350.
    KEGGi sce:YOR178C.

    Organism-specific databases

    CYGDi YOR178c.
    SGDi S000005704. GAC1.

    Phylogenomic databases

    eggNOGi NOG257148.
    GeneTreei ENSGT00530000068231.
    OrthoDBi EOG7G7M21.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-33690-MONOMER.

    Miscellaneous databases

    NextBioi 976437.

    Gene expression databases

    Genevestigatori P28006.

    Family and domain databases

    InterProi IPR005036. CBM_21.
    [Graphical view ]
    Pfami PF03370. CBM_21. 1 hit.
    [Graphical view ]
    PROSITEi PS51159. CBM21. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "GAC1 may encode a regulatory subunit for protein phosphatase type 1 in Saccharomyces cerevisiae."
      Francois J.M., Thompson-Jaeger S., Skroch J., Zellenka U., Spevak W., Tatchell K.
      EMBO J. 11:87-96(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
      Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
      , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
      Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-415 AND SER-424, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiGAC1_YEAST
    AccessioniPrimary (citable) accession number: P28006
    Secondary accession number(s): D6W2N4, Q08551
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XV
      Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

    External Data

    Dasty 3