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P28005 (POP5_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonucleases P/MRP protein subunit POP5

EC=3.1.26.5
Alternative name(s):
RNA-processing protein POP5
RNases P/MRP 19.6 kDa subunit
Gene names
Name:POP5
Ordered Locus Names:YAL033W
ORF Names:FUN53
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length173 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP, which cleaves pre-rRNA sequences. Ref.4

Catalytic activity

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

Subunit structure

Component of nuclear RNase P and RNase MRP complexes. RNase P consists of an RNA moiety and at least 9 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RPP1 and RPR2. RNase MRP complex consists of an RNA moiety and at least 10 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RMP1, RPP1 and SNM1, many of which are shared with the RNase P complex. Ref.4 Ref.7

Subcellular location

Cytoplasm. Nucleus Ref.5.

Miscellaneous

Present with 2230 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the eukaryotic/archaeal RNase P protein component 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 173173Ribonucleases P/MRP protein subunit POP5
PRO_0000140015

Sequences

Sequence LengthMass (Da)Tools
P28005 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: 918193631BD790DD

FASTA17319,574
        10         20         30         40         50         60 
MVRLKSRYIL FEIIFPPTDT NVEESVSKAD ILLSHHRASP ADVSIKSILQ EIRRSLSLNL 

        70         80         90        100        110        120 
GDYGSAKCNS LLQLKYFSNK TSTGIIRCHR EDCDLVIMAL MLMSKIGDVD GLIVNPVKVS 

       130        140        150        160        170 
GTIKKIEQFA MRRNSKILNI IKCSQSSHLS DNDFIINDFK KIGRENENEN EDD 

« Hide

References

« Hide 'large scale' references
[1]"Molecular analysis of Saccharomyces cerevisiae chromosome I. On the number of genes and the identification of essential genes using temperature-sensitive-lethal mutations."
Harris S.D., Cheng J., Pugh T.A., Pringle J.R.
J. Mol. Biol. 225:53-65(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The nucleotide sequence of chromosome I from Saccharomyces cerevisiae."
Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N., Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J., Storms R.K.
Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP."
Chamberlain J.R., Lee Y., Lane W.S., Engelke D.R.
Genes Dev. 12:1678-1690(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, IDENTIFICATION IN THE RNASE P COMPLEX BY MASS SPECTROMETRY.
[5]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[6]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]"Characterization and purification of Saccharomyces cerevisiae RNase MRP reveals a new unique protein component."
Salinas K., Wierzbicki S., Zhou L., Schmitt M.E.
J. Biol. Chem. 280:11352-11360(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE RNASE MRP COMPLEX BY MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X62577 Genomic DNA. Translation: CAA44457.1.
U12980 Genomic DNA. Translation: AAC04999.1.
BK006935 Genomic DNA. Translation: DAA06955.1.
PIRS23411.
RefSeqNP_009369.1. NM_001178178.1.

3D structure databases

ProteinModelPortalP28005.
SMRP28005. Positions 1-135.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31733. 20 interactions.
DIPDIP-3789N.
IntActP28005. 7 interactions.
MINTMINT-573609.
STRING4932.YAL033W.

Proteomic databases

MaxQBP28005.
PaxDbP28005.
PeptideAtlasP28005.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYAL033W; YAL033W; YAL033W.
GeneID851200.
KEGGsce:YAL033W.

Organism-specific databases

CYGDYAL033w.
SGDS000000031. POP5.

Phylogenomic databases

eggNOGCOG1369.
HOGENOMHOG000216538.
KOK03537.
OMAGTIKKCE.
OrthoDBEOG7M6DM5.

Enzyme and pathway databases

BioCycYEAST:YAL033W-MONOMER.

Gene expression databases

GenevestigatorP28005.

Family and domain databases

InterProIPR002759. RNase_P/MRP_subunit.
[Graphical view]
PfamPF01900. RNase_P_Rpp14. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio968055.

Entry information

Entry namePOP5_YEAST
AccessionPrimary (citable) accession number: P28005
Secondary accession number(s): D6VPI5
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: July 9, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome I

Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families