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P28005

- POP5_YEAST

UniProt

P28005 - POP5_YEAST

Protein

Ribonucleases P/MRP protein subunit POP5

Gene

POP5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Aug 1992)
      Previous versions | rss
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    Functioni

    Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP, which cleaves pre-rRNA sequences.1 Publication

    Catalytic activityi

    Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

    GO - Molecular functioni

    1. ribonuclease MRP activity Source: MGI
    2. ribonuclease P activity Source: UniProtKB-EC
    3. RNA binding Source: SGD

    GO - Biological processi

    1. intronic box C/D snoRNA processing Source: SGD
    2. mRNA cleavage Source: SGD
    3. RNA phosphodiester bond hydrolysis Source: GOC
    4. RNA phosphodiester bond hydrolysis, endonucleolytic Source: GOC
    5. rRNA processing Source: SGD
    6. tRNA processing Source: SGD

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    rRNA processing, tRNA processing

    Enzyme and pathway databases

    BioCyciYEAST:YAL033W-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonucleases P/MRP protein subunit POP5 (EC:3.1.26.5)
    Alternative name(s):
    RNA-processing protein POP5
    RNases P/MRP 19.6 kDa subunit
    Gene namesi
    Name:POP5
    Ordered Locus Names:YAL033W
    ORF Names:FUN53
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome I

    Organism-specific databases

    CYGDiYAL033w.
    SGDiS000000031. POP5.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleolar ribonuclease P complex Source: SGD
    3. ribonuclease MRP complex Source: SGD

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 173173Ribonucleases P/MRP protein subunit POP5PRO_0000140015Add
    BLAST

    Proteomic databases

    MaxQBiP28005.
    PaxDbiP28005.
    PeptideAtlasiP28005.

    Expressioni

    Gene expression databases

    GenevestigatoriP28005.

    Interactioni

    Subunit structurei

    Component of nuclear RNase P and RNase MRP complexes. RNase P consists of an RNA moiety and at least 9 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RPP1 and RPR2. RNase MRP complex consists of an RNA moiety and at least 10 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RMP1, RPP1 and SNM1, many of which are shared with the RNase P complex.2 Publications

    Protein-protein interaction databases

    BioGridi31733. 20 interactions.
    DIPiDIP-3789N.
    IntActiP28005. 7 interactions.
    MINTiMINT-573609.
    STRINGi4932.YAL033W.

    Structurei

    3D structure databases

    ProteinModelPortaliP28005.
    SMRiP28005. Positions 1-135.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1369.
    HOGENOMiHOG000216538.
    KOiK03537.
    OMAiGTIKKCE.
    OrthoDBiEOG7M6DM5.

    Family and domain databases

    InterProiIPR002759. RNase_P/MRP_subunit.
    [Graphical view]
    PfamiPF01900. RNase_P_Rpp14. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P28005-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVRLKSRYIL FEIIFPPTDT NVEESVSKAD ILLSHHRASP ADVSIKSILQ    50
    EIRRSLSLNL GDYGSAKCNS LLQLKYFSNK TSTGIIRCHR EDCDLVIMAL 100
    MLMSKIGDVD GLIVNPVKVS GTIKKIEQFA MRRNSKILNI IKCSQSSHLS 150
    DNDFIINDFK KIGRENENEN EDD 173
    Length:173
    Mass (Da):19,574
    Last modified:August 1, 1992 - v1
    Checksum:i918193631BD790DD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X62577 Genomic DNA. Translation: CAA44457.1.
    U12980 Genomic DNA. Translation: AAC04999.1.
    BK006935 Genomic DNA. Translation: DAA06955.1.
    PIRiS23411.
    RefSeqiNP_009369.1. NM_001178178.1.

    Genome annotation databases

    EnsemblFungiiYAL033W; YAL033W; YAL033W.
    GeneIDi851200.
    KEGGisce:YAL033W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X62577 Genomic DNA. Translation: CAA44457.1 .
    U12980 Genomic DNA. Translation: AAC04999.1 .
    BK006935 Genomic DNA. Translation: DAA06955.1 .
    PIRi S23411.
    RefSeqi NP_009369.1. NM_001178178.1.

    3D structure databases

    ProteinModelPortali P28005.
    SMRi P28005. Positions 1-135.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31733. 20 interactions.
    DIPi DIP-3789N.
    IntActi P28005. 7 interactions.
    MINTi MINT-573609.
    STRINGi 4932.YAL033W.

    Proteomic databases

    MaxQBi P28005.
    PaxDbi P28005.
    PeptideAtlasi P28005.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YAL033W ; YAL033W ; YAL033W .
    GeneIDi 851200.
    KEGGi sce:YAL033W.

    Organism-specific databases

    CYGDi YAL033w.
    SGDi S000000031. POP5.

    Phylogenomic databases

    eggNOGi COG1369.
    HOGENOMi HOG000216538.
    KOi K03537.
    OMAi GTIKKCE.
    OrthoDBi EOG7M6DM5.

    Enzyme and pathway databases

    BioCyci YEAST:YAL033W-MONOMER.

    Miscellaneous databases

    NextBioi 968055.

    Gene expression databases

    Genevestigatori P28005.

    Family and domain databases

    InterProi IPR002759. RNase_P/MRP_subunit.
    [Graphical view ]
    Pfami PF01900. RNase_P_Rpp14. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular analysis of Saccharomyces cerevisiae chromosome I. On the number of genes and the identification of essential genes using temperature-sensitive-lethal mutations."
      Harris S.D., Cheng J., Pugh T.A., Pringle J.R.
      J. Mol. Biol. 225:53-65(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP."
      Chamberlain J.R., Lee Y., Lane W.S., Engelke D.R.
      Genes Dev. 12:1678-1690(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION IN THE RNASE P COMPLEX BY MASS SPECTROMETRY.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    7. "Characterization and purification of Saccharomyces cerevisiae RNase MRP reveals a new unique protein component."
      Salinas K., Wierzbicki S., Zhou L., Schmitt M.E.
      J. Biol. Chem. 280:11352-11360(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE RNASE MRP COMPLEX BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiPOP5_YEAST
    AccessioniPrimary (citable) accession number: P28005
    Secondary accession number(s): D6VPI5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 2230 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome I
      Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

    External Data

    Dasty 3