P28003 (FUN19_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
SWIRM domain-containing protein FUN19

Gene names

Name:	FUN19
Ordered Locus Names:	YAL034C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	413 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Miscellaneous	FUN19 is a non-essential gene.
Sequence similarities	Contains 1 SWIRM domain.
Sequence caution	The sequence AAC04998.1 differs from that shown. Reason: Erroneous initiation. The sequence CAA44456.1 differs from that shown. Reason: Frameshift at position 416.

Ontologies

Keywords
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 413	413	SWIRM domain-containing protein FUN19		PRO_0000202417
Regions
	Domain	316 – 413	98	SWIRM
	Compositional bias	31 – 76	46	Asn-rich
Amino acid modifications
	Modified residue	5	1	Phosphoserine Ref.7
	Modified residue	82	1	Phosphoserine Ref.7
	Modified residue	94	1	Phosphoserine Ref.7
	Modified residue	116	1	Phosphoserine Ref.7
	Modified residue	122	1	Phosphothreonine Ref.7
	Modified residue	194	1	Phosphothreonine Ref.7
	Modified residue	207	1	Phosphoserine Ref.7
	Modified residue	211	1	Phosphoserine Ref.7
	Modified residue	258	1	Phosphothreonine Ref.6
Experimental info
	Sequence conflict	255	1	T → S in CAA44456. Ref.1
	Sequence conflict	369	1	L → S Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P28003 [UniParc]. Last modified May 16, 2006. Version 3. Checksum: B588358DBCF7A9AB	FASTA	413	47,068
	10 20 30 40 50 60 MGLYSPESEK SQLNMNYIGK DDSQSIFRRL NQNLKASNNN NDSNKNGLNM SDYSNNSPYG 70 80 90 100 110 120 RSYDVRINQN SQNNGNGCFS GSIDSLVDEH IIPSPPLSPK LESKISHNGS PRMASSVLVG 130 140 150 160 170 180 STPKGAVENV LFVKPVWPNG LSRKRYRYAT YGFLSQYKIF SNLAQPYSKN IINRYNNLAY 190 200 210 220 230 240 NARHKYSKYN DDMTPPPLPS SSSRLPSPLA SPNLNRQARY NMRKQALYNN NLGKFESDTE 250 260 270 280 290 300 WIPRKRKVYS PQRRTMTTSP HRAKKFSPSA STPHTNIASI EAIHDAPQYI PNVSWKKLPD 310 320 330 340 350 360 YSPPLSTLPT DSNKSLKIEW KGSPMDLSTD PLRNELHPAE LVLAQTLRLP CDLYLDSKRR 370 380 390 400 410 LFLEKVYRLK KGLPFRRTDA QKACRIDVNK ASRLFQAFEK VGWLQDSNFT KYL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular analysis of Saccharomyces cerevisiae chromosome I. On the number of genes and the identification of essential genes using temperature-sensitive-lethal mutations." Harris S.D., Cheng J., Pugh T.A., Pringle J.R. J. Mol. Biol. 225:53-65(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The nucleotide sequence of chromosome I from Saccharomyces cerevisiae." Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N., Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J., Storms R.K. Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	Vo D.T. Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[4]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[5]	"Sequencing and comparison of yeast species to identify genes and regulatory elements." Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S. Nature 423:241-254(2003) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION OF PROBABLE INITIATION SITE.
[6]	"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases." Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H. Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-258, MASS SPECTROMETRY.
[7]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-5; SER-82; SER-94; SER-116; THR-122; THR-194; SER-207 AND SER-211, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X62577 Genomic DNA. Translation: CAA44456.1. Frameshift. U12980 Genomic DNA. Translation: AAC04998.1. Different initiation. BK006935 Genomic DNA. Translation: DAA06954.1.
PIR	S23410.
RefSeq	NP_009368.2. NM_001180035.1.
3D structure databases
ProteinModelPortal	P28003.
SMR	P28003. Positions 320-406.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-6766N.
IntAct	P28003. 26 interactions.
MINT	MINT-617689.
STRING	4932.YAL034C.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YAL034C; YAL034C; YAL034C.
GeneID	851199.
KEGG	sce:YAL034C.
Organism-specific databases
CYGD	YAL034c.
SGD	S000002134. FUN19.
Phylogenomic databases
eggNOG	NOG77463.
GeneTree	ENSGT00530000068526.
HOGENOM	HOG000248211.
OrthoDB	EOG4FN7S8.
Gene expression databases
Genevestigator	P28003.
GermOnline	YAL034C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR009057. Homeodomain-like. IPR007526. SWIRM. [Graphical view]
Pfam	PF04433. SWIRM. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS50934. SWIRM. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	968052.

Entry information

Entry name

FUN19_YEAST

Accession

Primary (citable) accession number: P28003
Secondary accession number(s): D6VPI4

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	May 16, 2006
Last modified:	May 1, 2013
This is version 93 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program