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P28003

- FUN19_YEAST

UniProt

P28003 - FUN19_YEAST

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Protein

SWIRM domain-containing protein FUN19

Gene

FUN19

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. DNA binding Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-28891-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
SWIRM domain-containing protein FUN19
Gene namesi
Name:FUN19
Ordered Locus Names:YAL034C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome I

Organism-specific databases

CYGDiYAL034c.
SGDiS000002134. FUN19.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 413413SWIRM domain-containing protein FUN19PRO_0000202417Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei194 – 1941Phosphothreonine1 Publication
Modified residuei207 – 2071Phosphoserine2 Publications
Modified residuei211 – 2111Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP28003.

Expressioni

Gene expression databases

GenevestigatoriP28003.

Interactioni

Protein-protein interaction databases

BioGridi31732. 19 interactions.
DIPiDIP-6766N.
IntActiP28003. 26 interactions.
MINTiMINT-617689.
STRINGi4932.YAL034C.

Structurei

3D structure databases

ProteinModelPortaliP28003.
SMRiP28003. Positions 323-405.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini316 – 41398SWIRMPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi31 – 7646Asn-richAdd
BLAST

Sequence similaritiesi

Contains 1 SWIRM domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG77463.
GeneTreeiENSGT00530000068526.
HOGENOMiHOG000248211.
InParanoidiP28003.
OrthoDBiEOG7BCNNC.

Family and domain databases

InterProiIPR009057. Homeodomain-like.
IPR007526. SWIRM.
[Graphical view]
PfamiPF04433. SWIRM. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50934. SWIRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28003-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGLYSPESEK SQLNMNYIGK DDSQSIFRRL NQNLKASNNN NDSNKNGLNM
60 70 80 90 100
SDYSNNSPYG RSYDVRINQN SQNNGNGCFS GSIDSLVDEH IIPSPPLSPK
110 120 130 140 150
LESKISHNGS PRMASSVLVG STPKGAVENV LFVKPVWPNG LSRKRYRYAT
160 170 180 190 200
YGFLSQYKIF SNLAQPYSKN IINRYNNLAY NARHKYSKYN DDMTPPPLPS
210 220 230 240 250
SSSRLPSPLA SPNLNRQARY NMRKQALYNN NLGKFESDTE WIPRKRKVYS
260 270 280 290 300
PQRRTMTTSP HRAKKFSPSA STPHTNIASI EAIHDAPQYI PNVSWKKLPD
310 320 330 340 350
YSPPLSTLPT DSNKSLKIEW KGSPMDLSTD PLRNELHPAE LVLAQTLRLP
360 370 380 390 400
CDLYLDSKRR LFLEKVYRLK KGLPFRRTDA QKACRIDVNK ASRLFQAFEK
410
VGWLQDSNFT KYL
Length:413
Mass (Da):47,068
Last modified:May 16, 2006 - v3
Checksum:iB588358DBCF7A9AB
GO

Sequence cautioni

The sequence AAC04998.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAA44456.1 differs from that shown. Reason: Frameshift at position 416. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti255 – 2551T → S in CAA44456. (PubMed:1583694)Curated
Sequence conflicti369 – 3691L → S(PubMed:1583694)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62577 Genomic DNA. Translation: CAA44456.1. Frameshift.
U12980 Genomic DNA. Translation: AAC04998.1. Different initiation.
BK006935 Genomic DNA. Translation: DAA06954.1.
PIRiS23410.
RefSeqiNP_009368.2. NM_001180035.1.

Genome annotation databases

EnsemblFungiiYAL034C; YAL034C; YAL034C.
GeneIDi851199.
KEGGisce:YAL034C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62577 Genomic DNA. Translation: CAA44456.1 . Frameshift.
U12980 Genomic DNA. Translation: AAC04998.1 . Different initiation.
BK006935 Genomic DNA. Translation: DAA06954.1 .
PIRi S23410.
RefSeqi NP_009368.2. NM_001180035.1.

3D structure databases

ProteinModelPortali P28003.
SMRi P28003. Positions 323-405.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31732. 19 interactions.
DIPi DIP-6766N.
IntActi P28003. 26 interactions.
MINTi MINT-617689.
STRINGi 4932.YAL034C.

Proteomic databases

MaxQBi P28003.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YAL034C ; YAL034C ; YAL034C .
GeneIDi 851199.
KEGGi sce:YAL034C.

Organism-specific databases

CYGDi YAL034c.
SGDi S000002134. FUN19.

Phylogenomic databases

eggNOGi NOG77463.
GeneTreei ENSGT00530000068526.
HOGENOMi HOG000248211.
InParanoidi P28003.
OrthoDBi EOG7BCNNC.

Enzyme and pathway databases

BioCyci YEAST:G3O-28891-MONOMER.

Miscellaneous databases

NextBioi 968052.

Gene expression databases

Genevestigatori P28003.

Family and domain databases

InterProi IPR009057. Homeodomain-like.
IPR007526. SWIRM.
[Graphical view ]
Pfami PF04433. SWIRM. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS50934. SWIRM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular analysis of Saccharomyces cerevisiae chromosome I. On the number of genes and the identification of essential genes using temperature-sensitive-lethal mutations."
    Harris S.D., Cheng J., Pugh T.A., Pringle J.R.
    J. Mol. Biol. 225:53-65(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Vo D.T.
    Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. "Sequencing and comparison of yeast species to identify genes and regulatory elements."
    Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.
    Nature 423:241-254(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF PROBABLE INITIATION SITE.
  6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-194; SER-207 AND SER-211, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-207, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFUN19_YEAST
AccessioniPrimary (citable) accession number: P28003
Secondary accession number(s): D6VPI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: May 16, 2006
Last modified: October 29, 2014
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

FUN19 is a non-essential gene.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

External Data

Dasty 3