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Protein

SWIRM domain-containing protein FUN19

Gene

FUN19

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-28891-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
SWIRM domain-containing protein FUN19
Gene namesi
Name:FUN19
Ordered Locus Names:YAL034C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:YAL034C.
SGDiS000002134. FUN19.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002024171 – 413SWIRM domain-containing protein FUN19Add BLAST413

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei194PhosphothreonineCombined sources1
Modified residuei207PhosphoserineCombined sources1
Modified residuei211PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP28003.
PRIDEiP28003.
TopDownProteomicsiP28003.

PTM databases

iPTMnetiP28003.

Interactioni

Protein-protein interaction databases

BioGridi31732. 19 interactors.
DIPiDIP-6766N.
IntActiP28003. 26 interactors.
MINTiMINT-617689.

Structurei

3D structure databases

ProteinModelPortaliP28003.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini316 – 413SWIRMPROSITE-ProRule annotationAdd BLAST98

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi31 – 76Asn-richAdd BLAST46

Sequence similaritiesi

Contains 1 SWIRM domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00530000068526.
HOGENOMiHOG000248211.
InParanoidiP28003.
OMAiPQPEHAQ.
OrthoDBiEOG092C4WDC.

Family and domain databases

InterProiIPR009057. Homeodomain-like.
IPR007526. SWIRM.
[Graphical view]
PfamiPF04433. SWIRM. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50934. SWIRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28003-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLYSPESEK SQLNMNYIGK DDSQSIFRRL NQNLKASNNN NDSNKNGLNM
60 70 80 90 100
SDYSNNSPYG RSYDVRINQN SQNNGNGCFS GSIDSLVDEH IIPSPPLSPK
110 120 130 140 150
LESKISHNGS PRMASSVLVG STPKGAVENV LFVKPVWPNG LSRKRYRYAT
160 170 180 190 200
YGFLSQYKIF SNLAQPYSKN IINRYNNLAY NARHKYSKYN DDMTPPPLPS
210 220 230 240 250
SSSRLPSPLA SPNLNRQARY NMRKQALYNN NLGKFESDTE WIPRKRKVYS
260 270 280 290 300
PQRRTMTTSP HRAKKFSPSA STPHTNIASI EAIHDAPQYI PNVSWKKLPD
310 320 330 340 350
YSPPLSTLPT DSNKSLKIEW KGSPMDLSTD PLRNELHPAE LVLAQTLRLP
360 370 380 390 400
CDLYLDSKRR LFLEKVYRLK KGLPFRRTDA QKACRIDVNK ASRLFQAFEK
410
VGWLQDSNFT KYL
Length:413
Mass (Da):47,068
Last modified:May 16, 2006 - v3
Checksum:iB588358DBCF7A9AB
GO

Sequence cautioni

The sequence AAC04998 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA44456 differs from that shown. Reason: Frameshift at position 416.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti255T → S in CAA44456 (PubMed:1583694).Curated1
Sequence conflicti369L → S (PubMed:1583694).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62577 Genomic DNA. Translation: CAA44456.1. Frameshift.
U12980 Genomic DNA. Translation: AAC04998.1. Different initiation.
BK006935 Genomic DNA. Translation: DAA06954.1.
PIRiS23410.
RefSeqiNP_009368.2. NM_001180035.1.

Genome annotation databases

EnsemblFungiiYAL034C; YAL034C; YAL034C.
GeneIDi851199.
KEGGisce:YAL034C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62577 Genomic DNA. Translation: CAA44456.1. Frameshift.
U12980 Genomic DNA. Translation: AAC04998.1. Different initiation.
BK006935 Genomic DNA. Translation: DAA06954.1.
PIRiS23410.
RefSeqiNP_009368.2. NM_001180035.1.

3D structure databases

ProteinModelPortaliP28003.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31732. 19 interactors.
DIPiDIP-6766N.
IntActiP28003. 26 interactors.
MINTiMINT-617689.

PTM databases

iPTMnetiP28003.

Proteomic databases

MaxQBiP28003.
PRIDEiP28003.
TopDownProteomicsiP28003.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYAL034C; YAL034C; YAL034C.
GeneIDi851199.
KEGGisce:YAL034C.

Organism-specific databases

EuPathDBiFungiDB:YAL034C.
SGDiS000002134. FUN19.

Phylogenomic databases

GeneTreeiENSGT00530000068526.
HOGENOMiHOG000248211.
InParanoidiP28003.
OMAiPQPEHAQ.
OrthoDBiEOG092C4WDC.

Enzyme and pathway databases

BioCyciYEAST:G3O-28891-MONOMER.

Miscellaneous databases

PROiP28003.

Family and domain databases

InterProiIPR009057. Homeodomain-like.
IPR007526. SWIRM.
[Graphical view]
PfamiPF04433. SWIRM. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50934. SWIRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFUN19_YEAST
AccessioniPrimary (citable) accession number: P28003
Secondary accession number(s): D6VPI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: May 16, 2006
Last modified: November 2, 2016
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

FUN19 is a non-essential gene.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.