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P28003 (FUN19_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
SWIRM domain-containing protein FUN19
Gene names
Name:FUN19
Ordered Locus Names:YAL034C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length413 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Miscellaneous

FUN19 is a non-essential gene.

Sequence similarities

Contains 1 SWIRM domain.

Sequence caution

The sequence AAC04998.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAA44456.1 differs from that shown. Reason: Frameshift at position 416.

Ontologies

Keywords
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionDNA binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 413413SWIRM domain-containing protein FUN19
PRO_0000202417

Regions

Domain316 – 41398SWIRM
Compositional bias31 – 7646Asn-rich

Amino acid modifications

Modified residue1941Phosphothreonine Ref.6
Modified residue2071Phosphoserine Ref.6 Ref.7
Modified residue2111Phosphoserine Ref.6

Experimental info

Sequence conflict2551T → S in CAA44456. Ref.1
Sequence conflict3691L → S Ref.1

Sequences

Sequence LengthMass (Da)Tools
P28003 [UniParc].

Last modified May 16, 2006. Version 3.
Checksum: B588358DBCF7A9AB

FASTA41347,068
        10         20         30         40         50         60 
MGLYSPESEK SQLNMNYIGK DDSQSIFRRL NQNLKASNNN NDSNKNGLNM SDYSNNSPYG 

        70         80         90        100        110        120 
RSYDVRINQN SQNNGNGCFS GSIDSLVDEH IIPSPPLSPK LESKISHNGS PRMASSVLVG 

       130        140        150        160        170        180 
STPKGAVENV LFVKPVWPNG LSRKRYRYAT YGFLSQYKIF SNLAQPYSKN IINRYNNLAY 

       190        200        210        220        230        240 
NARHKYSKYN DDMTPPPLPS SSSRLPSPLA SPNLNRQARY NMRKQALYNN NLGKFESDTE 

       250        260        270        280        290        300 
WIPRKRKVYS PQRRTMTTSP HRAKKFSPSA STPHTNIASI EAIHDAPQYI PNVSWKKLPD 

       310        320        330        340        350        360 
YSPPLSTLPT DSNKSLKIEW KGSPMDLSTD PLRNELHPAE LVLAQTLRLP CDLYLDSKRR 

       370        380        390        400        410 
LFLEKVYRLK KGLPFRRTDA QKACRIDVNK ASRLFQAFEK VGWLQDSNFT KYL 

« Hide

References

« Hide 'large scale' references
[1]"Molecular analysis of Saccharomyces cerevisiae chromosome I. On the number of genes and the identification of essential genes using temperature-sensitive-lethal mutations."
Harris S.D., Cheng J., Pugh T.A., Pringle J.R.
J. Mol. Biol. 225:53-65(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The nucleotide sequence of chromosome I from Saccharomyces cerevisiae."
Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N., Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J., Storms R.K.
Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Vo D.T.
Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[4]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"Sequencing and comparison of yeast species to identify genes and regulatory elements."
Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.
Nature 423:241-254(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION OF PROBABLE INITIATION SITE.
[6]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-194; SER-207 AND SER-211, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-207, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X62577 Genomic DNA. Translation: CAA44456.1. Frameshift.
U12980 Genomic DNA. Translation: AAC04998.1. Different initiation.
BK006935 Genomic DNA. Translation: DAA06954.1.
PIRS23410.
RefSeqNP_009368.2. NM_001180035.1.

3D structure databases

ProteinModelPortalP28003.
SMRP28003. Positions 323-405.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31732. 18 interactions.
DIPDIP-6766N.
IntActP28003. 26 interactions.
MINTMINT-617689.
STRING4932.YAL034C.

Proteomic databases

MaxQBP28003.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYAL034C; YAL034C; YAL034C.
GeneID851199.
KEGGsce:YAL034C.

Organism-specific databases

CYGDYAL034c.
SGDS000002134. FUN19.

Phylogenomic databases

eggNOGNOG77463.
GeneTreeENSGT00530000068526.
HOGENOMHOG000248211.
OrthoDBEOG7BCNNC.

Enzyme and pathway databases

BioCycYEAST:G3O-28891-MONOMER.

Gene expression databases

GenevestigatorP28003.

Family and domain databases

InterProIPR009057. Homeodomain-like.
IPR007526. SWIRM.
[Graphical view]
PfamPF04433. SWIRM. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS50934. SWIRM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio968052.

Entry information

Entry nameFUN19_YEAST
AccessionPrimary (citable) accession number: P28003
Secondary accession number(s): D6VPI4
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: May 16, 2006
Last modified: May 14, 2014
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome I

Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families