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P28003

- FUN19_YEAST

UniProt

P28003 - FUN19_YEAST

Protein

SWIRM domain-containing protein FUN19

Gene

FUN19

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 3 (16 May 2006)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. DNA binding Source: InterPro

    Enzyme and pathway databases

    BioCyciYEAST:G3O-28891-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SWIRM domain-containing protein FUN19
    Gene namesi
    Name:FUN19
    Ordered Locus Names:YAL034C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome I

    Organism-specific databases

    CYGDiYAL034c.
    SGDiS000002134. FUN19.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 413413SWIRM domain-containing protein FUN19PRO_0000202417Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei194 – 1941Phosphothreonine1 Publication
    Modified residuei207 – 2071Phosphoserine2 Publications
    Modified residuei211 – 2111Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP28003.

    Expressioni

    Gene expression databases

    GenevestigatoriP28003.

    Interactioni

    Protein-protein interaction databases

    BioGridi31732. 18 interactions.
    DIPiDIP-6766N.
    IntActiP28003. 26 interactions.
    MINTiMINT-617689.
    STRINGi4932.YAL034C.

    Structurei

    3D structure databases

    ProteinModelPortaliP28003.
    SMRiP28003. Positions 323-405.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini316 – 41398SWIRMPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi31 – 7646Asn-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 SWIRM domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG77463.
    GeneTreeiENSGT00530000068526.
    HOGENOMiHOG000248211.
    OrthoDBiEOG7BCNNC.

    Family and domain databases

    InterProiIPR009057. Homeodomain-like.
    IPR007526. SWIRM.
    [Graphical view]
    PfamiPF04433. SWIRM. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS50934. SWIRM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P28003-1 [UniParc]FASTAAdd to Basket

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    MGLYSPESEK SQLNMNYIGK DDSQSIFRRL NQNLKASNNN NDSNKNGLNM    50
    SDYSNNSPYG RSYDVRINQN SQNNGNGCFS GSIDSLVDEH IIPSPPLSPK 100
    LESKISHNGS PRMASSVLVG STPKGAVENV LFVKPVWPNG LSRKRYRYAT 150
    YGFLSQYKIF SNLAQPYSKN IINRYNNLAY NARHKYSKYN DDMTPPPLPS 200
    SSSRLPSPLA SPNLNRQARY NMRKQALYNN NLGKFESDTE WIPRKRKVYS 250
    PQRRTMTTSP HRAKKFSPSA STPHTNIASI EAIHDAPQYI PNVSWKKLPD 300
    YSPPLSTLPT DSNKSLKIEW KGSPMDLSTD PLRNELHPAE LVLAQTLRLP 350
    CDLYLDSKRR LFLEKVYRLK KGLPFRRTDA QKACRIDVNK ASRLFQAFEK 400
    VGWLQDSNFT KYL 413
    Length:413
    Mass (Da):47,068
    Last modified:May 16, 2006 - v3
    Checksum:iB588358DBCF7A9AB
    GO

    Sequence cautioni

    The sequence CAA44456.1 differs from that shown. Reason: Frameshift at position 416.
    The sequence AAC04998.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti255 – 2551T → S in CAA44456. (PubMed:1583694)Curated
    Sequence conflicti369 – 3691L → S(PubMed:1583694)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X62577 Genomic DNA. Translation: CAA44456.1. Frameshift.
    U12980 Genomic DNA. Translation: AAC04998.1. Different initiation.
    BK006935 Genomic DNA. Translation: DAA06954.1.
    PIRiS23410.
    RefSeqiNP_009368.2. NM_001180035.1.

    Genome annotation databases

    EnsemblFungiiYAL034C; YAL034C; YAL034C.
    GeneIDi851199.
    KEGGisce:YAL034C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X62577 Genomic DNA. Translation: CAA44456.1 . Frameshift.
    U12980 Genomic DNA. Translation: AAC04998.1 . Different initiation.
    BK006935 Genomic DNA. Translation: DAA06954.1 .
    PIRi S23410.
    RefSeqi NP_009368.2. NM_001180035.1.

    3D structure databases

    ProteinModelPortali P28003.
    SMRi P28003. Positions 323-405.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31732. 18 interactions.
    DIPi DIP-6766N.
    IntActi P28003. 26 interactions.
    MINTi MINT-617689.
    STRINGi 4932.YAL034C.

    Proteomic databases

    MaxQBi P28003.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YAL034C ; YAL034C ; YAL034C .
    GeneIDi 851199.
    KEGGi sce:YAL034C.

    Organism-specific databases

    CYGDi YAL034c.
    SGDi S000002134. FUN19.

    Phylogenomic databases

    eggNOGi NOG77463.
    GeneTreei ENSGT00530000068526.
    HOGENOMi HOG000248211.
    OrthoDBi EOG7BCNNC.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-28891-MONOMER.

    Miscellaneous databases

    NextBioi 968052.

    Gene expression databases

    Genevestigatori P28003.

    Family and domain databases

    InterProi IPR009057. Homeodomain-like.
    IPR007526. SWIRM.
    [Graphical view ]
    Pfami PF04433. SWIRM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS50934. SWIRM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular analysis of Saccharomyces cerevisiae chromosome I. On the number of genes and the identification of essential genes using temperature-sensitive-lethal mutations."
      Harris S.D., Cheng J., Pugh T.A., Pringle J.R.
      J. Mol. Biol. 225:53-65(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Vo D.T.
      Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. "Sequencing and comparison of yeast species to identify genes and regulatory elements."
      Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.
      Nature 423:241-254(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION OF PROBABLE INITIATION SITE.
    6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-194; SER-207 AND SER-211, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-207, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiFUN19_YEAST
    AccessioniPrimary (citable) accession number: P28003
    Secondary accession number(s): D6VPI4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 102 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    FUN19 is a non-essential gene.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome I
      Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

    External Data

    Dasty 3