P27964 (VL1_HPVME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Major capsid protein L1

Gene names

Name:

L1

Organism

Human papillomavirus type ME180

Taxonomic identifier

10602 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Papillomaviridae › unclassified Papillomaviridae › Human papillomavirus types

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	505 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Forms an icosahedral capsid with a T=7 symmetry and about 55 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. The capsid encapsulates the genomic DNA, but does not bind DNA. Essential for the initial attachment to the host cell By similarity.
Subunit structure	Self-assembles into homopentamers. The capsid has an icosahedral symmetry and consists of 72 capsomers, with each capsomer being a pentamer of L1. Interacts with the minor capsid protein L2; this interaction is necessary for viral genome encapsidation By similarity.
Subcellular location	Virion Potential.
Sequence similarities	Belongs to the papillomaviridae L1 protein family.

Ontologies

Keywords
Biological process	Host-virus interaction Viral attachment to host cell Virus entry into host cell
Cellular component	Virion
Developmental stage	Late protein
Molecular function	Capsid protein T=7 icosahedral capsid protein
Gene Ontology (GO)
Biological_process	viral attachment to host cell Inferred from electronic annotation. Source: UniProtKB-KW viral entry into host cell Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	T=7 icosahedral viral capsid Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 505	505	Major capsid protein L1		PRO_0000133482

Sequences

	Sequence		Length	Mass (Da)
	P27964 [UniParc]. Last modified August 1, 1992. Version 1. Checksum: 595DE493B708207B	FASTA	505	56,805
	10 20 30 40 50 60 MALWRSSDNM VYLPPPSVAK VVNTDDYVTR TGIYYYAGTS RLLTVGHPYF KVPMSGGRKQ 70 80 90 100 110 120 DIPKVSAYQY RVFRISLPDP NKFSLPESTL YNPDTQRLVW ACVGVEIGRG QPLGVGLSGH 130 140 150 160 170 180 PLYNRLDDTE NSPFSSNKNP KDSRDNVSVD YKQTQLCIIG CVPAIGEHWA KGKSCKPSNV 190 200 210 220 230 240 QPGDCPPLEL VNTPIQDGDM IDTGYGAMDF STLQETKSEV PLDICQSVCK YPDYLQMSAD 250 260 270 280 290 300 VYGDSMFFCL RREQLFARHF WNRGGMVGDT IPTELYIKGT DIRDSPSSYV YAPSPSGSMV 310 320 330 340 350 360 SSDSQLFNKP YWLHKAQGHN NGICWHNQLF LTVVDTTRST NFTLSTTTES AVPNIYDPNK 370 380 390 400 410 420 FKEYIRHVEE YDLQFIFQLC TITLSTDVMS YIHTMNPAIL DDWNFGVAPP PSASLVDTYR 430 440 450 460 470 480 YLQSAAITCQ KDAPAPTKKD PYDGLNFWNV NLKEKFSSEL DQFPLGRKFL LQAGVRRRPT 490 500 IGPRKRPATA TTASTSKHKR KRVSK

References

[1]	"Characterization of a novel human papillomavirus DNA in the cervical carcinoma cell line ME180." Reuter S., Delius H., Kahn T., Hofmann B., zur Hausen H., Schwarz E. J. Virol. 65:5564-5568(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M73258 Genomic DNA. Translation: AAF14010.1.
PIR	P1WLPR. B40509.
3D structure databases
ProteinModelPortal	P27964.
SMR	P27964. Positions 21-475.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	2.60.175.20. 1 hit.
InterPro	IPR002210. Capsid_L1_Papillomavir. IPR011222. dsDNA_vir_gr_I_capsid. [Graphical view]
Pfam	PF00500. Late_protein_L1. 1 hit. [Graphical view]
PRINTS	PR00865. HPVCAPSIDL1.
SUPFAM	SSF88648. dsDNA_vir_gr_I_capsid. 1 hit.
ProtoNet	Search...

Entry information

Entry name

VL1_HPVME

Accession

Primary (citable) accession number: P27964

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	April 3, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program